CN113573697A - 药物制剂、含其的系统及其制备方法、应用 - Google Patents

药物制剂、含其的系统及其制备方法、应用 Download PDF

Info

Publication number
CN113573697A
CN113573697A CN202080021975.6A CN202080021975A CN113573697A CN 113573697 A CN113573697 A CN 113573697A CN 202080021975 A CN202080021975 A CN 202080021975A CN 113573697 A CN113573697 A CN 113573697A
Authority
CN
China
Prior art keywords
preparation
pain
lidocaine
pharmaceutical preparation
layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080021975.6A
Other languages
English (en)
Inventor
张洁
唐培克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Huzhou Enowei New Pharmaceutical Preparation Co ltd
Original Assignee
Huzhou Enowei New Pharmaceutical Preparation Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Huzhou Enowei New Pharmaceutical Preparation Co ltd filed Critical Huzhou Enowei New Pharmaceutical Preparation Co ltd
Publication of CN113573697A publication Critical patent/CN113573697A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245Amino benzoic acid types, e.g. procaine, novocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

药物制剂、含其的系统及其制备方法、应用。该药物制剂包括水和局部麻醉药;该药物制剂中的局部麻醉药包括溶解的和未溶解的局部麻醉药;药物制剂中的局部麻醉药的质量百分比为2%以上;溶解的局部麻醉药在药物制剂中的质量百分比为1%以下;局部麻醉药为利多卡因、丁卡因、布比卡因、阿替卡因、辛可卡因、地布卡因、依替卡因、左布比卡因、甲哌卡因、丙胺卡因、罗哌卡因、三甲卡因、苯佐卡因或普鲁卡因;所述药物制剂中各组分的质量百分比之和为100%。该系统包括含有网状胶层、屏障膜,和吸附层的覆盖膜。在许多镇痛应用中,该系统能够获得6、12、18、24、36,甚至48小时或更长的连续镇痛效果。

Description

PCT国内申请,说明书已公开。

Claims (20)

  1. PCT国内申请,权利要求书已公开。
CN202080021975.6A 2019-04-15 2020-04-15 药物制剂、含其的系统及其制备方法、应用 Pending CN113573697A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019102999643 2019-04-15
CN201910299964.3A CN111821257A (zh) 2019-04-15 2019-04-15 药物制剂、含其的系统及其制备方法、应用
PCT/CN2020/084970 WO2020211787A1 (zh) 2019-04-15 2020-04-15 药物制剂、含其的系统及其制备方法、应用

Publications (1)

Publication Number Publication Date
CN113573697A true CN113573697A (zh) 2021-10-29

Family

ID=72837026

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910299964.3A Withdrawn CN111821257A (zh) 2019-04-15 2019-04-15 药物制剂、含其的系统及其制备方法、应用
CN202080021975.6A Pending CN113573697A (zh) 2019-04-15 2020-04-15 药物制剂、含其的系统及其制备方法、应用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201910299964.3A Withdrawn CN111821257A (zh) 2019-04-15 2019-04-15 药物制剂、含其的系统及其制备方法、应用

Country Status (2)

Country Link
CN (2) CN111821257A (zh)
WO (1) WO2020211787A1 (zh)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102327161A (zh) * 2011-06-16 2012-01-25 安美得生医股份有限公司 创伤敷料的制备工艺
CN103596560A (zh) * 2010-11-09 2014-02-19 张洁 薄层和液体结合的透皮给药系统
CN203693902U (zh) * 2013-10-25 2014-07-09 稳健实业(深圳)有限公司 一种硅凝胶泡沫敷贴
CN104825386A (zh) * 2015-05-25 2015-08-12 湖北汇瑞药业股份有限公司 一种表皮麻醉凝胶及其制备方法
CN105579003A (zh) * 2013-07-10 2016-05-11 张洁 利用液体或半固体制剂持续经皮给药的工具及其使用方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0838225A3 (en) * 1996-10-25 1999-03-24 Hiji, Yasutake Aqueous local anesthetic solution
US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
US20080242731A1 (en) * 2003-07-22 2008-10-02 T&A Pharma Pty. Limited Topical anesthesia formulation for bodily cavities
US8741332B2 (en) * 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
AU2008101283A4 (en) * 2008-02-19 2011-07-07 T&A Pharma Pty Limited Topical anaesthesia compositions
CN101658692A (zh) * 2008-08-27 2010-03-03 山东省生物药物研究院 一种结冷胶组合物及其制备方法和用途
WO2011126898A2 (en) * 2010-03-30 2011-10-13 Sparkmed Research, Llc Drug releasing medical catheters, tubes, and devices
CN102018696B (zh) * 2010-11-22 2013-07-03 北京泰德制药股份有限公司 一种含有利多卡因或其药用盐的皮肤外用制剂
CN102198126B (zh) * 2011-05-04 2012-11-28 刘布鸣 治疗口腔及牙齿疾病的涂抹剂及其涂抹器
DK3097907T3 (en) * 2015-05-28 2018-12-10 Abdi Ibrahim Ilac Sanayi Ve Ticaret A S A GEL formulation comprising anesthetic and anesthetic agents
CN105903068A (zh) * 2016-06-02 2016-08-31 四川奎星医用高分子制品有限责任公司 含有镇痛药物的医用复合壳聚糖凝胶

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103596560A (zh) * 2010-11-09 2014-02-19 张洁 薄层和液体结合的透皮给药系统
CN106109444A (zh) * 2010-11-09 2016-11-16 张洁 薄层和液体结合的透皮给药系统
CN102327161A (zh) * 2011-06-16 2012-01-25 安美得生医股份有限公司 创伤敷料的制备工艺
CN105579003A (zh) * 2013-07-10 2016-05-11 张洁 利用液体或半固体制剂持续经皮给药的工具及其使用方法
CN203693902U (zh) * 2013-10-25 2014-07-09 稳健实业(深圳)有限公司 一种硅凝胶泡沫敷贴
CN104825386A (zh) * 2015-05-25 2015-08-12 湖北汇瑞药业股份有限公司 一种表皮麻醉凝胶及其制备方法

Also Published As

Publication number Publication date
CN111821257A (zh) 2020-10-27
WO2020211787A1 (zh) 2020-10-22

Similar Documents

Publication Publication Date Title
CA1336727C (en) Flexible, hydrophilic gel film, the process for its production and the use of it
US6461644B1 (en) Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods
ES2452517T3 (es) Composiciones y métodos para el tratamiento del trastorno de déficit de atención y del trastorno de déficit de atención e hiperactividad con metilfenidato
AU779570B2 (en) Local prevention or amelioration of pain from surgically closed wounds
US4725609A (en) Method of promoting healing
US8535709B2 (en) Agents for controlling biological fluids and methods of use thereof
US20070059350A1 (en) Agents for controlling biological fluids and methods of use thereof
AU2018384069A1 (en) Wound dressing
US20060029654A1 (en) Analgesic patch for sports injury rehabilitation medicine and method to alleviate pain
US20200179314A1 (en) Lidocaine Patch and Methods of Use Thereof
WO2020051117A1 (en) Cannabinoid and menthol gel compositions, patches and methods
US20240082175A1 (en) Cannabinoid and menthol transdermal delivery systems and methods
US6620852B2 (en) Topical anesthetic
CN111840553A (zh) 脂性药物制剂及其应用
CN111615383A (zh) 药物组合物、贴剂及其制备方法、镇痛方法、应用
US11147775B2 (en) Cannabinoid and menthol gel compositions, patches and methods
CN113573697A (zh) 药物制剂、含其的系统及其制备方法、应用
WO1998039042A1 (en) Anesthetizing plastics, drug delivery plastics, and related medical products, systems and methods
CN212913557U (zh) 一种将半固体制剂固定在皮肤上的系统
US11229610B2 (en) Cannabinoid and menthol gel compositions, patches and methods
CN113616626A (zh) 具有麻醉效果的医用敷贴及其应用
WO2020211763A1 (zh) 覆盖膜、含其的系统及其使用方法、应用
WO2021177940A1 (en) Cannabinoid and menthol gel compositions, patches and methods
JP2926914B2 (ja) 皮膚疾患治療用貼付剤及びその製造法
JP3782551B2 (ja) 鎮痛組成物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination