JP2020508317A5 - - Google Patents

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JP2020508317A5
JP2020508317A5 JP2019545324A JP2019545324A JP2020508317A5 JP 2020508317 A5 JP2020508317 A5 JP 2020508317A5 JP 2019545324 A JP2019545324 A JP 2019545324A JP 2019545324 A JP2019545324 A JP 2019545324A JP 2020508317 A5 JP2020508317 A5 JP 2020508317A5
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pharmaceutical composition
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antibody
amino acid
acid sequence
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JP2019545324A
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JP7324710B2 (ja
JP2020508317A (ja
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Priority claimed from PCT/US2018/018747 external-priority patent/WO2018156494A1/en
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Priority to JP2022037781A priority Critical patent/JP7384949B2/ja
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Publication of JP7324710B2 publication Critical patent/JP7324710B2/ja
Priority to JP2023190525A priority patent/JP7656012B2/ja
Priority to JP2025044340A priority patent/JP2025098103A/ja
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JP2019545324A 2017-02-21 2018-02-20 肺癌の処置のための抗pd-1抗体 Active JP7324710B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022037781A JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体
JP2023190525A JP7656012B2 (ja) 2017-02-21 2023-11-08 肺癌の処置のための抗pd-1抗体
JP2025044340A JP2025098103A (ja) 2017-02-21 2025-03-19 肺癌の処置のための抗pd-1抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762461672P 2017-02-21 2017-02-21
US62/461,672 2017-02-21
US201762595190P 2017-12-06 2017-12-06
US62/595,190 2017-12-06
PCT/US2018/018747 WO2018156494A1 (en) 2017-02-21 2018-02-20 Anti-pd-1 antibodies for treatment of lung cancer

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JP2022037781A Division JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体

Publications (3)

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JP2020508317A JP2020508317A (ja) 2020-03-19
JP2020508317A5 true JP2020508317A5 (enExample) 2021-07-26
JP7324710B2 JP7324710B2 (ja) 2023-08-10

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JP2019545324A Active JP7324710B2 (ja) 2017-02-21 2018-02-20 肺癌の処置のための抗pd-1抗体
JP2022037781A Active JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体
JP2023190525A Active JP7656012B2 (ja) 2017-02-21 2023-11-08 肺癌の処置のための抗pd-1抗体
JP2025044340A Pending JP2025098103A (ja) 2017-02-21 2025-03-19 肺癌の処置のための抗pd-1抗体

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JP2022037781A Active JP7384949B2 (ja) 2017-02-21 2022-03-11 肺癌の処置のための抗pd-1抗体
JP2023190525A Active JP7656012B2 (ja) 2017-02-21 2023-11-08 肺癌の処置のための抗pd-1抗体
JP2025044340A Pending JP2025098103A (ja) 2017-02-21 2025-03-19 肺癌の処置のための抗pd-1抗体

Country Status (12)

