ES2161715T3 - Hibridacion genomica comparativa (hgc). - Google Patents

Hibridacion genomica comparativa (hgc).

Info

Publication number
ES2161715T3
ES2161715T3 ES93907077T ES93907077T ES2161715T3 ES 2161715 T3 ES2161715 T3 ES 2161715T3 ES 93907077 T ES93907077 T ES 93907077T ES 93907077 T ES93907077 T ES 93907077T ES 2161715 T3 ES2161715 T3 ES 2161715T3
Authority
ES
Spain
Prior art keywords
subject
nucleic acid
sequences
genomes
copy numbers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93907077T
Other languages
English (en)
Inventor
Daniel Pinkel
Joe W Gray
Anne Kallioniemi
Olli Pekka Kallioniemi
Frederic Waldman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
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Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of ES2161715T3 publication Critical patent/ES2161715T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

SE PRESENTAN NUEVOS METODO QUE CONSISTEN EN LLEVAR A CABO UNA HIBRIDACION IN SITU PARA DETECTAR LOS NUMEROS DE COPIAS DE SECUENCIAS DE ACIDOS NUCLEICOS ANORMALES EN UNO O MAS GENOMAS EN DONDE LAS SECUENCIAS REPETITIVAS QUE SE ENLAZAN A MULTIPLES LUGARES DE UN CROMOSOMA DE REFERENCIA PROPAGADO BIEN SE ELIMINAN SUSTANCIALMENTE Y/O SE ELIMINAN SUS SEÑALES DE HIBRIDACION. EN LA INVENCION DENOMINADA HIBRIDACION GENOMICA COMPARATIVA (CGH) SE PRESENTAN LOS METODOS PARA DETERMINAR EL NUMERO RELATIVO DE COPIAS DE SECUENCIAS DE ACIDOS NUCLEICOS EN UNO O MAS GENOMAS OBJETIVO O PORCIONES DE LOS MISMOS (POR EJEMPLO, UNA CELULA TUMORAL) COMO UNA FUNCION DE LA UBICACION DE ESAS SECUENCIAS EN UN GENOMA DE REFERENCIA (POR EJEMPLO, UN GENOMA HUMANO NORMAL). SE COMPARAN LA INTENSIDAD O INTENSIDADES DE LAS SEÑALES DE CADA ACIDO NUCLEICO OBJETIVO ETIQUETADO Y/O LAS DIFERENCIAS EN LAS RELACIONES ENTRE LAS SEÑALES DIFERENTES DE LAS SECUENCIAS DE ACIDOS NUCLEICOS OBJETIVO ETIQUETADAS PARA DETERMINAR LOS NUMEROS DECOPIAS RELATIVOS DE LAS SECUENCIAS DE ACIDOS NUCLEICOS EN EL O LOS GENOMAS OBJETIVO COMO UNA FUNCION DE LA POSICION A LO LARGO DE LA PROPAGACION DEL CROMOSOMA DE REFERENCIA. SE PUEDEN DETECTAR LAS AMPLIFICACIONES, DUPLICACIONES Y/O ELIMINACIONES DEL O LOS GENOMAS OBJETIVO. TAMBIEN SE PRESENTA UN METODO PARA DETERMINAR LOS NUMEROS DE COPIAS ABSOLUTOS DE SUSTANCIALMENTE TODAS LAS SECUENCIAS DE ARN O DE ADN EN LA O LAS CELULAS OBJETIVO O EN LA O LAS POBLACIONES DE CELULAS.
ES93907077T 1992-03-04 1993-03-01 Hibridacion genomica comparativa (hgc). Expired - Lifetime ES2161715T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84665992A 1992-03-04 1992-03-04
US96994892A 1992-10-30 1992-10-30

Publications (1)

Publication Number Publication Date
ES2161715T3 true ES2161715T3 (es) 2001-12-16

Family

ID=27126656

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93907077T Expired - Lifetime ES2161715T3 (es) 1992-03-04 1993-03-01 Hibridacion genomica comparativa (hgc).

Country Status (8)

Country Link
US (3) US5665549A (es)
EP (2) EP0631635B1 (es)
JP (1) JP3645903B2 (es)
AT (1) ATE205542T1 (es)
CA (1) CA2131543C (es)
DE (1) DE69330750T2 (es)
ES (1) ES2161715T3 (es)
WO (1) WO1993018186A1 (es)

Families Citing this family (254)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721098A (en) * 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
AU647741B2 (en) * 1989-12-01 1994-03-31 Regents Of The University Of California, The Methods and compositions for chromosome-specific staining
US6025126A (en) 1991-10-28 2000-02-15 Arch Development Corporation Methods and compositions for the detection of chromosomal aberrations
US7534567B2 (en) 1992-03-04 2009-05-19 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US5856097A (en) 1992-03-04 1999-01-05 The Regents Of The University Of California Comparative genomic hybridization (CGH)
ES2161715T3 (es) 1992-03-04 2001-12-16 Univ California Hibridacion genomica comparativa (hgc).
US5472842A (en) * 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
DE4344726C2 (de) * 1993-12-27 1997-09-25 Deutsches Krebsforsch Verfahren zum Nachweis von nicht balanciertem genetischen Material einer Spezies oder zum Nachweis der Genexpression in Zellen einer Spezies
US5962332A (en) * 1994-03-17 1999-10-05 University Of Massachusetts Detection of trinucleotide repeats by in situ hybridization
US6472585B1 (en) 1994-04-25 2002-10-29 Genentech, Inc. Cardiotrophin-1 defective mouse
US7258983B2 (en) 1994-04-25 2007-08-21 Genentech, Inc. Cardiotrophin-1 compositions and methods for the treatment of tumor
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5830645A (en) * 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5635351A (en) * 1995-03-14 1997-06-03 The Regents Of The University Of California Genetic gain and loss in gliomas
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
WO1997005282A2 (en) * 1995-07-28 1997-02-13 Rijksuniversiteit Groningen Methods and materials for determining relative abundance of microorganisms in mixed populations
US20040175718A1 (en) * 1995-10-16 2004-09-09 Affymetrix, Inc. Computer-aided visualization and analysis system for sequence evaluation
US7455964B1 (en) 1996-07-15 2008-11-25 The Hospital For Sick Children Genes from the 20q13 amplicon and their uses
US5801021A (en) * 1995-10-20 1998-09-01 The Regents Of The University Of California Amplifications of chromosomal region 20q13 as a prognostic indicator in breast cancer
US7049424B2 (en) 1996-07-15 2006-05-23 The Regents Of The University Of California Genes from the 20Q13 amplicon and their uses
NZ320546A (en) * 1995-11-13 1999-01-28 Pasteur Institut Ultrahigh resolution comparative nucleic acid hybridization to combed dna fibers
ES2220997T3 (es) * 1995-12-22 2004-12-16 Exact Sciences Corporation Metodos para la deteccion de poblaciones clonales de celulas transformadas en una muestra celular genomicamente heterogenea.
US5837196A (en) * 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5776683A (en) * 1996-07-11 1998-07-07 California Pacific Medical Center Methods for identifying genes amplified in cancer cells
US6146828A (en) * 1996-08-14 2000-11-14 Exact Laboratories, Inc. Methods for detecting differences in RNA expression levels and uses therefor
US6100029A (en) * 1996-08-14 2000-08-08 Exact Laboratories, Inc. Methods for the detection of chromosomal aberrations
US6203993B1 (en) 1996-08-14 2001-03-20 Exact Science Corp. Methods for the detection of nucleic acids
US6300077B1 (en) 1996-08-14 2001-10-09 Exact Sciences Corporation Methods for the detection of nucleic acids
US5928870A (en) * 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US6020137A (en) * 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
FR2755149B1 (fr) 1996-10-30 1999-01-15 Pasteur Institut Procede de diagnostic de maladies genetiques par peignage moleculaire et coffret de diagnostic
FR2755147B1 (fr) * 1996-10-30 1999-01-15 Pasteur Institut Procede de diagnostic de maladies genetiques par peignage moleculaire et coffret de diagnostic
GB9704054D0 (en) 1997-02-27 1997-04-16 Univ Cambridge Tech Assay
CA2284481A1 (en) * 1997-03-24 1998-10-01 Smithkline Beecham Corporation Method of producing a subtraction library
EP0878552A1 (en) 1997-05-13 1998-11-18 Erasmus Universiteit Rotterdam Molecular detection of chromosome aberrations
US6268136B1 (en) 1997-06-16 2001-07-31 Exact Science Corporation Methods for stool sample preparation
DE19743301A1 (de) * 1997-09-30 1999-04-01 Metasystems Hard & Software Gm Verfahren zum Vergleich der Kopienzahl von Nukleinsäuresequenzen
US20050084875A1 (en) * 1997-10-24 2005-04-21 University Of Rochester Molecular markers for the diagnosis of Alzheimer's disease
JP2001521754A (ja) * 1997-10-30 2001-11-13 コールド スプリング ハーバー ラボラトリー Ｄｎａ識別のためのプローブアレイ及びプローブアレイの使用方法
WO1999028725A1 (en) 1997-12-02 1999-06-10 Ozo Diversified Automation, Inc. Automated system for chromosome microdissection and method of using same
JP2002510033A (ja) * 1998-01-12 2002-04-02 ザ・サルク・インスティチュート 二重微小ｄｎａを有する細胞を処理するための組成物およびその処理方法
US6289229B1 (en) 1998-01-20 2001-09-11 Scimed Life Systems, Inc. Readable probe array for in vivo use
US6673914B1 (en) 1998-01-22 2004-01-06 John Wayne Cancer Institute Human tumor-associated gene
DE59913678D1 (de) * 1998-02-16 2006-08-31 Metasystems Hard & Software Gm Verfahren zum Nachweis von Änderungen in Biopolymeren
WO1999043196A2 (fr) * 1998-02-25 1999-09-02 Sumitomo Electric Industries, Ltd. Procede de diagnostic du cancer fonde sur la detection d'anomalies chromosomiques
US6183957B1 (en) 1998-04-16 2001-02-06 Institut Pasteur Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a BAC-based DNA library application to the detection of mycobacteria
US6979728B2 (en) 1998-05-04 2005-12-27 Baylor College Of Medicine Articles of manufacture and methods for array based analysis of biological molecules
WO1999057309A1 (en) 1998-05-04 1999-11-11 Dako A/S Method and probes for the detection of chromosome aberrations
