PT87642A - Process for the preparation of dopamine-beta-hydroxylase inhibitors - Google Patents

Process for the preparation of dopamine-beta-hydroxylase inhibitors

Info

Publication number
PT87642A
PT87642A PT87642A PT8764288A PT87642A PT 87642 A PT87642 A PT 87642A PT 87642 A PT87642 A PT 87642A PT 8764288 A PT8764288 A PT 8764288A PT 87642 A PT87642 A PT 87642A
Authority
PT
Portugal
Prior art keywords
dopamine
beta
preparation
hydroxylase inhibitors
hydroxylase
Prior art date
Application number
PT87642A
Other languages
English (en)
Other versions
PT87642B (pt
Inventor
Joseph Alan Finkelstein
Lawrence Ivan Kruse
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of PT87642A publication Critical patent/PT87642A/pt
Publication of PT87642B publication Critical patent/PT87642B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT87642A 1987-06-01 1988-06-01 Processo de preparacao de inibidores da dopamina-beta-hidroxilase PT87642B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/056,018 US4835154A (en) 1987-06-01 1987-06-01 1-aralykyl-5-piperazinylmethyl-2-mercaptoimidazoles and 2-alkylthioimidazoles and their use as dopamine-βhydroxylase inhibitors

Publications (2)

Publication Number Publication Date
PT87642A true PT87642A (pt) 1988-07-01
PT87642B PT87642B (pt) 1992-09-30

Family

ID=22001632

Family Applications (1)

Application Number Title Priority Date Filing Date
PT87642A PT87642B (pt) 1987-06-01 1988-06-01 Processo de preparacao de inibidores da dopamina-beta-hidroxilase

Country Status (7)

Country Link
US (1) US4835154A (pt)
EP (1) EP0294973A1 (pt)
JP (1) JPS63310872A (pt)
AU (1) AU1644788A (pt)
DK (1) DK293088A (pt)
PT (1) PT87642B (pt)
ZA (1) ZA883851B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882348A (en) * 1987-12-29 1989-11-21 Smithkline Beckman Corporation 2-(aminoalkylthio)imidazoles as dopamine-β-hydroxylase inhibitors
ES2207091T3 (es) * 1989-06-14 2004-05-16 Smithkline Beecham Corporation Acido imidazolil-alquenoico.
CA2018443A1 (en) * 1989-06-14 1990-12-14 Joseph A. Finkelstein Imidazolyl-alkenoic acids
US5135944A (en) * 1989-06-21 1992-08-04 Syntex (U.S.A.) Inc. Bis(benzylpyrrolidine) derivatives useful for treating congestive heart failure and acute renal failure
US5100912A (en) * 1990-05-14 1992-03-31 Syntex (U.S.A.) Inc. Bis(benzylpyrrolidine) derivatives as dopamine agonists
US5093355A (en) * 1989-10-30 1992-03-03 Syntex (U.S.A.) Inc. Benzylpyrrolidine derivatives as dopamine agonists
WO1997036591A1 (en) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CA2249599A1 (en) * 1996-04-03 1997-10-09 Dong D. Wei Inhibitors of farnesyl-protein transferase
US5972942A (en) * 1997-03-27 1999-10-26 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JP2000086583A (ja) * 1998-09-17 2000-03-28 Asahi Glass Co Ltd 含フッ素ベンジル誘導体の製造方法
CN1340051A (zh) * 1999-02-11 2002-03-13 辉瑞产品公司 可用作抗癌剂的杂芳基取代的喹啉－2－酮衍生物
WO2004069809A1 (en) * 2003-02-03 2004-08-19 Janssen Pharmaceutica N.V. Mercaptoimidazoles as ccr2 receptor antagonists
PT2822936T (pt) 2012-03-07 2021-12-02 Univ Of Delhi Derivados da aminoquinolina e suas utilizações

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL131192C (pt) * 1965-06-16
US4022783A (en) * 1975-10-29 1977-05-10 Usv Pharmaceutical Corporation Piperazinyl-imidazolines
IT1159698B (it) * 1978-05-29 1987-03-04 Rotta Research Lab Derivati 5-nitro-imidazolici della piperazina ad attivita' antiprotozoica
US4338453A (en) * 1980-09-17 1982-07-06 The Upjohn Company Aminoalkyl-1,2,4-triazoles
JPS57106663A (en) * 1980-12-23 1982-07-02 Kyorin Pharmaceut Co Ltd 1,4-disubstituted piperazine derivative and its preparation
US4487761A (en) * 1982-04-05 1984-12-11 Merck & Co., Inc. Dopamine β-hydroxylase inhibitors
DE3217094A1 (de) * 1982-05-07 1983-11-10 Hoechst Ag, 6230 Frankfurt 1-substituierte imidazol-5-carbonsaeurederivate, ihre herstellung sowie ihre verwendung als biozide
PT78388B (en) * 1983-04-12 1986-09-15 Smithkline Beckman Corp Dopamine-beta-hydroxylase inhibitors
US4532331A (en) * 1983-04-12 1985-07-30 Smithkline Beckman Corporation 1-Benzyl-2-aminomethyl imidazole derivatives
JPS59199679A (ja) * 1983-04-27 1984-11-12 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
US4719223A (en) * 1985-10-31 1988-01-12 Smithkline Beckman Corporation Imidazolethiol dopamine-beta-hydroxylase inhibitors
US4743613A (en) * 1986-04-08 1988-05-10 Smithkline Beckman Corporation Ester prodrugs of dopamine-β-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-β-hydroxylase activity
NZ221427A (en) * 1986-08-18 1990-12-21 Smithkline Beckman Corp 2-mercaptoimidazole derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
EP0294973A1 (en) 1988-12-14
DK293088D0 (da) 1988-05-27
US4835154A (en) 1989-05-30
PT87642B (pt) 1992-09-30
JPS63310872A (ja) 1988-12-19
AU1644788A (en) 1988-12-01
ZA883851B (en) 1989-04-26
DK293088A (da) 1988-12-02

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Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19920316

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19940930