NO20020938D0 - Substituerte alfa-hydroksysyre-caspaseinhibitorer og deres anvendelse - Google Patents
Substituerte alfa-hydroksysyre-caspaseinhibitorer og deres anvendelseInfo
- Publication number
- NO20020938D0 NO20020938D0 NO20020938A NO20020938A NO20020938D0 NO 20020938 D0 NO20020938 D0 NO 20020938D0 NO 20020938 A NO20020938 A NO 20020938A NO 20020938 A NO20020938 A NO 20020938A NO 20020938 D0 NO20020938 D0 NO 20020938D0
- Authority
- NO
- Norway
- Prior art keywords
- hydroxy acid
- substituted alpha
- caspase inhibitors
- inhibitors
- cell death
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15107799P | 1999-08-27 | 1999-08-27 | |
US15837399P | 1999-10-12 | 1999-10-12 | |
PCT/US2000/023566 WO2001016093A1 (en) | 1999-08-27 | 2000-08-28 | SUBSTITUTED α-HYDROXY ACID CASPASE INHIBITORS AND THE USE THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20020938D0 true NO20020938D0 (no) | 2002-02-26 |
NO20020938L NO20020938L (no) | 2002-04-15 |
Family
ID=26848309
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20020938A NO20020938L (no) | 1999-08-27 | 2002-02-26 | Substituerte alfa-hydroksysyre-caspaseinhibitorer og deres anvendelse |
Country Status (15)
Country | Link |
---|---|
US (1) | US6495522B1 (no) |
EP (1) | EP1212295B1 (no) |
JP (1) | JP2003508379A (no) |
KR (1) | KR20020033777A (no) |
CN (1) | CN1235875C (no) |
AT (1) | ATE409688T1 (no) |
AU (1) | AU775291B2 (no) |
BR (1) | BR0013666A (no) |
CA (1) | CA2383002A1 (no) |
DE (1) | DE60040397D1 (no) |
EA (1) | EA200200301A1 (no) |
IL (1) | IL148426A0 (no) |
MX (1) | MXPA02002038A (no) |
NO (1) | NO20020938L (no) |
WO (1) | WO2001016093A1 (no) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6184210B1 (en) * | 1997-10-10 | 2001-02-06 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
ATE276754T1 (de) * | 1998-07-21 | 2004-10-15 | Cytovia Inc | Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung |
AU3876600A (en) * | 1999-03-16 | 2000-10-04 | Cytovia, Inc. | Substituted 2-aminobenzamide caspase inhibitors and the use thereof |
AU4213500A (en) * | 1999-04-09 | 2000-11-14 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
PT1268425E (pt) | 2000-03-29 | 2008-04-01 | Vertex Pharma | Inibidores de caspase do grupo do carbamato e as suas utilizações |
PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
US20040198650A1 (en) * | 2001-03-29 | 2004-10-07 | Poul Jensen | Means for inhibiting proteolytical processing of parkin |
US6777443B2 (en) * | 2001-05-15 | 2004-08-17 | Novartis Ag | Dipeptide derivatives |
US7351702B2 (en) * | 2001-05-23 | 2008-04-01 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
WO2003008373A1 (de) * | 2001-07-19 | 2003-01-30 | Merck Patent Gmbh | Tyrosinhydrazide |
AU2003211052A1 (en) | 2002-02-11 | 2003-09-04 | Vertex Pharmaceuticals Incorporated | Phospholipids as caspase inhibitor prodrugs |
AU2003272189A1 (en) * | 2002-04-05 | 2004-01-19 | Cytovia, Inc. | Caspase inhibitors for the treatment of diseases and conditions caused by exposure to radionuclides, biological agents, or chemical agents |
WO2003088917A2 (en) * | 2002-04-19 | 2003-10-30 | Vertex Pharmaceuticals Incorporated | Regulation of tnf-alpha |
CA2524882A1 (en) * | 2003-05-06 | 2004-11-25 | Cytovia, Inc. | Protease inhibitors for coronaviruses and sars-cov and the use thereof |
WO2005080353A1 (en) * | 2004-02-18 | 2005-09-01 | Georgia Tech Research Corporation | Propenoyl hydrazides |
SG150546A1 (en) | 2004-03-12 | 2009-03-30 | Vertex Pharma | Processes and intermediates |
NZ588448A (en) | 2004-05-15 | 2012-01-12 | Vertex Pharma | Treating seizures using interleukin-1beta converting enzyme (ICE) inhibitors |
CA2567080A1 (en) | 2004-05-27 | 2005-12-15 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
WO2009076598A1 (en) | 2007-12-12 | 2009-06-18 | Children's Hospital & Research Center At Oakland | Use of unsaturated sphingosine compounds as chemotherapeutic agents for the treatment of cancer |
WO2010030891A2 (en) * | 2008-09-11 | 2010-03-18 | The Regents Of The University Of Michigan | Aryl guanidine f1f0-atpase inhibitors and related methods |
HUP1000243A2 (en) | 2010-05-06 | 2012-01-30 | Avidin Kft | 8-hidroxy-quinoline derivatives |
EP2635907A4 (en) | 2010-11-05 | 2014-04-16 | Univ Brandeis | ALPHA-SYNUCLEINE CLIVED ICE AS A BIOLOGICAL MARKER |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
KR102310615B1 (ko) * | 2013-11-21 | 2021-10-08 | 알러간, 인코포레이티드 | 페닐카바메이트 유도체로서의 포밀 펩타이드 수용체 조절제 |
CN104803864B (zh) * | 2014-01-29 | 2017-01-11 | 华东师范大学 | β-羟基-α-氨基酸衍生物及其合成方法和应用 |
GB201712282D0 (en) * | 2017-07-31 | 2017-09-13 | Nodthera Ltd | Selective inhibitors of NLRP3 inflammasome |
Family Cites Families (45)
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FR2381023A1 (fr) | 1977-02-18 | 1978-09-15 | Delalande Sa | Nouveaux oligopeptides trifluoromethyles derives de la l-alanine, leur procede de preparation et leur application en therapeutique |
US4518528A (en) | 1983-05-19 | 1985-05-21 | Rasnick David W | α Amino fluoro ketones |
US5221607A (en) | 1989-09-18 | 1993-06-22 | Scios Nova Inc. | Assays and reagents for amyloid deposition |
US5416013A (en) | 1990-04-04 | 1995-05-16 | Sterling Winthrop Inc. | Interleukin 1β protease and interleukin 1β protease inhibitors |
US5252463A (en) | 1990-06-22 | 1993-10-12 | The Du Pont Merck Pharmaceutical Company | Clipsin, a chymotrypsin-like protease and method of using same |
US5824297A (en) | 1990-06-25 | 1998-10-20 | Oncogene Science, Inc. | Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof |
EP0519748B1 (en) | 1991-06-21 | 1998-09-02 | Merck & Co. Inc. | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme |
DK0600880T3 (da) | 1991-08-30 | 2004-04-13 | Vertex Pharma | Interleukin 1-beta-protease og interleukin 1-beta-proteasehæmmere |
EP0627926B1 (en) | 1992-02-21 | 1998-08-05 | Merck & Co., Inc. (a New Jersey corp.) | PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME |
EP0618223A3 (en) | 1993-03-08 | 1996-06-12 | Sandoz Ltd | Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents. |
TW494094B (en) * | 1993-04-29 | 2002-07-11 | Vertex Pharma | Peptide analogs as irreversible interleukin-1β protease inhibitors and pharmaceutical compositions comprising the same |
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JPH0789951A (ja) | 1993-06-03 | 1995-04-04 | Sterling Winthrop Inc | インターロイキン−1β転換酵素阻害剤 |
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US5869519A (en) | 1996-12-16 | 1999-02-09 | Idun Pharmaceuticals, Inc. | C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
ATE310528T1 (de) | 1996-09-12 | 2005-12-15 | Idun Pharmaceuticals Inc | Hemmung der apoptose unter verwendung von inhibitoren der interleukin-1 beta converting enzym (ice)/ced-3 familie |
NZ330451A (no) | 1996-09-12 | 2000-01-28 | Idun Pharmaceuticals Inc | |
US6200969B1 (en) | 1996-09-12 | 2001-03-13 | Idun Pharmaceuticals, Inc. | Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors |
US6184244B1 (en) | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US5877197A (en) | 1996-12-16 | 1999-03-02 | Karanewsky; Donald S. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
CA2282845A1 (en) | 1997-03-18 | 1998-09-24 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
JPH111491A (ja) | 1997-04-18 | 1999-01-06 | Takeda Chem Ind Ltd | ペプチド類及びその剤 |
US6184210B1 (en) | 1997-10-10 | 2001-02-06 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
AU741203B2 (en) | 1997-10-10 | 2001-11-22 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
JPH11180891A (ja) | 1997-12-25 | 1999-07-06 | Dai Ichi Seiyaku Co Ltd | 抗細胞死剤 |
EP1076563B1 (en) | 1998-03-16 | 2005-05-11 | Cytovia, Inc. | Dipeptide caspase inhibitors and the use thereof |
SK16732000A3 (sk) | 1998-05-05 | 2001-06-11 | Warner-Lambert Company | Sukcínamidové inhibítory konverzného enzýmu interleukínu-1beta |
US6197750B1 (en) | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6201118B1 (en) | 1998-08-19 | 2001-03-13 | Vertex Pharmaceuticals Inc. | Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor |
US6242422B1 (en) | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
JP2002531464A (ja) | 1998-12-02 | 2002-09-24 | メルク フロスト カナダ アンド カンパニー | カスパーゼ−3阻害薬としてのγ−ケト酸テトラペプチド類 |
EP1163214A1 (en) | 1999-03-16 | 2001-12-19 | Merck Frosst Canada & Co. | Gamma-ketoacid dipeptides as inhibitors of caspase-3 |
AU3876600A (en) | 1999-03-16 | 2000-10-04 | Cytovia, Inc. | Substituted 2-aminobenzamide caspase inhibitors and the use thereof |
AU4213500A (en) | 1999-04-09 | 2000-11-14 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
PT1163208E (pt) | 1999-08-06 | 2004-08-31 | Vertex Pharma | Inibidores de caspase e as suas utilizacoes |
US6566338B1 (en) | 1999-10-12 | 2003-05-20 | Cytovia, Inc. | Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death |
AR026748A1 (es) | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
PT1268425E (pt) | 2000-03-29 | 2008-04-01 | Vertex Pharma | Inibidores de caspase do grupo do carbamato e as suas utilizações |
US7053057B2 (en) | 2000-05-23 | 2006-05-30 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
EP1289993B9 (en) | 2000-06-07 | 2008-08-20 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
-
2000
- 2000-08-28 WO PCT/US2000/023566 patent/WO2001016093A1/en active IP Right Grant
- 2000-08-28 DE DE60040397T patent/DE60040397D1/de not_active Expired - Fee Related
- 2000-08-28 KR KR1020027002581A patent/KR20020033777A/ko not_active Application Discontinuation
- 2000-08-28 US US09/649,810 patent/US6495522B1/en not_active Expired - Fee Related
- 2000-08-28 EP EP00959495A patent/EP1212295B1/en not_active Expired - Lifetime
- 2000-08-28 AT AT00959495T patent/ATE409688T1/de not_active IP Right Cessation
- 2000-08-28 EA EA200200301A patent/EA200200301A1/ru unknown
- 2000-08-28 CN CNB008134464A patent/CN1235875C/zh not_active Expired - Fee Related
- 2000-08-28 IL IL14842600A patent/IL148426A0/xx unknown
- 2000-08-28 BR BR0013666-2A patent/BR0013666A/pt not_active Application Discontinuation
- 2000-08-28 MX MXPA02002038A patent/MXPA02002038A/es unknown
- 2000-08-28 JP JP2001519663A patent/JP2003508379A/ja not_active Withdrawn
- 2000-08-28 CA CA002383002A patent/CA2383002A1/en not_active Abandoned
- 2000-08-28 AU AU70809/00A patent/AU775291B2/en not_active Ceased
-
2002
- 2002-02-26 NO NO20020938A patent/NO20020938L/no unknown
Also Published As
Publication number | Publication date |
---|---|
US6495522B1 (en) | 2002-12-17 |
AU775291B2 (en) | 2004-07-29 |
CN1235875C (zh) | 2006-01-11 |
CN1382119A (zh) | 2002-11-27 |
AU7080900A (en) | 2001-03-26 |
MXPA02002038A (es) | 2002-10-31 |
EP1212295B1 (en) | 2008-10-01 |
EA200200301A1 (ru) | 2002-08-29 |
WO2001016093A1 (en) | 2001-03-08 |
KR20020033777A (ko) | 2002-05-07 |
NO20020938L (no) | 2002-04-15 |
JP2003508379A (ja) | 2003-03-04 |
ATE409688T1 (de) | 2008-10-15 |
IL148426A0 (en) | 2002-09-12 |
CA2383002A1 (en) | 2001-03-08 |
EP1212295A1 (en) | 2002-06-12 |
DE60040397D1 (de) | 2008-11-13 |
BR0013666A (pt) | 2002-05-14 |
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