JP2020514290A5 - - Google Patents
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- Publication number
- JP2020514290A5 JP2020514290A5 JP2019536228A JP2019536228A JP2020514290A5 JP 2020514290 A5 JP2020514290 A5 JP 2020514290A5 JP 2019536228 A JP2019536228 A JP 2019536228A JP 2019536228 A JP2019536228 A JP 2019536228A JP 2020514290 A5 JP2020514290 A5 JP 2020514290A5
- Authority
- JP
- Japan
- Prior art keywords
- drug delivery
- polypeptide
- preparation
- cancer
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762443698P | 2017-01-07 | 2017-01-07 | |
| US62/443,698 | 2017-01-07 | ||
| US201762581978P | 2017-11-06 | 2017-11-06 | |
| US62/581,978 | 2017-11-06 | ||
| PCT/US2018/012604 WO2018129331A1 (en) | 2017-01-07 | 2018-01-05 | Dosing regimens and dosage forms for targeted tgf-b inhibition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020514290A JP2020514290A (ja) | 2020-05-21 |
| JP2020514290A5 true JP2020514290A5 (enExample) | 2021-02-18 |
Family
ID=62791283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019536228A Pending JP2020514290A (ja) | 2017-01-07 | 2018-01-05 | 標的ｔｇｆ−β阻害のための投薬計画及び投薬形態 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20190330375A1 (enExample) |
| EP (1) | EP3565599A4 (enExample) |
| JP (1) | JP2020514290A (enExample) |
| KR (1) | KR20190102059A (enExample) |
| CN (1) | CN110198738A (enExample) |
| AU (1) | AU2018205233A1 (enExample) |
| BR (1) | BR112019013924A2 (enExample) |
| CA (1) | CA3048646A1 (enExample) |
| CL (1) | CL2019001871A1 (enExample) |
| IL (1) | IL267856A (enExample) |
| MX (1) | MX2019008001A (enExample) |
| PH (1) | PH12019501574A1 (enExample) |
| RU (1) | RU2019124875A (enExample) |
| SG (1) | SG11201906157YA (enExample) |
| WO (1) | WO2018129331A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105658672A (zh) | 2013-08-22 | 2016-06-08 | 阿塞勒隆制药公司 | TGF-β受体II型变体及其用途 |
| WO2017024171A1 (en) | 2015-08-04 | 2017-02-09 | Acceleron Pharma Inc. | Methods for treating myeloproliferative disorders |
| CN110785431B (zh) | 2017-05-04 | 2024-05-07 | 阿塞勒隆制药公司 | TGF-β受体II型融合蛋白及其用途 |
| KR20210022680A (ko) * | 2018-06-22 | 2021-03-03 | 메르크 파텐트 게엠베하 | 담도암의 치료에 사용하기 위한 표적화된 TGF-β 억제를 위한 투약 레지멘 |
| JP2021529777A (ja) * | 2018-07-02 | 2021-11-04 | メルク パテント ゲーエムベーハー | 進行非小細胞肺癌の治療のための標的ＴＧＦ−β阻害による組み合わせ療法 |
| AU2019301070B2 (en) | 2018-07-09 | 2025-09-11 | Precigen, Inc. | Fusion constructs and methods of using thereof |
| KR102881644B1 (ko) * | 2018-11-09 | 2025-11-06 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | TGF-β 수용체 융합 단백질 약학적 조성물 및 이의 용도 |
| TW202043267A (zh) | 2019-01-30 | 2020-12-01 | 美商供石公司 | TGFβ之LTBP複合物專一性抑制劑及其用途 |
| CN114206926B (zh) | 2019-06-10 | 2022-06-17 | 山东博安生物技术股份有限公司 | 抗PDL1和TGFβ的双功能融合蛋白及其用途 |
| CN112574314A (zh) * | 2019-09-30 | 2021-03-30 | 和铂医药(苏州)有限公司 | 一种融合蛋白及其应用 |
| AU2020370370A1 (en) * | 2019-10-24 | 2022-05-05 | Amgen Inc. | Systems and approaches for drug delivery |
| CA3154413A1 (en) * | 2019-11-01 | 2021-05-06 | Yan Lan | Combined inhibition of pd-1, tgf.beta. and atm together with radiotherapy for the treatment of cancer |
| US12527839B2 (en) | 2019-11-05 | 2026-01-20 | Acceleron Pharma Inc. | Treatments for systemic sclerosis |
| CA3158047A1 (en) * | 2019-12-11 | 2021-06-17 | Yunying CHEN | Bi-functional antibody against pd-l1 and tgf? |
| EP4076388A1 (en) * | 2019-12-20 | 2022-10-26 | Ares Trading S.A. | Igg:tgfbetarii fusion protein composition |
| CN111118064B (zh) * | 2019-12-24 | 2022-10-25 | 华南理工大学 | 一种精子生成障碍动物模型及其制备方法与应用 |
| AU2021205433A1 (en) | 2020-01-11 | 2022-08-18 | Scholar Rock, Inc. | Tgfß inhibitors and use thereof |
| US20230050148A1 (en) | 2020-01-11 | 2023-02-16 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| US20230093512A1 (en) * | 2020-02-18 | 2023-03-23 | Nanjing GenScript Biotech Co., Ltd. | Fusion proteins and uses thereof |
| EP4093779A4 (en) * | 2020-02-25 | 2024-03-06 | Wuxi Biologics Ireland Limited | BIFUNCTIONAL FUSION PROTEIN AND USES THEREOF |
| IL299764A (en) | 2020-07-10 | 2023-03-01 | Precigen Inc | Fusion constructs and methods for using them |
| CN116323657B (zh) * | 2020-09-24 | 2023-12-08 | 上海齐鲁制药研究中心有限公司 | 同时靶向PD-L1和TGFβ的双功能分子及其医药用途 |
| KR20230154074A (ko) | 2021-03-08 | 2023-11-07 | 난징 진스크립트 바이오테크 컴퍼니 리미티드 | 이중 바이러스 벡터 시스템을 이용한 항체 전달 |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| EP4348260A2 (en) | 2021-06-03 | 2024-04-10 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| WO2023089083A1 (en) * | 2021-11-19 | 2023-05-25 | Merus N.V. | Multispecific binding moieties comprising pd-1 and tgf-brii binding domains |
| JP2026507882A (ja) | 2023-03-07 | 2026-03-06 | スカラー ロック インコーポレイテッド | 患者の抵抗性又は不応答性癌を治療するためのＴＧＦ－β阻害剤及びその使用 |
| WO2025240343A1 (en) | 2024-05-13 | 2025-11-20 | Scholar Rock, Inc. | Tgf-beta inhibitors for treating cancer |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5785682A (en) * | 1995-03-22 | 1998-07-28 | Abbott Laboratories | Pre-filled syringe drug delivery system |
| CA3253628A1 (en) * | 2010-03-05 | 2025-11-29 | The Johns Hopkins University | Compositions and methods for targeted immunomodulatory antibodies and fusion proteins |
| US20130110045A1 (en) * | 2011-10-31 | 2013-05-02 | Ming-Yuan Wu | Single use intravenous therapy administering device with needle safety covers |
| MY174248A (en) * | 2012-04-30 | 2020-04-01 | Biocon Ltd | Targeted/immunomodulatory fusion proteins and methods for making same |
| JP6720075B2 (ja) * | 2013-05-31 | 2020-07-08 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 癌のための併用療法 |
| MX381141B (es) * | 2014-02-10 | 2025-03-12 | Merck Patent Gmbh | INHIBICIÓN DIRIGIDA DEL FACTOR DE CRECIMIENTO TRANSFORMADOR ß (TGF ß). |
| UY36351A (es) * | 2014-10-14 | 2016-06-01 | Novartis Ag | Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas |
| AU2015380397B2 (en) * | 2015-01-31 | 2021-10-21 | The Trustees Of The University Of Pennsylvania | Compositions and methods for T cell delivery of therapeutic molecules |
| CN116327915A (zh) * | 2015-04-03 | 2023-06-27 | 佐马技术有限公司 | 使用TGF-β抑制剂和PD-1抑制剂治疗癌症 |
| EP3294770B2 (en) * | 2015-05-12 | 2024-03-20 | F. Hoffmann-La Roche AG | Therapeutic and diagnostic methods for cancer |
-
2018
- 2018-01-05 JP JP2019536228A patent/JP2020514290A/ja active Pending
- 2018-01-05 SG SG11201906157YA patent/SG11201906157YA/en unknown
- 2018-01-05 CN CN201880006085.0A patent/CN110198738A/zh active Pending
- 2018-01-05 WO PCT/US2018/012604 patent/WO2018129331A1/en not_active Ceased
- 2018-01-05 AU AU2018205233A patent/AU2018205233A1/en not_active Abandoned
- 2018-01-05 RU RU2019124875A patent/RU2019124875A/ru unknown
- 2018-01-05 KR KR1020197022795A patent/KR20190102059A/ko not_active Ceased
- 2018-01-05 MX MX2019008001A patent/MX2019008001A/es unknown
- 2018-01-05 EP EP18736497.1A patent/EP3565599A4/en active Pending
- 2018-01-05 CA CA3048646A patent/CA3048646A1/en active Pending
- 2018-01-05 BR BR112019013924-9A patent/BR112019013924A2/pt not_active Application Discontinuation
-
2019
- 2019-07-02 US US16/460,792 patent/US20190330375A1/en not_active Abandoned
- 2019-07-03 PH PH12019501574A patent/PH12019501574A1/en unknown
- 2019-07-04 IL IL267856A patent/IL267856A/en unknown
- 2019-07-05 CL CL2019001871A patent/CL2019001871A1/es unknown
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