BR9608542A - Composição para a liberação sustentada de hormónio do crescimento humano - Google Patents
Composição para a liberação sustentada de hormónio do crescimento humanoInfo
- Publication number
- BR9608542A BR9608542A BR9608542-8A BR9608542A BR9608542A BR 9608542 A BR9608542 A BR 9608542A BR 9608542 A BR9608542 A BR 9608542A BR 9608542 A BR9608542 A BR 9608542A
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- sustained release
- biologically active
- hgh
- polymer
- Prior art date
Links
- 102000002265 Human Growth Hormone Human genes 0.000 title abstract 10
- 108010000521 Human Growth Hormone Proteins 0.000 title abstract 10
- 239000000854 Human Growth Hormone Substances 0.000 title abstract 10
- 239000000203 mixture Substances 0.000 title abstract 10
- 238000013268 sustained release Methods 0.000 title abstract 8
- 239000012730 sustained-release form Substances 0.000 title abstract 8
- 238000000034 method Methods 0.000 abstract 6
- 239000002245 particle Substances 0.000 abstract 4
- 229920000642 polymer Polymers 0.000 abstract 4
- 229920000249 biocompatible polymer Polymers 0.000 abstract 3
- 230000036765 blood level Effects 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 230000002459 sustained effect Effects 0.000 abstract 2
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Medical Informatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
"COMPOSIçãO PARA A LIBERAçãO SUSTENTADA DE HORMÈNIO DO CRESCIMENTO HUMANO", compreendendo uma composição e métodos para formar e utilizar essa composição, para a liberação sustentada de hormónio do crescimento humano (hGH) estabilizado, biologicamente ativo. A composição de liberação sustentada desta invenção compreende uma matriz polimérica de um polímero biocompatível e partículas de hGH estabilizado, biologicamente ativo, onde essas partículas são dispersas dentro do polímero biocompatível. O método da invenção para produzir uma composição para liberação sustentada de hGH biologicamente ativo inclui a dissolução de um polímero biocompatível em um solvente de polímero para formar uma solução de polímero, dispersando as partículas de hGH de metal estabilizado por cátion, biologicamente ativo na solução de polímero, e a seguir solidificando o polímero para formar uma matriz polimérica contendo uma dispersão dessas partículas de hGH. O método para utilizar a composição da invenção é o método de fornecer um nível sang³íneo terapeuticamente eficaz de hGH não agregado, biologicamente ativo em um sujeito por um período sustentado. Neste método, um sujeito recebe uma dose eficaz da composição de liberação sustentada da presente invenção. O método de utilização da composição de liberação sustentada da presente invenção compreende o fornecimento de um nível sang³íneo terapeuticamente eficaz de hormónio do crescimento humano não agregado, biologicamente ativo em um sujeito por um período sustentado, administrando ao sujeito uma dose da dita composição de liberação sustentada.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/473,544 US5654010A (en) | 1992-12-02 | 1995-06-07 | Composition for sustained release of human growth hormone |
| US08/477,725 US5667808A (en) | 1992-12-02 | 1995-06-07 | Composition for sustained release of human growth hormone |
| PCT/US1996/008086 WO1996040072A2 (en) | 1995-06-07 | 1996-06-03 | Composition for sustained release of human growth hormone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9608542A true BR9608542A (pt) | 1999-11-30 |
Family
