JP2020508317A5 - - Google Patents
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- JP2020508317A5 JP2020508317A5 JP2019545324A JP2019545324A JP2020508317A5 JP 2020508317 A5 JP2020508317 A5 JP 2020508317A5 JP 2019545324 A JP2019545324 A JP 2019545324A JP 2019545324 A JP2019545324 A JP 2019545324A JP 2020508317 A5 JP2020508317 A5 JP 2020508317A5
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022037781A JP7384949B2 (ja) | 2017-02-21 | 2022-03-11 | 肺癌の処置のための抗ｐｄ－１抗体 |
| JP2023190525A JP7656012B2 (ja) | 2017-02-21 | 2023-11-08 | 肺癌の処置のための抗ｐｄ－１抗体 |
| JP2025044340A JP2025098103A (ja) | 2017-02-21 | 2025-03-19 | 肺癌の処置のための抗ｐｄ－１抗体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762461672P | 2017-02-21 | 2017-02-21 | |
| US62/461,672 | 2017-02-21 | ||
| US201762595190P | 2017-12-06 | 2017-12-06 | |
| US62/595,190 | 2017-12-06 | ||
| PCT/US2018/018747 WO2018156494A1 (en) | 2017-02-21 | 2018-02-20 | Anti-pd-1 antibodies for treatment of lung cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022037781A Division JP7384949B2 (ja) | 2017-02-21 | 2022-03-11 | 肺癌の処置のための抗ｐｄ－１抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020508317A JP2020508317A (ja) | 2020-03-19 |
| JP2020508317A5 true JP2020508317A5 (enExample) | 2021-07-26 |
| JP7324710B2 JP7324710B2 (ja) | 2023-08-10 |
Family
ID=61628468
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019545324A Active JP7324710B2 (ja) | 2017-02-21 | 2018-02-20 | 肺癌の処置のための抗ｐｄ－１抗体 |
| JP2022037781A Active JP7384949B2 (ja) | 2017-02-21 | 2022-03-11 | 肺癌の処置のための抗ｐｄ－１抗体 |
| JP2023190525A Active JP7656012B2 (ja) | 2017-02-21 | 2023-11-08 | 肺癌の処置のための抗ｐｄ－１抗体 |
| JP2025044340A Pending JP2025098103A (ja) | 2017-02-21 | 2025-03-19 | 肺癌の処置のための抗ｐｄ－１抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022037781A Active JP7384949B2 (ja) | 2017-02-21 | 2022-03-11 | 肺癌の処置のための抗ｐｄ－１抗体 |
| JP2023190525A Active JP7656012B2 (ja) | 2017-02-21 | 2023-11-08 | 肺癌の処置のための抗ｐｄ－１抗体 |
| JP2025044340A Pending JP2025098103A (ja) | 2017-02-21 | 2025-03-19 | 肺癌の処置のための抗ｐｄ－１抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11292842B2 (enExample) |
| EP (1) | EP3585812A1 (enExample) |
| JP (4) | JP7324710B2 (enExample) |
| KR (2) | KR20240011262A (enExample) |
| CN (2) | CN110536905B (enExample) |
| AU (2) | AU2018225102B2 (enExample) |
| CA (1) | CA3054289A1 (enExample) |
| IL (3) | IL321717A (enExample) |
| MA (1) | MA47604A (enExample) |
| MX (2) | MX2019009772A (enExample) |
| WO (1) | WO2018156494A1 (enExample) |
| ZA (1) | ZA201905051B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160053301A1 (en) | 2014-08-22 | 2016-02-25 | Clearfork Bioscience, Inc. | Methods for quantitative genetic analysis of cell free dna |
| MY187739A (en) | 2015-08-11 | 2021-10-18 | Wuxi Biologics Cayman Inc | Novel anti-pd-1 antibodies |
| KR102850460B1 (ko) | 2016-08-25 | 2025-08-27 | 레졸루션 바이오사이언스, 인크. | Dna 샘플 중 게놈 카피 변화의 검출을 위한 방법 |
| TW202436356A (zh) | 2016-10-11 | 2024-09-16 | 美商艾吉納斯公司 | 抗ｌａｇ－３抗體及其使用方法 |
