IL158454A0 - Aromatic sulfone hydroxamates and their use as protease inhibitors - Google Patents
Aromatic sulfone hydroxamates and their use as protease inhibitorsInfo
- Publication number
- IL158454A0 IL158454A0 IL15845402A IL15845402A IL158454A0 IL 158454 A0 IL158454 A0 IL 158454A0 IL 15845402 A IL15845402 A IL 15845402A IL 15845402 A IL15845402 A IL 15845402A IL 158454 A0 IL158454 A0 IL 158454A0
- Authority
- IL
- Israel
- Prior art keywords
- protease inhibitors
- aromatic sulfone
- sulfone hydroxamates
- hydroxamates
- aromatic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
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- C—CHEMISTRY; METALLURGY
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
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- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29037501P | 2001-05-11 | 2001-05-11 | |
PCT/US2002/015257 WO2002092588A2 (en) | 2001-05-11 | 2002-05-10 | Aromatic sulfone hydroxamates and their use as protease inhibitors |
Publications (1)
Publication Number | Publication Date |
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IL158454A0 true IL158454A0 (en) | 2004-05-12 |
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ID=23115707
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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IL15845402A IL158454A0 (en) | 2001-05-11 | 2002-05-10 | Aromatic sulfone hydroxamates and their use as protease inhibitors |
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US (3) | US6689794B2 (es) |
EP (1) | EP1385836A2 (es) |
JP (1) | JP2004530691A (es) |
KR (1) | KR20040018368A (es) |
CN (1) | CN1764655A (es) |
AP (1) | AP2003002908A0 (es) |
AR (1) | AR040928A1 (es) |
BG (1) | BG108285A (es) |
BR (1) | BR0209525A (es) |
CA (1) | CA2446586A1 (es) |
CO (1) | CO5540386A2 (es) |
CR (1) | CR7146A (es) |
CZ (1) | CZ20032913A3 (es) |
EA (1) | EA200301116A1 (es) |
EC (1) | ECSP034839A (es) |
HR (1) | HRP20030901A2 (es) |
HU (1) | HUP0304069A2 (es) |
IL (1) | IL158454A0 (es) |
IS (1) | IS7003A (es) |
MX (1) | MXPA03010326A (es) |
NO (1) | NO20034995L (es) |
OA (1) | OA12602A (es) |
PL (1) | PL367487A1 (es) |
WO (1) | WO2002092588A2 (es) |
YU (1) | YU85403A (es) |
ZA (1) | ZA200308525B (es) |
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PL341379A1 (en) * | 1997-11-14 | 2001-04-09 | Searle & Co | Aromatic sulphone substituted hydroxamic acid as inhibitor of metalloprotease |
GB9901147D0 (en) * | 1999-01-19 | 1999-03-10 | Merck Sharp & Dohme | Therapeutic agents |
US6683093B2 (en) * | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
US20040024024A1 (en) * | 2001-05-11 | 2004-02-05 | Freskos John N. | Aromatic sulfone hydroxamates and their use as protease inhibitors |
US20050209278A1 (en) * | 2002-04-25 | 2005-09-22 | Mcdonald Joseph J | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
WO2003091247A2 (en) * | 2002-04-25 | 2003-11-06 | Pharmacia Corporation | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors |
WO2004000811A1 (en) * | 2002-06-25 | 2003-12-31 | Pharmacia Corporation | Arylsulfonylhydroxamic acid and amide derivatives and their use as protease inhibitors |
EP1613269B1 (en) | 2003-04-04 | 2015-02-25 | Incyte Corporation | Compositions, methods and kits relating to her-2 cleavage |
WO2004098582A2 (en) * | 2003-05-07 | 2004-11-18 | The University Court Of The University Of Aberdeen | Ketones and reduced ketones as therapeutic agents for the treatment of bone conditions |
