ATE222889T1 - Hydroxamsäure-derivate - Google Patents
Hydroxamsäure-derivateInfo
- Publication number
- ATE222889T1 ATE222889T1 AT98915209T AT98915209T ATE222889T1 AT E222889 T1 ATE222889 T1 AT E222889T1 AT 98915209 T AT98915209 T AT 98915209T AT 98915209 T AT98915209 T AT 98915209T AT E222889 T1 ATE222889 T1 AT E222889T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxamic acid
- acid derivatives
- derivatives
- treat
- inhibit
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 102000003958 Glutamate Carboxypeptidase II Human genes 0.000 abstract 3
- 108090000369 Glutamate Carboxypeptidase II Proteins 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000017497 prostate disease Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Psychology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/825,997 US5962521A (en) | 1997-04-04 | 1997-04-04 | Hydroxamic acid derivatives |
PCT/US1998/006382 WO1998045256A1 (en) | 1997-04-04 | 1998-04-02 | Hydroxamic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE222889T1 true ATE222889T1 (de) | 2002-09-15 |
Family
ID=25245426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98915209T ATE222889T1 (de) | 1997-04-04 | 1998-04-02 | Hydroxamsäure-derivate |
Country Status (8)
Country | Link |
---|---|
US (3) | US5962521A (de) |
EP (1) | EP0973731B1 (de) |
JP (1) | JP2001519809A (de) |
AT (1) | ATE222889T1 (de) |
AU (1) | AU742418B2 (de) |
CA (1) | CA2285906A1 (de) |
DE (1) | DE69807455D1 (de) |
WO (1) | WO1998045256A1 (de) |
Families Citing this family (49)
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US6953668B1 (en) | 1992-11-05 | 2005-10-11 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
US7070782B1 (en) * | 1992-11-05 | 2006-07-04 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
US7105159B1 (en) | 1992-11-05 | 2006-09-12 | Sloan-Kettering Institute For Cancer Research | Antibodies to prostate-specific membrane antigen |
US6569432B1 (en) * | 1995-02-24 | 2003-05-27 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
US7037647B1 (en) | 1995-02-24 | 2006-05-02 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
US20040253246A1 (en) * | 1996-02-23 | 2004-12-16 | Israeli Ron S. | Prostate-specific membrane antigen and uses thereof |
US6025344A (en) | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Certain dioic acid derivatives useful as NAALADase inhibitors |
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US6444657B1 (en) | 1998-12-31 | 2002-09-03 | Guilford Pharmaceuticals Inc. | Methods for treating certain diseases using naaladase inhibitors |
AU773915B2 (en) | 1999-04-28 | 2004-06-10 | Georgetown University | Ligands for metabotropic glutamate receptors |
US6528499B1 (en) | 2000-04-27 | 2003-03-04 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase |
US6228888B1 (en) | 1999-07-01 | 2001-05-08 | Guilford Pharmaceuticals Inc. | Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors |
CA2380820A1 (en) * | 1999-08-16 | 2001-02-22 | Revaax Pharmaceuticals, Llc | Neurotherapeutic clavulanate composition and method |
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AU2001265111A1 (en) * | 2000-05-30 | 2001-12-11 | Guilford Pharmaceuticals Inc. | Benzenedicarboxylic acid derivatives |
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US20020013295A1 (en) * | 2000-05-30 | 2002-01-31 | Slusher Barbara S. | Naaladase inhibitors for treating amyotrophic lateral sclerosis |
IT1318636B1 (it) * | 2000-07-21 | 2003-08-27 | Roberto Pellicciari | Derivati dell'acido 2- o 3- tenoico ad attivita' antagonista deirecettori del glutammato. |
EP1363920B1 (de) | 2001-02-07 | 2006-08-23 | Beth Israel Deaconess Medical Center | Modifizierte psma-liganden und deren verwendung |
EP1372551B1 (de) * | 2001-03-08 | 2008-09-17 | The Trustees Of The University Of Pennsylvania | Faciale amphiphile polymere als antiinfektiöse mittel |
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US7148250B2 (en) * | 2001-12-28 | 2006-12-12 | Guilford Pharmaceuticals Inc. | Indoles as NAALADase inhibitors |
PT1472541E (pt) | 2002-01-10 | 2009-12-21 | Univ Johns Hopkins | Agentes de imagiologia e métodos de imagiologia de naaladase de psma |