US7901887B2 (en) 1998-05-09 2011-03-08 Ikonisys, Inc. Automated cancer diagnostic methods using fish
CA2331508A1 (en) 1998-05-09 1999-11-18 Ikonisys, Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
US20020001800A1 (en) * 1998-08-14 2002-01-03 Stanley N. Lapidus Diagnostic methods using serial testing of polymorphic loci
EP1131470A4 (en) * 1998-10-28 2004-11-10 Vysis Inc CELLULAR ARRAYS AND METHOD FOR DETECTING AND USING MARKERS FOR GENETIC DISORDERS
EP1127163A2 (en) * 1998-11-02 2001-08-29 The Brigham & Women's Hospital, Inc. A method for genomic substractive hybridization
US20020048752A1 (en) * 1998-11-23 2002-04-25 Stanley N. Lapidus Methods for detecting lower-frequency molecules
US6280947B1 (en) 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US6503718B2 (en) 1999-01-10 2003-01-07 Exact Sciences Corporation Methods for detecting mutations using primer extension for detecting disease
US6387618B1 (en) * 1999-03-03 2002-05-14 The United States Of America As Represented By The Secretary Of The Navy Micronucleus assay with genomic DNA hybridization probe and enzymatic color pigment detection
US6174681B1 (en) * 1999-03-05 2001-01-16 Mayo Foundation For Medical Education And Research Method and probe set for detecting cancer
US6465182B1 (en) 1999-04-29 2002-10-15 The Regents Of The University Of California Comparative fluorescence hybridization to oligonucleotide microarrays
AU6350800A (en) * 1999-07-19 2001-02-05 American Laboratory Technologies, Inc. Removing repetitive sequences from dna
US6440706B1 (en) 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6524794B1 (en) * 1999-10-29 2003-02-25 Decode Genetics Ehf. Identical-by-descent fragment enrichment
US6613516B1 (en) 1999-10-30 2003-09-02 Affymetrix, Inc. Preparation of nucleic acid samples
US7346200B1 (en) 1999-11-18 2008-03-18 Ikonisys, Inc. Method and apparatus for computer controlled cell based diagnosis
DE60104392T2 (de) * 2000-01-12 2005-08-11 Ventana Medical Systems, Inc., Tucson Verfahren zum nachweis der effektivität einer krebstherapie
DE60137829D1 (de) 2000-01-13 2009-04-16 Genentech Inc Menschliche stra6 polypeptide
US20040014056A1 (en) * 2000-05-02 2004-01-22 Jorg Hager Identification of genetic markers
EP1356088A2 (en) * 2000-06-07 2003-10-29 Baylor College of Medicine Compositions and methods for array-based nucleic acid hybridization
US20030082605A1 (en) * 2000-09-06 2003-05-01 Hodge Timothy A. Genomic DNA detection method and system thereof
US20050266494A1 (en) * 2000-09-06 2005-12-01 Hodge Timothy A System and method for computer network ordering of biological testing
EP1978110B1 (en) * 2000-09-06 2010-05-26 Transnetyx, Inc. Computer-based method and system for screening genomic DNA
US7494817B2 (en) * 2000-09-06 2009-02-24 Transnet Yx, Inc. Methods for genotype screening using magnetic particles
US20050239125A1 (en) * 2000-09-06 2005-10-27 Hodge Timothy A Methods for genotype screening
US20030087286A1 (en) * 2000-09-06 2003-05-08 Hodge Timothy A. Isolation of eukaryotic genomic DNA using magnetically responsive solid functionalized particles
US20050272085A1 (en) * 2000-09-06 2005-12-08 Hodge Timothy A Methods for forensic and congenic screening
WO2002044411A1 (en) * 2000-12-01 2002-06-06 Rosetta Inpharmatics, Inc. Use of profiling for detecting aneuploidy
US20020142305A1 (en) * 2001-03-27 2002-10-03 Koei Chin Methods for diagnosing and monitoring ovarian cancer by screening gene copy numbers
US20040161741A1 (en) * 2001-06-30 2004-08-19 Elazar Rabani Novel compositions and processes for analyte detection, quantification and amplification
US20060014186A1 (en) * 2001-09-04 2006-01-19 Hodge Timothy A Methods for genotype screening of a strain disposed on an adsorbent carrier
EP1451318A4 (en) * 2001-10-12 2007-06-27 Perkinelmer Las Inc NUCLEIC ACID COMPILATIONS, NETWORKS AND METHODS OF USE THEREOF
US7439346B2 (en) 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
US20030082618A1 (en) * 2001-10-15 2003-05-01 Guangshan Li Methods for detecting genetic aberrations
US7767390B2 (en) 2001-11-20 2010-08-03 Oncomedx, Inc. Methods for evaluating drug-resistance gene expression in the cancer patient
US20030124542A1 (en) * 2001-12-28 2003-07-03 Spectral Genomics, Inc. Methods for mapping the chromosomal loci of genes expressed by a cell
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
EP1497447A4 (en) * 2002-04-12 2006-09-20 Univ Missouri US ECIST MICROARRAYSES FOR DUAL SCREENING OF DNA HYPERMETHYLATION AND GENE INACTIVATION, AND FOR USE IN AN INTEGRATED SYSTEM FOR EVALUATING GENE EXPRESSION, DNA METHYLATION AND ACETYLATION OF HISTONE
WO2004011665A2 (en) * 2002-05-17 2004-02-05 Nugen Technologies, Inc. Methods for fragmentation, labeling and immobilization of nucleic acids
AU2003243400B2 (en) 2002-06-07 2009-10-29 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US9388459B2 (en) 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
NL1021160C2 (nl) * 2002-07-26 2004-01-27 Multigen Internat B V Werkwijze voor het bepalen van het kopieaantal van een nucleotidevolgorde.
