MX2021010228A - Administracion de inhibidores de pd-1 para el tratamiento de cancer de piel. - Google Patents
Administracion de inhibidores de pd-1 para el tratamiento de cancer de piel.Info
- Publication number
- MX2021010228A MX2021010228A MX2021010228A MX2021010228A MX2021010228A MX 2021010228 A MX2021010228 A MX 2021010228A MX 2021010228 A MX2021010228 A MX 2021010228A MX 2021010228 A MX2021010228 A MX 2021010228A MX 2021010228 A MX2021010228 A MX 2021010228A
- Authority
- MX
- Mexico
- Prior art keywords
- skin cancer
- patient
- inhibitor
- effective amount
- therapeutically effective
- Prior art date
Links
- 208000000453 Skin Neoplasms Diseases 0.000 title abstract 7
- 201000000849 skin cancer Diseases 0.000 title abstract 7
- 239000012270 PD-1 inhibitor Substances 0.000 title abstract 5
- 239000012668 PD-1-inhibitor Substances 0.000 title abstract 5
- 229940121655 pd-1 inhibitor Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 abstract 5
- 238000001356 surgical procedure Methods 0.000 abstract 4
- 101710089372 Programmed cell death protein 1 Proteins 0.000 abstract 2
- 102100040678 Programmed cell death protein 1 Human genes 0.000 abstract 2
- 238000009098 adjuvant therapy Methods 0.000 abstract 2
- 238000009099 neoadjuvant therapy Methods 0.000 abstract 2
- 108010074708 B7-H1 Antigen Proteins 0.000 abstract 1
- 206010061819 Disease recurrence Diseases 0.000 abstract 1
- 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 abstract 1
- 101100407308 Mus musculus Pdcd1lg2 gene Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 abstract 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 abstract 1
- 102100024213 Programmed cell death 1 ligand 2 Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
Abstract
La descripción se refiere a métodos para tratar o inhibir el crecimiento de un tumor en un paciente con cáncer de piel, en donde los métodos incluyen administrar al paciente una cantidad terapéuticamente eficaz de un inhibidor de muerte programada-1 (PD-1) (por ejemplo, un anticuerpo o fragmento de unión a antígeno del mismo que se une específicamente a PD-1, PD-L1 y/o PD-L2). En determinadas modalidades, el método incluye administrar al paciente una cantidad terapéuticamente eficaz de un inhibidor de PD-1 como tratamiento adyuvante después de que el paciente haya completado la cirugía y, opcionalmente, la radioterapia para cáncer de piel, tal como CSCC, y tenga un alto riesgo de recurrencia de la enfermedad. En determinadas modalidades, el método incluye administrar al paciente con cáncer de piel una cantidad terapéuticamente eficaz de un inhibidor de PD-1 como tratamiento neoadyuvante antes de la cirugía planificada para cáncer de piel. En determinadas modalidades, el método incluye administrar a un paciente con cáncer de piel una cantidad terapéuticamente eficaz de un inhibidor de PD-1 como tratamiento neoadyuvante antes de la cirugía planificada para el cáncer de piel y posteriormente administrar al paciente un inhibidor de PD-1 como terapia adyuvante después de dicha cirugía.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962811827P | 2019-02-28 | 2019-02-28 | |
| PCT/US2020/020018 WO2020176699A1 (en) | 2019-02-28 | 2020-02-27 | Administration of pd-1 inhibitors for treating skin cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021010228A true MX2021010228A (es) | 2021-10-26 |
Family
ID=70057261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021010228A MX2021010228A (es) | 2019-02-28 | 2020-02-27 | Administracion de inhibidores de pd-1 para el tratamiento de cancer de piel. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220259313A1 (es) |
| EP (1) | EP3930848A1 (es) |
| JP (1) | JP2022521800A (es) |
| KR (1) | KR20210134690A (es) |
| CN (1) | CN113490529A (es) |
| AU (1) | AU2020228296A1 (es) |
| CA (1) | CA3137361A1 (es) |
| IL (1) | IL285050A (es) |
| MA (1) | MA55084A (es) |
| MX (1) | MX2021010228A (es) |
| SG (1) | SG11202108089SA (es) |
| WO (1) | WO2020176699A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI680138B (zh) * | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| IL304945A (en) * | 2021-02-11 | 2023-10-01 | Regeneron Pharma | Methods for treating cancer by administering a PD-1 inhibitor as adjuvant therapy |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4896327B2 (ja) | 1999-08-23 | 2012-03-14 | ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド | Ｐｄ−１、ｂ７−４の受容体、およびその使用 |
| US7595048B2 (en) | 2002-07-03 | 2009-09-29 | Ono Pharmaceutical Co., Ltd. | Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1 |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| CN105315373B (zh) | 2005-05-09 | 2018-11-09 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
| KR101607288B1 (ko) | 2005-07-01 | 2016-04-05 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| KR101562580B1 (ko) | 2007-06-18 | 2015-10-22 | 머크 샤프 앤 도메 비.브이. | 사람 프로그램된 사멸 수용체 ｐｄ-1에 대한 항체 |
| WO2009114335A2 (en) | 2008-03-12 | 2009-09-17 | Merck & Co., Inc. | Pd-1 binding proteins |
| PL2350129T3 (pl) | 2008-08-25 | 2015-12-31 | Amplimmune Inc | Kompozycje antagonistów PD-1 i sposoby stosowania |
| US8552154B2 (en) | 2008-09-26 | 2013-10-08 | Emory University | Anti-PD-L1 antibodies and uses therefor |
| SG196798A1 (en) | 2008-12-09 | 2014-02-13 | Genentech Inc | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| BR112013032552A2 (pt) | 2011-07-24 | 2017-12-12 | Curetech Ltd | variantes de anticorpos monoclonais humanizados imunomoduladores |
| PT2785375T (pt) | 2011-11-28 | 2020-10-29 | Merck Patent Gmbh | Anticorpos anti-pd-l1 e usos destes |
| EP2854843A4 (en) | 2012-05-31 | 2016-06-01 | Sorrento Therapeutics Inc | ANTIGEN BINDING PROTEINS THAT BIND PD-L1 |
| ES2742379T3 (es) | 2012-05-31 | 2020-02-14 | Hoffmann La Roche | Procedimientos de tratamiento del cáncer usando antagonistas de unión al eje de PD-1 y antagonistas de VEGF |
| US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對ｐｄ-１的人類抗體 |
| TWI680138B (zh) | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| JP6909153B2 (ja) | 2014-08-05 | 2021-07-28 | アポロミクス インコーポレイテッド | 抗ｐｄ−ｌ１抗体 |
| IL292449B2 (en) | 2015-03-13 | 2024-02-01 | Cytomx Therapeutics Inc | Nucleic acids encoding antibodies against PDL1 and methods for their preparation |
| AR105654A1 (es) | 2015-08-24 | 2017-10-25 | Lilly Co Eli | Anticuerpos pd-l1 (ligando 1 de muerte celular programada) |
| MX2018007423A (es) | 2015-12-17 | 2018-11-09 | Novartis Ag | Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas. |
| HRP20231156T1 (hr) | 2015-12-22 | 2024-01-05 | Regeneron Pharmaceuticals, Inc. | Kombinacija anti-pd-1 antitijela i bispecifičnih anti-cd20/anti-cd3 antitijela za liječenje raka |
| TWI808938B (zh) | 2016-04-07 | 2023-07-21 | 美商卡默森屈有限公司 | 藉由投予ccr1拮抗劑與pd-1抑制劑或pd-l1抑制劑之組合減少腫瘤負荷 |
| TWI755395B (zh) * | 2016-05-13 | 2022-02-21 | 美商再生元醫藥公司 | 抗-pd-1抗體與輻射治療癌症之組合 |
| EP3585812A1 (en) | 2017-02-21 | 2020-01-01 | Regeneron Pharmaceuticals, Inc. | Anti-pd-1 antibodies for treatment of lung cancer |
| US11603407B2 (en) | 2017-04-06 | 2023-03-14 | Regeneron Pharmaceuticals, Inc. | Stable antibody formulation |
| EP3641814A4 (en) * | 2017-06-19 | 2021-06-23 | Medicenna Therapeutics Inc. | USES AND METHODS FOR IL-2 SUPERAGONISTS, AGONISTS, AND FUSIONS THEREOF |
-
2020
- 2020-02-27 MX MX2021010228A patent/MX2021010228A/es unknown
- 2020-02-27 US US17/433,003 patent/US20220259313A1/en active Pending
- 2020-02-27 MA MA055084A patent/MA55084A/fr unknown
- 2020-02-27 WO PCT/US2020/020018 patent/WO2020176699A1/en unknown
- 2020-02-27 CA CA3137361A patent/CA3137361A1/en active Pending
- 2020-02-27 AU AU2020228296A patent/AU2020228296A1/en active Pending
- 2020-02-27 EP EP20715554.0A patent/EP3930848A1/en active Pending
- 2020-02-27 SG SG11202108089SA patent/SG11202108089SA/en unknown
- 2020-02-27 KR KR1020217030808A patent/KR20210134690A/ko unknown
- 2020-02-27 JP JP2021550167A patent/JP2022521800A/ja active Pending
- 2020-02-27 CN CN202080017060.8A patent/CN113490529A/zh active Pending
-
2021
- 2021-07-22 IL IL285050A patent/IL285050A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN113490529A (zh) | 2021-10-08 |
| AU2020228296A1 (en) | 2021-10-14 |
| WO2020176699A1 (en) | 2020-09-03 |
| JP2022521800A (ja) | 2022-04-12 |
| CA3137361A1 (en) | 2020-09-03 |
| SG11202108089SA (en) | 2021-08-30 |
| MA55084A (fr) | 2022-01-05 |
| EP3930848A1 (en) | 2022-01-05 |
| US20220259313A1 (en) | 2022-08-18 |
| KR20210134690A (ko) | 2021-11-10 |
| IL285050A (en) | 2021-09-30 |
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