MX9709699A - Composicion para la liberacion sostenida de eritropoyetina no agregada. - Google Patents
Composicion para la liberacion sostenida de eritropoyetina no agregada.Info
- Publication number
- MX9709699A MX9709699A MX9709699A MX9709699A MX9709699A MX 9709699 A MX9709699 A MX 9709699A MX 9709699 A MX9709699 A MX 9709699A MX 9709699 A MX9709699 A MX 9709699A MX 9709699 A MX9709699 A MX 9709699A
- Authority
- MX
- Mexico
- Prior art keywords
- composition
- sustained release
- biologically active
- epo
- polymer
- Prior art date
Links
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Abstract
Una composicion, y métodos para formar y usar dicha composicion, para la liberacion sostenida de la eritropoyetina biologicamente activa, no agregada (EPO). La composicion de liberacion sostenida de esta invencion comprende una matriz polimérica de un polímero biocompatible, y partículas de EPO estabilizada por agregacion, biologicamente activa, en donde dichas partículas se dispersan dentro del polímero biocompatible. El método de la invencion para producir una composicion para la liberacion sostenida de la EPO biologicamente activa incluye disolver un polímero biocompatible en unsolvente de polímero para formar una solucion de polímero, sispersar partículas de EPO estabilizada por agregacion, biologicamente activa, en la solucion de polímero, y luego solidificar el polímero para formar una matriz polimérica que contenga una dispersion de dichas partículas de EPO: El método para usar una composicion de la invencion es un método para proporcionar un nivel de sangre terapéuticamente efectivo de eritropoyetina no agregada, biologicamente activa, en un sujeto durante un periodo continuo. En este método, a un sujeto se le administra una dosis de la composicion de liberacion sostenida de la presente invencion.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/478,502 US5716644A (en) | 1992-06-11 | 1995-06-07 | Composition for sustained release of non-aggregated erythropoietin |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9709699A true MX9709699A (es) | 1998-07-31 |
Family
ID=23900212
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9709699A MX9709699A (es) | 1995-06-07 | 1997-12-05 | Composicion para la liberacion sostenida de eritropoyetina no agregada. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5716644A (es) |
EP (1) | EP0871433A2 (es) |
JP (1) | JPH11506764A (es) |
CN (1) | CN1177612C (es) |
AU (1) | AU705451B2 (es) |
CA (1) | CA2223834A1 (es) |
CZ (1) | CZ390897A3 (es) |
MX (1) | MX9709699A (es) |
NZ (1) | NZ309533A (es) |
PL (1) | PL323736A1 (es) |
WO (1) | WO1996040073A2 (es) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030035845A1 (en) * | 1992-06-11 | 2003-02-20 | Zale Stephen E. | Composition for sustained release of non-aggregated erythropoietin |
US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
AUPO066096A0 (en) * | 1996-06-26 | 1996-07-18 | Peptide Delivery Systems Pty Ltd | Oral delivery of peptides |
US20020052309A1 (en) * | 1996-09-11 | 2002-05-02 | Athanasius A. Anagnostou | Method of treating endothelial injury |
AU739469B2 (en) | 1996-12-20 | 2001-10-11 | Alza Corporation | Gel composition and methods |
US6531154B1 (en) | 1997-06-10 | 2003-03-11 | Brown University Research Foundation | Modulated release from biocompatible polymers |
US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
US20030180368A1 (en) * | 1998-03-14 | 2003-09-25 | Cenes Drug Delivery Limited | Production of microparticles |
AR020848A1 (es) * | 1998-10-23 | 2002-05-29 | Amgen Inc | Metodos y composiciones para la prevencion y el tratamiento de anemia |
US7304150B1 (en) * | 1998-10-23 | 2007-12-04 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
US6444223B1 (en) | 1999-05-28 | 2002-09-03 | Alkermes Controlled Therapeutics, Inc. | Method of producing submicron particles of a labile agent and use thereof |
US20030211974A1 (en) * | 2000-03-21 | 2003-11-13 | Brodbeck Kevin J. | Gel composition and methods |
WO2001087329A1 (en) * | 2000-05-15 | 2001-11-22 | F. Hoffmann-La Roche Ag | Liquid pharmaceutical composition containing an erythropoietin derivate |
AU2005225151B2 (en) * | 2000-05-15 | 2008-05-29 | F. Hoffmann-La Roche Ag | New pharmaceutical composition |
US20020076443A1 (en) * | 2000-06-19 | 2002-06-20 | Stanley Stein | Multiple phase cross-linked compositions and uses thereof |
US6998393B2 (en) | 2000-06-23 | 2006-02-14 | Biopharm Solutions, Inc. | Aquespheres, their preparation and uses thereof |
US6719970B1 (en) | 2000-07-10 | 2004-04-13 | Alkermes Controlled Therapeutics, Inc. | Method of generating cartilage |
US6296842B1 (en) | 2000-08-10 | 2001-10-02 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
US6479065B2 (en) | 2000-08-10 | 2002-11-12 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
CA2419115C (en) * | 2000-08-15 | 2011-03-08 | Board Of Trustees Of The University Of Illinois | Microparticles, and method and apparatus for forming same |
US6824822B2 (en) * | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
US6558702B2 (en) * | 2001-04-13 | 2003-05-06 | Alkermes Controlled Therapeutics, Inc. | Method of modifying the release profile of sustained release compositions |
US20060269602A1 (en) * | 2001-04-13 | 2006-11-30 | Dasch James R | Method of modifying the release profile of sustained release compositions |
PT1397155E (pt) | 2001-06-21 | 2015-12-07 | Genentech Inc | Formulação de libertação sustentada |
US6818613B2 (en) * | 2001-11-07 | 2004-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Aqueous sustained-release formulations of proteins |
CN104225574B (zh) | 2003-02-04 | 2017-01-11 | 科内尔研究基金会 | 用于防止线粒体通透性改变的方法 |
EP2604621B1 (en) | 2003-05-01 | 2015-10-21 | Cornell Research Foundation, Inc. | Method and carrier complexes for delivering molecules to cells |
EP1677735B1 (en) | 2003-10-17 | 2014-07-23 | Joslin Diabetes Center, Inc. | Methods and compositions for modulating adipocyte function |
US7309500B2 (en) * | 2003-12-04 | 2007-12-18 | The Board Of Trustees Of The University Of Illinois | Microparticles |
PL1699915T3 (pl) * | 2003-12-30 | 2010-11-30 | Augustinus Bader | Zastosowanie erytropoetyny do regeneracji tkanki wątrobowej |
JP4931604B2 (ja) | 2004-01-23 | 2012-05-16 | コーネル リサーチ ファウンデイション インコーポレイテッド | 酸化的損傷を低減する方法 |
AU2005238511A1 (en) * | 2004-04-23 | 2005-11-10 | Amgen Inc. | Low molecular weight polylactic acid polymers |
US20050260272A1 (en) * | 2004-05-05 | 2005-11-24 | Alkermes Controlled Therapeutics, Inc. | Method of forming microparticles that include a bisphosphonate and a polymer |
ES2432556T3 (es) * | 2004-08-04 | 2013-12-04 | Evonik Corporation | Métodos para fabricar dispositivos de suministro y sus dispositivos |
US7772182B2 (en) * | 2004-08-05 | 2010-08-10 | Alza Corporation | Stable suspension formulations of erythropoietin receptor agonists |
US20060029551A1 (en) * | 2004-08-05 | 2006-02-09 | Kui Liu | Stable particle formulations of erythropoietin receptor agonists |
US7748343B2 (en) | 2004-11-22 | 2010-07-06 | The Board Of Trustees Of The University Of Illinois | Electrohydrodynamic spraying system |
WO2007025441A1 (en) * | 2005-08-29 | 2007-03-08 | Tuo Jin | Polysaccharide microparticles containing biological agents: there preparation and applications |
CN102552874B (zh) | 2005-09-16 | 2015-04-22 | 科内尔研究基金会 | 用于减少cd36表达的方法 |
US8728528B2 (en) | 2007-12-20 | 2014-05-20 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
