FI56525C - Nya kromogena trombinsubstrat - Google Patents

Nya kromogena trombinsubstrat Download PDF

Info

Publication number
FI56525C
FI56525C FI762010A FI762010A FI56525C FI 56525 C FI56525 C FI 56525C FI 762010 A FI762010 A FI 762010A FI 762010 A FI762010 A FI 762010A FI 56525 C FI56525 C FI 56525C
Authority
FI
Finland
Prior art keywords
arg
phe
pna
analysis
group
Prior art date
Application number
FI762010A
Other languages
English (en)
Finnish (fi)
Other versions
FI762010A (sv
FI56525B (fi
Inventor
Bo Thuresson Af Ekenstam
Leif Erik Aurell
Karl Goeran Claeson
Birgitta Gunilla Karlsson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of FI762010A publication Critical patent/FI762010A/fi
Application granted granted Critical
Publication of FI56525B publication Critical patent/FI56525B/fi
Publication of FI56525C publication Critical patent/FI56525C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10Anilides
    • C12Q2337/12Para-Nitroanilides p-NA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI762010A 1975-07-11 1976-07-09 Nya kromogena trombinsubstrat FI56525C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (sv) 1975-07-11 1975-07-11 Nya kromogena trombinsubstrat
SE7507975 1975-07-11

Publications (3)

Publication Number Publication Date
FI762010A FI762010A (sv) 1977-01-12
FI56525B FI56525B (fi) 1979-10-31
FI56525C true FI56525C (fi) 1980-02-11

Family

ID=20325116

Family Applications (1)

Application Number Title Priority Date Filing Date
FI762010A FI56525C (fi) 1975-07-11 1976-07-09 Nya kromogena trombinsubstrat

Country Status (22)

Country Link
JP (1) JPS5224590A (sv)
AT (1) AT348686B (sv)
AU (1) AU497547B2 (sv)
BE (1) BE843970A (sv)
CA (1) CA1068261A (sv)
CH (1) CH622287A5 (sv)
CS (1) CS196314B2 (sv)
DD (1) DD128691A5 (sv)
DE (1) DE2629195C3 (sv)
DK (1) DK145799C (sv)
ES (1) ES449739A1 (sv)
FI (1) FI56525C (sv)
FR (1) FR2317280A1 (sv)
GB (1) GB1510926A (sv)
IL (1) IL49829A (sv)
IT (1) IT1062605B (sv)
NL (1) NL188355C (sv)
NO (1) NO142576C (sv)
PL (1) PL103003B1 (sv)
SE (1) SE407405B (sv)
SU (1) SU719492A3 (sv)
ZA (1) ZA763586B (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
DE2812943C3 (de) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
DE3061860D1 (en) * 1979-04-24 1983-03-17 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
FR2471410A2 (fr) * 1979-12-17 1981-06-19 Jozefonvicz Marcel Perfectionnements apportes a un procede de dosage des proteases et des anti-proteases et notamment des proteases et antiproteases des systemes de la coagulation et du complement
DE3005540A1 (de) * 1980-02-14 1981-08-20 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagens zur bestimmung der biologischen aktivitaet von heparin im plasma
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
DE3211254A1 (de) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
JPWO2006123789A1 (ja) 2005-05-20 2008-12-25 株式会社三菱化学ヤトロン 酵素分析方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser

Also Published As

Publication number Publication date
NO142576B (no) 1980-06-02
JPS5224590A (en) 1977-02-24
NO142576C (no) 1980-09-10
SE407405B (sv) 1979-03-26
DK145799C (da) 1983-08-29
JPS5615239B2 (sv) 1981-04-09
IT1062605B (it) 1984-10-20
DD128691A5 (de) 1977-12-07
ZA763586B (en) 1977-05-25
NL188355B (nl) 1992-01-02
FR2317280B1 (sv) 1980-05-16
DK312676A (da) 1977-01-12
NO762407L (sv) 1977-01-12
FR2317280A1 (fr) 1977-02-04
FI762010A (sv) 1977-01-12
AU1530576A (en) 1978-01-05
FI56525B (fi) 1979-10-31
IL49829A (en) 1978-12-17
ATA463976A (de) 1978-07-15
CA1068261A (en) 1979-12-18
AU497547B2 (en) 1978-12-14
DE2629195B2 (de) 1980-01-10
DK145799B (da) 1983-03-07
SU719492A3 (ru) 1980-02-29
DE2629195A1 (de) 1977-01-13
NL188355C (nl) 1992-06-01
IL49829A0 (en) 1976-08-31
CH622287A5 (en) 1981-03-31
CS196314B2 (en) 1980-03-31
GB1510926A (en) 1978-05-17
SE7507975L (sv) 1977-01-12
NL7607104A (nl) 1977-01-13
ES449739A1 (es) 1978-01-16
DE2629195C3 (de) 1983-11-17
AT348686B (de) 1979-02-26
PL103003B1 (pl) 1979-05-31
BE843970A (fr) 1976-11-03

Similar Documents

Publication Publication Date Title
US4061625A (en) Novel chromogenic thrombin substrates
SU957762A3 (ru) Способ получени пептидов или их солей
FI56524C (fi) Nya komogena substrat foer serinproteaser
SU1277904A3 (ru) Способ получени трипептидов
FI56828C (fi) Nya diagnostiskt verksamma substrat med hoeg specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
FI56829C (fi) Nya diagnostiskt verksamma substrat med hoeg specifitet foer trypsin och andra enzymer av typen peptidylpeptidhydrolaser
US4137225A (en) Novel chromogenic enzyme substrates
US4457866A (en) Chromogenic compounds and their use as enzyme substrates
FI56525C (fi) Nya kromogena trombinsubstrat
WO1982000641A1 (en) Peptide substrates for determination of protease activity
JPH0253040B2 (sv)
CA1086614A (en) Substrate for the determination of plasminogen activators
EP0170797B1 (en) Novel substrate for determining the activity of blood coagulation factor xa (stuart-prower factor)
US4247454A (en) Novel chromogenic thrombin substrates
US4428874A (en) Tripeptide derivatives
US4568636A (en) Tripeptide derivatives
US4169015A (en) Novel chromogenic thrombin substrates
US5097014A (en) Chromogenic tripeptides
US5063152A (en) Synthetic peptidic substrate for determination of trypsin and α1
JPS62122599A (ja) 酵素活性測定用ペプチド誘導体及びその使用法
KR840001485B1 (ko) 펩타이드의 제조방법
JPH0244518B2 (ja) Tanpakubunkaikosooteiryobunsekisuruhoho
JPH0776232B2 (ja) ペプチド誘導体及びその使用方法

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: AKTIEBOLAGET KABI