JP2017523141A5 - - Google Patents
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- JP2017523141A5 JP2017523141A5 JP2016572482A JP2016572482A JP2017523141A5 JP 2017523141 A5 JP2017523141 A5 JP 2017523141A5 JP 2016572482 A JP2016572482 A JP 2016572482A JP 2016572482 A JP2016572482 A JP 2016572482A JP 2017523141 A5 JP2017523141 A5 JP 2017523141A5
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- JP
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- Prior art keywords
- formula
- compound
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 17
- 208000024891 symptom Diseases 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000005647 linker group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- -1 CO 2 H Inorganic materials 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 229940125436 dual inhibitor Drugs 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- RLTPJVKHGBFGQA-UHFFFAOYSA-N thiadiazolidine Chemical group C1CSNN1 RLTPJVKHGBFGQA-UHFFFAOYSA-N 0.000 claims 2
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 2
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims 1
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims 1
- 108090000353 Histone deacetylase Proteins 0.000 claims 1
- 102000003964 Histone deacetylase Human genes 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 0 C*(C*(C)C(NO)=O)C(Nc(cc1)ccc1N(C(N1Cc2ccccc2)=O)SC1=O)=O Chemical compound C*(C*(C)C(NO)=O)C(Nc(cc1)ccc1N(C(N1Cc2ccccc2)=O)SC1=O)=O 0.000 description 1
- MZHOEBYFTUIMTG-UHFFFAOYSA-N COc1ccc(Cc2nnc(-c(cc3)ccc3C(NO)=O)[o]2)cc1 Chemical compound COc1ccc(Cc2nnc(-c(cc3)ccc3C(NO)=O)[o]2)cc1 MZHOEBYFTUIMTG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462011413P | 2014-06-12 | 2014-06-12 | |
| US62/011,413 | 2014-06-12 | ||
| PCT/US2015/035659 WO2015192078A1 (en) | 2014-06-12 | 2015-06-12 | Compositions and methods for treating cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023904A Division JP7015856B2 (ja) | 2014-06-12 | 2020-02-17 | がん治療のための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523141A JP2017523141A (ja) | 2017-08-17 |
| JP2017523141A5 true JP2017523141A5 (enExample) | 2018-07-26 |
| JP6663863B2 JP6663863B2 (ja) | 2020-03-13 |
Family
ID=54834452
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016572482A Active JP6663863B2 (ja) | 2014-06-12 | 2015-06-12 | がん治療のための組成物及び方法 |
| JP2020023904A Active JP7015856B2 (ja) | 2014-06-12 | 2020-02-17 | がん治療のための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020023904A Active JP7015856B2 (ja) | 2014-06-12 | 2020-02-17 | がん治療のための組成物及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US10029997B2 (enExample) |
| EP (2) | EP4306173A3 (enExample) |
| JP (2) | JP6663863B2 (enExample) |
| KR (1) | KR102567244B1 (enExample) |
| CN (1) | CN106794175B (enExample) |
| AU (3) | AU2015274334B2 (enExample) |
| CA (1) | CA2950774C (enExample) |
| ES (1) | ES2960601T3 (enExample) |
| MX (1) | MX388409B (enExample) |
| WO (1) | WO2015192078A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015192078A1 (en) | 2014-06-12 | 2015-12-17 | Cedars-Sinai Medical Center | Compositions and methods for treating cancers |
| IT201700041723A1 (it) * | 2017-04-14 | 2018-10-14 | Italfarmaco Spa | Nuovi inibitori selettivi di HDAC6 |
| CN115778943B (zh) * | 2020-02-26 | 2023-11-10 | 上海科技大学 | 秦皮素在抗冠状病毒中的应用 |
| CN111658766A (zh) * | 2020-07-06 | 2020-09-15 | 陈长宏 | GSK3β及其激动剂在上皮源性恶性肿瘤治疗与康复中的应用 |
| WO2024019667A1 (en) * | 2022-07-21 | 2024-01-25 | Agency For Science, Technology And Research | Method of inhibiting epithelial-mesenchymal transition and cancer metastasis |
| CN115197167B (zh) * | 2022-07-22 | 2023-07-28 | 中国药科大学 | 1,2,4-噻二唑烷-3,5-二酮化合物及其制备方法和应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3711492A (en) * | 1970-12-08 | 1973-01-16 | Basf Ag | Thiadiazolidinediones |
| CA1294215C (en) | 1986-10-27 | 1992-01-14 | Ze'ev Shaked | Pharmaceutical compositions of recombinant beta-interferon and formulation processes |
| CA1292686C (en) | 1986-10-27 | 1991-12-03 | Ze'ev Shaked | Pharmaceutical compositions of recombinant interleukin-2 and formulation process |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5565215A (en) | 1993-07-23 | 1996-10-15 | Massachusettes Institute Of Technology | Biodegradable injectable particles for imaging |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| EP0948489A1 (en) * | 1996-12-17 | 1999-10-13 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine compounds as inhibitors of mmp or tnf |
| US6045925A (en) | 1997-08-05 | 2000-04-04 | Kansas State University Research Foundation | Encapsulated nanometer magnetic particles |
| CA2366264A1 (en) * | 1999-04-02 | 2000-10-12 | Bristol-Myers Squibb Company | Novel amide derivatives as inhibitors of matrix metalloproteinases, tnf-.alpha., and aggrecanase |
| AP2003002908A0 (en) * | 2001-05-11 | 2003-12-31 | Pharmacia Corp | Aromatic sulfone hydroxamates and their use as protease inhibitors |
| EP1293205A1 (en) * | 2001-09-18 | 2003-03-19 | G2M Cancer Drugs AG | Valproic acid and derivatives thereof for the combination therapy of human cancers, for the treatment of tumour metastasis and minimal residual disease |
| US6676729B2 (en) | 2002-01-02 | 2004-01-13 | International Business Machines Corporation | Metal salt reduction to form alloy nanoparticles |
| EP1339075A1 (en) | 2002-02-25 | 2003-08-27 | Motorola, Inc. | Magnetic nanomaterials and synthesis method |
| US6878445B2 (en) | 2002-03-08 | 2005-04-12 | Fuji Photo Film Co., Ltd. | Nanoparticle coated material and production method of same |
| JP2006504755A (ja) | 2002-10-15 | 2006-02-09 | スミスクライン ビーチャム コーポレーション | Ｇｓｋ−３阻害薬としてのピリダジン化合物 |
| DE10331439B3 (de) | 2003-07-10 | 2005-02-03 | Micromod Partikeltechnologie Gmbh | Magnetische Nanopartikel mit verbesserten Magneteigenschaften |
| WO2004101512A2 (en) * | 2003-05-13 | 2004-11-25 | Smithkline Beecham Corporation | Naphthyridine integrase inhibitors |
| GB0313259D0 (en) | 2003-06-09 | 2003-07-16 | Consejo Superior Investigacion | Magnetic nanoparticles |
| US7396589B2 (en) | 2003-07-31 | 2008-07-08 | Industrial Technology Research Institute | Core-shell magnetic nanoparticles comprising an inner-transition element |
| TW593158B (en) | 2003-07-31 | 2004-06-21 | Ind Tech Res Inst | Magnetic nanoparticle |
| ES2456325T3 (es) | 2003-11-06 | 2014-04-22 | Seattle Genetics, Inc. | Compuestos de monometilvalina capaces de conjugación con ligandos |
| GB0402496D0 (en) * | 2004-02-04 | 2004-03-10 | Argenta Discovery Ltd | Novel compounds |
| EP1586318A1 (en) | 2004-04-05 | 2005-10-19 | Neuropharma S.A.U. | Thiadiazolidinones as GSK-3 inhibitors |
| GB0418328D0 (en) | 2004-08-17 | 2004-09-22 | Imp College Innovations Ltd | Cancer methods and medicaments |
| US7462446B2 (en) | 2005-03-18 | 2008-12-09 | University Of Washington | Magnetic nanoparticle compositions and methods |