| IL321717A (en) * | 2017-02-21 | 2025-08-01 | Regeneron Pharma | Anti-PD-1 antibodies for the treatment of lung cancer |
| EP3700561A1 (en) * | 2017-10-27 | 2020-09-02 | Statens Serum Institut | A polygene influenza vaccine |
| KR20210089146A (ko) | 2018-09-19 | 2021-07-15 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 변이체 cd80 단백질 및 관련 구축물의 방법 및 용도 |
| EP3880186B1 (en) | 2018-11-14 | 2024-04-03 | Regeneron Pharmaceuticals, Inc. | Intralesional administration of pd-1 inhibitors for treating skin cancer |
| WO2020154187A1 (en) * | 2019-01-21 | 2020-07-30 | Sanofi | Therapeutic rna for advanced stage solid tumor cancers |
| SG11202108089SA (en) * | 2019-02-28 | 2021-08-30 | Regeneron Pharma | Administration of pd-1 inhibitors for treating skin cancer |
| SG11202109003QA (en) | 2019-03-06 | 2021-09-29 | Regeneron Pharma | Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer |
| KR20220115803A (ko) * | 2019-12-13 | 2022-08-18 | 삼성바이오에피스 주식회사 | 안정한 항-pd-1 항체 약제학적 제제 |
| CN113244385A (zh) * | 2020-02-07 | 2021-08-13 | 上海君实生物医药科技股份有限公司 | 抗pd-1抗体在治疗恶性肿瘤中的用途 |
| IL296403A (en) * | 2020-03-13 | 2022-11-01 | Univ Texas | Sequential cancer treatment using 6-thio-dg, checkpoint inhibitors and radiation therapy |
| WO2023185720A1 (zh) * | 2022-03-28 | 2023-10-05 | 齐鲁制药有限公司 | 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途 |
| CN120225558A (zh) * | 2022-10-05 | 2025-06-27 | 朱拉隆功大学 | 针对人程序性细胞死亡蛋白1(pd-1)的单克隆抗体 |
| WO2025030110A1 (en) * | 2023-08-02 | 2025-02-06 | Sensei Biotherapeutics, Inc. | Cancer therapies targeting vista as monotherapy or in combination with anti-pd1 antibody to treat cancer |
| WO2025159618A1 (ko) | 2024-01-24 | 2025-07-31 | 주식회사 엘지에너지솔루션 | 전극탭 용접장치 및 전극탭 용접방법 |
| WO2025207705A1 (en) | 2024-03-26 | 2025-10-02 | Amgen Inc. | Cancer treatments using mta-cooperative prmt5 inhibitors |
| WO2025213154A1 (en) | 2024-04-05 | 2025-10-09 | Amgen Inc. | Gastrointestinal cancer treatments using mta-cooperative prmt5 inhibitors |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| WO2001014557A1 (en) | 1999-08-23 | 2001-03-01 | Dana-Farber Cancer Institute, Inc. | Pd-1, a receptor for b7-4, and uses therefor |
| AU2002258941A1 (en) | 2001-04-20 | 2002-11-05 | Mayo Foundation For Medical Education And Research | Methods of enhancing cell responsiveness |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| US7563869B2 (en) | 2003-01-23 | 2009-07-21 | Ono Pharmaceutical Co., Ltd. | Substance specific to human PD-1 |
| WO2006105021A2 (en) | 2005-03-25 | 2006-10-05 | Tolerrx, Inc. | Gitr binding molecules and uses therefor |
| ES2720160T3 (es) | 2005-05-09 | 2019-07-18 | Ono Pharmaceutical Co | Anticuerpos monoclonales humanos contra muerte programada 1(PD-1) y métodos para tratar el cáncer usando anticuerpos dirigidos contra PD-1 solos o junto con otras sustancias inmunoterapéuticas |
| EA019344B1 (ru) | 2005-07-01 | 2014-03-31 | МЕДАРЕКС, Эл.Эл.Си. | Человеческие моноклональные антитела против лиганда-1 запрограммированной гибели клеток (pd-l1) и их применения |
| JP5191537B2 (ja) | 2007-06-18 | 2013-05-08 | エム・エス・ディー・オス・ベー・フェー | ヒトのプログラムされたデスレセプターｐｄ−１に対する抗体 |
