ZA763586B - Novel chromogenic thrombin substrates - Google Patents

Novel chromogenic thrombin substrates

Info

Publication number
ZA763586B
ZA763586B ZA763586A ZA763586A ZA763586B ZA 763586 B ZA763586 B ZA 763586B ZA 763586 A ZA763586 A ZA 763586A ZA 763586 A ZA763586 A ZA 763586A ZA 763586 B ZA763586 B ZA 763586B
Authority
ZA
South Africa
Prior art keywords
thrombin substrates
chromogenic thrombin
novel chromogenic
novel
substrates
Prior art date
Application number
ZA763586A
Inventor
L Aurell
K Claeson
B Ekenstam
B Karlsson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of ZA763586B publication Critical patent/ZA763586B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10Anilides
    • C12Q2337/12Para-Nitroanilides p-NA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA763586A 1975-07-11 1976-06-16 Novel chromogenic thrombin substrates ZA763586B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (en) 1975-07-11 1975-07-11 NEW CHROMOGENATE THROMBIN SUBSTRATE

Publications (1)

Publication Number Publication Date
ZA763586B true ZA763586B (en) 1977-05-25

Family

ID=20325116

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA763586A ZA763586B (en) 1975-07-11 1976-06-16 Novel chromogenic thrombin substrates

Country Status (22)

Country Link
JP (1) JPS5224590A (en)
AT (1) AT348686B (en)
AU (1) AU497547B2 (en)
BE (1) BE843970A (en)
CA (1) CA1068261A (en)
CH (1) CH622287A5 (en)
CS (1) CS196314B2 (en)
DD (1) DD128691A5 (en)
DE (1) DE2629195C3 (en)
DK (1) DK145799C (en)
ES (1) ES449739A1 (en)
FI (1) FI56525C (en)
FR (1) FR2317280A1 (en)
GB (1) GB1510926A (en)
IL (1) IL49829A (en)
IT (1) IT1062605B (en)
NL (1) NL188355C (en)
NO (1) NO142576C (en)
PL (1) PL103003B1 (en)
SE (1) SE407405B (en)
SU (1) SU719492A3 (en)
ZA (1) ZA763586B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity
DE2757992A1 (en) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh METHOD FOR PROTHROMBIN DETERMINATION
DE2812943C3 (en) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Method and reagent for determining the biological activity of heparin in plasma
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
FR2471410A2 (en) * 1979-12-17 1981-06-19 Jozefonvicz Marcel Electrochemical protease or anti-protease determn. - by amperometric determn. of amine released from peptide amide substrate
EP0018002B1 (en) * 1979-04-24 1983-02-09 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
DE3005540A1 (en) * 1980-02-14 1981-08-20 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD AND REAGENT FOR DETERMINING THE BIOLOGICAL ACTIVITY OF HEPARIN IN PLASMA
DK155051C (en) * 1980-05-06 1989-07-03 Pentapharm Ag TRIPEPTIDE DERIVATIVES AND PROCEDURES FOR QUANTITATIVE ANALYSIS OF PROTEOLYTIC ENZYMES UNDER USE thereof
JPS5856695A (en) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd Novel substrate for assay of thrombin
DE3211254A1 (en) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD FOR DETECTING THE PRESENCE OF AN ALLERGY AND FOR SPECIFIC DETECTING THE ALLERGY RESPONSIBLE FOR THE ALLERGY
DK201084A (en) * 1983-04-28 1984-10-29 Kimberly Clark Co PROCEDURE FOR DETERMINING CATHEPSIN B IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES AND RELATIONSHIPS FOR USING THE PROCEDURE
CA2609113A1 (en) 2005-05-20 2006-11-23 Mitsubishi Kagaku Iatron, Inc. Method of analyzing enzyme

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (en) * 1972-05-02 1975-11-03 Bofors Ab NEW DIAGNOSTIC OPERATING SUBSTRATES WITH HIGH SPECIFICITY FOR THROMBIN AND OTHER PROTEOLYTIC ENZYMES OF THE PEPTIDYL-PEPTIDE HYDROLASES
IL42124A (en) * 1972-05-02 1977-02-28 Kabi Ab Substrate for the determination of proteolytic enzymes

Also Published As

Publication number Publication date
DK145799B (en) 1983-03-07
ATA463976A (en) 1978-07-15
SE7507975L (en) 1977-01-12
FR2317280B1 (en) 1980-05-16
NO762407L (en) 1977-01-12
NL188355B (en) 1992-01-02
NL188355C (en) 1992-06-01
JPS5615239B2 (en) 1981-04-09
SU719492A3 (en) 1980-02-29
IL49829A0 (en) 1976-08-31
CS196314B2 (en) 1980-03-31
CH622287A5 (en) 1981-03-31
DE2629195A1 (en) 1977-01-13
DE2629195B2 (en) 1980-01-10
SE407405B (en) 1979-03-26
FI762010A (en) 1977-01-12
NO142576B (en) 1980-06-02
FI56525B (en) 1979-10-31
DD128691A5 (en) 1977-12-07
FR2317280A1 (en) 1977-02-04
PL103003B1 (en) 1979-05-31
ES449739A1 (en) 1978-01-16
AU1530576A (en) 1978-01-05
AT348686B (en) 1979-02-26
GB1510926A (en) 1978-05-17
DK312676A (en) 1977-01-12
JPS5224590A (en) 1977-02-24
NL7607104A (en) 1977-01-13
FI56525C (en) 1980-02-11
IL49829A (en) 1978-12-17
AU497547B2 (en) 1978-12-14
CA1068261A (en) 1979-12-18
DE2629195C3 (en) 1983-11-17
BE843970A (en) 1976-11-03
NO142576C (en) 1980-09-10
DK145799C (en) 1983-08-29
IT1062605B (en) 1984-10-20

Similar Documents

Publication Publication Date Title
IL49830A0 (en) Novel chromogenic enzyme substrates
IL48506A0 (en) New chromogenic enzyme substrates
ZA762870B (en) Adhesives
IL53187A0 (en) Specific chromogenic enzyme substrates
JPS5589278A (en) Novel dibenzopyrans
GB1541482A (en) Sealant composition
IL49829A0 (en) Novel chromogenic thrombin substrates
GB1552833A (en) Adhesives
PT65688A (en) Novel 1-benzazolylalkyl-4-substituted-piperidines
GB1556705A (en) Adhesives
PT65631A (en) Novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
GB1547228A (en) Adhesives
JPS529015A (en) Substrate
JPS5190602A (en) Jiazo ps ofusetsutoinsatsubanyogenzoeki
JPS5250330A (en) Electricallyyconductive adhesive
JPS5233692A (en) Novel cephlosporin
JPS5589280A (en) Novel dibenzopyrans
JPS5253845A (en) Novel antiifertile agent
ZA765616B (en) Improved adhesives
HU175198B (en) Checker
JPS52915A (en) Nonnburned bricks
JPS51116023A (en) Panel
GB1558189A (en) Adhesives
AU1754876A (en) PROTEASE inhibitors
JPS5278068A (en) Heattproof substrate