ATE204468T1 - Mittel zur verzögerten freisetzung von menschlichem wachstumshormon - Google Patents

Mittel zur verzögerten freisetzung von menschlichem wachstumshormon

Info

Publication number
ATE204468T1
ATE204468T1 AT96919016T AT96919016T ATE204468T1 AT E204468 T1 ATE204468 T1 AT E204468T1 AT 96919016 T AT96919016 T AT 96919016T AT 96919016 T AT96919016 T AT 96919016T AT E204468 T1 ATE204468 T1 AT E204468T1
Authority
AT
Austria
Prior art keywords
composition
hgh
biologically active
sustained release
polymer
Prior art date
Application number
AT96919016T
Other languages
English (en)
Inventor
Olufunmi Lily Johnson
Medha M Ganmukhi
Howard Bernstein
Henry Auer
M Amin Khan
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/477,725 external-priority patent/US5667808A/en
Application filed by Alkermes Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of ATE204468T1 publication Critical patent/ATE204468T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AT96919016T 1995-06-07 1996-06-03 Mittel zur verzögerten freisetzung von menschlichem wachstumshormon ATE204468T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/477,725 US5667808A (en) 1992-12-02 1995-06-07 Composition for sustained release of human growth hormone
US08/473,544 US5654010A (en) 1992-12-02 1995-06-07 Composition for sustained release of human growth hormone
PCT/US1996/008086 WO1996040072A2 (en) 1995-06-07 1996-06-03 Composition for sustained release of human growth hormone

Publications (1)

Publication Number Publication Date
ATE204468T1 true ATE204468T1 (de) 2001-09-15

Family

ID=27044171

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96919016T ATE204468T1 (de) 1995-06-07 1996-06-03 Mittel zur verzögerten freisetzung von menschlichem wachstumshormon

Country Status (22)

Country Link
EP (1) EP0831787B1 (de)
JP (1) JPH11506740A (de)
CN (1) CN1102854C (de)
AT (1) ATE204468T1 (de)
AU (1) AU708756B2 (de)
BR (1) BR9608542A (de)
CA (1) CA2223436A1 (de)
CZ (1) CZ288147B6 (de)
DE (1) DE69614685T2 (de)
DK (1) DK0831787T3 (de)
ES (1) ES2161366T3 (de)
HK (1) HK1009089A1 (de)
HU (1) HUP9900870A3 (de)
IL (1) IL122385A (de)
MX (1) MX9709698A (de)
NO (1) NO316104B1 (de)
NZ (1) NZ310644A (de)
PL (1) PL184531B1 (de)
PT (1) PT831787E (de)
RU (1) RU2161502C2 (de)
SK (1) SK281571B6 (de)
WO (1) WO1996040072A2 (de)

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AR012448A1 (es) * 1997-04-18 2000-10-18 Ipsen Pharma Biotech Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada
US6306826B1 (en) 1997-06-04 2001-10-23 The Regents Of The University Of California Treatment of heart failure with growth hormone
US6663899B2 (en) 1997-06-13 2003-12-16 Genentech, Inc. Controlled release microencapsulated NGF formulation
US6113947A (en) * 1997-06-13 2000-09-05 Genentech, Inc. Controlled release microencapsulated NGF formulation
US6191107B1 (en) * 1997-09-26 2001-02-20 Takeda Chemical Industries, Ltd. Complex of human growth hormone and zinc
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EP3112468A1 (de) 1998-05-15 2017-01-04 Genentech, Inc. Il-17-homologe polypeptide und therapeutische verwendung davon
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DK0674506T3 (da) * 1992-12-02 2001-01-08 Alkermes Inc Væksthormonholdige mikrosfærer med styret frigivelse
ATE197398T1 (de) * 1994-09-09 2000-11-11 Takeda Chemical Industries Ltd Zubereitung mit verzögerter freigabe eines metallsalz eines peptids

Also Published As

Publication number Publication date
MX9709698A (es) 1998-07-31
WO1996040072A3 (en) 1997-01-23
CZ288147B6 (en) 2001-05-16
EP0831787B1 (de) 2001-08-22
HUP9900870A2 (hu) 1999-09-28
ES2161366T3 (es) 2001-12-01
PL323832A1 (en) 1998-04-27
NZ310644A (en) 1999-08-30
SK281571B6 (sk) 2001-05-10
IL122385A0 (en) 1998-06-15
PT831787E (pt) 2002-02-28
HK1009089A1 (en) 1999-09-10
DK0831787T3 (da) 2001-12-17
CN1102854C (zh) 2003-03-12
NO975708D0 (no) 1997-12-05
NO975708L (no) 1998-02-05
WO1996040072A2 (en) 1996-12-19
BR9608542A (pt) 1999-11-30
DE69614685D1 (de) 2001-09-27
AU708756B2 (en) 1999-08-12
HUP9900870A3 (en) 2001-04-28
JPH11506740A (ja) 1999-06-15
CN1187120A (zh) 1998-07-08
SK167197A3 (en) 1998-06-03
DE69614685T2 (de) 2002-06-27
CZ390797A3 (cs) 1998-07-15
EP0831787A2 (de) 1998-04-01
IL122385A (en) 2001-01-11
RU2161502C2 (ru) 2001-01-10
AU6146996A (en) 1996-12-30
PL184531B1 (pl) 2002-11-29
CA2223436A1 (en) 1996-12-19
NO316104B1 (no) 2003-12-15

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