| CA2693677C (en) | 2007-07-12 | 2018-02-13 | Tolerx, Inc. | Combination therapies employing gitr binding molecules |
| EP2195342A1 (en) | 2007-09-07 | 2010-06-16 | Ablynx N.V. | Binding molecules with multiple binding sites, compositions comprising the same and uses thereof |
| EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | PD-1 BINDING PROTEINS |
| RS54233B1 (sr) | 2008-08-25 | 2015-12-31 | Amplimmune Inc. | Kompozicije pd-1 antagonista i postupci za njihovu primenu |
| HUE065752T2 (hu) | 2008-12-09 | 2024-06-28 | Hoffmann La Roche | Anti-PD-L1 antitestek és felhasználásuk T-sejt funkció elõsegítésére |
| RU2595409C2 (ru) | 2009-09-03 | 2016-08-27 | Мерк Шарп И Доум Корп., | Анти-gitr-антитела |
| PT2504364T (pt) | 2009-11-24 | 2017-11-14 | Medimmune Ltd | Agentes de ligação direcionados contra b7-h1 |
| TW201134488A (en) | 2010-03-11 | 2011-10-16 | Ucb Pharma Sa | PD-1 antibodies |
| WO2011159877A2 (en) | 2010-06-18 | 2011-12-22 | The Brigham And Women's Hospital, Inc. | Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions |
| JP6240600B2 (ja) | 2011-07-24 | 2017-11-29 | キュアテク リミテッド | ヒト化免疫モノクローナル抗体の変異体 |
| EA026924B1 (ru) | 2011-08-01 | 2017-05-31 | Дженентек, Инк. | Способы лечения рака с использованием антагонистов, связывающихся с осью pd-1, и ингибиторов mek |
| EP3511343A1 (en) | 2012-05-04 | 2019-07-17 | Dana Farber Cancer Institute, Inc. | Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use |
| US9889982B2 (en) | 2012-07-23 | 2018-02-13 | Silgan Dispensing Systems Corporation | Aerosol actuators, devices, and methods of making and using the same |
| JOP20200236A1 (ar) | 2012-09-21 | 2017-06-16 | Regeneron Pharma | الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها |
| WO2015030929A1 (en) | 2013-08-30 | 2015-03-05 | Ebay, Inc. | Keyword bid optimization for text ads |
| US10241115B2 (en) | 2013-12-10 | 2019-03-26 | Merck Sharp & Dohme Corp. | Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue |
| KR102225489B1 (ko) | 2013-12-17 | 2021-03-10 | 제넨테크, 인크. | 항-cd3 항체 및 이의 사용 방법 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| TWI681969B (zh) * | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| ES2716685T3 (es) | 2014-01-24 | 2019-06-14 | Dana Farber Cancer Inst Inc | Moléculas de anticuerpo para PD-1 y usos de las mismas |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| JP2017515859A (ja) * | 2014-05-15 | 2017-06-15 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 抗ｐｄ−１抗体と他の抗癌剤の組み合わせを使用する肺癌の処置 |
| AU2015266958A1 (en) | 2014-05-28 | 2016-12-08 | Agenus Inc. | Anti-GITR antibodies and methods of use thereof |
| JP6449338B2 (ja) | 2014-06-06 | 2019-01-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | グルココルチコイド誘導腫瘍壊死因子受容体（ｇｉｔｒ）に対する抗体およびその使用 |
| US10092645B2 (en) | 2014-06-17 | 2018-10-09 | Medimmune Limited | Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy |
| HUE048677T2 (hu) | 2014-06-19 | 2020-07-28 | Regeneron Pharma | Humanizált programozott sejthalál 1 génnel rendelkezõ nem-humán állatok |
