JP2020508317A5 - - Google Patents

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JP2020508317A5
JP2020508317A5 JP2019545324A JP2019545324A JP2020508317A5 JP 2020508317 A5 JP2020508317 A5 JP 2020508317A5 JP 2019545324 A JP2019545324 A JP 2019545324A JP 2019545324 A JP2019545324 A JP 2019545324A JP 2020508317 A5 JP2020508317 A5 JP 2020508317A5
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pharmaceutical composition
seq
antibody
amino acid
acid sequence
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JP2019545324A
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JP2020508317A (ja
JP7324710B2 (ja
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Priority claimed from PCT/US2018/018747 external-priority patent/WO2018156494A1/en
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Priority to JP2022037781A priority Critical patent/JP7384949B2/ja
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Publication of JP7324710B2 publication Critical patent/JP7324710B2/ja
Priority to JP2023190525A priority patent/JP7656012B2/ja
Priority to JP2025044340A priority patent/JP2025098103A/ja
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JP2019545324A 2017-02-21 2018-02-20 肺癌の処置のための抗pd-1抗体 Active JP7324710B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022037781A JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体
JP2023190525A JP7656012B2 (ja) 2017-02-21 2023-11-08 肺癌の処置のための抗pd-1抗体
JP2025044340A JP2025098103A (ja) 2017-02-21 2025-03-19 肺癌の処置のための抗pd-1抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762461672P 2017-02-21 2017-02-21
US62/461,672 2017-02-21
US201762595190P 2017-12-06 2017-12-06
US62/595,190 2017-12-06
PCT/US2018/018747 WO2018156494A1 (en) 2017-02-21 2018-02-20 Anti-pd-1 antibodies for treatment of lung cancer

Related Child Applications (1)

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JP2022037781A Division JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体

Publications (3)

Publication Number Publication Date
JP2020508317A JP2020508317A (ja) 2020-03-19
JP2020508317A5 true JP2020508317A5 (enExample) 2021-07-26
JP7324710B2 JP7324710B2 (ja) 2023-08-10

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ID=61628468

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Application Number Title Priority Date Filing Date
JP2019545324A Active JP7324710B2 (ja) 2017-02-21 2018-02-20 肺癌の処置のための抗pd-1抗体
JP2022037781A Active JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体
JP2023190525A Active JP7656012B2 (ja) 2017-02-21 2023-11-08 肺癌の処置のための抗pd-1抗体
JP2025044340A Pending JP2025098103A (ja) 2017-02-21 2025-03-19 肺癌の処置のための抗pd-1抗体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2022037781A Active JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体
JP2023190525A Active JP7656012B2 (ja) 2017-02-21 2023-11-08 肺癌の処置のための抗pd-1抗体
JP2025044340A Pending JP2025098103A (ja) 2017-02-21 2025-03-19 肺癌の処置のための抗pd-1抗体

Country Status (12)