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US (3) US11292842B2 (enExample)
EP (1) EP3585812A1 (enExample)
JP (4) JP7324710B2 (enExample)
KR (2) KR102628557B1 (enExample)
CN (2) CN110536905B (enExample)
AU (2) AU2018225102B2 (enExample)
CA (1) CA3054289A1 (enExample)
IL (3) IL308805B2 (enExample)
MA (1) MA47604A (enExample)
MX (2) MX2019009772A (enExample)
WO (1) WO2018156494A1 (enExample)
ZA (1) ZA201905051B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160053301A1 (en) 2014-08-22 2016-02-25 Clearfork Bioscience, Inc. Methods for quantitative genetic analysis of cell free dna
DK3334763T3 (da) 2015-08-11 2024-10-07 Wuxi Biologics Ireland Ltd Nye anti-PD-1-antistoffer
TWI773694B (zh) 2016-10-11 2022-08-11 美商艾吉納斯公司 抗lag-3抗體及其使用方法
JP7324710B2 (ja) * 2017-02-21 2023-08-10 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 肺癌の処置のための抗pd-1抗体
CN111526886A (zh) * 2017-10-27 2020-08-11 国家血清研究所 多基因流感疫苗
US20220177587A1 (en) 2018-09-19 2022-06-09 Alpine Immune Sciences, Inc. Methods and uses of variant cd80 fusion proteins and related constructs
CN113038939A (zh) 2018-11-14 2021-06-25 瑞泽恩制药公司 损害内施用pd-1抑制剂用于治疗皮肤癌
EP3914354A1 (en) * 2019-01-21 2021-12-01 Sanofi Therapeutic rna for advanced stage solid tumor cancers
AU2020228296B2 (en) * 2019-02-28 2025-10-02 Regeneron Pharmaceuticals, Inc. Administration of PD-1 inhibitors for treating skin cancer
MX2021010560A (es) 2019-03-06 2021-11-12 Regeneron Pharma Inhibidores de la via il-4/il-13 para una eficacia aumentada en el tratamiento de cancer.
TW202138006A (zh) * 2019-12-13 2021-10-16 韓商三星Bioepis股份有限公司 穩定之抗-pd1抗體醫藥調配物
CN113244385A (zh) * 2020-02-07 2021-08-13 上海君实生物医药科技股份有限公司 抗pd-1抗体在治疗恶性肿瘤中的用途
MX2022011331A (es) * 2020-03-13 2022-10-27 Univ Texas Tratamiento secuencial de canceres utilizando 6-tio-dg, inhibidores de puntos de control y radioterapia.
CN119255817A (zh) * 2022-03-28 2025-01-03 齐鲁制药有限公司 包含抗ctla4和抗pd1的混合抗体的药物组合物及其治疗用途
WO2024077069A1 (en) * 2022-10-05 2024-04-11 Chulalongkorn University Monoclonal antibodies against human programmed cell death protein 1 (pd-1)
WO2025030110A1 (en) * 2023-08-02 2025-02-06 Sensei Biotherapeutics, Inc. Cancer therapies targeting vista as monotherapy or in combination with anti-pd1 antibody to treat cancer
WO2025159618A1 (ko) 2024-01-24 2025-07-31 주식회사 엘지에너지솔루션 전극탭 용접장치 및 전극탭 용접방법
WO2025207705A1 (en) 2024-03-26 2025-10-02 Amgen Inc. Cancer treatments using mta-cooperative prmt5 inhibitors
WO2025213154A1 (en) 2024-04-05 2025-10-09 Amgen Inc. Gastrointestinal cancer treatments using mta-cooperative prmt5 inhibitors

