SE407405B - Nya kromogena trombinsubstrat - Google Patents

Nya kromogena trombinsubstrat

Info

Publication number
SE407405B
SE407405B SE7507975-6A SE7507975A SE407405B SE 407405 B SE407405 B SE 407405B SE 7507975 A SE7507975 A SE 7507975A SE 407405 B SE407405 B SE 407405B
Authority
SE
Sweden
Prior art keywords
chromogenate
new
thrombin substrate
thrombin
substrate
Prior art date
Application number
SE7507975-6A
Other languages
English (en)
Other versions
SE7507975L (sv
Inventor
L E Aurell
K G Claeson
B G Karlsson
B Thuresson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Priority to SE7507975-6A priority Critical patent/SE407405B/sv
Priority to ZA763586A priority patent/ZA763586B/xx
Priority to IL49829A priority patent/IL49829A/xx
Priority to US05/697,003 priority patent/US4061625A/en
Priority to GB25580/76A priority patent/GB1510926A/en
Priority to AU15305/76A priority patent/AU497547B2/en
Priority to AT463976A priority patent/AT348686B/de
Priority to NLAANVRAGE7607104,A priority patent/NL188355C/xx
Priority to DE2629195A priority patent/DE2629195C3/de
Priority to CA256,417A priority patent/CA1068261A/en
Priority to CS764544A priority patent/CS196314B2/cs
Priority to DK312676A priority patent/DK145799C/da
Priority to FI762010A priority patent/FI56525C/fi
Priority to DD7600193785A priority patent/DD128691A5/xx
Priority to NO762407A priority patent/NO142576C/no
Priority to PL1976191068A priority patent/PL103003B1/pl
Priority to CH887476A priority patent/CH622287A5/de
Priority to FR7621196A priority patent/FR2317280A1/fr
Priority to BE168774A priority patent/BE843970A/xx
Priority to IT50364/76A priority patent/IT1062605B/it
Priority to ES449739A priority patent/ES449739A1/es
Priority to SU762379659A priority patent/SU719492A3/ru
Priority to JP51082442A priority patent/JPS5224590A/ja
Publication of SE7507975L publication Critical patent/SE7507975L/sv
Priority to US05/826,594 priority patent/US4169015A/en
Publication of SE407405B publication Critical patent/SE407405B/sv
Priority to US06/055,664 priority patent/US4247454A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE7507975-6A 1975-07-11 1975-07-11 Nya kromogena trombinsubstrat SE407405B (sv)

Priority Applications (25)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (sv) 1975-07-11 1975-07-11 Nya kromogena trombinsubstrat
ZA763586A ZA763586B (en) 1975-07-11 1976-06-16 Novel chromogenic thrombin substrates
IL49829A IL49829A (en) 1975-07-11 1976-06-17 Chromogenic thrombin substrates
US05/697,003 US4061625A (en) 1975-07-11 1976-06-17 Novel chromogenic thrombin substrates
GB25580/76A GB1510926A (en) 1975-07-11 1976-06-21 Chromogenic thrombin substrates
AU15305/76A AU497547B2 (en) 1975-07-11 1976-06-25 Chromogenic thrombin substrates
AT463976A AT348686B (de) 1975-07-11 1976-06-25 Verahren zur bestimmung von thrombin und thrombinartigen enzymen durch spaltung chromogener substrate
NLAANVRAGE7607104,A NL188355C (nl) 1975-07-11 1976-06-29 Werkwijze ter bereiding van chromogene thrombine-substraten.
DE2629195A DE2629195C3 (de) 1975-07-11 1976-06-29 Tripeptide und deren Verwendung zur Bestimmung von Thrombin
CA256,417A CA1068261A (en) 1975-07-11 1976-07-06 Chromogenic thrombin substrates
CS764544A CS196314B2 (en) 1975-07-11 1976-07-08 Process for preparing new chromogenous substrates specific especially for thrombine
DD7600193785A DD128691A5 (de) 1975-07-11 1976-07-09 Neue chromogensubstrate fuer thrombin
BE168774A BE843970A (fr) 1975-07-11 1976-07-09 Nouveaux substrats chromogenes de thrombine
DK312676A DK145799C (da) 1975-07-11 1976-07-09 Tripeptider eller salte deraf til anvendelse som diagnostisk kromogent substrat med hoej specificitet overfor thrombin og thrombinlignende enzymer
NO762407A NO142576C (no) 1975-07-11 1976-07-09 Nye diagnostisk aktive kromogene substrater med hoey spesifisitet for thrombin og thrombinlignende ensymer
PL1976191068A PL103003B1 (pl) 1975-07-11 1976-07-09 Sposob wytwarzania nowych chromogennych odczynnikow do oznaczania trombiny i podobnych do trombiny enzymow
CH887476A CH622287A5 (en) 1975-07-11 1976-07-09 Method for the determination of thrombin or of enzymes which cleave the substrates in the same way as thrombin, and use of the method
FR7621196A FR2317280A1 (fr) 1975-07-11 1976-07-09 Nouveaux substrats chromogenes pour la thrombine
FI762010A FI56525C (fi) 1975-07-11 1976-07-09 Nya kromogena trombinsubstrat
IT50364/76A IT1062605B (it) 1975-07-11 1976-07-09 Substrato cromogeno per trombine ed enzimi trombinici
ES449739A ES449739A1 (es) 1975-07-11 1976-07-09 Procedimiento de obtencion de nuevos sustratos cronogenicos para trombina.
SU762379659A SU719492A3 (ru) 1975-07-11 1976-07-09 Способ получени пептидов или их солей
JP51082442A JPS5224590A (en) 1975-07-11 1976-07-10 Colorrgenerating new thrombin substrae
US05/826,594 US4169015A (en) 1975-07-11 1977-08-22 Novel chromogenic thrombin substrates
US06/055,664 US4247454A (en) 1975-07-11 1979-07-09 Novel chromogenic thrombin substrates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (sv) 1975-07-11 1975-07-11 Nya kromogena trombinsubstrat

