DE69820239T2 - Cisplatinhaltige mikrogranulate - Google Patents

Cisplatinhaltige mikrogranulate Download PDF

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Publication number
DE69820239T2
DE69820239T2 DE69820239T DE69820239T DE69820239T2 DE 69820239 T2 DE69820239 T2 DE 69820239T2 DE 69820239 T DE69820239 T DE 69820239T DE 69820239 T DE69820239 T DE 69820239T DE 69820239 T2 DE69820239 T2 DE 69820239T2
Authority
DE
Germany
Prior art keywords
cisplatine
microgranules containing
microgranules
containing cisplatine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69820239T
Other languages
English (en)
Other versions
DE69820239D1 (de
Inventor
Patrice Debregeas
Gerard Leduc
Pascal Oury
Pascal Suplie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethypharm SAS
Original Assignee
Ethypharm SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm SAS filed Critical Ethypharm SAS
Application granted granted Critical
Publication of DE69820239D1 publication Critical patent/DE69820239D1/de
Publication of DE69820239T2 publication Critical patent/DE69820239T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69820239T 1997-02-11 1998-02-10 Cisplatinhaltige mikrogranulate Expired - Lifetime DE69820239T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9701545A FR2759293B1 (fr) 1997-02-11 1997-02-11 Microgranules contenant du cisplatine, procede de fabrication, preparation pharmaceutique et utilisation en polychimiotherapie ou en association avec une radiotherapie
PCT/FR1998/000251 WO1998034599A1 (fr) 1997-02-11 1998-02-10 Microgranules contenant du cisplatine

Publications (2)

Publication Number Publication Date
DE69820239D1 DE69820239D1 (de) 2004-01-15
DE69820239T2 true DE69820239T2 (de) 2004-10-07

Family

ID=9503556

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69820239T Expired - Lifetime DE69820239T2 (de) 1997-02-11 1998-02-10 Cisplatinhaltige mikrogranulate

Country Status (24)

Country Link
US (2) US6458389B1 (de)
EP (1) EP0971702B1 (de)
JP (1) JP4549445B2 (de)
KR (1) KR100471672B1 (de)
AR (1) AR011133A1 (de)
AT (1) ATE255409T1 (de)
BG (1) BG64247B1 (de)
BR (1) BR9807319A (de)
CA (1) CA2282082C (de)
DE (1) DE69820239T2 (de)
DK (1) DK0971702T3 (de)
EA (1) EA001760B1 (de)
ES (1) ES2210726T3 (de)
FR (1) FR2759293B1 (de)
HU (1) HU225425B1 (de)
IL (1) IL131326A (de)
IN (1) IN187998B (de)
NO (1) NO323230B1 (de)
NZ (1) NZ337216A (de)
PL (1) PL191631B1 (de)
PT (1) PT971702E (de)
TW (1) TW561055B (de)
WO (1) WO1998034599A1 (de)
ZA (1) ZA981123B (de)

Families Citing this family (25)

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US20050096304A1 (en) * 1998-09-08 2005-05-05 David White Method of treating cancer using dithiocarbamate derivatives
FR2790668B1 (fr) * 1999-03-12 2002-07-26 D B F Granules contenant une substance vegetale et leur procede de preparation
DE60026295T2 (de) * 1999-05-17 2006-10-12 D.B.F. Pflanzenmaterial enthaltendes granulat und verfahren zur herstellung
EP1689373B1 (de) * 2003-10-10 2019-04-03 Ethypharm Mikrogranulat mit verzögerter freisetzung mit ginkgo biloba extrakt und herstellungsverfahren dafür
FR2861990B1 (fr) * 2003-11-10 2006-02-10 Nouveaux Produits Pharma Comprimes faiblement doses a reseau de polymeres
PL1817013T3 (pl) * 2004-11-18 2009-01-30 Bristol Myers Squibb Co Dojelitowa powlekana peletka zawierająca Ixabepilone
WO2006062072A1 (ja) * 2004-12-10 2006-06-15 Tmrc Co., Ltd. 転移癌治療剤および癌転移抑制剤
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
FR2918567B1 (fr) * 2007-07-11 2012-08-03 Pf Medicament Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine.
FR2918566B1 (fr) 2007-07-11 2009-10-09 Pierre Fabre Medicament Sa Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
US9555006B2 (en) * 2007-09-21 2017-01-31 Evonik Roehm Gmbh PH-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol
KR101424653B1 (ko) * 2007-09-21 2014-08-06 에보니크 룀 게엠베하 에탄올의 영향에 대하여 내성을 가지는 ｐｈ-의존성 조절 방출 제약학적 오피오이드 조성물
SI2230932T1 (sl) * 2008-01-10 2017-07-31 Evonik Roehm Gmbh Oplaščeni farmacevtski ali nutracevtski pripravek s povečanim sproščanjem aktivne učinkovine v črevesu
US20110070302A2 (en) * 2008-01-10 2011-03-24 Evonik Roehm Gmbh Coated pharmaceutical or nutraceutical preparation with accelerated controlled active substance release
DK177529B1 (en) * 2009-10-23 2013-09-08 Bio Bedst Aps Liposomes with improved storage stability
CA2688202C (en) * 2009-12-11 2012-11-13 Bj Services Company Viscoelastic fluids containing hydroxyethyl cellulose
EP2371356B1 (de) * 2010-03-12 2012-12-19 Phoeme GmbH Pharmazeutische Mehrfachpartikelformulierung zur Kolonabsorption
US8070047B1 (en) * 2010-12-02 2011-12-06 Rohm And Haas Electronic Materials Llc Flux composition and method of soldering
WO2014039533A2 (en) 2012-09-04 2014-03-13 Eleison Pharmaceuticals, Llc Preventing pulmonary recurrence of cancer with lipid-complexed cisplatin
KR20170052626A (ko) * 2014-09-05 2017-05-12 심바이오믹스 세러퓨틱스 엘엘씨 세균질증 치료에 사용하기 위한 세크니다졸
US10238688B2 (en) * 2015-04-24 2019-03-26 Genedia Biotech Co., Ltd. Combination therapies for bladder cancer
CA2988082C (en) * 2015-06-01 2020-09-29 Symbiomix Therapeutics, Llc Novel nitroimidazole formulations and uses thereof
KR20240031420A (ko) 2015-06-12 2024-03-07 박사르트, 인크. Rsv 및 노로바이러스 항원들의 소장 내의 전달을 위한 제형들
MX2020011130A (es) * 2018-04-24 2022-09-09 Shionogi & Co Forma de dosificacion solida que tiene excelente estabilidad.
AR115354A1 (es) 2018-04-24 2020-12-23 Shionogi & Co Forma de dosis sólida con excelente estabilidad

