NO142576C - NEW DIAGNOSTIC ACTIVE CHROMOGENIC SUBSTRATES WITH HIGH SPECIFICITY FOR THROMBIN AND THROMBIN-LIKE ENZYMES - Google Patents

NEW DIAGNOSTIC ACTIVE CHROMOGENIC SUBSTRATES WITH HIGH SPECIFICITY FOR THROMBIN AND THROMBIN-LIKE ENZYMES

Info

Publication number
NO142576C
NO142576C NO762407A NO762407A NO142576C NO 142576 C NO142576 C NO 142576C NO 762407 A NO762407 A NO 762407A NO 762407 A NO762407 A NO 762407A NO 142576 C NO142576 C NO 142576C
Authority
NO
Norway
Prior art keywords
thrombin
enzymes
high specificity
chromogenic substrates
new diagnostic
Prior art date
Application number
NO762407A
Other languages
Norwegian (no)
Other versions
NO762407L (en
NO142576B (en
Inventor
Bo Thuresson Af Ekenstam
Leif Erik Aurell
Karl Goeran Claeson
Birgitta Gunilla Karlsson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of NO762407L publication Critical patent/NO762407L/no
Publication of NO142576B publication Critical patent/NO142576B/en
Publication of NO142576C publication Critical patent/NO142576C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10Anilides
    • C12Q2337/12Para-Nitroanilides p-NA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO762407A 1975-07-11 1976-07-09 NEW DIAGNOSTIC ACTIVE CHROMOGENIC SUBSTRATES WITH HIGH SPECIFICITY FOR THROMBIN AND THROMBIN-LIKE ENZYMES NO142576C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (en) 1975-07-11 1975-07-11 NEW CHROMOGENATE THROMBIN SUBSTRATE

Publications (3)

Publication Number Publication Date
NO762407L NO762407L (en) 1977-01-12
NO142576B NO142576B (en) 1980-06-02
NO142576C true NO142576C (en) 1980-09-10

Family

ID=20325116

Family Applications (1)

Application Number Title Priority Date Filing Date
NO762407A NO142576C (en) 1975-07-11 1976-07-09 NEW DIAGNOSTIC ACTIVE CHROMOGENIC SUBSTRATES WITH HIGH SPECIFICITY FOR THROMBIN AND THROMBIN-LIKE ENZYMES

Country Status (22)

Country Link
JP (1) JPS5224590A (en)
AT (1) AT348686B (en)
AU (1) AU497547B2 (en)
BE (1) BE843970A (en)
CA (1) CA1068261A (en)
CH (1) CH622287A5 (en)
CS (1) CS196314B2 (en)
DD (1) DD128691A5 (en)
DE (1) DE2629195C3 (en)
DK (1) DK145799C (en)
ES (1) ES449739A1 (en)
FI (1) FI56525C (en)
FR (1) FR2317280A1 (en)
GB (1) GB1510926A (en)
IL (1) IL49829A (en)
IT (1) IT1062605B (en)
NL (1) NL188355C (en)
NO (1) NO142576C (en)
PL (1) PL103003B1 (en)
SE (1) SE407405B (en)
SU (1) SU719492A3 (en)
ZA (1) ZA763586B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity
DE2757992A1 (en) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh METHOD FOR PROTHROMBIN DETERMINATION
DE2812943C3 (en) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Method and reagent for determining the biological activity of heparin in plasma
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
FR2471410A2 (en) * 1979-12-17 1981-06-19 Jozefonvicz Marcel Electrochemical protease or anti-protease determn. - by amperometric determn. of amine released from peptide amide substrate
EP0018002B1 (en) * 1979-04-24 1983-02-09 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
DE3005540A1 (en) * 1980-02-14 1981-08-20 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD AND REAGENT FOR DETERMINING THE BIOLOGICAL ACTIVITY OF HEPARIN IN PLASMA
DK155051C (en) * 1980-05-06 1989-07-03 Pentapharm Ag TRIPEPTIDE DERIVATIVES AND PROCEDURES FOR QUANTITATIVE ANALYSIS OF PROTEOLYTIC ENZYMES UNDER USE thereof
JPS5856695A (en) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd Novel substrate for assay of thrombin
DE3211254A1 (en) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD FOR DETECTING THE PRESENCE OF AN ALLERGY AND FOR SPECIFIC DETECTING THE ALLERGY RESPONSIBLE FOR THE ALLERGY
DK201084A (en) * 1983-04-28 1984-10-29 Kimberly Clark Co PROCEDURE FOR DETERMINING CATHEPSIN B IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES AND RELATIONSHIPS FOR USING THE PROCEDURE
CA2609113A1 (en) 2005-05-20 2006-11-23 Mitsubishi Kagaku Iatron, Inc. Method of analyzing enzyme

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (en) * 1972-05-02 1975-11-03 Bofors Ab NEW DIAGNOSTIC OPERATING SUBSTRATES WITH HIGH SPECIFICITY FOR THROMBIN AND OTHER PROTEOLYTIC ENZYMES OF THE PEPTIDYL-PEPTIDE HYDROLASES
IL42124A (en) * 1972-05-02 1977-02-28 Kabi Ab Substrate for the determination of proteolytic enzymes

Also Published As

Publication number Publication date
DK145799B (en) 1983-03-07
ATA463976A (en) 1978-07-15
SE7507975L (en) 1977-01-12
FR2317280B1 (en) 1980-05-16
NO762407L (en) 1977-01-12
NL188355B (en) 1992-01-02
NL188355C (en) 1992-06-01
JPS5615239B2 (en) 1981-04-09
SU719492A3 (en) 1980-02-29
IL49829A0 (en) 1976-08-31
CS196314B2 (en) 1980-03-31
CH622287A5 (en) 1981-03-31
DE2629195A1 (en) 1977-01-13
DE2629195B2 (en) 1980-01-10
SE407405B (en) 1979-03-26
FI762010A (en) 1977-01-12
NO142576B (en) 1980-06-02
ZA763586B (en) 1977-05-25
FI56525B (en) 1979-10-31
DD128691A5 (en) 1977-12-07
FR2317280A1 (en) 1977-02-04
PL103003B1 (en) 1979-05-31
ES449739A1 (en) 1978-01-16
AU1530576A (en) 1978-01-05
AT348686B (en) 1979-02-26
GB1510926A (en) 1978-05-17
DK312676A (en) 1977-01-12
JPS5224590A (en) 1977-02-24
NL7607104A (en) 1977-01-13
FI56525C (en) 1980-02-11
IL49829A (en) 1978-12-17
AU497547B2 (en) 1978-12-14
CA1068261A (en) 1979-12-18
DE2629195C3 (en) 1983-11-17
BE843970A (en) 1976-11-03
DK145799C (en) 1983-08-29
IT1062605B (en) 1984-10-20

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