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Priority to MYPI9805281priorityCriticalpatent/MY141460A/en
Publication of MY141460ApublicationCriticalpatent/MY141460A/en
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
A TREATMENT PROCESS IS DISCLOSED THAT COMPRISES ADMINISTERING AN EFFECTIVE AMOUNT OF AN AROMATIC SULFONE HYDROXAMIC ACID THAT EXHIBITS EXCELLENT INHIBITORY ACTIVITY OF ONE OR MORE MATRIX METALLOPROTEASE (MMP) ENZYMES, SUCH AS MMP-2, MMP-9 AND MMP-13, WHILE EXHIBITING SUBSTANTIALLY LESS INHIBITION AT LEAST OF MMP-L TO A HOST HAVING A CONDITION ASSOCIATED WITH PATHOLOGICAL MATRIX METALLOPROTEASE ACTIVITY. ALSO DISCLOSED ARE METALLOPROTEASE INHIBITOR COMPOUNDS HAVING THOSE SELECTIVE ACTIVITIES, PROCESSES FOR MANUFACTURE OF SUCH COMPOUNDS AND PHARMACEUTICAL COMPOSITION USING AN INHIBITOR.