|
US9328116B2
(en)
|
2012-12-07 |
2016-05-03 |
Chemocentryx, Inc. |
Diazole lactams
|
|
KR102330652B1
(ko)
|
2014-09-11 |
2021-11-23 |
브리스톨-마이어스 스큅 컴퍼니 |
Pd-1/pd-l1 및 cd80 (b7-1)/pd-li 단백질/단백질 상호작용의 마크로시클릭 억제제
|
|
US9732119B2
(en)
|
2014-10-10 |
2017-08-15 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US9856292B2
(en)
*
|
2014-11-14 |
2018-01-02 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
EP4218832A3
(en)
|
2014-11-25 |
2023-08-23 |
Bristol-Myers Squibb Company |
Methods and compositions for 18f-radiolabeling of the fibronectin type (iii) domain
|
|
AU2015353573B2
(en)
|
2014-11-25 |
2020-09-03 |
Bristol-Myers Squibb Company |
Novel PD-L1 binding polypeptides for imaging
|
|
US9861680B2
(en)
|
2014-12-18 |
2018-01-09 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US9944678B2
(en)
|
2014-12-19 |
2018-04-17 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US20160222060A1
(en)
|
2015-02-04 |
2016-08-04 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US9809625B2
(en)
|
2015-03-18 |
2017-11-07 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
PT3297438T
(pt)
|
2015-05-21 |
2022-01-25 |
Chemocentryx Inc |
Moduladores de ccr2
|
|
US10143746B2
(en)
|
2016-03-04 |
2018-12-04 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US10358463B2
(en)
|
2016-04-05 |
2019-07-23 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
WO2017176965A1
(en)
|
2016-04-07 |
2017-10-12 |
Chemocentryx, Inc. |
Reducing tumor burden by administering ccr1 antagonists in combination with pd-1 inhibitors or pd-l1 inhibitors
|
|
TWI794171B
(zh)
|
2016-05-11 |
2023-03-01 |
美商滬亞生物國際有限公司 |
Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
|
|
TWI808055B
(zh)
|
2016-05-11 |
2023-07-11 |
美商滬亞生物國際有限公司 |
Hdac 抑制劑與 pd-1 抑制劑之組合治療
|
|
ES2864091T3
(es)
*
|
2016-05-19 |
2021-10-13 |
Bristol Myers Squibb Co |
Inmunomoduladores de producción de imágenes de tomografía por emisión de positrones (PET)
|
|
US11344639B2
(en)
|
2016-06-01 |
2022-05-31 |
Bristol-Myers Squibb Company |
PET imaging with PD-L1 binding polypeptides
|
|
WO2017210335A1
(en)
|
2016-06-01 |
2017-12-07 |
Bristol-Myers Squibb Company |
Imaging methods using 18f-radiolabeled biologics
|
|
FI3526323T3
(fi)
|
2016-10-14 |
2023-06-06 |
Prec Biosciences Inc |
Hepatiitti B -viruksen genomissa oleville tunnistussekvensseille spesifisiä muokattuja meganukleaaseja
|
|
JP7085545B2
(ja)
*
|
2016-11-07 |
2022-06-16 |
ブリストル－マイヤーズ スクイブ カンパニー |
免疫修飾因子
|
|
AU2017367734B2
(en)
|
2016-12-01 |
2025-01-09 |
Regeneron Pharmaceuticals, Inc. |
Radiolabeled anti-PD-l1 antibodies for immuno-PET imaging
|
|
US20190336533A1
(en)
|
2016-12-28 |
2019-11-07 |
Green Cross Lab Cell Corporation |
Chimeric antigen receptor and natural killer cells expressing same
|
|
EP3642220A1
(en)
*
|
2017-06-23 |
2020-04-29 |
Bristol-Myers Squibb Company |
Immunomodulators acting as antagonists of pd-1
|
|
KR102677442B1
(ko)
|
2017-09-25 |
2024-06-20 |
케모센트릭스, 인크. |
케모카인 수용체 2(ccr2) 길항제 및 pd-1/pd-l1 억제제를 사용하는 병용 요법
|
|
US11492375B2
(en)
|
2017-10-03 |
2022-11-08 |
Bristol-Myers Squibb Company |
Cyclic peptide immunomodulators
|
|
CA3082328A1
(en)
|
2017-11-14 |
2019-05-23 |
Green Cross Lab Cell Corporation |
