EA200301116A1 - Гидроксаматы ароматических сульфонов и их применение в качестве ингибиторов протеаз - Google Patents

Гидроксаматы ароматических сульфонов и их применение в качестве ингибиторов протеаз

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Publication number
EA200301116A1
EA200301116A1 EA200301116A EA200301116A EA200301116A1 EA 200301116 A1 EA200301116 A1 EA 200301116A1 EA 200301116 A EA200301116 A EA 200301116A EA 200301116 A EA200301116 A EA 200301116A EA 200301116 A1 EA200301116 A1 EA 200301116A1
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EA
Eurasian Patent Office
Prior art keywords
activity
hydroxamates
mmp
application
aromatic
Prior art date
Application number
EA200301116A
Other languages
English (en)
Inventor
Томас Э. Барта
Даниэль П. Бекер
Луи Дж. Биделл
Терри Л. Бем
Иветт М. Фобиан
Джон Н. Фрескос
Сузан Л. Хокерман
Даррен Дж. Кассаб
Стив А. Колодзей
Джозеф Дж. Макдональд
Моника Б. Нортон
Джозеф Дж. Рико
Джон Дж. Талли
Клара И. Вилламил
Лихуан Ян Ванг
Дебора А. Мишке
Гари А. Декрещенцо
Джеффри Н. Кэррол
Original Assignee
Фармация Корпорейшн
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Publication date
Application filed by Фармация Корпорейшн filed Critical Фармация Корпорейшн
Publication of EA200301116A1 publication Critical patent/EA200301116A1/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Настоящее изобретение относится к гидроксаматам ароматических сульфонов (известным также под названием "гидроксамовые кислоты ароматических сульфонов"), которые наряду с другими видами эффектов ингибируют активность матричных металлопротеиназ (известных также под названием "матричных металлопротеаз" или "MMP") и/или активность агреканазы. Настоящее изобретение относится также к способу профилактики или лечения, включающему введение в организм живого существа, в частности млекопитающего, находящегося в патологическом состоянии, связанном с активностью MMP и/или агреканазы (или предрасположенного к такому состоянию), такого соединения или соли в количестве, эффективно ингибирующем активность MMP и/или агреканазы.
EA200301116A 2001-05-11 2002-05-10 Гидроксаматы ароматических сульфонов и их применение в качестве ингибиторов протеаз EA200301116A1 (ru)

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