SE407405B - NEW CHROMOGENATE THROMBIN SUBSTRATE - Google Patents

NEW CHROMOGENATE THROMBIN SUBSTRATE

Info

Publication number
SE407405B
SE407405B SE7507975-6A SE7507975A SE407405B SE 407405 B SE407405 B SE 407405B SE 7507975 A SE7507975 A SE 7507975A SE 407405 B SE407405 B SE 407405B
Authority
SE
Sweden
Prior art keywords
chromogenate
new
thrombin substrate
thrombin
substrate
Prior art date
Application number
SE7507975-6A
Other languages
Swedish (sv)
Other versions
SE7507975L (en
Inventor
L E Aurell
K G Claeson
B G Karlsson
B Thuresson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Priority to SE7507975-6A priority Critical patent/SE407405B/en
Priority to ZA763586A priority patent/ZA763586B/en
Priority to IL49829A priority patent/IL49829A/en
Priority to US05/697,003 priority patent/US4061625A/en
Priority to GB25580/76A priority patent/GB1510926A/en
Priority to AU15305/76A priority patent/AU497547B2/en
Priority to AT463976A priority patent/AT348686B/en
Priority to DE2629195A priority patent/DE2629195C3/en
Priority to NLAANVRAGE7607104,A priority patent/NL188355C/en
Priority to CA256,417A priority patent/CA1068261A/en
Priority to CS764544A priority patent/CS196314B2/en
Priority to IT50364/76A priority patent/IT1062605B/en
Priority to BE168774A priority patent/BE843970A/en
Priority to SU762379659A priority patent/SU719492A3/en
Priority to CH887476A priority patent/CH622287A5/en
Priority to PL1976191068A priority patent/PL103003B1/en
Priority to FR7621196A priority patent/FR2317280A1/en
Priority to ES449739A priority patent/ES449739A1/en
Priority to DK312676A priority patent/DK145799C/en
Priority to DD7600193785A priority patent/DD128691A5/en
Priority to NO762407A priority patent/NO142576C/en
Priority to FI762010A priority patent/FI56525C/en
Priority to JP51082442A priority patent/JPS5224590A/en
Publication of SE7507975L publication Critical patent/SE7507975L/en
Priority to US05/826,594 priority patent/US4169015A/en
Publication of SE407405B publication Critical patent/SE407405B/en
Priority to US06/055,664 priority patent/US4247454A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE7507975-6A 1975-07-11 1975-07-11 NEW CHROMOGENATE THROMBIN SUBSTRATE SE407405B (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (en) 1975-07-11 1975-07-11 NEW CHROMOGENATE THROMBIN SUBSTRATE
ZA763586A ZA763586B (en) 1975-07-11 1976-06-16 Novel chromogenic thrombin substrates
IL49829A IL49829A (en) 1975-07-11 1976-06-17 Chromogenic thrombin substrates
US05/697,003 US4061625A (en) 1975-07-11 1976-06-17 Novel chromogenic thrombin substrates
GB25580/76A GB1510926A (en) 1975-07-11 1976-06-21 Chromogenic thrombin substrates
AU15305/76A AU497547B2 (en) 1975-07-11 1976-06-25 Chromogenic thrombin substrates
AT463976A AT348686B (en) 1975-07-11 1976-06-25 METHOD FOR DETERMINING THROMBIN AND THROMBIN-LIKE ENZYMES BY CUTTING CHROMOGENIC SUBSTRATES
DE2629195A DE2629195C3 (en) 1975-07-11 1976-06-29 Tripeptides and their use for the determination of thrombin
NLAANVRAGE7607104,A NL188355C (en) 1975-07-11 1976-06-29 PROCESS FOR PREPARING CHROMOGENIC THROMBIN SUBSTRATES
CA256,417A CA1068261A (en) 1975-07-11 1976-07-06 Chromogenic thrombin substrates
CS764544A CS196314B2 (en) 1975-07-11 1976-07-08 Process for preparing new chromogenous substrates specific especially for thrombine
SU762379659A SU719492A3 (en) 1975-07-11 1976-07-09 Method of preparing peptides or their salts
DK312676A DK145799C (en) 1975-07-11 1976-07-09 TRIPEPTIDES OR SALTS THEREOF USED AS DIAGNOSTIC CHROMOGENT SUBSTRATE WITH HIGH SPECIFICITY ABOVE THROMBIN AND THROMBIN SIMILAR ENZYMES
IT50364/76A IT1062605B (en) 1975-07-11 1976-07-09 CHROMOGENIC SUBSTRATE FOR THROMBINES AND THROMBINIC ENZYMES
CH887476A CH622287A5 (en) 1975-07-11 1976-07-09 Method for the determination of thrombin or of enzymes which cleave the substrates in the same way as thrombin, and use of the method
PL1976191068A PL103003B1 (en) 1975-07-11 1976-07-09 METHOD OF PREPARATION OF NEW CHROMOGENE REAGENTS FOR TROMBINE AND TROMBINE-LIKE ENZYMES
FR7621196A FR2317280A1 (en) 1975-07-11 1976-07-09 NEW CHROMOGENIC SUBSTRATES FOR THROMBIN
ES449739A ES449739A1 (en) 1975-07-11 1976-07-09 Chromogenic thrombin substrates
BE168774A BE843970A (en) 1975-07-11 1976-07-09 NEW CHROMOGENIC THROMBIN SUBSTRATES
DD7600193785A DD128691A5 (en) 1975-07-11 1976-07-09 NEW CHROMOGEN SUBSTRATE FOR THROMBIN
NO762407A NO142576C (en) 1975-07-11 1976-07-09 NEW DIAGNOSTIC ACTIVE CHROMOGENIC SUBSTRATES WITH HIGH SPECIFICITY FOR THROMBIN AND THROMBIN-LIKE ENZYMES
FI762010A FI56525C (en) 1975-07-11 1976-07-09 NYA KROMOGENA TROMBINSUBSTRAT
JP51082442A JPS5224590A (en) 1975-07-11 1976-07-10 Colorrgenerating new thrombin substrae
US05/826,594 US4169015A (en) 1975-07-11 1977-08-22 Novel chromogenic thrombin substrates
US06/055,664 US4247454A (en) 1975-07-11 1979-07-09 Novel chromogenic thrombin substrates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (en) 1975-07-11 1975-07-11 NEW CHROMOGENATE THROMBIN SUBSTRATE