Anti-her2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
|
|
US11649294B2
(en)
|
2017-11-14 |
2023-05-16 |
GC Cell Corporation |
Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
|
|
CA3084569A1
(en)
|
2017-12-20 |
2019-06-27 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
|
KR102492115B1
(ko)
|
2017-12-20 |
2023-01-27 |
인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. |
Sting 어댑터 단백질을 활성화하는 포스포네이트 결합을 가진 2'3' 사이클릭 다이뉴클레오티드
|
|
US20190269664A1
(en)
|
2018-01-08 |
2019-09-05 |
Chemocentryx, Inc. |
Methods of treating solid tumors with ccr2 antagonists
|
|
JP7442141B2
(ja)
|
2018-01-08 |
2024-03-04 |
ケモセントリックス，インコーポレイティド |
Ｃｃｒ２アンタゴニストによる固形腫瘍の治療方法
|
|
BR112020015457A2
(pt)
*
|
2018-02-01 |
2020-12-08 |
Jiangsu Hengrui Medicine Co., Ltd. |
Composição farmacêutica compreendendo derivado acilado de análogo de insulina humana e método de preparação da mesma
|
|
WO2019152801A1
(en)
*
|
2018-02-02 |
2019-08-08 |
University Of Washington |
Caged amino acids for controlled metabolic incorporation and methods of use
|
|
CN108409830B
(zh)
*
|
2018-02-05 |
2021-04-23 |
郑州大学 |
一种人pd-1蛋白胞外段亲和环肽c8及其应用
|
|
EP4227302A1
(en)
|
2018-02-13 |
2023-08-16 |
Gilead Sciences, Inc. |
Pd-1/pd-l1 inhibitors
|
|
US10836769B2
(en)
|
2018-02-26 |
2020-11-17 |
Gilead Sciences, Inc. |
Substituted pyrrolizine compounds and uses thereof
|
|
US10870691B2
(en)
|
2018-04-05 |
2020-12-22 |
Gilead Sciences, Inc. |
Antibodies and fragments thereof that bind hepatitis B virus protein X
|
|
TWI833744B
(zh)
|
2018-04-06 |
2024-03-01 |
捷克科學院有機化學與生物化學研究所 |
3'3'-環二核苷酸
|
|
TW202005654A
(zh)
|
2018-04-06 |
2020-02-01 |
捷克科學院有機化學與生物化學研究所 |
２，２，─環二核苷酸
|
|
TWI818007B
(zh)
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-環二核苷酸
|
|
US11142750B2
(en)
|
2018-04-12 |
2021-10-12 |
Precision Biosciences, Inc. |
Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome
|
|
US10899735B2
(en)
|
2018-04-19 |
2021-01-26 |
Gilead Sciences, Inc. |
PD-1/PD-L1 inhibitors
|
|
TW202014193A
(zh)
|
2018-05-03 |
2020-04-16 |
捷克科學院有機化學與生物化學研究所 |
包含碳環核苷酸之2’3’－環二核苷酸
|
|
WO2019232319A1
(en)
|
2018-05-31 |
2019-12-05 |
Peloton Therapeutics, Inc. |
Compositions and methods for inhibiting cd73
|
|
CN118130807A
(zh)
|
2018-05-31 |
2024-06-04 |
小野药品工业株式会社 |
用于确定免疫检查点抑制剂的有效性的生物标志物
|
|
UA126421C2
(uk)
|
2018-07-13 |
2022-09-28 |
Гіліад Сайєнсіз, Інк. |
Інгібітори pd-1/pd-l1
|
|
WO2020028097A1
(en)
|
2018-08-01 |
2020-02-06 |
Gilead Sciences, Inc. |
Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
|
|
TWI855000B
(zh)
|
2018-10-11 |
2024-09-11 |
日商小野藥品工業股份有限公司 |
Ｓｔｉｎｇ促效化合物
|
|
AU2019366355B2
(en)
|
2018-10-24 |
2022-10-13 |
Gilead Sciences, Inc. |
PD-1/PD-L1 inhibitors
|
|
HRP20240541T1
(hr)
|
2018-10-31 |
2024-07-05 |
Gilead Sciences, Inc. |
Supstituirani spojevi 6-azabenzimidazola kao inhibitori hpk1
|
|
WO2020092528A1
(en)
|
2018-10-31 |
2020-05-07 |
Gilead Sciences, Inc. |
Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
|
|
WO2020178768A1
(en)
|
2019-03-07 |
2020-09-10 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
|
|
US12318403B2
(en)
|
2019-03-07 |
2025-06-03 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2′3′-cyclic dinucleotides and prodrugs thereof
|
|
EP3935066A1