| US7700193B2 (en) | 2005-04-08 | 2010-04-20 | Industrial Technology Research Institute | Core-shell structure with magnetic, thermal, and optical characteristics and manufacturing method thereof |
| US20070264199A1 (en) | 2005-09-26 | 2007-11-15 | Labhasetwar Vinod D | Magnetic nanoparticle composition and methods for using the same |
| EP1976976A4 (en) * | 2005-12-23 | 2010-12-15 | Univ Rochester | TREATMENT OF NEURO-AIDS USING INHIBITORS OF GLYCODY SYNTHASE KINASE (GSK) -3 |
| US20090142337A1 (en) | 2006-05-08 | 2009-06-04 | Astex Therapeutics Limited | Pharmaceutical Combinations of Diazole Derivatives for Cancer Treatment |
| AU2007275686B2 (en) * | 2006-07-18 | 2013-10-31 | University Of Rochester | Thiadiazolidinone derivatives |
| WO2008016123A1 (en) * | 2006-08-03 | 2008-02-07 | Takeda Pharmaceutical Company Limited | GSK-3β INHIBITOR |
| EP1988098A1 (en) * | 2007-04-27 | 2008-11-05 | AEterna Zentaris GmbH | Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors |
| EP2170814B1 (en) * | 2007-06-12 | 2016-08-17 | Achaogen, Inc. | Antibacterial agents |
| CN101896177A (zh) * | 2007-12-13 | 2010-11-24 | 诺瓦提斯公司 | 用于治疗癌症的治疗剂的组合 |
| US20120015942A1 (en) * | 2010-07-19 | 2012-01-19 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| DE102011106990B3 (de) | 2011-07-08 | 2013-01-03 | Technische Universität Darmstadt | Verbindungen als Glykogen Synthase Kinase 3 (GSK-3) Inhibitoren für die Behandlung von GSK-3-vermittelten Erkrankungen |
| BR112014000371A2 (pt) | 2011-07-08 | 2017-01-10 | Novartis Ag | derivados de trifluormetil-oxadiazol e uso dos mesmos no tratamento de doença |
| US9371299B2 (en) * | 2012-02-24 | 2016-06-21 | Asd Therapeutics Partners, Llc | Thiadiazolidinediones as GSK-3 inhibitors |
| JP5722264B2 (ja) | 2012-03-23 | 2015-05-20 | 株式会社日立ハイテクノロジーズ | データ処理装置、データ容量増加抑制方法 |
| EP2917202B1 (en) | 2012-11-07 | 2018-05-02 | Karus Therapeutics Limited | Novel histone deacetylase inhibitors and their use in therapy |
| CN103848795B (zh) | 2014-03-07 | 2016-08-17 | 山东大学 | 一种1,2,5-噁二唑-2-氧化物组蛋白去乙酰化酶抑制剂及其制备方法和应用 |
| WO2015192078A1 (en) | 2014-06-12 | 2015-12-17 | Cedars-Sinai Medical Center | Compositions and methods for treating cancers |
-
2015
- 2015-06-12 WO PCT/US2015/035659 patent/WO2015192078A1/en not_active Ceased
- 2015-06-12 KR KR1020177000702A patent/KR102567244B1/ko active Active
- 2015-06-12 EP EP23188783.7A patent/EP4306173A3/en active Pending
- 2015-06-12 MX MX2016016507A patent/MX388409B/es unknown
- 2015-06-12 ES ES15806839T patent/ES2960601T3/es active Active
- 2015-06-12 CN CN201580042796.XA patent/CN106794175B/zh active Active
- 2015-06-12 JP JP2016572482A patent/JP6663863B2/ja active Active
- 2015-06-12 EP EP15806839.5A patent/EP3154544B1/en active Active
- 2015-06-12 US US15/317,559 patent/US10029997B2/en active Active
- 2015-06-12 CA CA2950774A patent/CA2950774C/en active Active
- 2015-06-12 AU AU2015274334A patent/AU2015274334B2/en active Active
-
2018
- 2018-06-19 US US16/012,536 patent/US10266505B2/en active Active
-
2019
- 2019-03-04 US US16/292,011 patent/US10836735B2/en active Active
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2020
- 2020-02-17 JP JP2020023904A patent/JP7015856B2/ja active Active
- 2020-10-08 US US17/066,397 patent/US20210276964A1/en not_active Abandoned
-
2021
- 2021-03-17 AU AU2021201667A patent/AU2021201667B2/en active Active
-
2023
- 2023-02-16 AU AU2023200895A patent/AU2023200895A1/en not_active Abandoned