DE69728179D1 - System zur gezielten wirkstoffzufuhr, verfahren zu seiner herstellung und verwendung - Google Patents

System zur gezielten wirkstoffzufuhr, verfahren zu seiner herstellung und verwendung

Info

Publication number
DE69728179D1
DE69728179D1 DE69728179T DE69728179T DE69728179D1 DE 69728179 D1 DE69728179 D1 DE 69728179D1 DE 69728179 T DE69728179 T DE 69728179T DE 69728179 T DE69728179 T DE 69728179T DE 69728179 D1 DE69728179 D1 DE 69728179D1
Authority
DE
Germany
Prior art keywords
drug
nanoparticles
specific target
mammalian body
stabilizers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69728179T
Other languages
English (en)
Other versions
DE69728179T2 (de
Inventor
A Sabel
Ulrike Schroeder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NanoDel Technologies GmbH
Original Assignee
NanoPharm AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NanoPharm AG filed Critical NanoPharm AG
Application granted granted Critical
Publication of DE69728179D1 publication Critical patent/DE69728179D1/de
Publication of DE69728179T2 publication Critical patent/DE69728179T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A61K51/1251—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles micro- or nanospheres, micro- or nanobeads, micro- or nanocapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
DE69728179T 1997-06-13 1997-06-13 System zur gezielten wirkstoffzufuhr, verfahren zu seiner herstellung und verwendung Expired - Fee Related DE69728179T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1997/003099 WO1998056361A1 (en) 1997-06-13 1997-06-13 Drug targeting system, method of its preparation and its use

Publications (2)

Publication Number Publication Date
DE69728179D1 true DE69728179D1 (de) 2004-04-22
DE69728179T2 DE69728179T2 (de) 2004-11-25

Family

ID=8166655

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69728179T Expired - Fee Related DE69728179T2 (de) 1997-06-13 1997-06-13 System zur gezielten wirkstoffzufuhr, verfahren zu seiner herstellung und verwendung

Country Status (9)

Country Link
US (1) US7025991B2 (de)
EP (1) EP0986373B1 (de)
JP (1) JP3778575B2 (de)
AT (1) ATE261721T1 (de)
AU (1) AU3176097A (de)
CA (1) CA2295177C (de)
DE (1) DE69728179T2 (de)
ES (1) ES2218685T3 (de)
WO (1) WO1998056361A1 (de)

