CN113573697A - 药物制剂、含其的系统及其制备方法、应用 - Google Patents

药物制剂、含其的系统及其制备方法、应用 Download PDF

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CN113573697A
CN113573697A CN202080021975.6A CN202080021975A CN113573697A CN 113573697 A CN113573697 A CN 113573697A CN 202080021975 A CN202080021975 A CN 202080021975A CN 113573697 A CN113573697 A CN 113573697A
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preparation
pain
lidocaine
pharmaceutical preparation
layer
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张洁
唐培克
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Huzhou Enowei New Pharmaceutical Preparation Co ltd
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Huzhou Enowei New Pharmaceutical Preparation Co ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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Abstract

药物制剂、含其的系统及其制备方法、应用。该药物制剂包括水和局部麻醉药；该药物制剂中的局部麻醉药包括溶解的和未溶解的局部麻醉药；药物制剂中的局部麻醉药的质量百分比为2％以上；溶解的局部麻醉药在药物制剂中的质量百分比为1％以下；局部麻醉药为利多卡因、丁卡因、布比卡因、阿替卡因、辛可卡因、地布卡因、依替卡因、左布比卡因、甲哌卡因、丙胺卡因、罗哌卡因、三甲卡因、苯佐卡因或普鲁卡因；所述药物制剂中各组分的质量百分比之和为100％。该系统包括含有网状胶层、屏障膜，和吸附层的覆盖膜。在许多镇痛应用中，该系统能够获得6、12、18、24、36，甚至48小时或更长的连续镇痛效果。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN202080021975.6A 2019-04-15 2020-04-15 药物制剂、含其的系统及其制备方法、应用 Pending CN113573697A (zh)

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CN2019102999643 2019-04-15
CN201910299964.3A CN111821257A (zh) 2019-04-15 2019-04-15 药物制剂、含其的系统及其制备方法、应用
PCT/CN2020/084970 WO2020211787A1 (zh) 2019-04-15 2020-04-15 药物制剂、含其的系统及其制备方法、应用

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Citations (5)

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CN102327161A (zh) * 2011-06-16 2012-01-25 安美得生医股份有限公司 创伤敷料的制备工艺
CN103596560A (zh) * 2010-11-09 2014-02-19 张洁 薄层和液体结合的透皮给药系统
CN203693902U (zh) * 2013-10-25 2014-07-09 稳健实业(深圳)有限公司 一种硅凝胶泡沫敷贴
CN104825386A (zh) * 2015-05-25 2015-08-12 湖北汇瑞药业股份有限公司 一种表皮麻醉凝胶及其制备方法
CN105579003A (zh) * 2013-07-10 2016-05-11 张洁 利用液体或半固体制剂持续经皮给药的工具及其使用方法

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US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
US20080242731A1 (en) * 2003-07-22 2008-10-02 T&A Pharma Pty. Limited Topical anesthesia formulation for bodily cavities
US8741332B2 (en) * 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for dermally treating neuropathic pain
AU2008101283A4 (en) * 2008-02-19 2011-07-07 T&A Pharma Pty Limited Topical anaesthesia compositions
CN101658692A (zh) * 2008-08-27 2010-03-03 山东省生物药物研究院 一种结冷胶组合物及其制备方法和用途
WO2011126898A2 (en) * 2010-03-30 2011-10-13 Sparkmed Research, Llc Drug releasing medical catheters, tubes, and devices
CN102018696B (zh) * 2010-11-22 2013-07-03 北京泰德制药股份有限公司 一种含有利多卡因或其药用盐的皮肤外用制剂
CN102198126B (zh) * 2011-05-04 2012-11-28 刘布鸣 治疗口腔及牙齿疾病的涂抹剂及其涂抹器
DK3097907T3 (en) * 2015-05-28 2018-12-10 Abdi Ibrahim Ilac Sanayi Ve Ticaret A S A GEL formulation comprising anesthetic and anesthetic agents
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CN103596560A (zh) * 2010-11-09 2014-02-19 张洁 薄层和液体结合的透皮给药系统
CN106109444A (zh) * 2010-11-09 2016-11-16 张洁 薄层和液体结合的透皮给药系统
CN102327161A (zh) * 2011-06-16 2012-01-25 安美得生医股份有限公司 创伤敷料的制备工艺
CN105579003A (zh) * 2013-07-10 2016-05-11 张洁 利用液体或半固体制剂持续经皮给药的工具及其使用方法
CN203693902U (zh) * 2013-10-25 2014-07-09 稳健实业(深圳)有限公司 一种硅凝胶泡沫敷贴
CN104825386A (zh) * 2015-05-25 2015-08-12 湖北汇瑞药业股份有限公司 一种表皮麻醉凝胶及其制备方法

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