(en)
|
2019-03-07 |
2022-01-12 |
Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. |
3'3'-cyclic dinucleotides and prodrugs thereof
|
|
US20220041733A1
(en)
|
2019-03-28 |
2022-02-10 |
Bristol-Myers Squibb Company |
Methods of treating tumor
|
|
WO2020198676A1
(en)
|
2019-03-28 |
2020-10-01 |
Bristol-Myers Squibb Company |
Methods of treating tumor
|
|
TWI751517B
(zh)
|
2019-04-17 |
2022-01-01 |
美商基利科學股份有限公司 |
類鐸受體調節劑之固體形式
|
|
TW202210480A
(zh)
|
2019-04-17 |
2022-03-16 |
美商基利科學股份有限公司 |
類鐸受體調節劑之固體形式
|
|
JP2022533233A
(ja)
*
|
2019-05-21 |
2022-07-21 |
ブリストル－マイヤーズ スクイブ カンパニー |
免疫調整剤
|
|
EP3972695A1
(en)
|
2019-05-23 |
2022-03-30 |
Gilead Sciences, Inc. |
Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
|
|
KR20220016156A
(ko)
|
2019-05-30 |
2022-02-08 |
브리스톨-마이어스 스큅 컴퍼니 |
면역-종양학 요법에의 적합성을 위한 다종양 유전자 시그너쳐
|
|
WO2020243568A1
(en)
|
2019-05-30 |
2020-12-03 |
Bristol-Myers Squibb Company |
Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy
|
|
CN114174537A
(zh)
|
2019-05-30 |
2022-03-11 |
百时美施贵宝公司 |
细胞定位特征和组合疗法
|
|
BR112022002098A2
(pt)
|
2019-08-05 |
2022-04-12 |
Nat Cancer Ct |
Biomarcadores para determinar a eficácia de inibidores da via de sinalização imune
|
|
WO2021034804A1
(en)
|
2019-08-19 |
2021-02-25 |
Gilead Sciences, Inc. |
Pharmaceutical formulations of tenofovir alafenamide
|
|
BR112022004316A2
(pt)
|
2019-09-22 |
2022-06-21 |
Bristol Myers Squibb Co |
Caracterização espacial quantitativa para terapia de antagonista lag-3
|
|
JP7398556B2
(ja)
|
2019-09-30 |
2023-12-14 |
ギリアード サイエンシーズ， インコーポレイテッド |
Ｈｂｖワクチン及びｈｂｖを治療する方法
|
|
KR20220093349A
(ko)
|
2019-11-08 |
2022-07-05 |
브리스톨-마이어스 스큅 컴퍼니 |
흑색종에 대한 lag-3 길항제 요법
|
|
WO2021113765A1
(en)
|
2019-12-06 |
2021-06-10 |
Precision Biosciences, Inc. |
Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome
|
|
US12403174B2
(en)
|
2020-01-06 |
2025-09-02 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
CN115485288A
(zh)
*
|
2020-03-16 |
2022-12-16 |
百时美施贵宝公司 |
免疫调节剂
|
|
WO2021188959A1
(en)
|
2020-03-20 |
2021-09-23 |
Gilead Sciences, Inc. |
Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
|
|
ES2970547T3
(es)
|
2020-03-30 |
2024-05-29 |
Bristol Myers Squibb Co |
Inmunomoduladores
|
|
EP4134134A4
(en)
|
2020-04-10 |
2023-12-27 |
ONO Pharmaceutical Co., Ltd. |
STING AGONISTIC COMPOUND
|
|
US20230141284A1
(en)
|
2020-04-10 |
2023-05-11 |
Ono Pharmaceutical Co., Ltd. |
Cancer therapeutic method
|
|
WO2021226460A1
(en)
*
|
2020-05-08 |
2021-11-11 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
CN113754736A
(zh)
*
|
2020-06-02 |
2021-12-07 |
南京礼威生物医药有限公司 |
含酰肼结构的pd-l1环肽抑制剂
|
|
WO2022047189A1
(en)
|
2020-08-28 |
2022-03-03 |
Bristol-Myers Squibb Company |
Lag-3 antagonist therapy for hepatocellular carcinoma
|
|
MX2023002326A
(es)
|
2020-08-31 |
2023-03-21 |
Bristol Myers Squibb Co |
Firma de localizacion celular e inmunoterapia.
|
|
CA3193244A1
(en)
|
2020-09-22 |
2022-03-31 |
Geoffrey Martin Lynn |
Compositions and methods of manufacturing amphiphilic block copolymers that form nanoparticles in situ
|
|
MX2023004493A
(es)
|
2020-10-23 |
2023-05-10 |
Bristol Myers Squibb Co |
Terapia de agonista del gen-3 de activacion del linfocito (lag-3) para cancer de pulmon.