US7011949B2 (en) * 2002-09-30 2006-03-14 Agilent Technologies, Inc. Methods and compositions for producing labeled probe nucleic acids for use in array based comparative genomic hybridization applications
US7822555B2 (en) * 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
US7424368B2 (en) * 2002-11-11 2008-09-09 Affymetix, Inc. Methods for identifying DNA copy number changes
US10229244B2 (en) 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
US8232055B2 (en) 2002-12-23 2012-07-31 Agilent Technologies, Inc. Comparative genomic hybridization assays using immobilized oligonucleotide features and compositions for practicing the same
US7750908B2 (en) 2003-04-04 2010-07-06 Agilent Technologies, Inc. Focus plus context viewing and manipulation of large collections of graphs
US20040219532A1 (en) * 2003-04-30 2004-11-04 Sampson Jeffrey R. Internal references measurements
JP2006525814A (ja) * 2003-05-23 2006-11-16 コールド スプリング ハーバー ラボラトリー ヌクレオチド配列の実質的表示
US7211384B2 (en) * 2003-05-28 2007-05-01 Agilent Technologies, Inc. Comparative genomic hybridization assays using immobilized oligonucleotide targets with initially small sample sizes and compositions for practicing the same
JP2007521014A (ja) * 2003-08-01 2007-08-02 パーキンエルマー・エルエイエス・インコーポレイテッド 診断および毒物学用のシンテニーゲノムアレイの調製および使用のためのアレイ、方法およびキット
JP2007515947A (ja) * 2003-10-30 2007-06-21 タフツ−ニュー イングランド メディカル センター 羊水中の無細胞胎児ｄｎａを使用する出生前診断
US20050208538A1 (en) 2003-12-29 2005-09-22 Nurith Kurn Methods for analysis of nucleic acid methylation status and methods for fragmentation, labeling and immobilization of nucleic acids
US20060084067A1 (en) * 2004-02-03 2006-04-20 Zohar Yakhini Method and system for analysis of array-based, comparative-hybridization data
WO2005079474A2 (en) * 2004-02-17 2005-09-01 The Regents Of The University Of California Detection of nucleic acid sequence differences by comparative genomic hybridization
US8321138B2 (en) 2005-07-29 2012-11-27 Agilent Technologies, Inc. Method of characterizing quality of hybridized CGH arrays
US20070031883A1 (en) * 2004-03-04 2007-02-08 Kincaid Robert H Analyzing CGH data to identify aberrations
US20050233338A1 (en) * 2004-04-20 2005-10-20 Barrett Michael T Methods and compositions for assessing chromosome copy number
US20050233339A1 (en) * 2004-04-20 2005-10-20 Barrett Michael T Methods and compositions for determining the relationship between hybridization signal of aCGH probes and target genomic DNA copy number
EP1766061B1 (en) 2004-05-20 2013-07-17 Quest Diagnostics Investments Incorporated Single label comparative hybridization
US20050282211A1 (en) * 2004-06-21 2005-12-22 Nuwaysir Emile F Probe optimization methods
JP4476050B2 (ja) * 2004-06-30 2010-06-09 株式会社ニデック 視野計
EP1789786A4 (en) * 2004-08-18 2008-02-13 Abbott Molecular Inc DETERMINING DATA QUALITY AND / OR SEGMENTAL ANEUMS USING A COMPUTER SYSTEM
US20070099227A1 (en) * 2004-10-12 2007-05-03 Curry Bo U Significance analysis using data smoothing with shaped response functions
US20060078899A1 (en) * 2004-10-12 2006-04-13 Scheffer Alicia F Methods and compositions for reducing label variation in array-based comparative genome hybridization assays
US20060078898A1 (en) * 2004-10-12 2006-04-13 Curry Bo U Methods and compositions for reducing label variation in array-based comparative genome hybridization assays II
US20060080043A1 (en) * 2004-10-12 2006-04-13 Sampas Nicholas M Comparative genomic hybridization significance analysis using data smoothing with shaped response functions
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US20060110744A1 (en) 2004-11-23 2006-05-25 Sampas Nicolas M Probe design methods and microarrays for comparative genomic hybridization and location analysis
WO2006081353A2 (en) 2005-01-27 2006-08-03 Quest Diagnostics Investments Incorporated Rapid comparative genome hybridization
US7541144B2 (en) * 2005-01-31 2009-06-02 Agilent Technologies, Inc. RNA labeling method
US20060172314A1 (en) * 2005-01-31 2006-08-03 Song Min-Sun Quantification of amplified nucleic acids
US20060173635A1 (en) * 2005-02-01 2006-08-03 Yakhini Zohar H Analyzing and visualizing enrichment in DNA sequence alterations
US20060192570A1 (en) * 2005-02-15 2006-08-31 Mann & Hummel Gmbh Apparatus for monitoring consumable parts
JP5744371B2 (ja) * 2005-02-22 2015-07-08 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 脊髄小脳性運動失調５型に関する遺伝子の同定、及び使用方法。
WO2007044071A2 (en) 2005-04-21 2007-04-19 Exact Sciences Corporation Analysis of heterogeneous nucleic acid samples
US7544471B2 (en) 2005-07-30 2009-06-09 Agilent Technologies, Inc. Preparing RNA from a wax-embedded tissue specimen
US20070048743A1 (en) * 2005-08-26 2007-03-01 Sampas Nicholas M Methods and compositions for assessing candidate aCGH probe nucleic acids
US20070087355A1 (en) * 2005-10-14 2007-04-19 Barrett Michael T Comparative genomic hybridization assays and compositions for practicing the same
US8076074B2 (en) 2005-11-29 2011-12-13 Quest Diagnostics Investments Incorporated Balanced translocation in comparative hybridization
US11306351B2 (en) 2005-12-21 2022-04-19 Affymetrix, Inc. Methods for genotyping
US20070231803A1 (en) * 2006-03-31 2007-10-04 Jensen Mark A Multiplex pcr mixtures and kits containing the same
US20070238108A1 (en) * 2006-04-07 2007-10-11 Agilent Technologies, Inc. Validation of comparative genomic hybridization
US20070238106A1 (en) * 2006-04-07 2007-10-11 Agilent Technologies, Inc. Systems and methods of determining alleles and/or copy numbers
US8058055B2 (en) 2006-04-07 2011-11-15 Agilent Technologies, Inc. High resolution chromosomal mapping
US20070238104A1 (en) * 2006-04-07 2007-10-11 Agilent Technologies, Inc. Competitive oligonucleotides
US20080058218A1 (en) * 2006-05-03 2008-03-06 Gordon David B Arrays of compound probes and methods using the same
US20070259346A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Analysis of arrays
US20070259347A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Methods of increasing the effective probe densities of arrays
US20070259345A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Target determination using compound probes
US20070259344A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Compound probes and methods of increasing the effective probe densities of arrays
US7702468B2 (en) * 2006-05-03 2010-04-20 Population Diagnostics, Inc. Evaluating genetic disorders
US10522240B2 (en) 2006-05-03 2019-12-31 Population Bio, Inc. Evaluating genetic disorders
US20100022403A1 (en) * 2006-06-30 2010-01-28 Nurith Kurn Methods for fragmentation and labeling of nucleic acids
US7437249B2 (en) 2006-06-30 2008-10-14 Agilent Technologies, Inc. Methods and systems for detrending signal intensity data from chemical arrays
WO2008028044A2 (en) 2006-08-30 2008-03-06 Centocor, Inc. Markers and methods for assessing and treating ulcerative colitis and related disorders using 66 gene panel
US8077951B2 (en) 2006-10-12 2011-12-13 Agilent Technologies, Inc. Method and system for dynamic, automated detection of outlying feature and feature background regions during processing of data scanned from a chemical array
US7881876B2 (en) 2006-10-12 2011-02-01 Agilent Technologies, Inc. Methods and systems for removing offset bias in chemical array data
US20080090236A1 (en) * 2006-10-13 2008-04-17 Yakhini Zohar H Methods and systems for identifying tumor progression in comparative genomic hybridization data
US20080102453A1 (en) * 2006-10-31 2008-05-01 Jayati Ghosh Methods and systems and analysis of CGH data
US8105770B2 (en) 2007-01-31 2012-01-31 Wako Pure Chemical Industries, Ltd. Method of detecting amplification or deletion in genomic DNA Fragment
US20080241829A1 (en) * 2007-04-02 2008-10-02 Milligan Stephen B Methods And Kits For Producing Labeled Target Nucleic Acid For Use In Array Based Hybridization Applications
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
US7507539B2 (en) 2007-07-30 2009-03-24 Quest Diagnostics Investments Incorporated Substractive single label comparative hybridization
GB0715030D0 (en) * 2007-08-02 2007-09-12 Wilson Carol J Testing process
CA2639530A1 (en) * 2007-09-17 2009-03-17 Bassem Bejjani Methods and systems for the detection of microdeletion and microduplication syndromes
AU2008303080A1 (en) 2007-09-28 2009-04-02 Murdoch Childrens Research Institute Cell detection, monitoring and isolation method
US20090088330A1 (en) * 2007-09-28 2009-04-02 Leproust Emily M Methods And Kits For Producing Labeled Target Nucleic Acids For Use In Array Based Hybridization Applications
US8093063B2 (en) 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
WO2009085234A2 (en) 2007-12-20 2009-07-09 Signal Pharmaceuticals, Inc. Use of micro-rna as a biomarker of immunomodulatory drug activity
ES2581774T3 (es) 2008-08-29 2016-09-07 Janssen Biotech, Inc. Marcadores y métodos de evaluación y tratamiento de colitis ulcerosa y trastornos relacionados mediante un panel de 20 genes
US20100104513A1 (en) * 2008-10-28 2010-04-29 General Electric Company Method and system for dye assessment
US20100210471A1 (en) 2008-11-12 2010-08-19 University Of Utah Research Foundation Autism associated genetic markers
JP5645816B2 (ja) 2009-05-25 2014-12-24 国立大学法人東京工業大学 中枢神経細胞の増殖及び分化に係る中核因子を含む医薬組成物
WO2010138908A1 (en) 2009-05-29 2010-12-02 Ventana Medical Systems, Inc. Igfir gene copy number as a prognostic marker in a non-small cell lung cancer