SI2252312T1 (sl) | 2008-02-07 | 2014-08-29 | Cornell University, | Postopki za preprečevanje ali zdravljenje insulinske rezistence |
JP5677096B2 (ja) | 2008-02-26 | 2015-02-25 | コーネル ユニヴァーシティー | 急性腎障害を予防および治療するための方法 |
CA2725208A1 (en) | 2008-05-06 | 2009-11-12 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
JP2012515790A (ja) * | 2009-01-23 | 2012-07-12 | サーモディクス ファーマシューティカルズ, インコーポレイテッド | 微粒子製造のための連続二重エマルジョン工程 |
US20100331265A1 (en) | 2009-03-20 | 2010-12-30 | Tompkins Ronald G | Methods for the prevention and treatment of burn injuries and secondary complications |
JP2010251707A (ja) * | 2009-03-27 | 2010-11-04 | Fujitsu Ltd | 配線基板及び半導体装置 |
US20110039766A1 (en) * | 2009-08-12 | 2011-02-17 | Szeto Hazel H | Methods for preventing or treating metabolic syndrome |
EP3318264A1 (en) | 2009-08-24 | 2018-05-09 | Stealth Peptides International, Inc. | Methods ans compositions for preventing or treating opthalmic conditions |
US20110091518A1 (en) * | 2009-09-22 | 2011-04-21 | Danielle Biggs | Implant devices having varying bioactive agent loading configurations |
EP2764871A1 (en) | 2009-10-05 | 2014-08-13 | Cornell University | Methods for the prevention or treatment of heart failure |
US20130190244A1 (en) | 2009-12-31 | 2013-07-25 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
CN103751763A (zh) | 2009-12-31 | 2014-04-30 | 康肽德生物医药技术有限公司 | 用于预防或治疗血管阻塞损伤的方法 |
EP2528934A4 (en) | 2010-01-25 | 2013-08-21 | Univ Cornell | AROMATIC-CATIONIC PEPTIDES AND USES THEREOF |
WO2011106717A1 (en) | 2010-02-26 | 2011-09-01 | University Of Florida Research Foundation, Inc. | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
US8697657B2 (en) | 2010-03-15 | 2014-04-15 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
EP2566880A4 (en) | 2010-05-03 | 2014-10-08 | Stealth Peptides Int Inc | AROMATIC-CATIONIC PEPTIDES AND USES THEREOF |
EP2590664B1 (en) | 2010-07-09 | 2019-03-27 | Stealth Peptides International, Inc. | Methods for the prevention or treatment of no-reflow following ischemia/reperfusion injury |
WO2012050673A1 (en) | 2010-10-14 | 2012-04-19 | Wisconsin Alumni Research Foundation | Methods for the treatment of x-linked hypophosphatemia and related disorders |
CN109705192A (zh) | 2011-03-24 | 2019-05-03 | 康奈尔大学 | 芳香族阳离子肽及其用途 |
CA3123992A1 (en) | 2011-09-29 | 2013-04-04 | Mayo Foundation For Medical Education And Research | Aromatic-cationic peptides and methods for using same |
EP2768516A4 (en) | 2011-10-17 | 2015-08-19 | Univ Cornell | AROMATIC-CATIONIC PEPTIDES AND USES THEREOF |
CN104105499A (zh) | 2011-12-09 | 2014-10-15 | 康肽德生物医药技术有限公司 | 芳香族阳离子肽及其用途 |
EP2817018A4 (en) | 2012-02-22 | 2015-09-23 | Stealth Peptides Int Inc | METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OPHTHALMIC CONDITIONS |
EP2817021B1 (en) | 2012-02-23 | 2019-01-02 | Cornell University | Aromatic-cationic peptides and uses of same |
JP2015524439A (ja) | 2012-08-02 | 2015-08-24 | ステルス ペプチドズ インターナショナル インコーポレイテッド | アテローム性硬化症の処置方法 |
CN110193077A (zh) | 2012-10-22 | 2019-09-03 | 康德生物医疗技术公司 | 降低与心脏衰竭相关的风险和与其相关的因素的方法 |
JP2016506391A (ja) | 2012-12-06 | 2016-03-03 | ステルス ペプチドズ インターナショナル インコーポレイテッド | ペプチド治療薬およびその使用方法 |
HUE046924T2 (hu) | 2013-03-01 | 2020-03-30 | Stealth Biotherapeutics Corp | Módszerek és készítmények Barth szindróma megelõzésében vagy kezelésében történõ alkalmazásra |
EP3673913A1 (en) | 2013-03-01 | 2020-07-01 | Stealth Biotherapeutics Corp | Methods for the treatment of mitochondrial disease |
CA2912386A1 (en) | 2013-05-14 | 2014-11-20 | Stealth Biotherapeutics Corp | Methods for the prevention or treatment of left ventricular remodeling |
US9877997B2 (en) | 2013-06-26 | 2018-01-30 | Stealth Biotherapeutics Corp | Methods and compositions for regulating SRCA2A expression levels in myocardial infarction |
