UY26145A1 - METALOPROTEASE INHIBITOR AROMATIC SULFOHIDROXAMIC ACID LAW 17164 ART 127 - Google Patents
METALOPROTEASE INHIBITOR AROMATIC SULFOHIDROXAMIC ACID LAW 17164 ART 127Info
- Publication number
- UY26145A1 UY26145A1 UY26145A UY26145A UY26145A1 UY 26145 A1 UY26145 A1 UY 26145A1 UY 26145 A UY26145 A UY 26145A UY 26145 A UY26145 A UY 26145A UY 26145 A1 UY26145 A1 UY 26145A1
- Authority
- UY
- Uruguay
- Prior art keywords
- mmp
- sulfohidroxamic
- metaloprotease
- inhibitor
- art
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Se describe un proceso de tratamiento, el cual comprende la administración a un huésped que presenta una condición asociada con actividad patológica de la metaloproteasa matriz de una cantidad efectiva de un ácido sulfon-hidroxámico aromático que presenta una excelente actividad inhibitoria de una o más de las encimas de la metaloproteasa matriz (MMP), tales como MMP-2, MMP-9 y MMP-13, mientras que presenta una actividad inhibitoria sustancialmente menor al menos contra la MMP-1. También se describen compuestos inhibidores de la metaloproteasa que tienen esas actividades selectivas, procesos para la elaboración de dichos compuestos y composiciones farmacéuticas que utilizan un inhibidor.A treatment process is described, which comprises the administration to a host that presents a condition associated with pathological activity of the matrix metalloprotease of an effective amount of an aromatic sulfon-hydroxamic acid that has an excellent inhibitory activity of one or more of the matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibitory activity against at least MMP-1. Also described are metalloprotease inhibitor compounds that have these selective activities, processes for the elaboration of said compounds and pharmaceutical compositions that use an inhibitor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31183799A | 1999-05-14 | 1999-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY26145A1 true UY26145A1 (en) | 2000-12-29 |
Family
ID=27757522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY26145A UY26145A1 (en) | 1999-05-14 | 2000-05-15 | METALOPROTEASE INHIBITOR AROMATIC SULFOHIDROXAMIC ACID LAW 17164 ART 127 |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR035547A1 (en) |
| CO (1) | CO5251417A1 (en) |
| PE (1) | PE20010202A1 (en) |
| UY (1) | UY26145A1 (en) |
| ZA (1) | ZA200109006B (en) |
-
2000
- 2000-05-15 AR ARP000102342 patent/AR035547A1/en not_active Application Discontinuation
- 2000-05-15 CO CO00035030A patent/CO5251417A1/en not_active Application Discontinuation
- 2000-05-15 PE PE2000000455A patent/PE20010202A1/en not_active Application Discontinuation
- 2000-05-15 UY UY26145A patent/UY26145A1/en not_active Application Discontinuation
-
2001
- 2001-10-31 ZA ZA200109006A patent/ZA200109006B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR035547A1 (en) | 2004-06-16 |
| CO5251417A1 (en) | 2003-02-28 |
| PE20010202A1 (en) | 2001-02-19 |
| ZA200109006B (en) | 2002-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20100426 |