ID=27044171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9608542-8A BR9608542A (pt) | 1995-06-07 | 1996-06-03 | Composição para a liberação sustentada de hormónio do crescimento humano |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0831787B1 (pt) |
| JP (1) | JPH11506740A (pt) |
| CN (1) | CN1102854C (pt) |
| AT (1) | ATE204468T1 (pt) |
| AU (1) | AU708756B2 (pt) |
| BR (1) | BR9608542A (pt) |
| CA (1) | CA2223436A1 (pt) |
| CZ (1) | CZ288147B6 (pt) |
| DE (1) | DE69614685T2 (pt) |
| DK (1) | DK0831787T3 (pt) |
| ES (1) | ES2161366T3 (pt) |
| HK (1) | HK1009089A1 (pt) |
| HU (1) | HUP9900870A3 (pt) |
| IL (1) | IL122385A (pt) |
| MX (1) | MX9709698A (pt) |
| NO (1) | NO316104B1 (pt) |
| NZ (1) | NZ310644A (pt) |
| PL (1) | PL184531B1 (pt) |
| PT (1) | PT831787E (pt) |
| RU (1) | RU2161502C2 (pt) |
| SK (1) | SK281571B6 (pt) |
| WO (1) | WO1996040072A2 (pt) |
Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2224381A1 (en) * | 1995-06-27 | 1997-01-16 | Takeda Chemical Industries, Ltd. | Method of producing sustained-release preparation |
| KR20000057693A (ko) | 1996-12-20 | 2000-09-25 | 다케다 야쿠힌 고교 가부시키가이샤 | 지효성 제제의 제조 방법 |
| WO1999060127A2 (en) | 1998-05-15 | 1999-11-25 | Genentech, Inc. | Il-17 homologous polypeptides and therapeutic uses thereof |
| AR012448A1 (es) * | 1997-04-18 | 2000-10-18 | Ipsen Pharma Biotech | Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada |
| US6306826B1 (en) | 1997-06-04 | 2001-10-23 | The Regents Of The University Of California | Treatment of heart failure with growth hormone |
| US6113947A (en) * | 1997-06-13 | 2000-09-05 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
| US6663899B2 (en) | 1997-06-13 | 2003-12-16 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
| US6191107B1 (en) | 1997-09-26 | 2001-02-20 | Takeda Chemical Industries, Ltd. | Complex of human growth hormone and zinc |
| EP2050762A3 (en) | 1998-03-10 | 2009-07-08 | Genentech, Inc. | Human cornichon-like protein and nucleic acids encoding it |
| EP3112468A1 (en) | 1998-05-15 | 2017-01-04 | Genentech, Inc. | Il-17 homologous polypeptides and therapeutic uses thereof |
| US20020172678A1 (en) | 2000-06-23 | 2002-11-21 | Napoleone Ferrara | EG-VEGF nucleic acids and polypeptides and methods of use |
| EP1953173B1 (en) | 1999-06-15 | 2009-11-18 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids endoding the same |
| EP1690872A3 (en) | 1999-12-01 | 2006-08-23 | Genentech, Inc. | Composition and methods for the diagnosis of tumours |
| EP1897944B1 (en) | 1999-12-23 | 2011-08-10 | Genentech, Inc. | IL-17 homologous polypeptides and therapeutic uses thereof |
| ES2323220T3 (es) | 2000-01-13 | 2009-07-09 | Genentech, Inc. | Polipeptidos humanos stra6. |
| US6740520B2 (en) | 2000-03-21 | 2004-05-25 | Genentech, Inc. | Cytokine receptor and nucleic acids encoding the same |
| DE60120372T2 (de) | 2000-03-24 | 2007-07-05 | Genentech Inc., San Francisco | Verwendung von insulin zur behandlung von knorpelkrankheiten |
| US6998137B2 (en) * | 2000-04-07 | 2006-02-14 | Macromed, Inc. | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix |
| AU6531101A (en) | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| DE60136281D1 (de) | 2000-08-24 | 2008-12-04 | Genentech Inc | Methode zur inhibierung von il-22 induziertem pap1 |
| EP1944317A3 (en) | 2000-09-01 | 2008-09-17 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| US6673580B2 (en) | 2000-10-27 | 2004-01-06 | Genentech, Inc. | Identification and modification of immunodominant epitopes in polypeptides |
| EP1356809A4 (en) | 2000-12-28 | 2008-05-14 | Takeda Pharmaceutical | SUSTAINED RELEASE PREPARATIONS |
| US7271150B2 (en) | 2001-05-14 | 2007-09-18 | United States Of America, Represented By The Secretary, Department Of Health And Human Services | Modified growth hormone |
| US20070160576A1 (en) | 2001-06-05 | 2007-07-12 | Genentech, Inc. | IL-17A/F heterologous polypeptides and therapeutic uses thereof |
| ES2554106T3 (es) | 2001-06-21 | 2015-12-16 | Genentech, Inc. | Formulación de liberación sostenida |
| WO2003072740A2 (en) | 2002-02-25 | 2003-09-04 | Genentech, Inc. | Novel type-1 cytokine receptor glm-r |
| PT1610820E (pt) | 2003-04-04 | 2010-12-16 | Novartis Ag | Formulações de elevada concentração de anticorpos e proteínas |
| KR20110117728A (ko) | 2003-06-06 | 2011-10-27 | 제넨테크, 인크. | Ｈｇｆ 베타 쇄와 ｃ-ｍｅｔ 사이의 상호작용의 변조 |
| MX341074B (es) | 2003-07-08 | 2016-08-05 | Genentech Inc | Polipeptidos heterologos il-17 a/f y usos terapeuticos de los mismos. |
| AU2004298483A1 (en) | 2003-12-11 | 2005-06-30 | Genentech, Inc. | Methods and compositions for inhibiting c-met dimerization and activation |
| US7481997B1 (en) | 2004-02-12 | 2009-01-27 | Montana State University | Snow mountain virus genome sequence, virus-like particles and methods of use |
| PL1745069T3 (pl) | 2004-03-30 | 2009-10-30 | Nsgene As | Zastosowanie terapeutyczne czynnika wzrostu NSG33 |
| KR101150242B1 (ko) | 2004-10-27 | 2012-06-13 | 유니버시티 오브 덴버 | 부신피질 자극 호르몬 유사체 및 관련 방법 |
| CA2590136A1 (en) | 2004-12-10 | 2006-06-15 | Talima Therapeutics, Inc. | Compositions and methods for treating conditions of the nail unit |
| US20060275230A1 (en) | 2004-12-10 | 2006-12-07 | Frank Kochinke | Compositions and methods for treating conditions of the nail unit |
| NZ563341A (en) | 2005-06-06 | 2009-10-30 | Genentech Inc | Methods for identifying agents that modulate a gene that encodes for a PRO1568 polypeptide |
| US8389469B2 (en) | 2005-06-06 | 2013-03-05 | The Rockefeller University | Bacteriophage lysins for Bacillus anthracis |
| HUE029021T2 (en) | 2005-06-21 | 2017-02-28 | Xoma (Us) Llc | IL-1beta-binding antibodies and fragments thereof |
| US7582291B2 (en) | 2005-06-30 | 2009-09-01 | The Rockefeller University | Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria |
| CA2619577A1 (en) | 2005-08-15 | 2007-02-22 | Genentech, Inc. | Gene disruptions, compositions and methods relating thereto |
| WO2007024628A2 (en) | 2005-08-24 | 2007-03-01 | The Rockefeller University | Ply-gbs mutant lysins |
| JP2009516514A (ja) | 2005-11-21 | 2009-04-23 | ジェネンテック・インコーポレーテッド | 新規遺伝子破壊、それらに関する組成物および方法 |
| US20080032343A1 (en) | 2005-12-22 | 2008-02-07 | Genentech, Inc. | Recombinant Production of Heparin Binding Proteins |
| ZA200807714B (en) | 2006-02-17 | 2010-01-27 | Genentech Inc | Gene disruptions, compositions and methods relating thereto |
| CA2647107A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Anti-tumor cell antigen antibody therapeutics |
| AU2007238186B2 (en) | 2006-04-10 | 2014-01-09 | Genentech, Inc. | Disheveled PDZ modulators |
| CA2649387A1 (en) | 2006-04-19 | 2008-03-27 | Genentech, Inc. | Novel gene disruptions, compositions and methods relating thereto |
| PT2059260E (pt) * | 2006-08-31 | 2013-09-03 | Novartis Ag | Composições farmacêuticas compreendendo hgh para distribuição oral |
| CA2673592C (en) | 2006-12-20 | 2014-03-25 | Xoma Technology Ltd. | Methods for the treatment of il-1.beta. related diseases |
| CN101361968B (zh) | 2007-08-06 | 2011-08-03 | 健能隆医药技术（上海）有限公司 | 白介素-22在治疗脂肪肝中的应用 |
| AU2008287340A1 (en) * | 2007-08-15 | 2009-02-19 | Amunix, Inc. | Compositions and methods for modifying properties of biologically active polypeptides |
