MXPA04010555A - Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa. - Google Patents

Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa.

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Publication number
MXPA04010555A
MXPA04010555A MXPA04010555A MXPA04010555A MXPA04010555A MX PA04010555 A MXPA04010555 A MX PA04010555A MX PA04010555 A MXPA04010555 A MX PA04010555A MX PA04010555 A MXPA04010555 A MX PA04010555A MX PA04010555 A MXPA04010555 A MX PA04010555A
Authority
MX
Mexico
Prior art keywords
hydroxamic acids
piperazinyl
piperidinyl
activity
protease inhibitors
Prior art date
Application number
MXPA04010555A
Other languages
English (en)
Inventor
Clara I Villamill
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of MXPA04010555A publication Critical patent/MXPA04010555A/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Esta invencion se refiere de manera general a inhibidores de proteinaza (tambien conocida como "proteasa"), y en particular, acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos que, Inter alia, inhiben la actividad de metaloproteinasa de matriz (tambien conocida como "metaloproteasa de matriz" o "MMP") y/o actividad de agrecanasa, dichos acidos hidroxamicos generalmente corresponden en estructura a la formula (I)(ver formula I)(en donde A1, A2 , Y, E1, E2, R3, y Rx son como se definen en esta especificacion), e incluyen ademas sales de dichos compuestos; esta invencion tambien se refiere a composiciones de dichos acidos hidroxamicos, intermedirios para las sintesis de dichos acidos hidroxamicos, metodos ara hacer dichos acidos hidroxamicos y metodos para tratar condiciones (particularmente condiciones patologicas) asociadas con actividad de MMP y/o actividad de agrecanasa.
MXPA04010555A 2002-04-25 2003-04-25 Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa. MXPA04010555A (es)

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PCT/US2003/013123 WO2003091247A2 (en) 2002-04-25 2003-04-25 Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors

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