Country Link
US (3) US11292842B2 (enExample)
EP (1) EP3585812A1 (enExample)
JP (4) JP7324710B2 (enExample)
KR (2) KR20240011262A (enExample)
CN (2) CN110536905B (enExample)
AU (2) AU2018225102B2 (enExample)
CA (1) CA3054289A1 (enExample)
IL (3) IL308805B1 (enExample)
MA (1) MA47604A (enExample)
MX (2) MX2019009772A (enExample)
WO (1) WO2018156494A1 (enExample)
ZA (1) ZA201905051B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
UA124379C2 (uk) 2015-08-11 2021-09-08 Усі Байолоджікс Айрленд Лімітед Нові антитіла проти білка pd-1
CA3037380A1 (en) 2016-10-11 2018-04-19 Agenus Inc. Anti-lag-3 antibodies and methods of use thereof
IL308805B1 (en) * 2017-02-21 2025-08-01 Regeneron Pharma Anti-pd-1 antibodies for treatment of lung cancer
US11389525B2 (en) * 2017-10-27 2022-07-19 Statens Serum Institut Polygene influenza vaccine
CN113544144A (zh) 2018-09-19 2021-10-22 高山免疫科学股份有限公司 变体cd80融合蛋白和相关构建体的方法和用途
HRP20240825T1 (hr) 2018-11-14 2024-09-27 Regeneron Pharmaceuticals, Inc. Intralezijsko davanje pd-1 inhibitora za liječenje raka kože
KR20210119451A (ko) * 2019-01-21 2021-10-05 사노피 진행성 단계의 고형 종양 암에 대한 치료용 rna
AU2020228296B2 (en) 2019-02-28 2025-10-02 Regeneron Pharmaceuticals, Inc. Administration of PD-1 inhibitors for treating skin cancer
CA3129963A1 (en) 2019-03-06 2020-09-10 Regeneron Pharmaceuticals, Inc. Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer
US20230054413A1 (en) * 2019-12-13 2023-02-23 Samsung Bioepis Co., Ltd. Stable anti-pd1 antibody pharmaceutical formulations
CN113244385A (zh) * 2020-02-07 2021-08-13 上海君实生物医药科技股份有限公司 抗pd-1抗体在治疗恶性肿瘤中的用途
FI4117667T3 (fi) 2020-03-13 2025-02-10 Univ Texas Syöpien jaksottainen hoito käyttäen 6-tio-dg- ja tarkistuspisteen inhibiittoreita
WO2023185720A1 (zh) * 2022-03-28 2023-10-05 齐鲁制药有限公司 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途
EP4598960A1 (en) * 2022-10-05 2025-08-13 Chulalongkorn University Monoclonal antibodies against human programmed cell death protein 1 (pd-1)
WO2025030110A1 (en) * 2023-08-02 2025-02-06 Sensei Biotherapeutics, Inc. Cancer therapies targeting vista as monotherapy or in combination with anti-pd1 antibody to treat cancer
WO2025159618A1 (ko) 2024-01-24 2025-07-31 주식회사 엘지에너지솔루션 전극탭 용접장치 및 전극탭 용접방법
WO2025207705A1 (en) 2024-03-26 2025-10-02 Amgen Inc. Cancer treatments using mta-cooperative prmt5 inhibitors
WO2025213154A1 (en) 2024-04-05 2025-10-09 Amgen Inc. Gastrointestinal cancer treatments using mta-cooperative prmt5 inhibitors