Publications (2)

Publication Number Publication Date
SE7507975L SE7507975L (en) 1977-01-12
SE407405B true SE407405B (en) 1979-03-26

Family

ID=20325116

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7507975-6A SE407405B (en) 1975-07-11 1975-07-11 NEW CHROMOGENATE THROMBIN SUBSTRATE

Country Status (22)

Country Link
JP (1) JPS5224590A (en)
AT (1) AT348686B (en)
AU (1) AU497547B2 (en)
BE (1) BE843970A (en)
CA (1) CA1068261A (en)
CH (1) CH622287A5 (en)
CS (1) CS196314B2 (en)
DD (1) DD128691A5 (en)
DE (1) DE2629195C3 (en)
DK (1) DK145799C (en)
ES (1) ES449739A1 (en)
FI (1) FI56525C (en)
FR (1) FR2317280A1 (en)
GB (1) GB1510926A (en)
IL (1) IL49829A (en)
IT (1) IT1062605B (en)
NL (1) NL188355C (en)
NO (1) NO142576C (en)
PL (1) PL103003B1 (en)
SE (1) SE407405B (en)
SU (1) SU719492A3 (en)
ZA (1) ZA763586B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity
DE2757992A1 (en) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh METHOD FOR PROTHROMBIN DETERMINATION
DE2812943C3 (en) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Method and reagent for determining the biological activity of heparin in plasma
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
EP0018002B1 (en) * 1979-04-24 1983-02-09 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
FR2471410A2 (en) * 1979-12-17 1981-06-19 Jozefonvicz Marcel Electrochemical protease or anti-protease determn. - by amperometric determn. of amine released from peptide amide substrate
DE3005540A1 (en) * 1980-02-14 1981-08-20 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD AND REAGENT FOR DETERMINING THE BIOLOGICAL ACTIVITY OF HEPARIN IN PLASMA
DK155051C (en) * 1980-05-06 1989-07-03 Pentapharm Ag TRIPEPTIDE DERIVATIVES AND PROCEDURES FOR QUANTITATIVE ANALYSIS OF PROTEOLYTIC ENZYMES UNDER USE thereof
JPS5856695A (en) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd Novel substrate for assay of thrombin
DE3211254A1 (en) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD FOR DETECTING THE PRESENCE OF AN ALLERGY AND FOR SPECIFIC DETECTING THE ALLERGY RESPONSIBLE FOR THE ALLERGY
DK201084A (en) * 1983-04-28 1984-10-29 Kimberly Clark Co PROCEDURE FOR DETERMINING CATHEPSIN B IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES AND RELATIONSHIPS FOR USING THE PROCEDURE
EP1889919A4 (en) 2005-05-20 2009-04-15 Mitsubishi Kagaku Iatron Inc Method of analyzing enzyme

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380258B (en) * 1972-05-02 1975-11-03 Bofors Ab NEW DIAGNOSTIC OPERATING SUBSIDIES WITH HIGH SPECIFICITY FOR TRYPSIN AND OTHER PEPTIDYL-PEPTIDE HYDROLASES OF THE PEPTIDYL TYPE
SE380257B (en) * 1972-05-02 1975-11-03 Bofors Ab NEW DIAGNOSTIC OPERATING SUBSTRATES WITH HIGH SPECIFICITY FOR THROMBIN AND OTHER PROTEOLYTIC ENZYMES OF THE PEPTIDYL-PEPTIDE HYDROLASES

Also Published As

Publication number Publication date
SE7507975L (en) 1977-01-12
NL188355C (en) 1992-06-01
AU1530576A (en) 1978-01-05
ES449739A1 (en) 1978-01-16
NO142576B (en) 1980-06-02
DD128691A5 (en) 1977-12-07
AT348686B (en) 1979-02-26
ZA763586B (en) 1977-05-25
FI56525B (en) 1979-10-31
NO762407L (en) 1977-01-12
IL49829A0 (en) 1976-08-31
SU719492A3 (en) 1980-02-29
AU497547B2 (en) 1978-12-14
IL49829A (en) 1978-12-17
IT1062605B (en) 1984-10-20
FR2317280B1 (en) 1980-05-16
CA1068261A (en) 1979-12-18
NO142576C (en) 1980-09-10
CH622287A5 (en) 1981-03-31
DE2629195A1 (en) 1977-01-13
JPS5615239B2 (en) 1981-04-09
ATA463976A (en) 1978-07-15
DK145799B (en) 1983-03-07
DK312676A (en) 1977-01-12
NL188355B (en) 1992-01-02
BE843970A (en) 1976-11-03
DE2629195B2 (en) 1980-01-10
FR2317280A1 (en) 1977-02-04
DK145799C (en) 1983-08-29
DE2629195C3 (en) 1983-11-17
PL103003B1 (en) 1979-05-31
FI762010A (en) 1977-01-12
CS196314B2 (en) 1980-03-31
FI56525C (en) 1980-02-11
GB1510926A (en) 1978-05-17
JPS5224590A (en) 1977-02-24
NL7607104A (en) 1977-01-13

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