|
|
WO2022120179A1
(en)
|
2020-12-03 |
2022-06-09 |
Bristol-Myers Squibb Company |
Multi-tumor gene signatures and uses thereof
|
|
EP4314012A1
(en)
*
|
2021-03-24 |
2024-02-07 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
JP2024514245A
(ja)
|
2021-03-29 |
2024-03-29 |
ジュノー セラピューティクス インコーポレイテッド |
チェックポイント阻害剤療法とｃａｒ ｔ細胞療法との組合せを用いた投薬および処置のための方法
|
|
WO2022241134A1
(en)
|
2021-05-13 |
2022-11-17 |
Gilead Sciences, Inc. |
COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS
|
|
WO2022261301A1
(en)
|
2021-06-11 |
2022-12-15 |
Gilead Sciences, Inc. |
Combination mcl-1 inhibitors with anti-cancer agents
|
|
JP7673255B2
(ja)
|
2021-06-11 |
2025-05-08 |
ギリアード サイエンシーズ， インコーポレイテッド |
Ｍｃｌ－１阻害剤と抗体薬物コンジュゲートとの組み合わせ
|
|
AU2022297367B2
(en)
|
2021-06-23 |
2025-04-10 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
IL309378A
(en)
|
2021-06-23 |
2024-02-01 |
Gilead Sciences Inc |
Diacylglyercol kinase modulating compounds
|
|
CN117377671A
(zh)
|
2021-06-23 |
2024-01-09 |
吉利德科学公司 |
二酰基甘油激酶调节化合物
|
|
CA3222277A1
(en)
|
2021-06-23 |
2022-12-29 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
CN113461519A
(zh)
*
|
2021-08-12 |
2021-10-01 |
浙江泽瑞生物医药有限公司 |
一种十八烷二酸单叔丁酯-pfp的制备方法
|
|
JP2024540950A
(ja)
*
|
2021-10-20 |
2024-11-06 |
ブリストル－マイヤーズ スクイブ カンパニー |
免疫調節剤
|
|
US20240417473A1
(en)
|
2021-10-29 |
2024-12-19 |
Bristol-Myers Squibb Company |
Lag-3 antagonist therapy for hematological cancer
|
|
WO2023122945A1
(zh)
*
|
2021-12-28 |
2023-07-06 |
知和(山东)大药厂有限公司 |
环状多肽化合物及其用途
|
|
MX2024008831A
(es)
|
2022-01-26 |
2024-07-25 |
Bristol Myers Squibb Co |
Terapia combinada para carcinoma hepatocelular.
|
|
EP4493164A1
(en)
|
2022-03-17 |
2025-01-22 |
Bristol-Myers Squibb Company |
Pharmaceutical compositions comprising salts of salcaprozate and nicotinamide for improving oral bioavailability
|
|
US20230326022A1
(en)
|
2022-04-08 |
2023-10-12 |
Bristol-Myers Squibb Company |
Machine Learning Identification, Classification, and Quantification of Tertiary Lymphoid Structures
|
|
EP4554957A1
(en)
*
|
2022-07-15 |
2025-05-21 |
Universiteit Utrecht Holding B.V. |
Antiviral cyclic compounds
|
|
JPWO2024043227A1
(enExample)
|
2022-08-23 |
2024-02-29 |
|
|
|
WO2024059472A1
(en)
*
|
2022-09-12 |
2024-03-21 |
Bristol-Myers Squibb Company |
Macrocyclic immunomodulators
|
|
AU2023409221A1
(en)
|
2022-12-21 |
2025-06-12 |
Bristol-Myers Squibb Company |
Combination therapy for lung cancer
|
|
KR20250156840A
(ko)
|
2023-03-17 |
2025-11-03 |
브리스톨-마이어스 스큅 컴퍼니 |
경구 생체이용률을 개선하기 위한 약학적 조성물
|
|
WO2024196952A1
(en)
|
2023-03-20 |
2024-09-26 |
Bristol-Myers Squibb Company |
Tumor subtype assessment for cancer therapy
|
|
WO2025240242A1
(en)
|
2024-05-13 |
2025-11-20 |
Gilead Sciences, Inc. |
Combination therapies with ribavirin
|
|
WO2025240246A1
(en)
|
2024-05-13 |
2025-11-20 |
Gilead Sciences, Inc. |
Combination therapies with ribavirin
|
|
US20250345389A1
(en)
|
2024-05-13 |
2025-11-13 |
Gilead Sciences, Inc. |
Combination therapies
|
|
WO2025240244A1
(en)
|
2024-05-13 |
2025-11-20 |
Gilead Sciences, Inc. |
Combination therapies comprising bulevirtide and lonafarnib for use in the treatment of hepatitis d virus infection
|
|
WO2025245489A1
(en)
|
2024-05-24 |
2025-11-27 |
Bristol-Myers Squibb Company |
Treatment of tumors in subjects having fgl-1 positive samples
|