YU85403A - Aromatični sulfonski hidroksamati i njihova upotreba kao proteaznih inhibitora - Google Patents
Aromatični sulfonski hidroksamati i njihova upotreba kao proteaznih inhibitoraInfo
- Publication number
- YU85403A YU85403A YU85403A YUP85403A YU85403A YU 85403 A YU85403 A YU 85403A YU 85403 A YU85403 A YU 85403A YU P85403 A YUP85403 A YU P85403A YU 85403 A YU85403 A YU 85403A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- aromatic sulfone
- mmp
- protease inhibitors
- aggrecanase
- activity
- Prior art date
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- Ophthalmology & Optometry (AREA)
Abstract
Ovaj pronalazak je usmeren na aromatične sulfonske hidroksamate (takodje, poznate kao "hidroksamske kiseline aromatičnog sulfona") i njihove soli, koji inter alia, inhibiraju aktivnost matriksne metaloproteinaze (takodje, poznata kao "matriksna metaloproteaza" ili "MMP") i/ili aktivnost agrekanaze. Ovaj pronalazak je, takodje, usmeren na postupke prevencije ili lečenja, koji uključuju primenjivanje takvog jedinjenja ili soli životinji, naročito sisaru, koja ima (ili je sklona) patološko stanje koje je u vezi sa aktivnošću MMP-e i/ili agrekanaze, a u efektivnoj količini za inhibiranje MMP-e i/ili agrekanaze.[This invention is directed to aromatic sulfone hydroxamates (also known as "aromatic sulfone hydroxamic acids") and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.
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US29037501P | 2001-05-11 | 2001-05-11 |
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YU85403A YU85403A (sh) | 2001-05-11 | 2002-05-10 | Aromatični sulfonski hidroksamati i njihova upotreba kao proteaznih inhibitora |
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US (3) | US6689794B2 (sh) |
EP (1) | EP1385836A2 (sh) |
JP (1) | JP2004530691A (sh) |
KR (1) | KR20040018368A (sh) |
CN (1) | CN1764655A (sh) |
AP (1) | AP2003002908A0 (sh) |
AR (1) | AR040928A1 (sh) |
BG (1) | BG108285A (sh) |
BR (1) | BR0209525A (sh) |
CA (1) | CA2446586A1 (sh) |
CO (1) | CO5540386A2 (sh) |
CR (1) | CR7146A (sh) |
CZ (1) | CZ20032913A3 (sh) |
EA (1) | EA200301116A1 (sh) |
EC (1) | ECSP034839A (sh) |
HR (1) | HRP20030901A2 (sh) |
HU (1) | HUP0304069A2 (sh) |
IL (1) | IL158454A0 (sh) |
IS (1) | IS7003A (sh) |
MX (1) | MXPA03010326A (sh) |
NO (1) | NO20034995L (sh) |
OA (1) | OA12602A (sh) |
PL (1) | PL367487A1 (sh) |
WO (1) | WO2002092588A2 (sh) |
YU (1) | YU85403A (sh) |
ZA (1) | ZA200308525B (sh) |
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2002
- 2002-05-10 YU YU85403A patent/YU85403A/sh unknown
- 2002-05-10 HU HU0304069A patent/HUP0304069A2/hu unknown
- 2002-05-10 AP APAP/P/2003/002908A patent/AP2003002908A0/en unknown
- 2002-05-10 KR KR10-2003-7014663A patent/KR20040018368A/ko not_active Application Discontinuation
- 2002-05-10 CA CA002446586A patent/CA2446586A1/en not_active Abandoned
- 2002-05-10 US US10/142,737 patent/US6689794B2/en not_active Expired - Fee Related
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- 2002-05-10 MX MXPA03010326A patent/MXPA03010326A/es unknown
- 2002-05-10 AR ARP020101724A patent/AR040928A1/es unknown
- 2002-05-10 JP JP2002589473A patent/JP2004530691A/ja not_active Withdrawn
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- 2002-05-10 EA EA200301116A patent/EA200301116A1/ru unknown
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- 2003-11-11 EC EC2003004839A patent/ECSP034839A/es unknown
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Also Published As
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WO2002092588A3 (en) | 2003-02-27 |
HUP0304069A2 (hu) | 2004-04-28 |
BR0209525A (pt) | 2004-03-09 |
MXPA03010326A (es) | 2004-07-30 |
HRP20030901A2 (en) | 2005-10-31 |
US6689794B2 (en) | 2004-02-10 |
US20050101641A1 (en) | 2005-05-12 |
JP2004530691A (ja) | 2004-10-07 |
CO5540386A2 (es) | 2005-07-29 |
CZ20032913A3 (cs) | 2004-05-12 |
AR040928A1 (es) | 2005-04-27 |
EA200301116A1 (ru) | 2004-06-24 |
OA12602A (en) | 2006-06-09 |
IS7003A (is) | 2003-10-29 |
CN1764655A (zh) | 2006-04-26 |
US20040110805A1 (en) | 2004-06-10 |
EP1385836A2 (en) | 2004-02-04 |
US20040010019A1 (en) | 2004-01-15 |
NO20034995D0 (no) | 2003-11-10 |
US6890928B2 (en) | 2005-05-10 |
ECSP034839A (es) | 2003-12-24 |
KR20040018368A (ko) | 2004-03-03 |
CA2446586A1 (en) | 2002-11-21 |
AP2003002908A0 (en) | 2003-12-31 |
BG108285A (bg) | 2004-09-30 |
ZA200308525B (en) | 2005-02-17 |
IL158454A0 (en) | 2004-05-12 |
CR7146A (es) | 2008-02-11 |
WO2002092588A2 (en) | 2002-11-21 |
PL367487A1 (en) | 2005-02-21 |
NO20034995L (no) | 2003-12-16 |
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