MXPA03010326A - Sulfona-hidroxamatos aromaticos y su uso como inhibidores de proteasas. - Google Patents

Sulfona-hidroxamatos aromaticos y su uso como inhibidores de proteasas.

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Publication number
MXPA03010326A
MXPA03010326A MXPA03010326A MXPA03010326A MXPA03010326A MX PA03010326 A MXPA03010326 A MX PA03010326A MX PA03010326 A MXPA03010326 A MX PA03010326A MX PA03010326 A MXPA03010326 A MX PA03010326A MX PA03010326 A MXPA03010326 A MX PA03010326A
Authority
MX
Mexico
Prior art keywords
aromatic sulfone
mmp
protease inhibitors
aggrecanase
activity
Prior art date
Application number
MXPA03010326A
Other languages
English (en)
Inventor
L Hockerman Susan
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of MXPA03010326A publication Critical patent/MXPA03010326A/es

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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)

Abstract

Sulfona hidroxamatos aromaticos (tambien conocidos como "acidos sulfona hidroxamicos aromaticos") y sales de los mismos que, entre otras propiedades, inhiben la actividad de metaloproteasas de matriz (tambien conocidas como "metaloproteasas de matriz" o "MMP") y/o la actividad de la agrecanasa. Esta invencion tambien tiene como objeto un metodo de prevencion o tratamiento que comprende administrar dicho compuesto o sal en una cantidad eficaz para inhibir las MMP y/o la agrecanasa en un animal, particularmente un animal afectado (o con predisposicion a ser afectado) por una condicion patologica asociada con la actividad de MMP y/o de agrecanasa.
MXPA03010326A 2001-05-11 2002-05-10 Sulfona-hidroxamatos aromaticos y su uso como inhibidores de proteasas. MXPA03010326A (es)

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US20040110805A1 (en) 2004-06-10
AR040928A1 (es) 2005-04-27
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ZA200308525B (en) 2005-02-17
ECSP034839A (es) 2003-12-24
CZ20032913A3 (cs) 2004-05-12
JP2004530691A (ja) 2004-10-07
EA200301116A1 (ru) 2004-06-24
HRP20030901A2 (en) 2005-10-31
BG108285A (bg) 2004-09-30
WO2002092588A2 (en) 2002-11-21
YU85403A (sh) 2006-03-03
WO2002092588A3 (en) 2003-02-27
KR20040018368A (ko) 2004-03-03
NO20034995L (no) 2003-12-16
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CR7146A (es) 2008-02-11
US6890928B2 (en) 2005-05-10
US20050101641A1 (en) 2005-05-12
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US6689794B2 (en) 2004-02-10
PL367487A1 (en) 2005-02-21
CA2446586A1 (en) 2002-11-21
BR0209525A (pt) 2004-03-09
HUP0304069A2 (hu) 2004-04-28
CO5540386A2 (es) 2005-07-29
IS7003A (is) 2003-10-29
NO20034995D0 (no) 2003-11-10
CN1764655A (zh) 2006-04-26

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