BR9807319A - Microgrânulos com liberação controlada, para administração oral, contendo cisplatina, processo de preparação dos mesmos, preparação farmacêutica, e, utilização dos microgrânulos. - Google Patents

Microgrânulos com liberação controlada, para administração oral, contendo cisplatina, processo de preparação dos mesmos, preparação farmacêutica, e, utilização dos microgrânulos.

Info

Publication number
BR9807319A
BR9807319A BR9807319-2A BR9807319A BR9807319A BR 9807319 A BR9807319 A BR 9807319A BR 9807319 A BR9807319 A BR 9807319A BR 9807319 A BR9807319 A BR 9807319A
Authority
BR
Brazil
Prior art keywords
microgranules
controlled release
oral administration
preparation
pharmaceutical preparation
Prior art date
Application number
BR9807319-2A
Other languages
English (en)
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Original Assignee
Ethypharm Lab Prod Ethiques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm Lab Prod Ethiques filed Critical Ethypharm Lab Prod Ethiques
Publication of BR9807319A publication Critical patent/BR9807319A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

"MICROGRâNULOS COM LIBERAçãO CONTROLADA, PARA ADMINISTRAçãO ORAL, CONTENDO CISPLATINA, PROCESSO DE PREPARAçãO DOS MESMOS, PREPARAçãO FARMACêUTICA, E, UTILIZAçãO DOS MICROGRâNULOS". A presente invenção refere-se a uma nova formulação de cisplatina, para administração oral, sob forma de microgrânulos com liberação controlada, assim como seu processo de preparação por montagem em meio aquoso. Ela se refere igualmente a uma preparação farmacêutica contendo microgrânulos de cisplatina com liberação controlada e um agente anti-canceroso como produto de combinação para uma utilização simultânea, separada ou escalonada no tempo em terapia anti-cancerosa, assim como a utilização dos referidos microgrânulos para fabricar um medicamento para administrar por via oral destinado a ser usado em poliquimioterapia ou em associação com uma radioterapia.
BR9807319-2A 1997-02-11 1998-02-10 Microgrânulos com liberação controlada, para administração oral, contendo cisplatina, processo de preparação dos mesmos, preparação farmacêutica, e, utilização dos microgrânulos. BR9807319A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9701545A FR2759293B1 (fr) 1997-02-11 1997-02-11 Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie
PCT/FR1998/000251 WO1998034599A1 (fr) 1997-02-11 1998-02-10 Microgranules contenant du cisplatine

Publications (1)

Publication Number Publication Date
BR9807319A true BR9807319A (pt) 2000-04-18

Family

ID=9503556

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807319-2A BR9807319A (pt) 1997-02-11 1998-02-10 Microgrânulos com liberação controlada, para administração oral, contendo cisplatina, processo de preparação dos mesmos, preparação farmacêutica, e, utilização dos microgrânulos.

Country Status (24)

Country Link
US (2) US6458389B1 (pt)
EP (1) EP0971702B1 (pt)
JP (1) JP4549445B2 (pt)
KR (1) KR100471672B1 (pt)
AR (1) AR011133A1 (pt)
AT (1) ATE255409T1 (pt)
BG (1) BG64247B1 (pt)
BR (1) BR9807319A (pt)
CA (1) CA2282082C (pt)
DE (1) DE69820239T2 (pt)
DK (1) DK0971702T3 (pt)
EA (1) EA001760B1 (pt)
ES (1) ES2210726T3 (pt)
FR (1) FR2759293B1 (pt)
HU (1) HU225425B1 (pt)
IL (1) IL131326A (pt)
IN (1) IN187998B (pt)
NO (1) NO323230B1 (pt)
NZ (1) NZ337216A (pt)
PL (1) PL191631B1 (pt)
PT (1) PT971702E (pt)
TW (1) TW561055B (pt)
WO (1) WO1998034599A1 (pt)
ZA (1) ZA981123B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050096304A1 (en) * 1998-09-08 2005-05-05 David White Method of treating cancer using dithiocarbamate derivatives
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
EP1178778B1 (fr) * 1999-05-17 2006-03-01 D.B.F. Granules contenant une substance vegetale et leur procede de preparation
US7569236B2 (en) * 2003-10-10 2009-08-04 Ethypharm Sustained-release microgranules containing gingko biloba extract and the process for manufacturing these
FR2861990B1 (fr) * 2003-11-10 2006-02-10 Nouveaux Produits Pharma Comprimes faiblement doses a reseau de polymeres
SI1817013T1 (sl) * 2004-11-18 2008-12-31 Bristol Myers Squibb Co Peleta z gastrorezistentno oblogo, ki vsebuje iksabepilon
WO2006062072A1 (ja) * 2004-12-10 2006-06-15 Tmrc Co., Ltd. 転移癌治療剤および癌転移抑制剤
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
FR2918566B1 (fr) * 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
ES2393805T3 (es) * 2007-09-21 2012-12-28 Evonik Röhm Gmbh Composición farmacéutica de liberación controlada dependiente del pH para compuestos no opioides con resistencia frente a la influencia del etanol
SI2187876T1 (sl) * 2007-09-21 2012-12-31 Evonik Roehm Gmbh Od pH odvisen opioidni farmacevtski sestavek z nadzorovanim sproščanjem z odpornostjo na vpliv etanola
CA2711473C (en) * 2008-01-10 2016-01-26 Evonik Roehm Gmbh Coated pharmaceutical or nutraceutical preparation with enhanced active substance release in the colon
BRPI0821985A2 (pt) * 2008-01-10 2015-06-23 Evonik Roehm Gmbh Preparacao farmacêutica ou nutracêutica revestida tendo liberação de substância ativa controlada
DK177529B1 (en) * 2009-10-23 2013-09-08 Bio Bedst Aps Liposomes with improved storage stability
CA2688202C (en) * 2009-12-11 2012-11-13 Bj Services Company Viscoelastic fluids containing hydroxyethyl cellulose
EP2371356B1 (en) * 2010-03-12 2012-12-19 Phoeme GmbH Multi-particle pharmaceutical formulation for colon absorption
US8070047B1 (en) * 2010-12-02 2011-12-06 Rohm And Haas Electronic Materials Llc Flux composition and method of soldering
DK2892524T3 (da) 2012-09-04 2021-01-25 Eleison Pharmaceuticals LLC Forebyggelse af pulmonalt kræfttilbagefald med lipid-komplekseret cisplatin
CA2959414C (en) 2014-09-05 2023-03-14 Symbiomix Therapeutics, Llc Secnidazole for use in the treatment of bacterial vaginosis
US10238688B2 (en) * 2015-04-24 2019-03-26 Genedia Biotech Co., Ltd. Combination therapies for bladder cancer
WO2016196653A1 (en) * 2015-06-01 2016-12-08 Symbiomix Therapeutics, Llc Novel nitroimidazole formulations and uses thereof
AU2016274599B2 (en) 2015-06-12 2021-09-02 Vaxart, Inc. Formulations for small intestinal delivery of RSV and norovirus antigens
MX2020011130A (es) * 2018-04-24 2022-09-09 Shionogi & Co Forma de dosificacion solida que tiene excelente estabilidad.
AR115354A1 (es) * 2018-04-24 2020-12-23 Shionogi & Co Forma de dosis sólida con excelente estabilidad

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3172570D1 (en) * 1981-03-11 1985-11-14 Mirko Beljanski Serpentine, alstonine and sempervirine drugs for the specific inhibition of tumurous and cancerous cells
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
DE3523454A1 (de) * 1985-07-01 1987-01-08 Eberhard Prof Dr Nuernberg Formkoerper
US4925674A (en) * 1988-08-25 1990-05-15 Himedics, Inc. Amoxicillin microencapsulated granules
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
JPH05294839A (ja) * 1992-04-20 1993-11-09 Biomaterial Universe Kk シスプラチン含有生体内分解吸収性高分子の微小球お よびその製造法
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
JPH07112932A (ja) * 1993-08-27 1995-05-02 Mitsui Toatsu Chem Inc 徐放性医薬製剤
JPH0789849A (ja) * 1993-09-20 1995-04-04 Fujisawa Pharmaceut Co Ltd 徐放性製剤
JPH0859460A (ja) * 1994-08-22 1996-03-05 Tanaka Kikinzoku Kogyo Kk 抗ガン剤内包キトサンミクロスフェア及びその製造法
US5637319A (en) * 1995-03-01 1997-06-10 Takada; Kanji Controlled-release preparations
US5614206A (en) * 1995-03-07 1997-03-25 Wright Medical Technology, Inc. Controlled dissolution pellet containing calcium sulfate
DE69725747T2 (de) * 1996-08-23 2004-07-29 Sequus Pharmaceuticals, Inc., Menlo Park Liposome enthaltend cisplatin

Also Published As

Publication number Publication date
US20030017210A1 (en) 2003-01-23
KR100471672B1 (ko) 2005-03-07
BG64247B1 (bg) 2004-07-30
DE69820239D1 (de) 2004-01-15
HUP0001719A3 (en) 2005-11-28
JP4549445B2 (ja) 2010-09-22
NO323230B1 (no) 2007-02-05
BG103647A (en) 2000-03-31
AU6626798A (en) 1998-08-26
HUP0001719A2 (hu) 2000-11-28
IL131326A (en) 2005-03-20
NO993881L (no) 1999-09-29
KR20000070997A (ko) 2000-11-25
ATE255409T1 (de) 2003-12-15
AU744001B2 (en) 2002-02-14
NO993881D0 (no) 1999-08-11
EA001760B1 (ru) 2001-08-27
EP0971702B1 (fr) 2003-12-03
US6458389B1 (en) 2002-10-01
EP0971702A1 (fr) 2000-01-19
PL335107A1 (en) 2000-04-10
AR011133A1 (es) 2000-08-02
FR2759293B1 (fr) 1999-04-30
DK0971702T3 (da) 2004-04-13
JP2001512433A (ja) 2001-08-21
FR2759293A1 (fr) 1998-08-14
CA2282082A1 (fr) 1998-08-13
WO1998034599A1 (fr) 1998-08-13
CA2282082C (fr) 2005-10-18
DE69820239T2 (de) 2004-10-07
IL131326A0 (en) 2001-01-28
NZ337216A (en) 2000-09-29
ZA981123B (en) 1998-08-20
TW561055B (en) 2003-11-11
PT971702E (pt) 2004-04-30
ES2210726T3 (es) 2004-07-01
IN187998B (pt) 2002-08-03
PL191631B1 (pl) 2006-06-30
HU225425B1 (en) 2006-11-28
EA199900734A1 (ru) 2000-04-24

Similar Documents

Publication Publication Date Title
BR9807319A (pt) Microgrânulos com liberação controlada, para administração oral, contendo cisplatina, processo de preparação dos mesmos, preparação farmacêutica, e, utilização dos microgrânulos.
ES2178430T3 (es) Utilizacion de composiciones farmaceuticas gelificables en parodontologia.
PT740650E (pt) Co-farmacos como um metodo de administracao controlada de farmacos
ES2162615T3 (es) Metodo para tratar o prevenir diabetes de tipo 1 mediante la administracion oral de insulina.
GEP20043269B (en) Purine Derivatives, Method for Their Production and Composition Containing the Same
ATE219363T1 (de) Lösliche prodrugs von paclitaxel
BR0209658A (pt) Derivados de 4-amino-5-fenil-7-1ciclobutil-pirrolo [2,3-d] pirimidina
BR0012136A (pt) Inibidores de reabsorção de norepinefrina altamente seletivos e métodos de uso dos mesmos
ES2171469T3 (es) Composicion administrada por via nasal y preparacion que la contiene.
KR960700061A (ko) 니코틴 의존상태 치료를 위한 약리학적 제형 (pharmaceutical composition for treating nicotine dependence)
KR970025615A (ko) 암 전이 억제제
ATE99172T1 (de) Verwendung von acetyl-l-carnitin zur behandlung von katarakt, sowie pharmazeutische zusammensetzungen fuer eine derartige behandlung.
DE58901002D1 (de) Mittel mit zerstoerender wirkung auf maligne tumore, verfahren zu dessen herstellung und praeparation zur anwendung in der therapie von krebskranken.
BR9401199A (pt) Preparados de medicamentos, processo para a preparação de um preparado de medicamento, processo para a preparação de uma formulação de medicamento.
BR0211198A (pt) Composições farmacêuticas e seu uso
TR200101633T2 (tr) Farmasötik bileşim
MXPA02003495A (es) Derivados de piridinio para el manejo de complicaciones vasculares diabeticas y relacionadas con la edad, proceso para su preparacion, y usos terapeuticos de los mismos.
PT760668E (pt) Utilizacao de produto a base de magnesio para o tratamento ou profilaxia de doencas neoplasicas e auto-imunes
KR830002510A (ko) 생물학적 활성화합물과 하이드록시알킬 전분으로 구성되는 조성물
KR910005858A (ko) 지방산 요법
NO172043C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive n-2,3-butadienyl-triamioalkanderivater
BR0116653A (pt) Medicamento contendo uma poliamina como substância ativa
CA2078869A1 (en) Pharmaceutical compositions containing ipriflavone, process for the preparation thereof and relative therapeutic use
ATE91890T1 (de) Herstellung eines arzneimittels gegen arthritis und rheumatismus.
CA2283739A1 (en) Ascorbic acid as an adjuvant in treatment of malignant tumors by chemotherapy and radiotherapy

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE NAO ATENDE AOS REQUISITOS NOVIDADE ATIVIDADE INVENTIVA ( ARTS. 8O,10 ( VIII ), 13, 24 E 25 DA LPI 9279/96

B12B Appeal against refusal [chapter 12.2 patent gazette]