PT87652A - Process for the preparation of peptide bobonic acid inhibitors of trypsin-like proteases - Google Patents

Process for the preparation of peptide bobonic acid inhibitors of trypsin-like proteases

Info

Publication number
PT87652A
PT87652A PT87652A PT8765288A PT87652A PT 87652 A PT87652 A PT 87652A PT 87652 A PT87652 A PT 87652A PT 8765288 A PT8765288 A PT 8765288A PT 87652 A PT87652 A PT 87652A
Authority
PT
Portugal
Prior art keywords
bobonic
proteases
trypsin
peptide
preparation
Prior art date
Application number
PT87652A
Other languages
English (en)
Other versions
PT87652B (pt
Inventor
Charles Adrian Kettner
Ashokkumar Bhikkappa Shenvi
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of PT87652A publication Critical patent/PT87652A/pt
Publication of PT87652B publication Critical patent/PT87652B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT87652A 1987-06-05 1988-06-03 Processo para a preparacao de derivados peptidicos do acido boronico apropriados como inibidores de proteases semelhantes a tripsina PT87652B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5967087A 1987-06-05 1987-06-05
US07/178,368 US5187157A (en) 1987-06-05 1988-04-06 Peptide boronic acid inhibitors of trypsin-like proteases

Publications (2)

Publication Number Publication Date
PT87652A true PT87652A (pt) 1988-07-01
PT87652B PT87652B (pt) 1992-09-30

Family

ID=26739035

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87652A PT87652B (pt) 1987-06-05 1988-06-03 Processo para a preparacao de derivados peptidicos do acido boronico apropriados como inibidores de proteases semelhantes a tripsina

Country Status (16)

Country Link
US (1) US5187157A (pt)
EP (1) EP0293881B1 (pt)
JP (1) JPH0730090B2 (pt)
KR (1) KR910003619B1 (pt)
AU (1) AU623592B2 (pt)
CA (1) CA1328332C (pt)
DE (1) DE3878991T2 (pt)
DK (1) DK304488A (pt)
ES (1) ES2046237T3 (pt)
FI (1) FI97297C (pt)
HU (1) HU205141B (pt)
IE (1) IE64787B1 (pt)
IL (1) IL86613A (pt)
NO (1) NO882472L (pt)
NZ (1) NZ224903A (pt)
PT (1) PT87652B (pt)

Families Citing this family (177)

* Cited by examiner, † Cited by third party
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KR890000514A (ko) 1989-03-15
HUT49629A (en) 1989-10-30
DE3878991D1 (de) 1993-04-15
US5187157A (en) 1993-02-16
DK304488A (da) 1988-12-06
DK304488D0 (da) 1988-06-03
HU205141B (en) 1992-03-30
JPH0730090B2 (ja) 1995-04-05
CA1328332C (en) 1994-04-05
FI97297C (fi) 1996-11-25
IE881666L (en) 1988-12-05
PT87652B (pt) 1992-09-30
NZ224903A (en) 1990-02-26
EP0293881B1 (en) 1993-03-10
DE3878991T2 (de) 1993-07-15
ES2046237T3 (es) 1994-02-01
NO882472D0 (no) 1988-06-03
AU623592B2 (en) 1992-05-21
FI97297B (fi) 1996-08-15
IL86613A (en) 1993-04-04
NO882472L (no) 1988-12-06
IE64787B1 (en) 1995-09-06
FI882638L (fi) 1988-12-06
KR910003619B1 (ko) 1991-06-07
EP0293881A3 (en) 1990-05-30
IL86613A0 (en) 1988-11-30
EP0293881A2 (en) 1988-12-07
FI882638A0 (fi) 1988-06-03
JPS6463583A (en) 1989-03-09
AU1733288A (en) 1988-12-08

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