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
MXPA02001877A (es) 1999-08-23 2002-08-20 Dana Farber Cancer Inst Inc Pd-1, un receptor para b7-4, y usos del mismo.
WO2002086083A2 (en) 2001-04-20 2002-10-31 Mayo Foundation For Medical Education And Research Methods of enhancing cell responsiveness
MXPA05006828A (es) 2002-12-23 2005-09-08 Wyeth Corp Anticuerpos contra pd-1, y sus usos.
EP2270051B1 (en) 2003-01-23 2019-05-15 Ono Pharmaceutical Co., Ltd. Antibody specific for human PD-1 and CD3
DK1866339T3 (da) 2005-03-25 2013-09-02 Gitr Inc GTR-bindende molekyler og anvendelser heraf
JP4361545B2 (ja) 2005-05-09 2009-11-11 小野薬品工業株式会社 ProgrammedDeath1(PD−1)に対するヒトモノクローナル抗体および抗PD−1抗体単独または他の免疫療法と併用した癌治療方法
HRP20151102T1 (xx) 2005-07-01 2015-11-20 E. R. Squibb & Sons, L.L.C. Humana monoklonska antitijela za ligand programirane smrti 1 (pd-l1)
NZ582150A (en) 2007-06-18 2012-08-31 Msd Oss Bv Antibodies to human programmed death receptor pd-1
PT2175884T (pt) 2007-07-12 2016-09-21 Gitr Inc Terapias de combinação empregando moléculas de ligação a gitr
WO2009030285A1 (en) 2007-09-07 2009-03-12 Ablynx N.V. Binding molecules with multiple binding sites, compositions comprising the same and uses thereof
WO2009114335A2 (en) 2008-03-12 2009-09-17 Merck & Co., Inc. Pd-1 binding proteins
CN102203132A (zh) 2008-08-25 2011-09-28 安普利穆尼股份有限公司 Pd-1拮抗剂的组合物和使用方法
KR20250091300A (ko) 2008-12-09 2025-06-20 제넨테크, 인크. 항-pd-l1 항체 및 t 세포 기능을 향상시키기 위한 그의 용도
CN103951753B (zh) 2009-09-03 2018-01-12 默沙东公司 抗‑gitr抗体
DK2504364T3 (da) 2009-11-24 2017-11-06 Medimmune Ltd Målrettede bindemidler mod b7-h1
TW201134488A (en) 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
CA2802344C (en) 2010-06-18 2023-06-13 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
CA2840018C (en) 2011-07-24 2019-07-16 Curetech Ltd. Variants of humanized immunomodulatory monoclonal antibodies
AR087405A1 (es) 2011-08-01 2014-03-19 Genentech Inc Metodos para tratar el cancer por el uso de antagonistas de union al eje pd-1 e inhibidores de mek
CA2871751C (en) 2012-05-04 2021-08-24 Dana-Farber Cancer Institute, Inc. Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use
US9889982B2 (en) 2012-07-23 2018-02-13 Silgan Dispensing Systems Corporation Aerosol actuators, devices, and methods of making and using the same
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
WO2015030929A1 (en) 2013-08-30 2015-03-05 Ebay, Inc. Keyword bid optimization for text ads
US10241115B2 (en) 2013-12-10 2019-03-26 Merck Sharp & Dohme Corp. Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue
CA3131724A1 (en) 2013-12-17 2015-06-25 Genentech, Inc. Anti-cd3 antibodies and methods of use
TWI680138B (zh) 2014-01-23 2019-12-21 美商再生元醫藥公司 抗pd-l1之人類抗體
TWI681969B (zh) * 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
KR20170003692A (ko) * 2014-05-15 2017-01-09 브리스톨-마이어스 스큅 컴퍼니 항-pd-1 항체 및 또 다른 항암제의 조합물을 사용한 폐암의 치료
PH12016502345B1 (en) 2014-05-28 2023-03-01 Agenus Inc Anti-gitr antibodies and methods of use thereof
ES2901705T3 (es) 2014-06-06 2022-03-23 Bristol Myers Squibb Co Anticuerpos contra el receptor del factor de necrosis tumoral inducido por glucocorticoides (GITR) y usos de los mismos
US10092645B2 (en) 2014-06-17 2018-10-09 Medimmune Limited Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy
US10390522B2 (en) 2014-06-19 2019-08-27 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized programmed cell death 1 gene
MX2017007321A (es) * 2014-12-02 2017-08-25 Celgene Corp Terapias de combinacion.
EP3254110B1 (en) 2015-02-03 2020-03-18 Ventana Medical Systems, Inc. Histochemical assay for evaluating expression of programmed death ligand 1 (pd-l1)
SG11201707383PA (en) 2015-03-13 2017-10-30 Cytomx Therapeutics Inc Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
SG11201708223QA (en) * 2015-04-17 2017-11-29 Bristol Myers Squibb Co Compositions comprising a combination of an anti-pd-1 antibody and another antibody
CN107667119A (zh) * 2015-05-12 2018-02-06 豪夫迈·罗氏有限公司 用于癌症的治疗和诊断方法
US20180155429A1 (en) 2015-05-28 2018-06-07 Bristol-Myers Squibb Company Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody
US11434294B2 (en) 2016-02-25 2022-09-06 Cell Medica, Inc. Binding members to PD-L1
EP3548515A1 (en) 2016-12-01 2019-10-09 Regeneron Pharmaceuticals, Inc. Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging
IL308805B1 (en) * 2017-02-21 2025-08-01 Regeneron Pharma Anti-pd-1 antibodies for treatment of lung cancer
US11603407B2 (en) 2017-04-06 2023-03-14 Regeneron Pharmaceuticals, Inc. Stable antibody formulation
JP2025533075A (ja) * 2022-10-03 2025-10-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 二重特異性EGFRxCD28抗体単独又は抗PD-1抗体との併用による癌治療方法

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