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0059817B1 (de) * 1981-03-11 1985-10-09 Mirko Beljanski Serpentin, Alstonin und Sempervirin, Medikamente, die die Tumor- und Krebszellen spezifisch hemmen
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
DE3523454A1 (de) * 1985-07-01 1987-01-08 Eberhard Prof Dr Nuernberg Formkoerper
US4925674A (en) * 1988-08-25 1990-05-15 Himedics, Inc. Amoxicillin microencapsulated granules
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
JPH05294839A (ja) * 1992-04-20 1993-11-09 Biomaterial Universe Kk シスプラチン含有生体内分解吸収性高分子の微小球お よびその製造法
US5795882A (en) * 1992-06-22 1998-08-18 Bone Care International, Inc. Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations
JPH07112932A (ja) * 1993-08-27 1995-05-02 Mitsui Toatsu Chem Inc 徐放性医薬製剤
JPH0789849A (ja) * 1993-09-20 1995-04-04 Fujisawa Pharmaceut Co Ltd 徐放性製剤
JPH0859460A (ja) * 1994-08-22 1996-03-05 Tanaka Kikinzoku Kogyo Kk 抗ガン剤内包キトサンミクロスフェア及びその製造法
US5637319A (en) * 1995-03-01 1997-06-10 Takada; Kanji Controlled-release preparations
US5614206A (en) * 1995-03-07 1997-03-25 Wright Medical Technology, Inc. Controlled dissolution pellet containing calcium sulfate
ES2208946T3 (es) * 1996-08-23 2004-06-16 Sequus Pharmaceuticals, Inc. Liposomas que contienen un compuesto de cisplatino.

Also Published As

Publication number Publication date
NZ337216A (en) 2000-09-29
US20030017210A1 (en) 2003-01-23
PL335107A1 (en) 2000-04-10
DK0971702T3 (da) 2004-04-13
IL131326A0 (en) 2001-01-28
HU225425B1 (en) 2006-11-28
US6458389B1 (en) 2002-10-01
NO323230B1 (no) 2007-02-05
HUP0001719A3 (en) 2005-11-28
IN187998B (de) 2002-08-03
AU6626798A (en) 1998-08-26
JP4549445B2 (ja) 2010-09-22
NO993881D0 (no) 1999-08-11
HUP0001719A2 (hu) 2000-11-28
CA2282082C (fr) 2005-10-18
AR011133A1 (es) 2000-08-02
IL131326A (en) 2005-03-20
BG103647A (en) 2000-03-31
ATE255409T1 (de) 2003-12-15
WO1998034599A1 (fr) 1998-08-13
PL191631B1 (pl) 2006-06-30
KR100471672B1 (ko) 2005-03-07
BG64247B1 (bg) 2004-07-30
EA199900734A1 (ru) 2000-04-24
EP0971702A1 (de) 2000-01-19
TW561055B (en) 2003-11-11
BR9807319A (pt) 2000-04-18
FR2759293B1 (fr) 1999-04-30
DE69820239D1 (de) 2004-01-15
NO993881L (no) 1999-09-29
FR2759293A1 (fr) 1998-08-14
ZA981123B (en) 1998-08-20
ES2210726T3 (es) 2004-07-01
KR20000070997A (ko) 2000-11-25
EA001760B1 (ru) 2001-08-27
EP0971702B1 (de) 2003-12-03
CA2282082A1 (fr) 1998-08-13
AU744001B2 (en) 2002-02-14
PT971702E (pt) 2004-04-30
JP2001512433A (ja) 2001-08-21

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Legal Events

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8364 No opposition during term of opposition