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US6808710B1 (en) 1999-08-23 2004-10-26 Genetics Institute, Inc. Downmodulating an immune response with multivalent antibodies to PD-1
US7794710B2 (en) 2001-04-20 2010-09-14 Mayo Foundation For Medical Education And Research Methods of enhancing T cell responsiveness
JP4511943B2 (ja) 2002-12-23 2010-07-28 ワイス エルエルシー Pd−1に対する抗体およびその使用
EP2270051B1 (en) 2003-01-23 2019-05-15 Ono Pharmaceutical Co., Ltd. Antibody specific for human PD-1 and CD3
CA2602777C (en) 2005-03-25 2018-12-11 Tolerrx, Inc. Gitr binding molecules and uses therefor
PL2161336T5 (pl) 2005-05-09 2017-10-31 Ono Pharmaceutical Co Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi
CN104356236B (zh) 2005-07-01 2020-07-03 E.R.施贵宝&圣斯有限责任公司 抗程序性死亡配体1(pd-l1)的人单克隆抗体
CA2691357C (en) 2007-06-18 2014-09-23 N.V. Organon Antibodies to human programmed death receptor pd-1
ES2591281T3 (es) 2007-07-12 2016-11-25 Gitr, Inc. Terapias de combinación que emplean moléculas de enlazamiento a GITR
US20120039870A9 (en) 2007-09-07 2012-02-16 Ablynx N.V. Binding molecules with multiple binding sites, compositions comprising the same and uses thereof
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
PL2350129T3 (pl) 2008-08-25 2015-12-31 Amplimmune Inc Kompozycje antagonistów PD-1 i sposoby stosowania
EP4331604B9 (en) 2008-12-09 2025-07-23 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
CA2772613C (en) 2009-09-03 2020-03-10 Schering Corporation Anti-gitr antibodies
CA2778714C (en) 2009-11-24 2018-02-27 Medimmune Limited Targeted binding agents against b7-h1
TW201134488A (en) 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
CA2802344C (en) 2010-06-18 2023-06-13 The Brigham And Women's Hospital, Inc. Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
RU2604814C2 (ru) 2011-07-24 2016-12-10 Кьюртек Лтд. Варианты гуманизированных иммуномодулирующих моноклональных антител
KR20190133790A (ko) 2011-08-01 2019-12-03 제넨테크, 인크. Pd-1 축 결합 길항제 및 mek 억제제를 사용하는 암 치료 방법
HK1207655A1 (en) 2012-05-04 2016-02-05 Dana-Farber Cancer Institute, Inc. Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use
WO2014018498A1 (en) 2012-07-23 2014-01-30 Meadwestvaco Calmar, Inc. Aerosol actuators, devices, and methods of making and using the same
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
WO2015030929A1 (en) 2013-08-30 2015-03-05 Ebay, Inc. Keyword bid optimization for text ads
US10241115B2 (en) 2013-12-10 2019-03-26 Merck Sharp & Dohme Corp. Immunohistochemical proximity assay for PD-1 positive cells and PD-ligand positive cells in tumor tissue
EP3192812B1 (en) 2013-12-17 2020-05-27 Genentech, Inc. Anti-cd3 antibodies and methods of use
TWI680138B (zh) 2014-01-23 2019-12-21 美商再生元醫藥公司 抗pd-l1之人類抗體
TWI681969B (zh) * 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
TWI754319B (zh) 2014-03-19 2022-02-01 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
RU2695332C2 (ru) * 2014-05-15 2019-07-23 Бристол-Маерс Сквибб Компани Лечение рака легкого с помощью комбинации антитела против pd-1 и другого противоракового средства
SMT202100116T1 (it) 2014-05-28 2021-05-07 Agenus Inc Anticorpi anti-gitr e metodi di utilizzo degli stessi
PT3151921T (pt) 2014-06-06 2019-11-21 Bristol Myers Squibb Co Anticorpos contra recetor do fator de necrose tumoral induzido por glicocorticoide e utilizações dos mesmos
US10092645B2 (en) 2014-06-17 2018-10-09 Medimmune Limited Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy
SG10201811116UA (en) 2014-06-19 2019-01-30 Regeneron Pharma Non-human animals having a humanized programmed cell death 1 gene
WO2016089873A1 (en) * 2014-12-02 2016-06-09 Celgene Corporation Combination therapies
EP3254110B1 (en) 2015-02-03 2020-03-18 Ventana Medical Systems, Inc. Histochemical assay for evaluating expression of programmed death ligand 1 (pd-l1)
SG11201707383PA (en) 2015-03-13 2017-10-30 Cytomx Therapeutics Inc Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
DK3283107T3 (da) * 2015-04-17 2020-08-31 Bristol Myers Squibb Co Sammensætninger omfattende en kombination af ipilimumab og nivolumab
HRP20201900T4 (hr) * 2015-05-12 2024-06-07 F. Hoffmann - La Roche Ag Terapeutski i dijagnostički postupci kod raka
US20180155429A1 (en) * 2015-05-28 2018-06-07 Bristol-Myers Squibb Company Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody
KR20190003938A (ko) 2016-02-25 2019-01-10 셀 메디카 스위처란트 아게 면역치료를 위한 변형된 세포
MA46952A (fr) 2016-12-01 2019-10-09 Regeneron Pharma Anticorps anti-pd-l1 radiomarqués pour imagerie immuno-pet
JP7324710B2 (ja) * 2017-02-21 2023-08-10 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 肺癌の処置のための抗pd-1抗体
US11603407B2 (en) 2017-04-06 2023-03-14 Regeneron Pharmaceuticals, Inc. Stable antibody formulation
KR20250099774A (ko) * 2022-10-03 2025-07-02 리제너론 파아마슈티컬스, 인크. 이중특이적 egfr x cd28 항체를 단독으로 또는 항-pd-1 항체와 조합하여 사용하여 암을 치료하는 방법

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