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US7025991B2 (en) 1997-06-13 2006-04-11 Nanodel Technologies Gmbh Drug targeting system, method of its preparation and its use
US7651875B2 (en) * 1998-06-08 2010-01-26 Borealis Technical Limited Catalysts
AU4373499A (en) * 1999-06-02 2000-12-28 Medinova Medical Consulting Gmbh Use of drug-loaded nanoparticles for the treatment of cancers
AU5218500A (en) * 1999-06-22 2001-01-09 Aventis Research & Technologies Gmbh & Co. Kg Stable, radioactively marked nanoparticles, method for the production and utilization thereof
AU2001275078A1 (en) * 2000-06-01 2001-12-11 The Board Of Regents For Oklahoma State University Bioconjugates of nanoparticles as radiopharmaceuticals
DE10121982B4 (de) * 2001-05-05 2008-01-24 Lts Lohmann Therapie-Systeme Ag Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung
US20050191359A1 (en) * 2001-09-28 2005-09-01 Solubest Ltd. Water soluble nanoparticles and method for their production
US7763663B2 (en) * 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
US7381426B2 (en) * 2002-01-24 2008-06-03 Southwest Research Institute Targeted delivery of bioactive factors to the systemic skeleton
MXPA04010283A (es) * 2002-04-18 2005-08-18 Acuity Pharmaceuticals Inc Medios y metodos para la modulacion especifica de genes objetivo en el cns y el ojo y metodos para su identificacion.
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
DE60229003D1 (de) * 2002-07-29 2008-10-30 Nanodel Technologies Gmbh Nanopartikele für dna verabreichung zu einem zielorgan
US7618948B2 (en) 2002-11-26 2009-11-17 Medtronic, Inc. Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
JP2007502833A (ja) * 2003-08-21 2007-02-15 サウスウエスト・リサーチ・インスティチュート 骨格に標的とされるナノ粒子
JP2007520555A (ja) * 2004-02-05 2007-07-26 バクスター・インターナショナル・インコーポレイテッド 自己安定化剤の使用により調製された分散剤
CA2568640C (en) * 2004-06-04 2011-08-09 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
DE602005012289D1 (de) * 2004-09-14 2009-02-26 Nanodel Technologies Gmbh Abgabevehikel mit nanoteilchen
EP1661559A1 (de) * 2004-11-25 2006-05-31 NanoDel Technologies GmbH Verabreichungssystem hergestellt durch ein Miniemulsionsverfahren
WO2006056362A2 (en) * 2004-11-25 2006-06-01 Nanodel Technologies Gmbh Delivery vehicle manufactured by the miniemulsion method
US20090280064A1 (en) * 2005-06-24 2009-11-12 Rao Papineni Transdermal delivery of optical, spect, multimodal, drug or biological cargo laden nanoparticle(s) in small animals or humans
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
WO2007072982A1 (en) * 2005-12-20 2007-06-28 Fujifilm Corporation Protein nanoparticles and the use of the same
EP1815851A1 (de) * 2006-02-03 2007-08-08 NanoDel Technologies GmbH Nanopartikel zur Arzneistoffverabreichung
DE102006013531A1 (de) 2006-03-24 2007-09-27 Lts Lohmann Therapie-Systeme Ag Polylactid-Nanopartikel
US20070231360A1 (en) * 2006-03-28 2007-10-04 Minu, L.L.C. Neural conduit agent dissemination
ATE510538T1 (de) 2006-08-11 2011-06-15 Univ Johns Hopkins Zusammensetzungen und verfahren für nervenschutz
US20080081067A1 (en) * 2006-10-03 2008-04-03 Gupta Manishkumar Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof
JP5201763B2 (ja) * 2007-02-28 2013-06-05 昇一 城武 異なる平均粒径サイズの粒子からなる混合微粒子カプセルの製造方法
US20090061009A1 (en) * 2007-08-29 2009-03-05 Joseph Schwarz Composition and Method of Treatment of Bacterial Infections
MX2010012137A (es) * 2008-05-06 2010-12-17 Glaxo Group Ltd Encapsulacion de agentes biologicamente activos.
NZ593743A (en) 2008-12-04 2012-07-27 Opko Ophthalmics Llc Compositions and methods for selective inhibition of pro-angiogenic vegf isoforms
US10105317B2 (en) * 2009-07-07 2018-10-23 Anpac Bio-Medical Science Co., Ltd. Method of drug delivery
US8828246B2 (en) * 2010-02-18 2014-09-09 Anpac Bio-Medical Science Co., Ltd. Method of fabricating micro-devices
EP2560624B1 (de) * 2010-04-23 2018-07-04 KemPharm, Inc. Therapeutische formulierung für reduzierte medikamenten-nebenwirkungen
WO2013166487A1 (en) 2012-05-04 2013-11-07 Yale University Highly penetrative nanocarriers for treatment of cns disease
CA2913328C (en) 2013-05-28 2021-08-24 Sintef Tto As Process for preparing stealth nanoparticles
CN117731591A (zh) 2016-11-21 2024-03-22 艾里奥治疗公司 大试剂的透皮递送
KR20190097729A (ko) * 2018-02-13 2019-08-21 서강대학교산학협력단 안질환 치료용 약물 전달 임플란트 및 이의 제조방법
ES2926253T3 (es) 2018-08-23 2022-10-24 Sintef Tto As Nanopartículas
EP3952836A1 (de) 2019-04-10 2022-02-16 Sintef Tto As Nanopartikel mit copolymeren oder homopolymeren verbindungen, die cyanoacrylatuntereinheiten enthalten

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2634397B2 (fr) 1986-12-31 1991-04-19 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules
FR2612400A1 (fr) * 1987-03-16 1988-09-23 Centre Nat Rech Scient Microcapsules contenant un marqueur radioactif et/ou paramagnetique sous forme de chelate, et leur utilisation dans le domaine de l'imagerie medicale
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
WO1994015590A1 (en) * 1993-01-11 1994-07-21 Abacol Limited Small diameter nanocapsules, process for their preparation and applications thereof
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
AU1947395A (en) * 1994-02-28 1995-09-11 Medinova Medical Consulting Gmbh Drug targeting system, method for preparing same and its use
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
US7025991B2 (en) 1997-06-13 2006-04-11 Nanodel Technologies Gmbh Drug targeting system, method of its preparation and its use
DE19745950A1 (de) 1997-10-17 1999-04-22 Dds Drug Delivery Service Ges Arzneistoffträgerpartikel für die gewebespezifische Arzneistoffapplikation
AU4373499A (en) 1999-06-02 2000-12-28 Medinova Medical Consulting Gmbh Use of drug-loaded nanoparticles for the treatment of cancers

Also Published As

Publication number Publication date
ATE261721T1 (de) 2004-04-15
US7025991B2 (en) 2006-04-11
JP2001502721A (ja) 2001-02-27
ES2218685T3 (es) 2004-11-16
DE69728179T2 (de) 2004-11-25
CA2295177C (en) 2007-01-09
CA2295177A1 (en) 1998-12-17
US20020034474A1 (en) 2002-03-21
JP3778575B2 (ja) 2006-05-24
WO1998056361A1 (en) 1998-12-17
AU3176097A (en) 1998-12-30
EP0986373A1 (de) 2000-03-22
EP0986373B1 (de) 2004-03-17

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: NANODEL TECHNOLOGIES GMBH, 39120 MAGDEBURG, DE

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee