HUP0001719A2 - Ciszplatin tartalmú mikrogranulátumok - Google Patents

Ciszplatin tartalmú mikrogranulátumok

Info

Publication number
HUP0001719A2
HUP0001719A2 HU0001719A HUP0001719A HUP0001719A2 HU P0001719 A2 HUP0001719 A2 HU P0001719A2 HU 0001719 A HU0001719 A HU 0001719A HU P0001719 A HUP0001719 A HU P0001719A HU P0001719 A2 HUP0001719 A2 HU P0001719A2
Authority
HU
Hungary
Prior art keywords
cisplatin
microgranules
microgranule
additives
active ingredients
Prior art date
Application number
HU0001719A
Other languages
English (en)
Inventor
Patrice Debregeas
Gérard LeDuc
Pascal Oury
Pascal Suplie
Original Assignee
Laboratoires Des Produits Ethiques Ethypharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Des Produits Ethiques Ethypharm filed Critical Laboratoires Des Produits Ethiques Ethypharm
Publication of HUP0001719A2 publication Critical patent/HUP0001719A2/hu
Publication of HUP0001719A3 publication Critical patent/HUP0001719A3/hu
Publication of HU225425B1 publication Critical patent/HU225425B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgya ciszplatin tartalmú, orális adagolású, szabályozottfelszabadulású mikrogranulátum, melynek átlagos szemcsemérete 0,4 és1,5 mm között van, előnyösen 1 és 1,25 mm között. A találmány tárgyaközelebbről olyan mikrogranulátum, melyben minden mikrogranulátumtartalmaz egy alap mikrogranulátumot, amihez egy bevonószerttartalmazó bevonat kötődik, ami lehetővé teszi a ciszplatin és/vagymás hatóanyag szabályozott felszabadulását, és a nevezett alapmikrogranulátum vagy adalékanyagokból, vagy ciszpla- tinból és tetszésszerinti más hatóanyagokból áll, vagy egy semleges támasztó szemcséttartalmaz, amit adalékanyagok, ciszplatin és tetszés szerint máshatóanyagok keveréke von be. A találmány tárgyát képezik továbbá afenti mikrogranulátumot tartalmazó gyógyászati készítmények. Ó
HU0001719A 1997-02-11 1998-02-10 Microgranules containing cisplatin HU225425B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9701545A FR2759293B1 (fr) 1997-02-11 1997-02-11 Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie
PCT/FR1998/000251 WO1998034599A1 (fr) 1997-02-11 1998-02-10 Microgranules contenant du cisplatine

Publications (3)

Publication Number Publication Date
HUP0001719A2 true HUP0001719A2 (hu) 2000-11-28
HUP0001719A3 HUP0001719A3 (en) 2005-11-28
HU225425B1 HU225425B1 (en) 2006-11-28

Family

ID=9503556

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001719A HU225425B1 (en) 1997-02-11 1998-02-10 Microgranules containing cisplatin

Country Status (24)

Country Link
US (2) US6458389B1 (hu)
EP (1) EP0971702B1 (hu)
JP (1) JP4549445B2 (hu)
KR (1) KR100471672B1 (hu)
AR (1) AR011133A1 (hu)
AT (1) ATE255409T1 (hu)
BG (1) BG64247B1 (hu)
BR (1) BR9807319A (hu)
CA (1) CA2282082C (hu)
DE (1) DE69820239T2 (hu)
DK (1) DK0971702T3 (hu)
EA (1) EA001760B1 (hu)
ES (1) ES2210726T3 (hu)
FR (1) FR2759293B1 (hu)
HU (1) HU225425B1 (hu)
IL (1) IL131326A (hu)
IN (1) IN187998B (hu)
NO (1) NO323230B1 (hu)
NZ (1) NZ337216A (hu)
PL (1) PL191631B1 (hu)
PT (1) PT971702E (hu)
TW (1) TW561055B (hu)
WO (1) WO1998034599A1 (hu)
ZA (1) ZA981123B (hu)

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US20050096304A1 (en) * 1998-09-08 2005-05-05 David White Method of treating cancer using dithiocarbamate derivatives
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
PT1178778E (pt) * 1999-05-17 2006-06-30 D B F Granulos que contem uma substancia vegetal e o seu procedimento de preparacao
BRPI0415242B8 (pt) * 2003-10-10 2021-05-25 Ethypharm Sa microgrânulos de liberação gradual contendo extrato de gingko biloba e o processo para fabricar estes
FR2861990B1 (fr) 2003-11-10 2006-02-10 Nouveaux Produits Pharma Comprimes faiblement doses a reseau de polymeres
KR20070084325A (ko) * 2004-11-18 2007-08-24 브리스톨-마이어스 스큅 컴퍼니 익사베필론을 포함하는 장용성 코팅된 비드 및 그의 제조방법
KR20070092972A (ko) * 2004-12-10 2007-09-14 테무릭크 가부시키가이샤 전이암 치료제 및 암 전이 억제제
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
FR2918566B1 (fr) 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
US9700520B2 (en) * 2007-09-21 2017-07-11 Evonik Roehm Gmbh PH-dependent controlled release pharmaceutical opioid composition with resistance against the influence of ethanol
CA2699224C (en) * 2007-09-21 2014-12-16 Evonik Roehm Gmbh Ph-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol
CA2711473C (en) * 2008-01-10 2016-01-26 Evonik Roehm Gmbh Coated pharmaceutical or nutraceutical preparation with enhanced active substance release in the colon
WO2009086942A1 (en) * 2008-01-10 2009-07-16 Evonik Röhm Gmbh Coated pharmaceutical or nutraceutical preparation with accelerated controlled active substance release
DK177529B1 (en) * 2009-10-23 2013-09-08 Bio Bedst Aps Liposomes with improved storage stability
CA2688202C (en) * 2009-12-11 2012-11-13 Bj Services Company Viscoelastic fluids containing hydroxyethyl cellulose
EP2371356B1 (en) * 2010-03-12 2012-12-19 Phoeme GmbH Multi-particle pharmaceutical formulation for colon absorption
US8070047B1 (en) * 2010-12-02 2011-12-06 Rohm And Haas Electronic Materials Llc Flux composition and method of soldering
US11291644B2 (en) 2012-09-04 2022-04-05 Eleison Pharmaceuticals, Llc Preventing pulmonary recurrence of cancer with lipid-complexed cisplatin
KR20190026962A (ko) 2014-09-05 2019-03-13 심바이오믹스 세러퓨틱스 엘엘씨 세균질증 치료에 사용하기 위한 세크니다졸
US10238688B2 (en) * 2015-04-24 2019-03-26 Genedia Biotech Co., Ltd. Combination therapies for bladder cancer
CA2988082C (en) 2015-06-01 2020-09-29 Symbiomix Therapeutics, Llc Novel nitroimidazole formulations and uses thereof
WO2016200951A1 (en) 2015-06-12 2016-12-15 Vaxart, Inc. Formulations for small intestinal delivery of rsv and norovirus antigens
TWI795462B (zh) 2017-11-17 2023-03-11 日商鹽野義製藥股份有限公司 光安定性及溶出性優異的醫藥製劑
KR102501180B1 (ko) 2018-04-24 2023-02-21 시오노기세야쿠 가부시키가이샤 안정성이 우수한 고형 제제
MX2020011130A (es) * 2018-04-24 2022-09-09 Shionogi & Co Forma de dosificacion solida que tiene excelente estabilidad.

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DE3172570D1 (en) * 1981-03-11 1985-11-14 Mirko Beljanski Serpentine, alstonine and sempervirine drugs for the specific inhibition of tumurous and cancerous cells
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
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Also Published As

Publication number Publication date
ZA981123B (en) 1998-08-20
EP0971702A1 (fr) 2000-01-19
PL191631B1 (pl) 2006-06-30
CA2282082A1 (fr) 1998-08-13
US20030017210A1 (en) 2003-01-23
FR2759293B1 (fr) 1999-04-30
DK0971702T3 (da) 2004-04-13
IL131326A0 (en) 2001-01-28
IL131326A (en) 2005-03-20
ES2210726T3 (es) 2004-07-01
TW561055B (en) 2003-11-11
DE69820239T2 (de) 2004-10-07
EP0971702B1 (fr) 2003-12-03
NO993881L (no) 1999-09-29
HU225425B1 (en) 2006-11-28
IN187998B (hu) 2002-08-03
CA2282082C (fr) 2005-10-18
DE69820239D1 (de) 2004-01-15
ATE255409T1 (de) 2003-12-15
NO993881D0 (no) 1999-08-11
PL335107A1 (en) 2000-04-10
NZ337216A (en) 2000-09-29
KR20000070997A (ko) 2000-11-25
BG64247B1 (bg) 2004-07-30
KR100471672B1 (ko) 2005-03-07
WO1998034599A1 (fr) 1998-08-13
US6458389B1 (en) 2002-10-01
JP2001512433A (ja) 2001-08-21
NO323230B1 (no) 2007-02-05
AR011133A1 (es) 2000-08-02
EA199900734A1 (ru) 2000-04-24
BG103647A (en) 2000-03-31
AU744001B2 (en) 2002-02-14
BR9807319A (pt) 2000-04-18
FR2759293A1 (fr) 1998-08-14
PT971702E (pt) 2004-04-30
EA001760B1 (ru) 2001-08-27
HUP0001719A3 (en) 2005-11-28
AU6626798A (en) 1998-08-26
JP4549445B2 (ja) 2010-09-22

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees