ATE145672T1 - Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze - Google Patents
Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätzeInfo
- Publication number
- ATE145672T1 ATE145672T1 AT90913627T AT90913627T ATE145672T1 AT E145672 T1 ATE145672 T1 AT E145672T1 AT 90913627 T AT90913627 T AT 90913627T AT 90913627 T AT90913627 T AT 90913627T AT E145672 T1 ATE145672 T1 AT E145672T1
- Authority
- AT
- Austria
- Prior art keywords
- substrates
- methods
- tests
- hydrolytic enzymes
- new inhibitors
- Prior art date
Links
- 230000003301 hydrolyzing effect Effects 0.000 title abstract 5
- 108090000790 Enzymes Proteins 0.000 title abstract 4
- 102000004190 Enzymes Human genes 0.000 title abstract 4
- 239000000758 substrate Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108090000371 Esterases Proteins 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108010064785 Phospholipases Proteins 0.000 abstract 1
- 102000015439 Phospholipases Human genes 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 230000000937 inactivator Effects 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 238000011269 treatment regimen Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
- C12Q2334/10—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases p-Nitrophenol derivatives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
- G01N2333/918—Carboxylic ester hydrolases (3.1.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
- G01N2405/04—Phospholipids, i.e. phosphoglycerides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39979989A | 1989-08-29 | 1989-08-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE145672T1 true ATE145672T1 (de) | 1996-12-15 |
Family
ID=23581012
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90913627T ATE145672T1 (de) | 1989-08-29 | 1990-08-17 | Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze |
Country Status (8)
Country | Link |
---|---|
US (2) | US5427919A (de) |
EP (1) | EP0489839B1 (de) |
JP (1) | JP3100057B2 (de) |
AT (1) | ATE145672T1 (de) |
AU (1) | AU643952B2 (de) |
CA (1) | CA2064793C (de) |
DE (1) | DE69029269T2 (de) |
WO (1) | WO1991003544A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991003544A1 (en) * | 1989-08-29 | 1991-03-21 | The Regents Of The University Of California | Novel hydrolytic enzyme inhibitors and substrates and assays, methods and kits embodying same |
AU4058297A (en) * | 1996-08-08 | 1998-02-25 | Children's Hospital Medical Center Of North America | Phospholipase a2 as a marker for the presence of pulmonary fat embolism |
US6264937B1 (en) | 1998-01-09 | 2001-07-24 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
US7048917B1 (en) | 1998-01-09 | 2006-05-23 | Genzyme Corporation | Fat-binding polymers |
US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
US6299868B1 (en) | 1999-07-14 | 2001-10-09 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
GB0111987D0 (en) * | 2001-05-16 | 2001-07-04 | Univ Sheffield | Method |
US7049345B2 (en) * | 2001-06-29 | 2006-05-23 | Genzyme Corporation | Fat-binding polymers |
US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
AU2003237397A1 (en) * | 2002-06-04 | 2003-12-19 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
EP1581095A4 (de) * | 2002-06-27 | 2006-10-18 | Harkness Pharmaceuticals Inc | Therapeutische methoden zur reduzierung der fettablagerung und zur behandlung von damit einhergehenden erkrankungen |
AU2003248793A1 (en) * | 2002-06-27 | 2004-01-19 | Sequenom, Inc | Diagnosing predisposition to fat deposition and associated condition |
US7041469B2 (en) * | 2002-10-10 | 2006-05-09 | Quidel Corporation | Assays for trichomonal and other hydrolases |
FR2847267B1 (fr) * | 2002-11-19 | 2006-07-28 | Coletica | Procede de test de l'activite d'une substance potentiellement active pour inhiber l'activite enzymatique de la phospholipase a2 |
