AU6448794A - Boronic acid and ester inhibitors of thrombin - Google Patents

Boronic acid and ester inhibitors of thrombin

Info

Publication number
AU6448794A
AU6448794A AU64487/94A AU6448794A AU6448794A AU 6448794 A AU6448794 A AU 6448794A AU 64487/94 A AU64487/94 A AU 64487/94A AU 6448794 A AU6448794 A AU 6448794A AU 6448794 A AU6448794 A AU 6448794A
Authority
AU
Australia
Prior art keywords
thrombin
boronic acid
ester inhibitors
inhibitors
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU64487/94A
Inventor
Eugene Cruz Amparo
William Henry Miller
Gregory James Pacofsky
John Wityak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of AU6448794A publication Critical patent/AU6448794A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
AU64487/94A 1993-03-24 1994-03-23 Boronic acid and ester inhibitors of thrombin Abandoned AU6448794A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US036377 1987-04-09
US3637793A 1993-03-24 1993-03-24
PCT/US1994/002965 WO1994021650A1 (en) 1993-03-24 1994-03-23 Boronic acid and ester inhibitors of thrombin

Publications (1)

Publication Number Publication Date
AU6448794A true AU6448794A (en) 1994-10-11

Family

ID=21888279

Family Applications (1)

Application Number Title Priority Date Filing Date
AU64487/94A Abandoned AU6448794A (en) 1993-03-24 1994-03-23 Boronic acid and ester inhibitors of thrombin

Country Status (3)

Country Link
AU (1) AU6448794A (en)
WO (1) WO1994021650A1 (en)
ZA (1) ZA942082B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563127A (en) * 1993-03-24 1996-10-08 The Dupont Merck Pharmaceutical Company Boronic acid and ester inhibitors of thrombin
IL111175A0 (en) * 1993-10-07 1994-12-29 Du Pont Merck Pharma Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them
FR2745288B1 (en) * 1996-02-27 1998-04-17 Adir NOVEL BORONIC ACID DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP1695711A3 (en) * 2002-09-09 2008-01-02 Trigen Limited Parenteral formulations comprising boronic acid species for selective thrombin inhibition
US7371729B2 (en) 2002-09-09 2008-05-13 Trigen Limited Boronic acid salts useful in parenteral formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
GB9017694D0 (en) * 1990-08-13 1990-09-26 Sandoz Ltd Improvements in or relating to organic chemistry
GB9024129D0 (en) * 1990-11-06 1990-12-19 Thrombosis Research Trust Inhibitors and substrates of thrombin

Also Published As

Publication number Publication date
ZA942082B (en) 1995-09-26
WO1994021650A1 (en) 1994-09-29

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