AT349648B - Verfahren zur bestimmung von enzymen des typus serinproteasen, bei dem aminosaeurereste ent- haltende chromogene substrate durch diese enzyme gespalten werden - Google Patents

Verfahren zur bestimmung von enzymen des typus serinproteasen, bei dem aminosaeurereste ent- haltende chromogene substrate durch diese enzyme gespalten werden

Info

Publication number
AT349648B
AT349648B AT464076A AT464076A AT349648B AT 349648 B AT349648 B AT 349648B AT 464076 A AT464076 A AT 464076A AT 464076 A AT464076 A AT 464076A AT 349648 B AT349648 B AT 349648B
Authority
AT
Austria
Prior art keywords
enzymes
amino acid
containing amino
serine proteases
substrates containing
Prior art date
Application number
AT464076A
Other languages
English (en)
Other versions
ATA464076A (de
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of ATA464076A publication Critical patent/ATA464076A/de
Application granted granted Critical
Publication of AT349648B publication Critical patent/AT349648B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT464076A 1975-07-11 1976-06-25 Verfahren zur bestimmung von enzymen des typus serinproteasen, bei dem aminosaeurereste ent- haltende chromogene substrate durch diese enzyme gespalten werden AT349648B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7507974A SE407571B (sv) 1975-07-11 1975-07-11 Nya kromogena enzymsubstrat for serinproteaser

Publications (2)

Publication Number Publication Date
ATA464076A ATA464076A (de) 1978-09-15
AT349648B true AT349648B (de) 1979-04-10

Family

ID=20325115

Family Applications (1)

Application Number Title Priority Date Filing Date
AT464076A AT349648B (de) 1975-07-11 1976-06-25 Verfahren zur bestimmung von enzymen des typus serinproteasen, bei dem aminosaeurereste ent- haltende chromogene substrate durch diese enzyme gespalten werden

Country Status (23)

Country Link
US (1) US4214049A (de)
JP (1) JPS5224581A (de)
AT (1) AT349648B (de)
AU (1) AU497546B2 (de)
BE (1) BE843969A (de)
CA (1) CA1081212A (de)
CH (1) CH622285A5 (de)
CS (1) CS199631B2 (de)
DD (1) DD127320A5 (de)
DE (1) DE2629067A1 (de)
DK (1) DK146937C (de)
ES (1) ES449738A1 (de)
FI (1) FI56524C (de)
FR (1) FR2317278A1 (de)
GB (1) GB1510925A (de)
IL (1) IL49830A (de)
IT (1) IT1062604B (de)
NL (1) NL187693C (de)
NO (1) NO142812C (de)
PL (1) PL103098B1 (de)
SE (1) SE407571B (de)
SU (1) SU700060A3 (de)
ZA (1) ZA763585B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3108322A1 (de) 1980-03-18 1981-12-24 Immuno Aktiengesellschaft für chemisch-medizinische Produkte, 1220 Wien Chromogenes enzymsubstrat

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
SE7801373L (sv) * 1978-02-07 1979-08-08 Kabi Ab Lett spjelkbara substrat for kvantifiering av proteaser
EP0009010B1 (de) * 1978-07-18 1983-03-02 Kabi AB Bradykininhemmende Tripeptid-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
JPS5537120A (en) * 1978-09-06 1980-03-15 Kanji Tsuchiya Method and device for preparation of food from oilseed
JPS5559149A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
JPS59499B2 (ja) * 1978-11-02 1984-01-07 味の素株式会社 ペプチド誘導体
US4327178A (en) 1979-05-01 1982-04-27 University Of Miami Urinary kallikrein assay: specific substrates and assay method
CA1161431A (en) * 1979-05-11 1984-01-31 Lars G. Svendsen Tripeptide derivatives
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
CA1161432A (en) * 1980-02-12 1984-01-31 Lars G. Svendsen Tripeptide derivatives and their application in assaying enzymes
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
JPS57177985U (de) * 1981-04-30 1982-11-11
US4406832A (en) * 1981-09-03 1983-09-27 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
US4510241A (en) * 1981-09-03 1985-04-09 Mallinckrodt, Inc. Peptide-type substrates useful in the quantitative determination of endotoxin
JPS5863399A (ja) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd 新規なプラスミン測定用基質
ATE17262T1 (de) * 1981-11-02 1986-01-15 Pentapharm Ag Verfahren zur quantitativen bestimmung von blutgerinnungsfaktor xii in humanplasma.
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
NL8201987A (nl) * 1982-05-13 1983-12-01 Tno Werkwijze voor het bepalen van de activiteit van plasminogeenactivator van het weefseltype, alsmede voor gebruik bij deze werkwijze geschikte combinatie van het "kit"-type.
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
EP0182929A1 (de) * 1984-11-26 1986-06-04 American Hospital Supply Corporation Koaktivator zur Aktivierung von Protein C
DE3536903A1 (de) * 1985-10-16 1987-04-16 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung von protein c
JPS62126196A (ja) * 1985-11-26 1987-06-08 Nitto Boseki Co Ltd 新規なα１−アンチトリプシン測定用化合物
DE3710937A1 (de) * 1987-04-01 1988-10-13 Boehringer Mannheim Gmbh Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate
JPH01112157A (ja) * 1987-07-10 1989-04-28 Yamanouchi Pharmaceut Co Ltd 組織プラスミノーゲンアクチベーター活性の測定法，測定具及び測定用キット
JPH0383093U (de) * 1989-12-09 1991-08-23
EP0802986B1 (de) 1995-01-10 2001-09-19 Hendrik Coenraad Hemker Verfahren zum nachweis des endogenen thrombin-potentials und thrombin substrate zur verwendung in diesen verfahren
WO2021045182A1 (ja) * 2019-09-05 2021-03-11 国立大学法人東京農工大学 トリプターゼ活性測定用基質

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
DE2527932C2 (de) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
SE407058B (sv) * 1974-12-05 1979-03-12 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
CH622286A5 (de) * 1975-06-23 1981-03-31 Pentapharm Ag

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3108322A1 (de) 1980-03-18 1981-12-24 Immuno Aktiengesellschaft für chemisch-medizinische Produkte, 1220 Wien Chromogenes enzymsubstrat

Also Published As

Publication number Publication date
FR2317278A1 (fr) 1977-02-04
DK312776A (da) 1977-01-12
FI56524B (fi) 1979-10-31
DE2629067A1 (de) 1977-01-13
JPS5224581A (en) 1977-02-24
ZA763585B (en) 1977-05-25
NO762406L (de) 1977-01-12
ES449738A1 (es) 1977-12-16
ATA464076A (de) 1978-09-15
NO142812B (no) 1980-07-14
JPS5615238B2 (de) 1981-04-09
DK146937C (da) 1984-07-30
IL49830A (en) 1978-12-17
IT1062604B (it) 1984-10-20
US4214049A (en) 1980-07-22
PL103098B1 (pl) 1979-05-31
CH622285A5 (de) 1981-03-31
FI56524C (fi) 1980-02-11
DD127320A5 (de) 1977-09-14
SU700060A3 (ru) 1979-11-25
CS199631B2 (en) 1980-07-31
GB1510925A (en) 1978-05-17
DK146937B (da) 1984-02-20
SE7507974L (sv) 1977-01-12
IL49830A0 (en) 1976-08-31
SE407571B (sv) 1979-04-02
DE2629067C2 (de) 1989-08-03
NO142812C (no) 1980-10-22
NL187693B (nl) 1991-07-16
BE843969A (fr) 1976-11-03
NL7607433A (nl) 1977-01-13
NL187693C (nl) 1991-12-16
CA1081212A (en) 1980-07-08
FI762009A (de) 1977-01-12
AU1530476A (en) 1978-01-05
FR2317278B1 (de) 1981-01-30
AU497546B2 (en) 1978-12-14

Similar Documents

Publication Publication Date Title
AT349648B (de) Verfahren zur bestimmung von enzymen des typus serinproteasen, bei dem aminosaeurereste ent- haltende chromogene substrate durch diese enzyme gespalten werden
ATA453876A (de) Verfahren zur bestimmung von proteolytischen enzymen der gruppe e.c. 3.4.4.
Ryan et al. An inhibitor of chymotrypsin from Solanum tuberosum and its behavior toward trypsin
MY8600605A (en) Agent for the detection of esterolytic and/or proteolytic enzymes and phenoxyamino acid and phenoxy peptide esters suitable as substrates therefor processes for their preparation as well as their use for the preparation of the agent according to the invention.
DD130178A5 (de) Verfahren zur bestimmung von substraten oder enzymaktivitaeten
PT87652A (pt) Process for the preparation of peptide bobonic acid inhibitors of trypsin-like proteases
IT1039558B (it) Substrato cromogend o fluorescente in particolare per la determinazione quantitativia di enzimi
NO142074C (no) Nye kromogene enzymsubstrater for serinproteaser
DE69705838D1 (de) Substrate und inhibitoren von proteolytischen enzymen
AT358203B (de) Verfahren zur herstellung von neuen als spezifische chromogene enzymsubstrate fuer serinproteasen geeigneten peptiden
ATE117311T1 (de) Substrate für hydrolasen, verfahren zu ihrer herstellung und ihre verwendung.
ES8607243A1 (es) Esteres de aminoacidos y de peptidos cromogenos
DE3888689D1 (de) Substrate für enzymtests.
ATA463976A (de) Verahren zur bestimmung von thrombin und thrombinartigen enzymen durch spaltung chromogene substrate
ATE145672T1 (de) Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze
NO851142L (no) Analysefremgangsmaate og innretning til paavisning av esterolyttiske og/eller proteolyttiske enzymer
ATE131066T1 (de) Mittel zur hemmung von hiv-proteasen.
ATE4453T1 (de) Aminosaeure- und peptidester von leukoindoanilinen, verfahren zu deren herstellung sowie diese verbindungen enthaltende mittel zum nachweis proteolytischer enzyme.
DE68910087D1 (de) Verfahren zur Herstellung von harten, ein Enzym enthaltenden Kandis.
ATA520476A (de) Verfahren zur destillativen reinigung von 2,5-dioxo -1-oxa-2- phospholanen
KLEINE et al. Separation and comparative characterization of the cationic protease and anionic protease from the culture medium of Thermoactinomyces vulgaris
ATA377975A (de) Verfahren zur alkoholischen vergarung von zuckerhaltigen substraten
SU542762A1 (ru) Способ выделени инвертазы из дрожжей
DD130279A1 (de) Verfahren zur bestimmung des enzyms glutathionperoxidase
ATE28186T1 (de) Alpha-allenyl-alpha-amino carbonsaeuren.

Legal Events

Date Code Title Description
EIH Change in the person of patent owner
ELA Expired due to lapse of time