SE380258B - Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser - Google Patents

Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser

Info

Publication number
SE380258B
SE380258B SE7205758A SE575872A SE380258B SE 380258 B SE380258 B SE 380258B SE 7205758 A SE7205758 A SE 7205758A SE 575872 A SE575872 A SE 575872A SE 380258 B SE380258 B SE 380258B
Authority
SE
Sweden
Prior art keywords
peptidyl
subsidies
trypsin
type
high specificity
Prior art date
Application number
SE7205758A
Other languages
English (en)
Inventor
K G Claesson
L G Svendsen
B G Karlsson
Original Assignee
Bofors Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bofors Ab filed Critical Bofors Ab
Priority to IL42124A priority Critical patent/IL42124A/en
Priority to SE7205758A priority patent/SE380258B/sv
Priority to US354038A priority patent/US3886136A/en
Priority to FI1308/73A priority patent/FI56829C/fi
Priority to IL42124A priority patent/IL42124A0/xx
Priority to HUBO001429 priority patent/HU170669B/hu
Priority to CA169,885A priority patent/CA1019724A/en
Priority to BE130584A priority patent/BE798917A/xx
Priority to NO1791/73A priority patent/NO135362C/no
Priority to ES414251A priority patent/ES414251A1/es
Priority to AT381273A priority patent/AT324558B/de
Priority to AU55039/73A priority patent/AU474908B2/en
Priority to GB2069473A priority patent/GB1426385A/en
Priority to DD170559A priority patent/DD108282A5/xx
Priority to NL7306088A priority patent/NL7306088A/xx
Priority to CS3129A priority patent/CS172974B2/cs
Priority to DE2322115A priority patent/DE2322115B2/de
Priority to FR7315736A priority patent/FR2183170B1/fr
Priority to CH626673A priority patent/CH590475A5/xx
Priority to PL1973162269A priority patent/PL89227B1/pl
Priority to ZA732975A priority patent/ZA732975B/xx
Priority to IT50125/73A priority patent/IT1051562B/it
Publication of SE380258B publication Critical patent/SE380258B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/968—Plasmin, i.e. fibrinolysin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/976—Trypsin; Chymotrypsin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802—Chromogenic or luminescent peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SE7205758A 1972-05-02 1972-05-02 Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser SE380258B (sv)

Priority Applications (22)

Application Number Priority Date Filing Date Title
IL42124A IL42124A (en) 1972-05-02 1972-05-02 Substrate for the determination of proteolytic enzymes
SE7205758A SE380258B (sv) 1972-05-02 1972-05-02 Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
US354038A US3886136A (en) 1972-05-02 1973-04-24 New substrates for diagnostic use, with high susceptibility to trypsin and other proteolytic enzymes of the type peptide peptidohydrolases
FI1308/73A FI56829C (fi) 1972-05-02 1973-04-25 Nya diagnostiskt verksamma substrat med hoeg specifitet foer trypsin och andra enzymer av typen peptidylpeptidhydrolaser
IL42124A IL42124A0 (en) 1972-05-02 1973-04-27 Substrate for the determination of proteolytic enzymes
HUBO001429 HU170669B (sv) 1972-05-02 1973-04-28
CA169,885A CA1019724A (en) 1972-05-02 1973-04-30 Substrates for diagnostic use, with high susceptibility to trypsin and other proteolytic enzymes of the type peptide peptidohydrolases
BE130584A BE798917A (fr) 1972-05-02 1973-04-30 Nouveaux substrats pour diagnostic
NO1791/73A NO135362C (sv) 1972-05-02 1973-04-30
ES414251A ES414251A1 (es) 1972-05-02 1973-04-30 Procedimiento de obtencion de un nuevo sustrato para uso diagnostico, altamente sensible a la tripsina y otras enzi- mas proteoliticas del tipo peptido peptidohidrolasas.
AT381273A AT324558B (de) 1972-05-02 1973-04-30 Bestimmung von peptid-peptidchydrolasen oder deren proenzymen, aktivatoren, antienzymen und enzyminhibitoren
AU55039/73A AU474908B2 (en) 1972-05-02 1973-05-01 New substrates for diagnostic use, with high susceptibility to trypsin andother proteolytic enzymes ofthe type peptide peptidohydrolases
GB2069473A GB1426385A (en) 1972-05-02 1973-05-01 Compounds for diagnostic use with high susceptibility to trypsin and other proteolytic enzymes of the type peptide peptidohydro lases
DD170559A DD108282A5 (sv) 1972-05-02 1973-05-02
NL7306088A NL7306088A (sv) 1972-05-02 1973-05-02
CS3129A CS172974B2 (sv) 1972-05-02 1973-05-02
DE2322115A DE2322115B2 (de) 1972-05-02 1973-05-02 Tripeptide und deren Verwendung zur Bestimmung von Peptid-Peptidohydrolasen
FR7315736A FR2183170B1 (sv) 1972-05-02 1973-05-02
CH626673A CH590475A5 (sv) 1972-05-02 1973-05-02
PL1973162269A PL89227B1 (sv) 1972-05-02 1973-05-02
ZA732975A ZA732975B (en) 1972-05-02 1973-05-02 New substrates for diagnostic use,with high susceptibility to trypsin and other proteolytic enzymes of the type peptide peptidohydrolases
IT50125/73A IT1051562B (it) 1972-05-02 1973-05-22 Composizione per substrati per la determinazione quantitativa di enzimi

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7205758A SE380258B (sv) 1972-05-02 1972-05-02 Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser

Publications (1)

Publication Number Publication Date
SE380258B true SE380258B (sv) 1975-11-03

Family

ID=20267173

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7205758A SE380258B (sv) 1972-05-02 1972-05-02 Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser

Country Status (20)

Country Link
US (1) US3886136A (sv)
AT (1) AT324558B (sv)
AU (1) AU474908B2 (sv)
BE (1) BE798917A (sv)
CA (1) CA1019724A (sv)
CH (1) CH590475A5 (sv)
CS (1) CS172974B2 (sv)
DD (1) DD108282A5 (sv)
DE (1) DE2322115B2 (sv)
ES (1) ES414251A1 (sv)
FI (1) FI56829C (sv)
FR (1) FR2183170B1 (sv)
GB (1) GB1426385A (sv)
IL (2) IL42124A (sv)
IT (1) IT1051562B (sv)
NL (1) NL7306088A (sv)
NO (1) NO135362C (sv)
PL (1) PL89227B1 (sv)
SE (1) SE380258B (sv)
ZA (1) ZA732975B (sv)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2527932C2 (de) * 1974-07-02 1983-04-21 Pentapharm AG, 4052 Basel Säureadditionssalze von Tripeptidderivaten und deren Verwendung als Substrate zur Bestimmung von Plasmakallikrein
US4016259A (en) * 1974-07-26 1977-04-05 Research Corporation Contraceptive polypeptides
US4162941A (en) * 1974-12-05 1979-07-31 Ab Kabi Method for determining a proteolytic enzyme
CH622286A5 (sv) * 1975-06-23 1981-03-31 Pentapharm Ag
SE407405B (sv) * 1975-07-11 1979-03-26 Kabi Ab Nya kromogena trombinsubstrat
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
US4061625A (en) * 1975-07-11 1977-12-06 Ab Kabi Novel chromogenic thrombin substrates
US4169015A (en) * 1975-07-11 1979-09-25 Ab Kabi Novel chromogenic thrombin substrates
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
US4147692A (en) * 1977-02-26 1979-04-03 Ajinomoto Co., Inc. Novel dipeptide derivatives, and method of measuring enzymatic activity
SE7801373L (sv) * 1978-02-07 1979-08-08 Kabi Ab Lett spjelkbara substrat for kvantifiering av proteaser
IL60888A (en) * 1978-06-16 1984-07-31 Yeda Res & Dev Substrates and process for the quantitative assay of enzymes
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
US4336186A (en) * 1978-08-03 1982-06-22 Gargiulo Robert J Analytical fluorogenic substrates for proteolytic enzymes
US4166825A (en) * 1978-08-17 1979-09-04 Abbott Laboratories Chromogenic substrates
US4161488A (en) * 1978-08-17 1979-07-17 Abbott Laboratories Enzymatic substrates
JPS5559150A (en) * 1978-10-30 1980-05-02 Torii Yakuhin Kk Aminoacid derivative
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
US4219497A (en) 1979-04-06 1980-08-26 Abbott Laboratories Chromogenic substrates
US4409140A (en) * 1979-04-23 1983-10-11 Smith Robert E Substrates and method for determining enzymes
DE3061860D1 (en) * 1979-04-24 1983-03-17 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
DE2936543A1 (de) * 1979-09-10 1981-04-09 Behringwerke Ag, 3550 Marburg Chromogene verbindungen