US20040072815A1 (en) * | 2002-02-12 | 2004-04-15 | Koppel Gary A. | Antibiotic composition and method |
AU2003220222A1 (en) | 2002-03-13 | 2003-09-29 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
DE602004021476D1 (de) * | 2003-03-03 | 2009-07-23 | Eisai Corp North America | THIOLACTONE ALS NAALADase INHIBITOREN |
EP2471526A3 (de) * | 2003-03-17 | 2012-12-12 | The Trustees Of The University Of Pennsylvania | Fazial-amphiphile Polymere und Oligomere sowie Verwendungen davon |
EP1711455A4 (de) | 2004-01-23 | 2007-11-07 | Univ Pennsylvania | Fazial amphiphile polyaryl- und polyarylalkinylpolymere und -oligomere und deren anwendungen |
US8221804B2 (en) | 2005-02-03 | 2012-07-17 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
JP2008531585A (ja) * | 2005-02-25 | 2008-08-14 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 表面が両親媒性のポリマーおよびオリゴマー、それらの組成物そして癌治療方法におけるそれらの使用 |
EP4023624A1 (de) | 2006-11-08 | 2022-07-06 | Molecular Insight Pharmaceuticals, Inc. | Heterodimere von glutaminsäure |
ES2768224T3 (es) | 2007-08-17 | 2020-06-22 | Purdue Research Foundation | Conjugados ligando-enlazador de unión a PSMA y métodos para su uso |
WO2009132051A1 (en) | 2008-04-21 | 2009-10-29 | Signum Biosciences, Inc. | Compounds, compositions and methods for making the same |
EP2706057B1 (de) | 2008-12-05 | 2016-04-20 | Molecular Insight Pharmaceuticals, Inc. | Bis(imidazolyl)verbindungen and Radionuclidkomplexe |
BR112012000209B8 (pt) | 2009-06-15 | 2021-07-27 | Molecular Insight Pharm Inc | heterodímeros de ácido glutâmico e seus processos de preparação |
AU2010328230B2 (en) | 2009-12-07 | 2016-06-02 | Cardioxyl Pharmaceuticals, Inc. | Bis-acylated hydroxylamine derivatives |
IN2012DN05025A (de) * | 2009-12-07 | 2015-10-23 | Univ Johns Hopkins | |
US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
EP2800471A4 (de) | 2012-01-06 | 2015-11-04 | Molecular Insight Pharm Inc | Metallkomplexe von poly(carboxyl)aminhaltigen liganden mit einer affinität für carboanhydrase ix |
EA201590783A1 (ru) | 2012-11-15 | 2015-11-30 | Эндосайт, Инк. | Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma |
EP3300746B1 (de) | 2013-01-14 | 2019-05-15 | Molecular Insight Pharmaceuticals, Inc. | Radiopharmazeutika auf triazinbasis und strahlungsabbildungsmittel |
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CA2930581A1 (en) | 2013-11-14 | 2015-05-21 | Endocyte, Inc. | Compounds for positron emission tomography |
US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
EP4046989A1 (de) | 2017-01-09 | 2022-08-24 | Shuttle Pharmaceuticals, Inc. | Selektive histondeacetylaseinhibitoren zur behandlung von menschlichen erkrankungen |
US11584733B2 (en) | 2017-01-09 | 2023-02-21 | Shuttle Pharmaceuticals, Inc. | Selective histone deacetylase inhibitors for the treatment of human disease |
EP3737376B1 (de) | 2018-01-09 | 2024-04-17 | Shuttle Pharmaceuticals, Inc. | Selektive histondeacetylaseinhibitoren zur behandlung von menschlichen erkrankungen |
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-
1997
- 1997-04-04 US US08/825,997 patent/US5962521A/en not_active Expired - Lifetime
-
1998
- 1998-04-02 DE DE69807455T patent/DE69807455D1/de not_active Expired - Lifetime
- 1998-04-02 AU AU69451/98A patent/AU742418B2/en not_active Ceased
- 1998-04-02 EP EP98915209A patent/EP0973731B1/de not_active Expired - Lifetime
- 1998-04-02 JP JP54287198A patent/JP2001519809A/ja active Pending
- 1998-04-02 CA CA002285906A patent/CA2285906A1/en not_active Abandoned
- 1998-04-02 WO PCT/US1998/006382 patent/WO1998045256A1/en active IP Right Grant
- 1998-04-02 AT AT98915209T patent/ATE222889T1/de not_active IP Right Cessation
-
1999
- 1999-06-01 US US09/322,688 patent/US6271245B1/en not_active Expired - Fee Related
-
2001
- 2001-06-15 US US09/880,861 patent/US20010044459A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2001519809A (ja) | 2001-10-23 |
AU742418B2 (en) | 2002-01-03 |
CA2285906A1 (en) | 1998-10-15 |
AU6945198A (en) | 1998-10-30 |
WO1998045256A1 (en) | 1998-10-15 |
US6271245B1 (en) | 2001-08-07 |
US5962521A (en) | 1999-10-05 |
EP0973731A1 (de) | 2000-01-26 |
DE69807455D1 (de) | 2002-10-02 |
EP0973731B1 (de) | 2002-08-28 |
US20010044459A1 (en) | 2001-11-22 |
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