Publications (2)

Publication Number Publication Date
SE7507975L SE7507975L (sv) 1977-01-12
SE407405B true SE407405B (sv) 1979-03-26

Family

ID=20325116

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7507975-6A SE407405B (sv) 1975-07-11 1975-07-11 Nya kromogena trombinsubstrat

Country Status (22)

Country Link
JP (1) JPS5224590A (sv)
AT (1) AT348686B (sv)
AU (1) AU497547B2 (sv)
BE (1) BE843970A (sv)
CA (1) CA1068261A (sv)
CH (1) CH622287A5 (sv)
CS (1) CS196314B2 (sv)
DD (1) DD128691A5 (sv)
DE (1) DE2629195C3 (sv)
DK (1) DK145799C (sv)
ES (1) ES449739A1 (sv)
FI (1) FI56525C (sv)
FR (1) FR2317280A1 (sv)
GB (1) GB1510926A (sv)
IL (1) IL49829A (sv)
IT (1) IT1062605B (sv)
NL (1) NL188355C (sv)
NO (1) NO142576C (sv)
PL (1) PL103003B1 (sv)
SE (1) SE407405B (sv)
SU (1) SU719492A3 (sv)
ZA (1) ZA763586B (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
DE2812943C3 (de) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
FR2471410A2 (fr) * 1979-12-17 1981-06-19 Jozefonvicz Marcel Perfectionnements apportes a un procede de dosage des proteases et des anti-proteases et notamment des proteases et antiproteases des systemes de la coagulation et du complement
EP0018002B1 (de) * 1979-04-24 1983-02-09 Marcel Jozefonvicz Neues Bestimmungsverfahren für Proteasen und Antiproteasen
DE3005540A1 (de) * 1980-02-14 1981-08-20 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagens zur bestimmung der biologischen aktivitaet von heparin im plasma
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
DE3211254A1 (de) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
US20090075298A1 (en) 2005-05-20 2009-03-19 Mitsubishi Kagaku Iatron, Inc. Method of analyzing enzyme

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL42124A (en) * 1972-05-02 1977-02-28 Kabi Ab Substrate for the determination of proteolytic enzymes
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser

Also Published As

Publication number Publication date
DK145799C (da) 1983-08-29
NL188355B (nl) 1992-01-02
FR2317280A1 (fr) 1977-02-04
BE843970A (fr) 1976-11-03
AT348686B (de) 1979-02-26
NL188355C (nl) 1992-06-01
DK312676A (da) 1977-01-12
ES449739A1 (es) 1978-01-16
IT1062605B (it) 1984-10-20
CS196314B2 (en) 1980-03-31
IL49829A (en) 1978-12-17
FI56525B (fi) 1979-10-31
GB1510926A (en) 1978-05-17
DE2629195C3 (de) 1983-11-17
ATA463976A (de) 1978-07-15
FI56525C (fi) 1980-02-11
DK145799B (da) 1983-03-07
IL49829A0 (en) 1976-08-31
DE2629195B2 (de) 1980-01-10
NO142576C (no) 1980-09-10
JPS5224590A (en) 1977-02-24
DD128691A5 (de) 1977-12-07
AU497547B2 (en) 1978-12-14
CA1068261A (en) 1979-12-18
JPS5615239B2 (sv) 1981-04-09
AU1530576A (en) 1978-01-05
FI762010A (sv) 1977-01-12
SE7507975L (sv) 1977-01-12
CH622287A5 (en) 1981-03-31
DE2629195A1 (de) 1977-01-13
ZA763586B (en) 1977-05-25
NO142576B (no) 1980-06-02
SU719492A3 (ru) 1980-02-29
NL7607104A (nl) 1977-01-13
PL103003B1 (pl) 1979-05-31
NO762407L (sv) 1977-01-12
FR2317280B1 (sv) 1980-05-16

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