JP2012528569A (ja) 2009-05-29 2012-11-15 ヴェンタナ メディカル システムズ， インク． インサイツハイブリダイゼーションを使用した生物学試料の遺伝子コピー数のスコアリング法
CN102630250A (zh) 2009-09-25 2012-08-08 基因诊断测试公司 用于检测与癌症和其他疾病相关的染色体异常的多重(+/-)链阵列和测试
WO2011048499A1 (en) 2009-10-19 2011-04-28 Stichting Het Nederlands Kanker Instituut Predicting response to anti-cancer therapy via array comparative genomic hybridization
WO2011048495A1 (en) 2009-10-19 2011-04-28 Stichting Het Nederlands Kanker Instituut Predicting benefit of anti-cancer therapy via array comparative genomic hybridization
EP2491141A2 (en) 2009-10-19 2012-08-29 Stichting Het Nederlands Kanker Instituut Differentiation between brca2-associated tumours and sporadic tumours via array comparative genomic hybridization
EP2494076B1 (en) 2009-10-26 2017-11-22 Abbott Molecular Inc. Detection of chromosomal abnormalities associated with prognosis of non small cell lung cancer
WO2011082200A1 (en) 2009-12-29 2011-07-07 Cancer Genetics, Inc. Tool for diagnosis and prognosis of mature b-cell neoplasms
WO2011082293A1 (en) 2009-12-31 2011-07-07 Ventana Medical Systems, Inc. Methods for producing uniquely specific nucleic acid probes
WO2011083312A1 (en) 2010-01-08 2011-07-14 Oxford Gene Technology (Operations) Ltd Combined cgh & allele-specific hybridisation method
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
ES2621812T3 (es) 2010-05-10 2017-07-05 Mayo Foundation For Medical Education And Research Detección de anomalías cromosómicas asociadas con el cáncer endometrial
NZ603375A (en) 2010-06-15 2014-10-31 Celgene Corp Biomarkers for the treatment of psoriasis
EP2591433A4 (en) * 2010-07-06 2017-05-17 Life Technologies Corporation Systems and methods to detect copy number variation
CN103392182B (zh) 2010-08-02 2017-07-04 众有生物有限公司 用于发现遗传疾病中致病突变的系统和方法
EP2619326A2 (en) 2010-09-20 2013-07-31 Stichting Het Nederlands Kanker Instituut Methods for predicting response to anti-cancer therapy in cancer patients
WO2012149299A2 (en) 2011-04-29 2012-11-01 Celgene Corporaiton Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor
EP2732049A1 (en) 2011-07-14 2014-05-21 Traslational Cancer Drugs Pharma, S.L. Method for predicting outcome of cancer in a subject
US20130078632A1 (en) 2011-09-23 2013-03-28 Academisch Medisch Centrum Materials and methods for prognosis of progression of barrett's esophagus
US10221454B2 (en) 2011-10-10 2019-03-05 The Hospital For Sick Children Methods and compositions for screening and treating developmental disorders
WO2013055911A1 (en) 2011-10-14 2013-04-18 Dana-Farber Cancer Institute, Inc. Znf365/zfp365 biomarker predictive of anti-cancer response
SG11201401628WA (en) 2011-10-19 2014-05-29 Nugen Technologies Inc Compositions and methods for directional nucleic acid amplification and sequencing
US9121051B2 (en) 2011-10-31 2015-09-01 Arkray, Inc. Method of determining the abundance of a target nucleotide sequence of a gene of interest
EP2773779B1 (en) 2011-11-04 2020-10-14 Population Bio, Inc. Methods and compositions for diagnosing, prognosing, and treating neurological conditions
TWI455461B (zh) * 2011-11-23 2014-10-01 Delta Electronics Inc 冷卻套
JP2015500035A (ja) 2011-12-10 2015-01-05 アボツト・モレキユラー・インコーポレイテツド 悪性黒色腫の診断および悪性黒色腫の転移の予後予測のための物質および方法
CN104254617B (zh) 2011-12-22 2017-04-26 国家科学研究中心 通过单分子杂交和操作进行的dna检测和定量的方法
CN110055325A (zh) 2011-12-30 2019-07-26 雅培分子公司 用于前列腺癌的诊断、预后和评估治疗性/预防性治疗的材料和方法
WO2013101613A1 (en) 2011-12-30 2013-07-04 Abbott Molecular Inc. Materials and methods for diagnosis, prognosis, monitoring of recurrence, and assessment of therapeutic/prophylactic treatment of pancreatobiliary cancer
JP6284487B2 (ja) 2011-12-30 2018-02-28 アボツト・モレキユラー・インコーポレイテツド 膀胱癌の診断及びその再発のモニタリングのための材料及び方法
CA2862552A1 (en) 2012-01-26 2013-08-01 Nugen Technologies, Inc. Compositions and methods for targeted nucleic acid sequence enrichment and high efficiency library generation
DK2812452T3 (da) 2012-02-09 2020-06-29 Population Bio Inc Fremgangsmåder og sammensætninger til screening og behandling af udviklingsforstyrrelser
WO2013124740A2 (en) 2012-02-23 2013-08-29 Stichting Vu-Vumc BRCA DEFICIENCY PROTEIN AND mRNA SIGNATURES USEFUL IN IDENTIFICATION OF PATIENTS WITH BRCA-DEFICIENT TUMORS AND PREDICTING BENEFIT OF ANTI-CANCER THERAPY IN CANCER PATIENTS
WO2013167387A1 (en) 2012-05-10 2013-11-14 Ventana Medical Systems, Inc. Uniquely specific probes for pten, pik3ca, met, top2a, and mdm2
ITMI20120846A1 (it) 2012-05-16 2013-11-17 Bongulielmi Reto Metodo e sistema per valutare molecole in campioni biologici tramite immagini derivate da microarray
JP6181751B2 (ja) 2012-06-18 2017-08-16 ニューゲン テクノロジーズ， インコーポレイテッド 望まれない核酸配列のネガティブ選択のための組成物および方法