| MX2017007321A (es) * | 2014-12-02 | 2017-08-25 | Celgene Corp | Terapias de combinacion. |
| EP3254110B1 (en) | 2015-02-03 | 2020-03-18 | Ventana Medical Systems, Inc. | Histochemical assay for evaluating expression of programmed death ligand 1 (pd-l1) |
| AU2016233495B2 (en) | 2015-03-13 | 2022-02-24 | Cytomx Therapeutics, Inc | Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of use thereof |
| SG11201708223QA (en) * | 2015-04-17 | 2017-11-29 | Bristol Myers Squibb Co | Compositions comprising a combination of an anti-pd-1 antibody and another antibody |
| EP3294770B2 (en) * | 2015-05-12 | 2024-03-20 | F. Hoffmann-La Roche AG | Therapeutic and diagnostic methods for cancer |
| WO2016191751A1 (en) * | 2015-05-28 | 2016-12-01 | Bristol-Myers Squibb Company | Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody |
| KR20180111870A (ko) | 2016-02-25 | 2018-10-11 | 셀 메디카 스위처란트 아게 | Pd-l1에 대한 결합 성분 |
| FI3548515T3 (fi) | 2016-12-01 | 2026-03-04 | Regeneron Pharma | Radioleimattuja anti-PD-L1-vasta-aineita immuno-PET-kuvantamiseen |
| IL321717A (en) * | 2017-02-21 | 2025-08-01 | Regeneron Pharma | Anti-PD-1 antibodies for the treatment of lung cancer |
| US11603407B2 (en) | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
| JP2025533075A (ja) * | 2022-10-03 | 2025-10-03 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 二重特異性ＥＧＦＲｘＣＤ２８抗体単独又は抗ＰＤ－１抗体との併用による癌治療方法 |
-
2018
- 2018-02-20 IL IL321717A patent/IL321717A/en unknown
- 2018-02-20 MA MA047604A patent/MA47604A/fr unknown
- 2018-02-20 JP JP2019545324A patent/JP7324710B2/ja active Active
- 2018-02-20 MX MX2019009772A patent/MX2019009772A/es unknown
- 2018-02-20 IL IL308805A patent/IL308805B2/en unknown
- 2018-02-20 IL IL268479A patent/IL268479B2/en unknown
- 2018-02-20 US US16/486,688 patent/US11292842B2/en active Active
- 2018-02-20 CN CN201880026252.8A patent/CN110536905B/zh active Active
- 2018-02-20 CN CN202311425489.2A patent/CN117442719A/zh active Pending
- 2018-02-20 KR KR1020247001790A patent/KR20240011262A/ko active Pending
- 2018-02-20 CA CA3054289A patent/CA3054289A1/en active Pending
- 2018-02-20 EP EP18711195.0A patent/EP3585812A1/en active Pending
- 2018-02-20 AU AU2018225102A patent/AU2018225102B2/en active Active
- 2018-02-20 WO PCT/US2018/018747 patent/WO2018156494A1/en not_active Ceased
- 2018-02-20 KR KR1020197027687A patent/KR102628557B1/ko active Active
-
2019
- 2019-07-31 ZA ZA2019/05051A patent/ZA201905051B/en unknown
- 2019-08-15 MX MX2024000780A patent/MX2024000780A/es unknown
-
2022
- 2022-02-28 US US17/652,709 patent/US11926668B2/en active Active
- 2022-03-11 JP JP2022037781A patent/JP7384949B2/ja active Active
-
2023
- 2023-11-08 JP JP2023190525A patent/JP7656012B2/ja active Active
-
2024
- 2024-01-29 US US18/425,027 patent/US20240209090A1/en active Pending
-
2025
- 2025-02-13 AU AU2025201018A patent/AU2025201018A1/en active Pending
- 2025-03-19 JP JP2025044340A patent/JP2025098103A/ja active Pending
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