ZA942082B - Boronic acid and ester inhibitors of thrombin - Google Patents
Boronic acid and ester inhibitors of thrombinInfo
- Publication number
- ZA942082B ZA942082B ZA942082A ZA942082A ZA942082B ZA 942082 B ZA942082 B ZA 942082B ZA 942082 A ZA942082 A ZA 942082A ZA 942082 A ZA942082 A ZA 942082A ZA 942082 B ZA942082 B ZA 942082B
- Authority
- ZA
- South Africa
- Prior art keywords
- thrombin
- boronic acid
- ester inhibitors
- inhibitors
- ester
- Prior art date
Links
- 108090000190 Thrombin Proteins 0.000 title 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229960004072 thrombin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3637793A | 1993-03-24 | 1993-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA942082B true ZA942082B (en) | 1995-09-26 |
Family
ID=21888279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA942082A ZA942082B (en) | 1993-03-24 | 1994-03-24 | Boronic acid and ester inhibitors of thrombin |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU6448794A (en) |
| WO (1) | WO1994021650A1 (en) |
| ZA (1) | ZA942082B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5563127A (en) * | 1993-03-24 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Boronic acid and ester inhibitors of thrombin |
| IL111175A0 (en) * | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
| FR2745288B1 (en) * | 1996-02-27 | 1998-04-17 | Adir | NOVEL BORONIC ACID DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US7371729B2 (en) | 2002-09-09 | 2008-05-13 | Trigen Limited | Boronic acid salts useful in parenteral formulations |
| PT1396270E (en) * | 2002-09-09 | 2006-08-31 | Trigen Ltd | PROCESS FOR THE PREPARATION OF UTEISNCOMO INTERMEDIATE COMPOUNDS. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5187157A (en) * | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| GB9017694D0 (en) * | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
| GB9024129D0 (en) * | 1990-11-06 | 1990-12-19 | Thrombosis Research Trust | Inhibitors and substrates of thrombin |
-
1994
- 1994-03-23 WO PCT/US1994/002965 patent/WO1994021650A1/en active Application Filing
- 1994-03-23 AU AU64487/94A patent/AU6448794A/en not_active Abandoned
- 1994-03-24 ZA ZA942082A patent/ZA942082B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6448794A (en) | 1994-10-11 |
| WO1994021650A1 (en) | 1994-09-29 |
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