US4308202A (en) * 1979-10-25 1981-12-29 Torii & Co., Ltd. Prolylphenylalanylarginine derivatives, process for producing same and method for measuring activity of enzymes using same
CA1161432A (en) * 1980-02-12 1984-01-31 Lars G. Svendsen Tripeptide derivatives and their application in assaying enzymes
JPS57501234A (sv) * 1980-08-25 1982-07-15
JPS5753445A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide compound
US4849353A (en) * 1980-09-30 1989-07-18 Cornell Research Foundation, Inc. Immunocapture of enzyme inhibitor, enzyme complexes and uses thereof
US4428874A (en) 1981-03-25 1984-01-31 Pentapharm A.G. Tripeptide derivatives
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
US4388233A (en) * 1981-05-15 1983-06-14 The Regents Of The University Of California Synthetic substrates for enzyme analysis
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
DE3139719A1 (de) * 1981-10-06 1983-04-21 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur bestimmung der aktivitaet von chymotrypsin oder trypsin im stuhl
JPS5863399A (ja) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd 新規なプラスミン測定用基質
ATE17262T1 (de) * 1981-11-02 1986-01-15 Pentapharm Ag Verfahren zur quantitativen bestimmung von blutgerinnungsfaktor xii in humanplasma.
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
FR2546164B1 (fr) * 1983-05-16 1987-07-17 Centre Nat Rech Scient Nouveaux derives de peptides, leur preparation et leur application comme inhibiteurs de l'elastase
JPS6117956A (ja) * 1984-07-04 1986-01-25 Nitto Boseki Co Ltd 新規な尿中カリクレイン測定用基質
US4897444A (en) * 1985-05-31 1990-01-30 The Research Foundation Of The State University Of New York Immobilized fluorogenic substrates for enzymes; and processes for their preparation
JPS62126196A (ja) * 1985-11-26 1987-06-08 Nitto Boseki Co Ltd 新規なα１−アンチトリプシン測定用化合物
US5399487A (en) * 1993-03-04 1995-03-21 Haematologic Technologies, Inc. 6-peptidylamino-1-naphthalenesulfonamides useful as fluorogenic proteolytic enzyme substrates
US6297024B1 (en) 1998-10-15 2001-10-02 Cell Activation, Inc. Methods for assessing complement activation
US6235494B1 (en) 1999-02-08 2001-05-22 The Scripps Research Institute Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates
US6455734B1 (en) 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states

Also Published As

Publication number Publication date
PL89227B1 (sv) 1976-11-30
IL42124A0 (en) 1973-06-29
ES414251A1 (es) 1976-06-16
NO135362C (sv) 1977-03-30
BE798917A (fr) 1973-08-16
FI56829B (fi) 1979-12-31
DE2322115B2 (de) 1980-01-10
NO135362B (sv) 1976-12-20
NL7306088A (sv) 1973-11-06
AU5503973A (en) 1974-11-07
AT324558B (de) 1975-09-10
IT1051562B (it) 1981-05-20
CS172974B2 (sv) 1977-01-28
FI56829C (fi) 1980-04-10
DE2322115A1 (de) 1973-11-22
ZA732975B (en) 1974-04-24
AU474908B2 (en) 1976-08-05
FR2183170B1 (sv) 1977-02-11
DD108282A5 (sv) 1974-09-12
US3886136A (en) 1975-05-27
CA1019724A (en) 1977-10-25
GB1426385A (en) 1976-02-25
FR2183170A1 (sv) 1973-12-14
IL42124A (en) 1977-02-28
CH590475A5 (sv) 1977-08-15

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