CA2916977A1 (en) | 2013-06-26 | 2014-12-31 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
WO2014210062A1 (en) | 2013-06-26 | 2014-12-31 | Stealth Peptides International, Inc. | Methods for the regulation of matrix metalloproteinase expression |
WO2014210056A1 (en) | 2013-06-27 | 2014-12-31 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
CA2920020C (en) | 2013-08-02 | 2023-03-14 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention and treatment of friedreich's ataxia |
WO2015084875A1 (en) | 2013-12-02 | 2015-06-11 | Stealth Peptides International, Inc. | Compositions and methods for treating vitiligo |
WO2015183995A2 (en) | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof |
WO2015183988A1 (en) | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including therapeutic small molecules and uses thereof |
EP3151827A4 (en) | 2014-06-04 | 2018-01-24 | Tersus Pharmaceuticals, LLC | METHODS OF TREATING CHRONIC DRY EYE DISEASE USING C16:1n7 PALMITOLEATE AND DERIVATIVES THEREOF |
US10627392B2 (en) | 2014-06-17 | 2020-04-21 | Stealth Biotherapeutics Corp | Methods of identifying and monitoring mitochondrial dysfunction using monocyte screening |
WO2016029027A2 (en) | 2014-08-21 | 2016-02-25 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention and treatment of disease |
US10449259B2 (en) | 2015-10-02 | 2019-10-22 | Cornell University | Enzyme-responsive peptide nanofiber compositions and uses thereof |
EP4233887A1 (en) | 2016-01-06 | 2023-08-30 | Stealth BioTherapeutics Inc. | Methods for the treatment of duchenne muscular dystrophy |
EP4000690A1 (en) | 2016-05-19 | 2022-05-25 | Stealth BioTherapeutics Inc. | Compositions and methods for the prevention and treatment of mitochondrial myopathies |
CN106273027A (zh) * | 2016-08-19 | 2017-01-04 | 安庆仁生塑胶有限公司 | 一种均匀型塑料粒子搅拌机 |
CA3072200A1 (en) | 2017-08-08 | 2019-02-14 | Memorial Sloan Kettering Cancer Center | Use of braf inhibitors for treating cutaneous reactions caused by treatment with a mek inhibitor |
RU2705723C1 (ru) * | 2018-06-26 | 2019-11-11 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Южно-Уральский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ЮУГМУ Минздрава России) | Суппозитории ректальные с эритропоэтином, обладающие репаративной и антиоксидантной активностью |
FI3890765T3 (fi) | 2018-12-06 | 2023-10-16 | Stealth Biotherapeutics Inc | D-ARG-2'6'-DMT-LYS-PHE-NH2 käytettäväksi sengersin syndrooman hoidossa tai estämisessä |
CA3140406A1 (en) | 2019-05-28 | 2020-12-03 | Shanghaitech University | Composition and methods to treat ectodermal dysplasia 2, clouston type |
CN114466656A (zh) | 2019-07-24 | 2022-05-10 | 康德生物医疗有限公司 | 在治疗神经变性病症中的模拟肽化合物(r)-2-氨基-n-((s)-1-(((s)-5-氨基-1-(3-苄基-1,2,4-噁二唑-5-基)戊基)氨基)-3-(4-羟基-2,6-二甲苯基)-1-氧代丙-2-基)-5-胍基戊酰胺 |
KR20220078644A (ko) | 2019-10-04 | 2022-06-10 | 스텔스 바이오테라퓨틱스 인코포레이티드 | 미토콘드리아 질환 치료를 위한 바티퀴논의 퀴논-, 히드로퀴논- 및 나프토퀴논-유사체 |
JP2023520462A (ja) | 2020-04-03 | 2023-05-17 | ステルス バイオセラピューティクス インコーポレイテッド | フリードライヒ運動失調症を含むミトコンドリア病の予防および/または治療のための組成物および方法 |
WO2023069255A1 (en) | 2021-10-20 | 2023-04-27 | Stealth Biotherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
WO2023101963A2 (en) | 2021-11-30 | 2023-06-08 | Northwestern University | Compositions for inhibiting dipeptide repeat protein-ribosomal rna interaction and uses thereof |
WO2023133321A1 (en) | 2022-01-10 | 2023-07-13 | Stealth Biotherapeutics Inc. | Small molecule peptidomimetic for the treatment of tauopathies |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3699244A (en) * | 1971-08-23 | 1972-10-17 | Singer Co | Apparatus to match the color of a monochrome display to average color of an adjacent full color display |
US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4637905A (en) * | 1982-03-04 | 1987-01-20 | Batelle Development Corporation | Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones |
US4906474A (en) * | 1983-03-22 | 1990-03-06 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4891225A (en) * | 1984-05-21 | 1990-01-02 | Massachusetts Institute Of Technology | Bioerodible polyanhydrides for controlled drug delivery |
JPS6191131A (ja) * | 1984-10-09 | 1986-05-09 | Chugai Pharmaceut Co Ltd | 医薬品の吸着防止方法および組成物 |
JPS6197229A (ja) * | 1984-10-18 | 1986-05-15 | Chugai Pharmaceut Co Ltd | 安定なエリトロポエチン製剤 |
US4732889A (en) * | 1985-02-06 | 1988-03-22 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for the treatment of the anemia of rheumatoid arthritis |
US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
US4981696A (en) * | 1986-12-22 | 1991-01-01 | E. I. Du Pont De Nemours And Company | Polylactide compositions |
JPS6427374A (en) * | 1987-03-19 | 1989-01-30 | Eizou Center Kk | Large screen display device |
DE3729863A1 (de) * | 1987-09-05 | 1989-03-16 | Boehringer Mannheim Gmbh | Stabilisierte erythropoietin-lyophilisate |
US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
GB2209937B (en) * | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
JP2708189B2 (ja) * | 1988-09-16 | 1998-02-04 | 日本放送協会 | 広視野立体画像表示方法および装置 |
US4990336A (en) * | 1989-02-08 | 1991-02-05 | Biosearch, Inc. | Sustained release dosage form |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
FR2658432B1 (fr) * | 1990-02-22 | 1994-07-01 | Medgenix Group Sa | Microspheres pour la liberation controlee des substances hydrosolubles et procede de preparation. |
JPH0463092A (ja) * | 1990-06-29 | 1992-02-28 | Sanyo Electric Co Ltd | 3次元シーン表示システム |
WO1992011844A1 (en) * | 1991-01-03 | 1992-07-23 | Alkermes Controlled Therapeutics, Inc. | Stabilization of proteins by cationic biopolymers |
AU2605592A (en) * | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
US5288502A (en) * | 1991-10-16 | 1994-02-22 | The University Of Texas System | Preparation and uses of multi-phase microspheres |
JPH07507768A (ja) * | 1992-03-12 | 1995-08-31 | アルカーメス コントロールド セラピューティクス,インコーポレイテッド | Acth含有マイクロスフェアの制御放出 |
ATE222500T1 (de) * | 1992-06-11 | 2002-09-15 | Alkermes Inc | Enythropoietin enthaltendes arzneimittelabgabesystem |
CA2150803C (en) * | 1992-12-02 | 2006-01-31 | Henry Auer | Controlled release growth hormone containing microspheres |
PT779806E (pt) * | 1994-09-09 | 2001-02-28 | Takeda Chemical Industries Ltd | Preparacao de libertacao sustentada contendo um sal metalico de um peptido |
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1996
- 1996-06-03 NZ NZ309533A patent/NZ309533A/xx unknown
- 1996-06-03 WO PCT/US1996/008474 patent/WO1996040073A2/en not_active Application Discontinuation
- 1996-06-03 CZ CZ973908A patent/CZ390897A3/cs unknown
- 1996-06-03 JP JP9501068A patent/JPH11506764A/ja not_active Ceased
- 1996-06-03 EP EP96917028A patent/EP0871433A2/en not_active Withdrawn
- 1996-06-03 PL PL96323736A patent/PL323736A1/xx unknown
- 1996-06-03 AU AU59724/96A patent/AU705451B2/en not_active Ceased
- 1996-06-03 CA CA002223834A patent/CA2223834A1/en not_active Abandoned
- 1996-06-03 CN CNB961946113A patent/CN1177612C/zh not_active Expired - Fee Related
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1997
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AU705451B2 (en) | 1999-05-20 |
WO1996040073A3 (en) | 1997-01-23 |
CA2223834A1 (en) | 1996-12-19 |
CZ390897A3 (cs) | 1998-05-13 |
PL323736A1 (en) | 1998-04-14 |
NZ309533A (en) | 1999-08-30 |
JPH11506764A (ja) | 1999-06-15 |
CN1187134A (zh) | 1998-07-08 |
AU5972496A (en) | 1996-12-30 |
CN1177612C (zh) | 2004-12-01 |
WO1996040073A2 (en) | 1996-12-19 |
US5716644A (en) | 1998-02-10 |
EP0871433A2 (en) | 1998-10-21 |
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