AU1530576A - Chromogenic thrombin substrates - Google Patents

Chromogenic thrombin substrates

Info

Publication number
AU1530576A
AU1530576A AU15305/76A AU1530576A AU1530576A AU 1530576 A AU1530576 A AU 1530576A AU 15305/76 A AU15305/76 A AU 15305/76A AU 1530576 A AU1530576 A AU 1530576A AU 1530576 A AU1530576 A AU 1530576A
Authority
AU
Australia
Prior art keywords
thrombin substrates
chromogenic thrombin
chromogenic
substrates
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU15305/76A
Other versions
AU497547B2 (en
Inventor
B. Ta. Sorell Le. Claeson K. G. Karlsson B. G Arenstam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phadia AB
Original Assignee
Kabi AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi AB filed Critical Kabi AB
Publication of AU1530576A publication Critical patent/AU1530576A/en
Application granted granted Critical
Publication of AU497547B2 publication Critical patent/AU497547B2/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10Anilides
    • C12Q2337/12Para-Nitroanilides p-NA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU15305/76A 1975-07-11 1976-06-25 Chromogenic thrombin substrates Expired AU497547B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (en) 1975-07-11 1975-07-11 NEW CHROMOGENATE THROMBIN SUBSTRATE
SESE750797 1975-07-11

Publications (2)

Publication Number Publication Date
AU1530576A true AU1530576A (en) 1978-01-05
AU497547B2 AU497547B2 (en) 1978-12-14

Family

ID=20325116

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15305/76A Expired AU497547B2 (en) 1975-07-11 1976-06-25 Chromogenic thrombin substrates

Country Status (22)

Country Link
JP (1) JPS5224590A (en)
AT (1) AT348686B (en)
AU (1) AU497547B2 (en)
BE (1) BE843970A (en)
CA (1) CA1068261A (en)
CH (1) CH622287A5 (en)
CS (1) CS196314B2 (en)
DD (1) DD128691A5 (en)
DE (1) DE2629195C3 (en)
DK (1) DK145799C (en)
ES (1) ES449739A1 (en)
FI (1) FI56525C (en)
FR (1) FR2317280A1 (en)
GB (1) GB1510926A (en)
IL (1) IL49829A (en)
IT (1) IT1062605B (en)
NL (1) NL188355C (en)
NO (1) NO142576C (en)
PL (1) PL103003B1 (en)
SE (1) SE407405B (en)
SU (1) SU719492A3 (en)
ZA (1) ZA763586B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity
DE2757992A1 (en) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh METHOD FOR PROTHROMBIN DETERMINATION
DE2812943C3 (en) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Method and reagent for determining the biological activity of heparin in plasma
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
FR2471410A2 (en) * 1979-12-17 1981-06-19 Jozefonvicz Marcel Electrochemical protease or anti-protease determn. - by amperometric determn. of amine released from peptide amide substrate
EP0018002B1 (en) * 1979-04-24 1983-02-09 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
DE3005540A1 (en) * 1980-02-14 1981-08-20 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD AND REAGENT FOR DETERMINING THE BIOLOGICAL ACTIVITY OF HEPARIN IN PLASMA
DK155051C (en) * 1980-05-06 1989-07-03 Pentapharm Ag TRIPEPTIDE DERIVATIVES AND PROCEDURES FOR QUANTITATIVE ANALYSIS OF PROTEOLYTIC ENZYMES UNDER USE thereof
JPS5856695A (en) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd Novel substrate for assay of thrombin
DE3211254A1 (en) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD FOR DETECTING THE PRESENCE OF AN ALLERGY AND FOR SPECIFIC DETECTING THE ALLERGY RESPONSIBLE FOR THE ALLERGY
DK201084A (en) * 1983-04-28 1984-10-29 Kimberly Clark Co PROCEDURE FOR DETERMINING CATHEPSIN B IN THE PRESENCE OF OTHER PROTEOLYTIC ENZYMES AND RELATIONSHIPS FOR USING THE PROCEDURE
US20090075298A1 (en) 2005-05-20 2009-03-19 Mitsubishi Kagaku Iatron, Inc. Method of analyzing enzyme

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (en) * 1972-05-02 1975-11-03 Bofors Ab NEW DIAGNOSTIC OPERATING SUBSTRATES WITH HIGH SPECIFICITY FOR THROMBIN AND OTHER PROTEOLYTIC ENZYMES OF THE PEPTIDYL-PEPTIDE HYDROLASES
SE380258B (en) * 1972-05-02 1975-11-03 Bofors Ab NEW DIAGNOSTIC OPERATING SUBSIDIES WITH HIGH SPECIFICITY FOR TRYPSIN AND OTHER PEPTIDYL-PEPTIDE HYDROLASES OF THE PEPTIDYL TYPE

Also Published As

Publication number Publication date
SE407405B (en) 1979-03-26
ES449739A1 (en) 1978-01-16
JPS5615239B2 (en) 1981-04-09
NL188355B (en) 1992-01-02
SU719492A3 (en) 1980-02-29
IL49829A0 (en) 1976-08-31
SE7507975L (en) 1977-01-12
JPS5224590A (en) 1977-02-24
ATA463976A (en) 1978-07-15
ZA763586B (en) 1977-05-25
FR2317280A1 (en) 1977-02-04
CA1068261A (en) 1979-12-18
NO142576C (en) 1980-09-10
GB1510926A (en) 1978-05-17
DK145799B (en) 1983-03-07
AT348686B (en) 1979-02-26
CH622287A5 (en) 1981-03-31
DE2629195A1 (en) 1977-01-13
NO762407L (en) 1977-01-12
NL7607104A (en) 1977-01-13
FR2317280B1 (en) 1980-05-16
CS196314B2 (en) 1980-03-31
DD128691A5 (en) 1977-12-07
AU497547B2 (en) 1978-12-14
DE2629195B2 (en) 1980-01-10
DK145799C (en) 1983-08-29
NO142576B (en) 1980-06-02
PL103003B1 (en) 1979-05-31
IL49829A (en) 1978-12-17
BE843970A (en) 1976-11-03
FI762010A (en) 1977-01-12
DE2629195C3 (en) 1983-11-17
IT1062605B (en) 1984-10-20
FI56525B (en) 1979-10-31
FI56525C (en) 1980-02-11
NL188355C (en) 1992-06-01
DK312676A (en) 1977-01-12

Similar Documents

Publication Publication Date Title
AU497546B2 (en) Chromogenic enzyme substrate
ZA757441B (en) New chromogenic enzyme substrates
AU499357B2 (en) Inhilator
AU1108376A (en) Polyhemoglobin
AU1025376A (en) Pourer-stopper
AU1230276A (en) Amidinoureas
AU1230176A (en) Imidinoureas
AU503794B2 (en) Pancreatin
AU514768B2 (en) Specific chromogenic enzyme substrates
AU497547B2 (en) Chromogenic thrombin substrates
CA1029705A (en) Industrial technique
AU1128976A (en) Magneto-alternator
AU504770B2 (en) Isoxazolylalkyl phosphates
AU504939B2 (en) Building block
AU1191776A (en) Fluoro-prostaglandins
AU1393076A (en) Dihydromocimycin
AU507836B2 (en) Ambient-illuminated display
AU510354B2 (en) Reflectometer
AU506666B2 (en) Building
AU1754876A (en) PROTEASE inhibitors
AU492334B2 (en) Ih-tetrazole derivatives
AU499644B2 (en) Building block
AU491076B2 (en) Joist
AU1170776A (en) Gaslamp
AU1062876A (en) Benzodiazepin-10-onfs