WO2005058884A2 (en) * | 2003-12-15 | 2005-06-30 | Japan Tobacco Inc. | Cyclopropane compounds and pharmaceutical use thereof |
WO2005061448A1 (en) * | 2003-12-24 | 2005-07-07 | Monash University | Compositions and methods for treating vascular conditions |
US20050250789A1 (en) * | 2004-04-20 | 2005-11-10 | Burns David M | Hydroxamic acid derivatives as metalloprotease inhibitors |
US7709516B2 (en) * | 2005-06-17 | 2010-05-04 | Endorecherche, Inc. | Helix 12 directed non-steroidal antiandrogens |
BRPI0720043A2 (pt) | 2006-12-15 | 2014-01-07 | Abbott Lab | Composto oxadiazol |
WO2014031784A1 (en) | 2012-08-23 | 2014-02-27 | Alios Biopharma, Inc. | Compounds for the treatment of paramoxyvirus viral infections |
MX2016016507A (es) | 2014-06-12 | 2017-04-27 | Cedars Sinai Medical Center | Composiciones y metodos para tratar canceres. |
CN104292180A (zh) * | 2014-10-12 | 2015-01-21 | 湖南华腾制药有限公司 | 一种恶二唑衍生物的制备方法 |
CA3073810A1 (en) * | 2017-08-31 | 2019-03-07 | Ahammune Biosciences Private Limited | Thiophene-derived compounds, process for synthesis and use thereof |
KR102533605B1 (ko) * | 2018-01-10 | 2023-05-17 | 주식회사 라이조테크 | 신규한 페닐설포닐 옥사졸 유도체 및 이의 용도 |
EP4377321A1 (en) * | 2021-07-28 | 2024-06-05 | University of KwaZulu-Natal | Metallo-?-lactamase inhibitors |
CN117800921B (zh) * | 2024-02-28 | 2024-06-11 | 南京市鸿舜医药科技有限公司 | 一种咪唑烷二酮类hdac抑制剂、制备方法及应用 |
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CN1193978A (zh) | 1994-10-05 | 1998-09-23 | 奇罗斯恩有限公司 | 肽基化合物和它们作为金属蛋白酶抑制剂的医疗用途 |
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WO1997049679A1 (fr) | 1996-06-27 | 1997-12-31 | Ono Pharmaceutical Co., Ltd. | Derives d'aryle (sulfure, oxyde sulfonique et sulfone) et medicaments les contenant en tant que principe actif |
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KR20000075809A (ko) | 1997-02-27 | 2000-12-26 | 윌리암 에이취 캘넌, 에곤 이 버그 | 매트릭스 메탈로프로테이나제 억제제로서의 n-하이드록시-2-(알킬, 아릴 또는 헤테로아릴 설파닐, 설피닐 또는 설포닐)-3-치환된 알킬, 아릴 또는 헤테로아릴아미드 |
US6300514B1 (en) | 1997-06-25 | 2001-10-09 | Ono Pharmaceutical Co., Ltd. | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient |
US6576664B1 (en) | 1997-08-18 | 2003-06-10 | Bristol-Myers Squibb Pharma Company | Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis |
PL341379A1 (en) | 1997-11-14 | 2001-04-09 | Searle & Co | Aromatic sulphone substituted hydroxamic acid as inhibitor of metalloprotease |
US6750228B1 (en) | 1997-11-14 | 2004-06-15 | Pharmacia Corporation | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
US20010039287A1 (en) | 1997-11-14 | 2001-11-08 | Thomas E Barta | Aromatic sulfone hydroxamic acid metalloprotease inhibitor |
IL127496A0 (en) | 1997-12-19 | 1999-10-28 | Pfizer Prod Inc | The use of MMP inhibitors for the treatment of ocular angiogenesis |
IL137566A0 (en) | 1998-02-19 | 2001-07-24 | American Cyanamid Co | N-hydroxy-2-(alkyl, aryl or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted-alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
AU775701B2 (en) | 1999-02-08 | 2004-08-12 | G.D. Searle & Co. | Sulfamato hydroxamic acid metalloprotease inhibitor |
WO2000059874A1 (en) | 1999-04-02 | 2000-10-12 | Du Pont Pharmaceuticals Company | NOVEL AMIDE DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES, TNF-α, AND AGGRECANASE |