ES2872967T3 (es) 2012-06-29 2021-11-03 Celgene Corp Métodos para determinar la eficacia de fármacos usando IKZF3 (AIOLOS)
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US9587281B2 (en) 2012-08-14 2017-03-07 Celgene Corporation Cereblon isoforms and their use as biomarkers for therapeutic treatment
DK2895621T3 (da) 2012-09-14 2020-11-30 Population Bio Inc Fremgangsmåder og sammensætning til diagnosticering, prognose og behandling af neurologiske tilstande
WO2014048942A1 (en) 2012-09-25 2014-04-03 Ventana Medical Systems, Inc. Probes for pten, pik3ca, met, and top2a, and method for using the probes
CA2922005A1 (en) 2012-09-27 2014-04-03 Population Diagnostics, Inc. Methods and compositions for screening and treating developmental disorders
RS58023B2 (sr) 2012-11-01 2021-12-31 Infinity Pharmaceuticals Inc Lečenje kancera korišćenjem modulatora izoformi pi3 kinaza
US9994908B2 (en) 2013-03-14 2018-06-12 Abbott Molecular Inc. Materials and methods for assessment of colorectal adenoma
EP2971130A4 (en) 2013-03-15 2016-10-05 Nugen Technologies Inc SEQUENTIAL SEQUENCING
US20160113932A1 (en) 2013-05-30 2016-04-28 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
EP2813571A1 (en) 2013-06-13 2014-12-17 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Method for the treatment of lung cancer
US11104950B2 (en) 2013-09-11 2021-08-31 The Regents Of The University Of California Human blood molecular biodosimeter panel for distinguishing radiation exposure from inflammation stress
EP2891722B1 (en) 2013-11-12 2018-10-10 Population Bio, Inc. Methods and compositions for diagnosing, prognosing, and treating endometriosis
US9546399B2 (en) 2013-11-13 2017-01-17 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
MX2016007239A (es) 2013-12-06 2017-01-05 Celgene Corp Metodos para determinar la eficacia del farmaco para el tratamiento de linfoma difuso de celulas b grandes, mieloma multiple, y canceres mieloides.
WO2015131107A1 (en) 2014-02-28 2015-09-03 Nugen Technologies, Inc. Reduced representation bisulfite sequencing with diversity adaptors
AU2015249374A1 (en) 2014-04-24 2016-12-01 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
JP6640126B2 (ja) 2014-06-27 2020-02-05 セルジーン コーポレイション セレブロン及び他のｅ３ユビキチンリガーゼの立体構造の変化を誘導するための組成物及び方法
US9994912B2 (en) 2014-07-03 2018-06-12 Abbott Molecular Inc. Materials and methods for assessing progression of prostate cancer
CA2996445A1 (en) 2014-09-05 2016-03-10 Eli Hatchwell Methods and compositions for inhibiting and treating neurological conditions
WO2016057367A1 (en) 2014-10-06 2016-04-14 Dana-Farber Cancer Institute, Inc. Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
CN113230384A (zh) 2014-10-09 2021-08-10 丹娜法伯癌症研究院 用于治疗免疫失调的多次-可变il-2剂量方案
EP3218482A4 (en) 2014-11-11 2018-05-09 Abbott Molecular Inc. Hybridization probes and methods
CA2977532A1 (en) 2015-03-06 2016-09-15 Dana-Farber Cancer Institute, Inc. Pd-l2 biomarkers predictive of pd-1 pathway inhibitor responses in esophagogastric cancers
DK3109324T5 (en) * 2015-06-23 2019-02-11 Zytovision Gmbh PROCEDURE FOR THE DETECTION OF CHROMOSOMA DIFFERENCES
RS59158B9 (sr) 2015-08-17 2020-09-30 Kura Oncology Inc Postupci lečenja pacijenata obolelih od kancera pomoću inhibitora farneziltransferaze
WO2017117118A1 (en) 2015-12-28 2017-07-06 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases
EP3399980A4 (en) 2016-01-08 2019-09-04 Celgene Corporation METHODS OF TREATING CANCER AND USE OF BIOMARKERS AS FACTORS PREDICTIVE OF CLINICAL SENSITIVITY TO TREATMENTS
US20190119758A1 (en) 2016-04-22 2019-04-25 Kura Oncology, Inc. Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
JP7466308B2 (ja) 2016-09-20 2024-04-12 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｕｓｐ１０バイオマーカーおよびモジュレーターを用いたａｍｌの同定、評価、予防および処置のための組成物および方法
AR110031A1 (es) 2016-11-03 2019-02-13 Kura Oncology Inc Métodos de tratamiento de pacientes con cáncer con inhibidores de farnesiltransferasa
JP2020510632A (ja) 2017-02-03 2020-04-09 セルジーン コーポレイション セレブロンに対する小分子の親和性の測定方法
US10240205B2 (en) 2017-02-03 2019-03-26 Population Bio, Inc. Methods for assessing risk of developing a viral disease using a genetic test
TWI738314B (zh) 2017-02-21 2021-09-01 美商庫拉腫瘤技術股份有限公司 以法呢基轉移酶(farnesyltransferase)抑制劑治療癌症之方法
US9956215B1 (en) 2017-02-21 2018-05-01 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
EP3634496A4 (en) 2017-06-06 2021-09-08 Dana-Farber Cancer Institute, Inc. METHOD FOR RISING AWARENESS IN CANCER CELLS AGAINST T-CELL-MEDIATED KILLING BY MODULATING MOLECULAR SIGNAL PATHS
JP7325400B2 (ja) 2017-08-07 2023-08-14 クラ オンコロジー， インコーポレイテッド ファルネシルトランスフェラーゼ阻害剤を用いてがんを治療する方法
US10806730B2 (en) 2017-08-07 2020-10-20 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
WO2019125184A1 (en) 2017-12-19 2019-06-27 Auckland Uniservices Limited Use of biomarker in cancer therapy
EP3796909A4 (en) 2018-05-23 2022-03-16 Celgene Corporation TREATMENT OF MULTIPLE MYELoma AND USE OF BIOMARKERS FOR 4-(4-(4-(((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-4-YL)OXY)METHYL)BENZYL)-PIPERAZINE -1-YL)-3-FLUOROBENZONITRILE
EP4177356A1 (en) 2018-08-08 2023-05-10 PML Screening, LLC Methods for assessing risk of developing a viral disease using a genetic test
US20220002396A1 (en) 2018-11-01 2022-01-06 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2020180663A1 (en) 2019-03-01 2020-09-10 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
TW202043487A (zh) 2019-03-29 2020-12-01 美商庫拉腫瘤技術股份有限公司 以法尼基轉移酶(farnesyltransferase)抑制劑治療鱗狀細胞癌之方法
US20220168296A1 (en) 2019-04-01 2022-06-02 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2020223583A1 (en) 2019-05-02 2020-11-05 Kura Oncology, Inc. Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors
AU2022229805A1 (en) 2021-03-02 2023-09-21 Dana-Farber Cancer Institute, Inc. Methods of treating red blood cell disorders
WO2022261183A2 (en) 2021-06-08 2022-12-15 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating and/or identifying an agent for treating intestinal cancers
WO2023097119A2 (en) 2021-11-29 2023-06-01 Dana-Farber Cancer Institute, Inc. Methods and compositions to modulate riok2
WO2023201348A1 (en) 2022-04-15 2023-10-19 Celgene Corporation Methods for predicting responsiveness of lymphoma to drug and methods for treating lymphoma

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4681840A (en) * 1984-01-18 1987-07-21 The United States Of America As Represented By The Secretary Of Commerce Deoxyribonucleic acid molecules useful as probes for detecting oncogenes incorporated into chromosomal DNA
US4707440A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US4710465A (en) * 1984-04-19 1987-12-01 Yale University Junction-fragment DNA probes and probe clusters
US4647529A (en) * 1984-06-01 1987-03-03 Rodland Karin D Hybridization method of detecting nucleic acid sequences with probe containing thionucleotide
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4721669A (en) * 1985-01-18 1988-01-26 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4772691A (en) * 1985-06-05 1988-09-20 The Medical College Of Wisconsin, Inc. Chemically cleavable nucleotides
US4725536A (en) * 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4888278A (en) * 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US4770992A (en) * 1985-11-27 1988-09-13 Den Engh Gerrit J Van Detection of specific DNA sequences by flow cytometry
US5447841A (en) * 1986-01-16 1995-09-05 The Regents Of The Univ. Of California Methods for chromosome-specific staining
US5721098A (en) 1986-01-16 1998-02-24 The Regents Of The University Of California Comparative genomic hybridization
WO1987005027A1 (en) * 1986-02-21 1987-08-27 Whitehead Institute For Biomedical Research Y-specific dna hybridization probes and uses therefor
US5348855A (en) 1986-03-05 1994-09-20 Miles Inc. Assay for nucleic acid sequences in an unpurified sample
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US5085983A (en) * 1988-08-19 1992-02-04 City Of Hope Detection of human tumor progression and drug resistance
US5194300A (en) 1987-07-15 1993-03-16 Cheung Sau W Methods of making fluorescent microspheres
JP2589729B2 (ja) * 1988-01-30 1997-03-12 極東製薬工業株式会社 染色体ｄｎａを用いた細菌の同定方法および該同定用キット
US5064948A (en) * 1988-02-12 1991-11-12 The United States Of America As Represented By The Department Of Energy Chromosome specific repetitive dna sequences
AU4642089A (en) * 1988-11-15 1990-06-12 Yale University In situ suppression hybridization and uses therefor
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
GB8920211D0 (en) 1989-09-07 1989-10-18 Ici Plc Diagnostic method
AU647741B2 (en) * 1989-12-01 1994-03-31 Regents Of The University Of California, The Methods and compositions for chromosome-specific staining
US5427932A (en) * 1991-04-09 1995-06-27 Reagents Of The University Of California Repeat sequence chromosome specific nucleic acid probes and methods of preparing and using
ES2161715T3 (es) 1992-03-04 2001-12-16 Univ California Hibridacion genomica comparativa (hgc).
US5856097A (en) * 1992-03-04 1999-01-05 The Regents Of The University Of California Comparative genomic hybridization (CGH)
US5840484A (en) 1992-07-17 1998-11-24 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
US5472842A (en) * 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays

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