| DK2391650T3 (en) | 2007-12-20 | 2015-01-12 | Xoma Us Llc | Methods of treating gout |
| GB0812742D0 (en) | 2008-07-11 | 2008-08-20 | Critical Pharmaceuticals Ltd | Process |
| EP2488643A4 (en) | 2009-10-15 | 2013-07-03 | Hoffmann La Roche | CHIMERIC FIBROBLAST GROWTH FACTORS WITH CHANGED RECEPTOR SPECIFICITY |
| WO2011056561A1 (en) | 2009-10-27 | 2011-05-12 | Beth Israel Deaconess Medical Center | Methods and compositions for the generation and use of conformation-specific antibodies |
| JP5878477B2 (ja) | 2010-01-15 | 2016-03-08 | ユニバーシティ オブ メディスン アンド デンティストリー オブ ニュー ジャージー | 骨の治癒を加速するためのバナジウム化合物の使用 |
| EP3513810A1 (en) | 2010-03-22 | 2019-07-24 | F. Hoffmann-La Roche AG | Compositions and methods useful for stabilizing protein- containing formulations |
| BR112012027828A2 (pt) | 2010-05-03 | 2016-08-09 | Genentech Inc | composição de matéria, artigo de fabricação e método de redução da viscosidade de uma formulação contendo proteína e de preparação de uma formulação aquosa contendo proteína |
| MX339666B (es) | 2010-06-24 | 2016-06-03 | Genentech Inc * | Composiciones y metodos para estabilizar formulaciones que contienen proteinas. |
| CN102380091A (zh) | 2010-08-31 | 2012-03-21 | 健能隆医药技术（上海）有限公司 | 白介素-22在治疗病毒性肝炎中的应用 |
| ES2584068T3 (es) | 2010-10-01 | 2016-09-23 | Nsgene A/S | Uso de meteorina para el tratamiento de alodinia, hiperalgesia, dolor espontáneo y dolor fantasma |
| KR101687060B1 (ko) | 2010-10-08 | 2016-12-15 | 상하이 켁신 바이오테크 씨오., 엘티디. | 모에신 조절제 및 그의 용도 |
| US9345765B2 (en) | 2010-10-08 | 2016-05-24 | Shanghai Kexin Biotech Co., Ltd. | Diagnostic and therapeutic uses of moesin fragments |
| WO2012092539A2 (en) | 2010-12-31 | 2012-07-05 | Takeda Pharmaceutical Company Limited | Antibodies to dll4 and uses thereof |
| US10487114B2 (en) | 2011-04-27 | 2019-11-26 | Beth Israel Deaconess Medical Center, Inc. | Methods for administering peptides for the generation of effective c/s conformation-specific antibodies to a human subject in need thereof |
| CN102875683B (zh) * | 2011-07-11 | 2014-06-11 | 旭华（上海）生物研发中心有限公司 | 长效重组人生长激素的Fc融合蛋白 |
| MX363226B (es) | 2011-10-31 | 2019-03-15 | Genentech Inc | Formulaciones de anticuerpos. |
| JP6320300B2 (ja) | 2011-12-19 | 2018-05-09 | ゾーマ （ユーエス） リミテッド ライアビリティ カンパニー | 座瘡を治療するための方法 |
| AU2013208007A1 (en) | 2012-01-09 | 2014-07-31 | The Scripps Research Institute | Humanized antibodies with ultralong CDR3 |
| CA2863224A1 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
| CA2904703A1 (en) | 2013-03-14 | 2014-10-02 | Hallux, Inc. | Method of treating infections, diseases or disorders of nail unit |
| CN105283196B (zh) | 2013-03-15 | 2018-10-12 | 贝丝以色列女执事医疗中心 | 用于产生和使用构象-特异性抗体的方法和组合物 |
| EP3022224A2 (en) | 2013-07-18 | 2016-05-25 | Fabrus, Inc. | Antibodies with ultralong complementarity determining regions |
| CN105814074B (zh) | 2013-07-18 | 2020-04-21 | 图鲁斯生物科学有限责任公司 | 具有超长互补决定区的人源化抗体 |
| KR102302634B1 (ko) | 2013-09-13 | 2021-09-14 | 더 스크립스 리서치 인스티튜트 | 변형된 치료제 및 이의 조성물 |
| CN105829349B (zh) | 2013-10-15 | 2023-02-03 | 斯克利普斯研究所 | 肽嵌合抗原受体t细胞开关和其用途 |
| WO2015057852A1 (en) | 2013-10-15 | 2015-04-23 | The California Institute For Biomedical Research | Chimeric antigen receptor t cell switches and uses thereof |
| CN104623637A (zh) | 2013-11-07 | 2015-05-20 | 健能隆医药技术（上海）有限公司 | Il-22二聚体在制备静脉注射药物中的应用 |
| CN104623639A (zh) | 2013-11-07 | 2015-05-20 | 健能隆医药技术（上海）有限公司 | 白介素22二聚体在制备治疗胰腺炎药物中的应用 |
| JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
| AU2014364589B2 (en) | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| NL2014230B1 (en) | 2015-02-04 | 2016-10-12 | Stichting Vu-Vumc | Wound healing formulation. |
| MA41629A (fr) | 2015-03-04 | 2018-01-09 | Center For Human Reproduction | Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité |
| US10800828B2 (en) | 2015-03-26 | 2020-10-13 | The Scripps Research Institute | Switchable non-scFv chimeric receptors, switches, and methods of use thereof to treat cancer |
| US11091546B2 (en) | 2015-04-15 | 2021-08-17 | The Scripps Research Institute | Optimized PNE-based chimeric receptor T cell switches and uses thereof |
| CN107921098A (zh) | 2015-06-17 | 2018-04-17 | 加州生物医学研究所 | 修饰的治疗剂及其组合物 |
| WO2017181143A1 (en) | 2016-04-15 | 2017-10-19 | Generon (Shanghai) Corporation, Ltd. | Use of il-22 in treating necrotizing enterocolitis |
| EP3529268A1 (en) | 2016-10-19 | 2019-08-28 | The Scripps Research Institute | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof |
| AU2020254582A1 (en) | 2019-04-01 | 2021-09-30 | Genentech, Inc. | Compositions and methods for stabilizing protein-containing formulations |
| US12098212B2 (en) | 2019-08-12 | 2024-09-24 | Purinomia Biotech, Inc. | Methods and compositions for promoting and potentiating T-cell mediated immune responses through ADCC targeting of CD39 expressing cells |
| JP2022554187A (ja) | 2019-10-24 | 2022-12-28 | ミノトール セラピューティクス インコーポレイテッド | キメラサイトカイン改変抗体およびその使用方法 |
| EP4329887A1 (en) | 2021-04-28 | 2024-03-06 | Minotaur Therapeutics, Inc. | Humanized chimeric bovine antibodies and methods of use |
| JP2024518433A (ja) | 2021-05-06 | 2024-05-01 | ホバ セラピューティクス エーピーエス | 化学療法誘発性神経障害性疼痛の予防及び治療 |
| CA3239550A1 (en) | 2021-12-10 | 2023-06-15 | Kenneth Petersen | Treatment of nociceptive pain |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656297A (en) * | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| JPH08503950A (ja) * | 1992-12-02 | 1996-04-30 | アルカーメス・コントロールド・セラピユーテイクス・インコーポレーテツド | 徐放性成長ホルモン含有マイクロスフェア |
| PT779806E (pt) * | 1994-09-09 | 2001-02-28 | Takeda Chemical Industries Ltd | Preparacao de libertacao sustentada contendo um sal metalico de um peptido |
-
1996
- 1996-06-03 PT PT96919016T patent/PT831787E/pt unknown
- 1996-06-03 EP EP96919016A patent/EP0831787B1/en not_active Expired - Lifetime
- 1996-06-03 IL IL12238596A patent/IL122385A/xx not_active IP Right Cessation
- 1996-06-03 CA CA002223436A patent/CA2223436A1/en not_active Abandoned
- 1996-06-03 JP JP9500870A patent/JPH11506740A/ja active Pending
- 1996-06-03 CN CN96194614A patent/CN1102854C/zh not_active Expired - Fee Related
- 1996-06-03 ES ES96919016T patent/ES2161366T3/es not_active Expired - Lifetime
- 1996-06-03 HU HU9900870A patent/HUP9900870A3/hu unknown
- 1996-06-03 BR BR9608542-8A patent/BR9608542A/pt not_active Application Discontinuation
- 1996-06-03 NZ NZ310644A patent/NZ310644A/xx unknown
- 1996-06-03 SK SK1671-97A patent/SK281571B6/sk unknown
- 1996-06-03 CZ CZ19973907A patent/CZ288147B6/cs not_active IP Right Cessation
- 1996-06-03 DK DK96919016T patent/DK0831787T3/da active
- 1996-06-03 RU RU97119935/14A patent/RU2161502C2/ru not_active IP Right Cessation
- 1996-06-03 PL PL96323832A patent/PL184531B1/pl not_active IP Right Cessation
- 1996-06-03 AT AT96919016T patent/ATE204468T1/de not_active IP Right Cessation
- 1996-06-03 WO PCT/US1996/008086 patent/WO1996040072A2/en not_active Application Discontinuation
- 1996-06-03 DE DE69614685T patent/DE69614685T2/de not_active Expired - Fee Related
- 1996-06-03 AU AU61469/96A patent/AU708756B2/en not_active Ceased
-
1997
- 1997-12-05 NO NO19975708A patent/NO316104B1/no unknown
- 1997-12-05 MX MX9709698A patent/MX9709698A/es not_active IP Right Cessation
-
1998
- 1998-08-19 HK HK98110029A patent/HK1009089A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE204468T1 (de) | 2001-09-15 |
| JPH11506740A (ja) | 1999-06-15 |
| PL184531B1 (pl) | 2002-11-29 |
| NO316104B1 (no) | 2003-12-15 |
| NO975708D0 (no) | 1997-12-05 |
| CN1102854C (zh) | 2003-03-12 |
| RU2161502C2 (ru) | 2001-01-10 |
| SK167197A3 (en) | 1998-06-03 |
| AU708756B2 (en) | 1999-08-12 |
| PT831787E (pt) | 2002-02-28 |
| CZ288147B6 (en) | 2001-05-16 |
| CA2223436A1 (en) | 1996-12-19 |
| EP0831787B1 (en) | 2001-08-22 |
| ES2161366T3 (es) | 2001-12-01 |
| NO975708L (no) | 1998-02-05 |
| IL122385A0 (en) | 1998-06-15 |
| DE69614685D1 (de) | 2001-09-27 |
| MX9709698A (es) | 1998-07-31 |
| WO1996040072A3 (en) | 1997-01-23 |
| NZ310644A (en) | 1999-08-30 |
| HUP9900870A3 (en) | 2001-04-28 |
| EP0831787A2 (en) | 1998-04-01 |
| WO1996040072A2 (en) | 1996-12-19 |
| AU6146996A (en) | 1996-12-30 |
| SK281571B6 (sk) | 2001-05-10 |
| HK1009089A1 (en) | 1999-09-10 |
| CZ390797A3 (cs) | 1998-07-15 |
| HUP9900870A2 (hu) | 1999-09-28 |
| IL122385A (en) | 2001-01-11 |
| CN1187120A (zh) | 1998-07-08 |
| DK0831787T3 (da) | 2001-12-17 |
| DE69614685T2 (de) | 2002-06-27 |
| PL323832A1 (en) | 1998-04-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9608542A (pt) | Composição para a liberação sustentada de hormónio do crescimento humano | |
| MX9709699A (es) | Composicion para la liberacion sostenida de eritropoyetina no agregada. | |
| KR0136870B1 (ko) | 전신적 경피 투여용 약학적 조성물 | |
| DE3853853T2 (de) | Verabreichungsformen für Pharmaka. | |
| DE69814917T2 (de) | Transdermale therapeutische vorrichtung mit capsaicin und seinen analogen | |
| CA2474698A1 (en) | Polymer-based compositions for sustained release | |
| JP2660839B2 (ja) | 局所塗布用浸透促進製薬組成物 | |
| JPH07187994A (ja) | 薬物放出制御製剤 | |
| BR9815510A (pt) | Sistema terapêutico transdérmico (tts), para a administração transcutânea de esteróides sexuais e método para produção em um tts | |
| JPS62234017A (ja) | 膣用医薬組成物 | |
| BR0016012A (pt) | Implante farmacêutico contendo componentes de liberação imediata e de liberação prolongada, além de processo de administração | |
| HUP9700322A2 (hu) | Hosszabb lokálanesztézist biztosító készítmény és módszerek | |
| DE69529054D1 (de) | System zur gezielten wirkstoffzufuhr, verfahren zu seiner herstellung und verwendung | |
| DK0706401T3 (da) | Lægemiddelafgivelsessystem | |
| WO2001058474A3 (en) | Microencapsulation and sustained release of biologically active agent | |
| ATE315409T1 (de) | Verbesserte formulierung zur gesteuerten arzneistofffreisetzung durch kombination hydrophiler und hydrophober stoffe | |
| DE69728179D1 (de) | System zur gezielten wirkstoffzufuhr, verfahren zu seiner herstellung und verwendung | |
| RU2096044C1 (ru) | Ветеринарный имплантируемый препарат для регулирования биологического ритма животных | |
| NO302016B1 (no) | Anordning for tilförsel i et legeme av innkapslet biologisk materiale | |
| DE60101206T2 (de) | Transdermale verabreichung von lasofoxifen | |
| Hsieh et al. | Enhanced release of drugs from silicone elastomers (I) release kinetics of pineal and steroidal hormones | |
| CA2038969A1 (en) | Compositions comprising cytotoxic agent and permeation enhancers | |
| JPH0733643A (ja) | 歯周投与用基剤及び歯周投与用製剤 | |
| CN113573697A (zh) | 药物制剂、含其的系统及其制备方法、应用 | |
| KR20000017706A (ko) | 국소마취제를함유한약용겔제조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD5 | Application fees: dismissal - article 86 of industrial property law | ||
| HIX | Notification cancelled | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO DE ACORDO COM O ART. 8O DA LPI. |