CO5251417A1 - SULFOHYDROXAMIC AROMATIC ACIMA MATALOPROTEASE INHIBITOR - Google Patents

SULFOHYDROXAMIC AROMATIC ACIMA MATALOPROTEASE INHIBITOR

Info

Publication number
CO5251417A1
CO5251417A1 CO00035030A CO00035030A CO5251417A1 CO 5251417 A1 CO5251417 A1 CO 5251417A1 CO 00035030 A CO00035030 A CO 00035030A CO 00035030 A CO00035030 A CO 00035030A CO 5251417 A1 CO5251417 A1 CO 5251417A1
Authority
CO
Colombia
Prior art keywords
mmp
aromatic
mataloprotease
sulfohydroxamic
acima
Prior art date
Application number
CO00035030A
Other languages
Spanish (es)
Inventor
Thomas E Barta
Daniel P Becker
Louis J Bedell
Terri L Boehm
Jeffrey N Carroll
Gary A Decrescenzo
M Fobian Yvette
John N Freskos
Daniel P Getman
Joseph J Mcdonald
Susan L Hockerman
Susan C Howard
Stephen A Kolodziej
H Li Madeleine
Deborah A Mischke
Joseph G Rico
W Stehle Nathan
Michael B Tollefson
William F Vernier
Clara I Villamil
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of CO5251417A1 publication Critical patent/CO5251417A1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un proceso de tratamiento de un mamífero huésped que presenta una condición asociada con actividad patológica de la metaloproteasa matriz de una cantidad efectiva de un ácido sulfon-hidroxámico aromático que presenta una excelente actividad inhibitoria de una o más de las encimas de la metaloproteasa matriz (MMP), tales como MMP-2, MMP-9 y MMP-13, mientras que presenta una actividad inhibitoria sustancialmente menor al menos contra la MMP-1. <EMI FILE="00035030_1" ID="1" IMF=JPEG >A process of treating a host mammal that has a condition associated with pathological activity of the matrix metalloprotease of an effective amount of an aromatic sulfon-hydroxamic acid that exhibits excellent inhibitory activity of one or more of the enzymes of the matrix metalloprotease (MMP) ), such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibitory activity against at least MMP-1. <EMI FILE = "00035030_1" ID = "1" MFI = JPEG>

CO00035030A 1999-05-14 2000-05-15 SULFOHYDROXAMIC AROMATIC ACIMA MATALOPROTEASE INHIBITOR CO5251417A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31183799A 1999-05-14 1999-05-14

Publications (1)

Publication Number Publication Date
CO5251417A1 true CO5251417A1 (en) 2003-02-28

Family

ID=27757522

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00035030A CO5251417A1 (en) 1999-05-14 2000-05-15 SULFOHYDROXAMIC AROMATIC ACIMA MATALOPROTEASE INHIBITOR

Country Status (5)

Country Link
AR (1) AR035547A1 (en)
CO (1) CO5251417A1 (en)
PE (1) PE20010202A1 (en)
UY (1) UY26145A1 (en)
ZA (1) ZA200109006B (en)

Also Published As

Publication number Publication date
PE20010202A1 (en) 2001-02-19
AR035547A1 (en) 2004-06-16
UY26145A1 (en) 2000-12-29
ZA200109006B (en) 2002-12-02

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Legal Events

Date Code Title Description
FC Application refused