AU7922694A - Dipeptide boronic acid inhibitors of trypsin-like enzymes - Google Patents
Dipeptide boronic acid inhibitors of trypsin-like enzymesInfo
- Publication number
- AU7922694A AU7922694A AU79226/94A AU7922694A AU7922694A AU 7922694 A AU7922694 A AU 7922694A AU 79226/94 A AU79226/94 A AU 79226/94A AU 7922694 A AU7922694 A AU 7922694A AU 7922694 A AU7922694 A AU 7922694A
- Authority
- AU
- Australia
- Prior art keywords
- trypsin
- enzymes
- boronic acid
- acid inhibitors
- dipeptide boronic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010016626 Dipeptides Proteins 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000001810 trypsinlike Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US139444 | 1980-04-11 | ||
US13325293A | 1993-10-07 | 1993-10-07 | |
US133252 | 1993-10-07 | ||
US08/139,444 US5462964A (en) | 1993-10-20 | 1993-10-20 | Dipeptide boronic acid inhibitors of trypsin-like enzymes |
PCT/US1994/011048 WO1995009858A1 (en) | 1993-10-07 | 1994-10-06 | Dipeptide boronic acid inhibitors of trypsin-like enzymes |
Publications (1)
Publication Number | Publication Date |
---|---|
AU7922694A true AU7922694A (en) | 1995-05-01 |
Family
ID=26831205
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU79226/94A Abandoned AU7922694A (en) | 1993-10-07 | 1994-10-06 | Dipeptide boronic acid inhibitors of trypsin-like enzymes |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU7922694A (en) |
IL (1) | IL111176A0 (en) |
WO (1) | WO1995009858A1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
US5602101A (en) * | 1994-03-04 | 1997-02-11 | Eli Lilly And Company | Antithrombotic agents |
ZA951618B (en) * | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
CA2143533A1 (en) * | 1994-03-04 | 1995-09-05 | Kenneth D. Kurz | Antithrombotic agents |
US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
US5885967A (en) * | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
US5693617A (en) * | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
US6083903A (en) | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
US20050288253A1 (en) | 2002-09-09 | 2005-12-29 | Trigen Limited | Boronic acid salts |
KR20050057294A (en) * | 2002-09-09 | 2005-06-16 | 트라이젠 리미티드 | Boronic acid salts and their use in the treatment of thrombosis |
CN1729174B (en) * | 2002-12-20 | 2015-10-21 | 西巴特殊化学品控股有限公司 | The synthesis of amine and the intermediate for the synthesis of amine |
US7417040B2 (en) | 2004-03-01 | 2008-08-26 | Bristol-Myers Squibb Company | Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
US7378426B2 (en) | 2004-03-01 | 2008-05-27 | Bristol-Myers Squibb Company | Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
GB0505969D0 (en) | 2005-03-23 | 2005-04-27 | Novartis Ag | Organic compounds |
BRPI0620736A2 (en) | 2005-12-30 | 2011-12-20 | Novartis Ag | organic compounds |
ES2541107T3 (en) | 2007-06-25 | 2015-07-16 | Novartis Ag | N5- (2-ethoxyethyl) -N3- (2-pyridinyl) -3,5-piperidindicarboxamide derivatives for use as renin inhibitors |
KR102595723B1 (en) | 2016-06-21 | 2023-10-27 | 오리온 옵탈몰로지 엘엘씨 | Heterocyclic Prolinamide Derivatives |
JP7164521B2 (en) | 2016-06-21 | 2022-11-01 | オリオン・オフサルモロジー・エルエルシー | carbocyclic prolinamide derivatives |
CA3183740A1 (en) | 2020-06-10 | 2021-12-16 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
KR20240035513A (en) | 2021-07-09 | 2024-03-15 | 알리고스 테라퓨틱스 인코포레이티드 | antiviral compounds |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
GB9017694D0 (en) * | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
GB9024129D0 (en) * | 1990-11-06 | 1990-12-19 | Thrombosis Research Trust | Inhibitors and substrates of thrombin |
EP0503203A1 (en) * | 1991-03-15 | 1992-09-16 | Merrell Dow Pharmaceuticals Inc. | Novel thrombin inhibitors |
-
1994
- 1994-10-05 IL IL11117694A patent/IL111176A0/en unknown
- 1994-10-06 WO PCT/US1994/011048 patent/WO1995009858A1/en active Application Filing
- 1994-10-06 AU AU79226/94A patent/AU7922694A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1995009858A1 (en) | 1995-04-13 |
IL111176A0 (en) | 1994-12-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU7922694A (en) | Dipeptide boronic acid inhibitors of trypsin-like enzymes | |
AU7966494A (en) | Electrophilic peptide analogs as inhibitors of trypsin-like enzymes | |
AU1733288A (en) | Peptide boronic acid inhibitors of trypsin-like proteases | |
AU4640496A (en) | Boronic acid and ester inhibitors of thrombin | |
AU5533094A (en) | Enzyme inhibitors | |
AU3967195A (en) | Amidino and guanidino substituted inhibitors of trypsin-like enzymes | |
AU4980697A (en) | Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors | |
AU4153197A (en) | Phosphinic acid amides as matrix metalloprotease inhibitors | |
PL323710A1 (en) | Reversible inhibitors of cysteinic protease | |
AU3193489A (en) | Renin inhibitors containing alpha-heteroatom amino acids | |
PL314838A1 (en) | Inhibitors of bp-iv-serine protease | |
AU3972697A (en) | Inhibitors of cysteine protease | |
AU6897094A (en) | Identification and use of protease inhibitors | |
AU5687396A (en) | N-aroylamino acid amides as endothelin inhibitors | |
AU5665396A (en) | Novel hydroxamic acid and amino-carboxylate compounds as met alloprotease and tnf inhibitors | |
AU4422096A (en) | Hydroxamic acid-containing inhibitors of matrix metalloproteases | |
AU3479593A (en) | Peptidyl derivatives as inhibitors of interleukin-1beta converting enzyme | |
AU9663798A (en) | Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases | |
AU6703894A (en) | Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes | |
AU5913190A (en) | Peptidyl aminodiol renin inhibitors | |
AU2277597A (en) | New inhibitors of sh2-mediated processes | |
AU9624398A (en) | Pyrrolopyrrolidine derivatives and their use as serine protease inhibitors | |
AU4672996A (en) | Serine protease inhibitors | |
AU2938997A (en) | Subsituted 4-arylbutyric acid derivatives as matrix metalloprotease inhibitors | |
AU2126895A (en) | Parasite enzyme inhibitors and substrate analogs |