CN110452262A (zh) * | 2019-08-22 | 2019-11-15 | 深圳上泰生物工程有限公司 | 血小板激活因子(paf)类似物的合成方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4833152A (en) * | 1980-03-05 | 1989-05-23 | University Of Miami | Anti-hypertensive agents |
DE3011061C2 (de) * | 1980-03-21 | 1983-12-22 | Siemens AG, 1000 Berlin und 8000 München | Verfahren zur Intensivierung von Spül- und Reinigungsprozessen für Perforationen in Formstücken in Spül- und Reinigungsautomaten |
FI63064C (fi) * | 1980-04-09 | 1983-04-11 | Ksv Chemicals Oy | Foerfarande foer fluorometrisk bestaemning av aktiviteten av fettspjaelkande enzymer och medel foer att genomfoera foerfarandet |
US4616089A (en) * | 1983-08-03 | 1986-10-07 | University Of California | Synthetic anti-inflammatory derivatives of manoalide |
US4447445A (en) * | 1983-08-03 | 1984-05-08 | The Regents Of The University Of Calif. | Manoalide, an anti-inflammatory analgesic marine natural product |
US4826958A (en) * | 1984-12-14 | 1989-05-02 | Abbott Laboratories | Renin inhibiting compounds |
AU5770786A (en) * | 1985-04-15 | 1986-11-05 | Biotechnology Research Partners Limited | Human anti-inflammatory phospholipase inhibitor protein |
DE3516001A1 (de) * | 1985-05-03 | 1986-11-06 | Boehringer Mannheim Gmbh, 6800 Mannheim | Lipasefarbtest |
US4835099A (en) * | 1986-11-20 | 1989-05-30 | Becton, Dickinson And Company | Signal enhancement in immunoassay by modulation of enzymatic catalysis |
US4788304A (en) * | 1987-12-07 | 1988-11-29 | American Home Products Corporation | Phospholipase A2 inhibitors |
DE3807123A1 (de) * | 1988-03-04 | 1989-09-14 | Boehringer Mannheim Gmbh | Substrate fuer phospholipasen |
FR2628914B1 (fr) * | 1988-03-18 | 1990-06-29 | Alcatel Thomson Faisceaux | Recepteur pour systeme de transmission par voie hertzienne a diversite d'espace, comprenant un combineur de diversite |
WO1991003544A1 (en) * | 1989-08-29 | 1991-03-21 | The Regents Of The University Of California | Novel hydrolytic enzyme inhibitors and substrates and assays, methods and kits embodying same |
US5308766A (en) * | 1989-08-29 | 1994-05-03 | The Regents Of The University Of California | Hydrolytic enzyme inhibitors/inactivators and methods for using same |
US5352673A (en) * | 1989-08-29 | 1994-10-04 | Dennis Edward A | Prodrugs |
US5314815A (en) * | 1992-03-04 | 1994-05-24 | The Catholic University Of America | Method for temporarily inhibiting or deactivating serine hydrolase and adduct of serine hydrolase with a phosphonate or phosphate compound |
-
1990
- 1990-08-17 WO PCT/US1990/004641 patent/WO1991003544A1/en active IP Right Grant
- 1990-08-17 JP JP02512726A patent/JP3100057B2/ja not_active Expired - Fee Related
- 1990-08-17 EP EP90913627A patent/EP0489839B1/de not_active Expired - Lifetime
- 1990-08-17 CA CA002064793A patent/CA2064793C/en not_active Expired - Fee Related
- 1990-08-17 DE DE69029269T patent/DE69029269T2/de not_active Expired - Fee Related
- 1990-08-17 AU AU63530/90A patent/AU643952B2/en not_active Ceased
- 1990-08-17 AT AT90913627T patent/ATE145672T1/de not_active IP Right Cessation
-
1993
- 1993-12-02 US US08/162,578 patent/US5427919A/en not_active Expired - Fee Related
-
1995
- 1995-02-14 US US08/388,377 patent/US5567597A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU643952B2 (en) | 1993-12-02 |
JPH05500157A (ja) | 1993-01-21 |
DE69029269T2 (de) | 1997-05-28 |
AU6353090A (en) | 1991-04-08 |
DE69029269D1 (de) | 1997-01-09 |
CA2064793A1 (en) | 1991-03-01 |
CA2064793C (en) | 2001-11-13 |
JP3100057B2 (ja) | 2000-10-16 |
WO1991003544A1 (en) | 1991-03-21 |
US5567597A (en) | 1996-10-22 |
US5427919A (en) | 1995-06-27 |
EP0489839A4 (en) | 1992-10-28 |
EP0489839A1 (de) | 1992-06-17 |
EP0489839B1 (de) | 1996-11-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |