ATE276754T1 - Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung - Google Patents
Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendungInfo
- Publication number
- ATE276754T1 ATE276754T1 AT99935751T AT99935751T ATE276754T1 AT E276754 T1 ATE276754 T1 AT E276754T1 AT 99935751 T AT99935751 T AT 99935751T AT 99935751 T AT99935751 T AT 99935751T AT E276754 T1 ATE276754 T1 AT E276754T1
- Authority
- AT
- Austria
- Prior art keywords
- protease
- caspases
- reporter molecules
- enzymes
- peptidases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9364298P | 1998-07-21 | 1998-07-21 | |
PCT/US1999/016423 WO2000004914A1 (en) | 1998-07-21 | 1999-07-21 | Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE276754T1 true ATE276754T1 (de) | 2004-10-15 |
Family
ID=22240008
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99935751T ATE276754T1 (de) | 1998-07-21 | 1999-07-21 | Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung |
Country Status (6)
Country | Link |
---|---|
US (2) | US6248904B1 (de) |
EP (1) | EP1100520B1 (de) |
AT (1) | ATE276754T1 (de) |
AU (1) | AU5116099A (de) |
DE (1) | DE69920473T2 (de) |
WO (1) | WO2000004914A1 (de) |
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ATE276754T1 (de) | 1998-07-21 | 2004-10-15 | Cytovia Inc | Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung |
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EP1628674A2 (de) | 2003-05-06 | 2006-03-01 | Cytovia, Inc. | Protease-hemmer für coronaviren und sars-cov und ihre verwendung |
AU2003241559A1 (en) * | 2003-05-16 | 2004-12-13 | The Board Of Trustees Of The Leland Stanford Junior University | Protein kinase c peptides for use in withdrawal |
EP1598428A1 (de) | 2004-05-18 | 2005-11-23 | Georg Dewald | Verfahren und Kits zum Nachweis von erblichen angioedema typ III |
WO2006056487A2 (en) * | 2004-11-24 | 2006-06-01 | Theraptosis S.A. | Peptides useful as dual caspase-2/-6 inhibitors and their biological applications |
US8173819B2 (en) * | 2005-09-02 | 2012-05-08 | Visen Medical, Inc. | Nicotinic and picolinic acid derived near-infrared fluorophores |
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US7452973B2 (en) * | 2005-11-07 | 2008-11-18 | Wisconsin Alumni Research Foundation | Cell-permeable fluorescent proteins |
WO2007065080A2 (en) * | 2005-11-29 | 2007-06-07 | University Of Maryland, College Park | Control of apoptosis by controlling the propensity of ceramide channel formation |
KR100909996B1 (ko) | 2007-09-19 | 2009-07-29 | 한국생명공학연구원 | 카스파제-3(caspase-3)의 활성 검출용 융합 단백질및 이를 이용한 카스파제-3의 활성 검출방법 |
US8679836B2 (en) * | 2007-10-01 | 2014-03-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of monitoring angiogenesis and metastasis in three dimensional co-cultures |
US20090088341A1 (en) * | 2007-10-01 | 2009-04-02 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Multiplex assay method for mixed cell populations |
JP2011503579A (ja) * | 2007-11-09 | 2011-01-27 | ジェンザイム・コーポレーション | 対照細胞を使用しない細胞生存率の測定方法 |
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RU2482128C1 (ru) * | 2011-12-28 | 2013-05-20 | Замертон Холдингс Лимитед | Пептиды, обладающие цитопротекторной активностью |
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WO2019117812A1 (en) * | 2017-12-12 | 2019-06-20 | Nanyang Technological University | Near infra-red molecular probes for use in diagnosis of fibrotic conditions and screening of anti-fibrotic drugs |
KR102186097B1 (ko) * | 2017-12-26 | 2020-12-03 | 주식회사 엘지화학 | 잔텐계 화합물 및 이를 포함하는 감광성 수지 조성물 |
WO2020053808A1 (en) | 2018-09-12 | 2020-03-19 | Georg Dewald | Method of diagnosing vasoregulatory disorders |
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ATE276754T1 (de) | 1998-07-21 | 2004-10-15 | Cytovia Inc | Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung |
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-
1999
- 1999-07-21 AT AT99935751T patent/ATE276754T1/de not_active IP Right Cessation
- 1999-07-21 WO PCT/US1999/016423 patent/WO2000004914A1/en active IP Right Grant
- 1999-07-21 AU AU51160/99A patent/AU5116099A/en not_active Abandoned
- 1999-07-21 US US09/357,952 patent/US6248904B1/en not_active Expired - Lifetime
- 1999-07-21 EP EP99935751A patent/EP1100520B1/de not_active Expired - Lifetime
- 1999-07-21 DE DE69920473T patent/DE69920473T2/de not_active Expired - Fee Related
-
2002
- 2002-05-06 US US10/138,375 patent/US6984718B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6984718B2 (en) | 2006-01-10 |
WO2000004914A1 (en) | 2000-02-03 |
EP1100520A1 (de) | 2001-05-23 |
DE69920473D1 (de) | 2004-10-28 |
AU5116099A (en) | 2000-02-14 |
US6248904B1 (en) | 2001-06-19 |
US20030208037A1 (en) | 2003-11-06 |
EP1100520B1 (de) | 2004-09-22 |
DE69920473T2 (de) | 2006-02-23 |
EP1100520A4 (de) | 2002-07-17 |
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