EP1081137A1 (en) | 1999-08-12 | 2001-03-07 | Pfizer Products Inc. | Selective inhibitors of aggrecanase in osteoarthritis treatment |
US6683093B2 (en) | 2000-05-12 | 2004-01-27 | Pharmacia Corporation | Aromatic sulfone hydroxamic acids and their use as protease inhibitors |
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2002
- 2002-05-10 AP APAP/P/2003/002908A patent/AP2003002908A0/en unknown
- 2002-05-10 OA OA1200300293A patent/OA12602A/en unknown
- 2002-05-10 EA EA200301116A patent/EA200301116A1/ru unknown
- 2002-05-10 HU HU0304069A patent/HUP0304069A2/hu unknown
- 2002-05-10 CA CA002446586A patent/CA2446586A1/en not_active Abandoned
- 2002-05-10 JP JP2002589473A patent/JP2004530691A/ja not_active Withdrawn
- 2002-05-10 CN CNA02809672XA patent/CN1764655A/zh active Pending
- 2002-05-10 YU YU85403A patent/YU85403A/sh unknown
- 2002-05-10 KR KR10-2003-7014663A patent/KR20040018368A/ko not_active Application Discontinuation
- 2002-05-10 MX MXPA03010326A patent/MXPA03010326A/es unknown
- 2002-05-10 WO PCT/US2002/015257 patent/WO2002092588A2/en not_active Application Discontinuation
- 2002-05-10 BR BR0209525-4A patent/BR0209525A/pt not_active IP Right Cessation
- 2002-05-10 IL IL15845402A patent/IL158454A0/xx unknown
- 2002-05-10 EP EP02729204A patent/EP1385836A2/en not_active Withdrawn
- 2002-05-10 US US10/142,737 patent/US6689794B2/en not_active Expired - Fee Related
- 2002-05-10 AR ARP020101724A patent/AR040928A1/es unknown
- 2002-05-10 PL PL02367487A patent/PL367487A1/xx unknown
- 2002-05-10 CZ CZ20032913A patent/CZ20032913A3/cs unknown
-
2003
- 2003-01-31 ZA ZA200308525A patent/ZA200308525B/en unknown
- 2003-09-05 US US10/657,034 patent/US6890928B2/en not_active Expired - Fee Related
- 2003-10-23 BG BG108285A patent/BG108285A/bg unknown
- 2003-10-29 IS IS7003A patent/IS7003A/is unknown
- 2003-11-07 HR HR20030901A patent/HRP20030901A2/hr not_active Application Discontinuation
- 2003-11-10 CO CO03099304A patent/CO5540386A2/es not_active Application Discontinuation
- 2003-11-10 NO NO20034995A patent/NO20034995L/no not_active Application Discontinuation
- 2003-11-11 EC EC2003004839A patent/ECSP034839A/es unknown
- 2003-11-11 CR CR7146A patent/CR7146A/es not_active Application Discontinuation
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2004
- 2004-11-17 US US10/992,483 patent/US20050101641A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
OA12602A (en) | 2006-06-09 |
US20040110805A1 (en) | 2004-06-10 |
AR040928A1 (es) | 2005-04-27 |
US20040010019A1 (en) | 2004-01-15 |
ZA200308525B (en) | 2005-02-17 |
ECSP034839A (es) | 2003-12-24 |
CZ20032913A3 (cs) | 2004-05-12 |
JP2004530691A (ja) | 2004-10-07 |
MXPA03010326A (es) | 2004-07-30 |
EA200301116A1 (ru) | 2004-06-24 |
HRP20030901A2 (en) | 2005-10-31 |
BG108285A (bg) | 2004-09-30 |
WO2002092588A2 (en) | 2002-11-21 |
YU85403A (sh) | 2006-03-03 |
WO2002092588A3 (en) | 2003-02-27 |
KR20040018368A (ko) | 2004-03-03 |
NO20034995L (no) | 2003-12-16 |
EP1385836A2 (en) | 2004-02-04 |
CR7146A (es) | 2008-02-11 |
US6890928B2 (en) | 2005-05-10 |
US20050101641A1 (en) | 2005-05-12 |
AP2003002908A0 (en) | 2003-12-31 |
US6689794B2 (en) | 2004-02-10 |
PL367487A1 (en) | 2005-02-21 |
CA2446586A1 (en) | 2002-11-21 |
BR0209525A (pt) | 2004-03-09 |
HUP0304069A2 (hu) | 2004-04-28 |
CO5540386A2 (es) | 2005-07-29 |
IS7003A (is) | 2003-10-29 |
NO20034995D0 (no) | 2003-11-10 |
CN1764655A (zh) | 2006-04-26 |
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