AT348686B - Verahren zur bestimmung von thrombin und thrombinartigen enzymen durch spaltung chromogener substrate - Google Patents

Verahren zur bestimmung von thrombin und thrombinartigen enzymen durch spaltung chromogener substrate

Info

Publication number
AT348686B
AT348686B AT463976A AT463976A AT348686B AT 348686 B AT348686 B AT 348686B AT 463976 A AT463976 A AT 463976A AT 463976 A AT463976 A AT 463976A AT 348686 B AT348686 B AT 348686B
Authority
AT
Austria
Prior art keywords
thrombin
enzymes
cutting
determining
chromogenic substrates
Prior art date
Application number
AT463976A
Other languages
German (de)
English (en)
Other versions
ATA463976A (de
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of ATA463976A publication Critical patent/ATA463976A/de
Application granted granted Critical
Publication of AT348686B publication Critical patent/AT348686B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT463976A 1975-07-11 1976-06-25 Verahren zur bestimmung von thrombin und thrombinartigen enzymen durch spaltung chromogener substrate AT348686B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (sv) 1975-07-11 1975-07-11 Nya kromogena trombinsubstrat

Publications (2)

Publication Number Publication Date
ATA463976A ATA463976A (de) 1978-07-15
AT348686B true AT348686B (de) 1979-02-26

Family

ID=20325116

Family Applications (1)

Application Number Title Priority Date Filing Date
AT463976A AT348686B (de) 1975-07-11 1976-06-25 Verahren zur bestimmung von thrombin und thrombinartigen enzymen durch spaltung chromogener substrate

Country Status (22)

Country Link
JP (1) JPS5224590A (sv)
AT (1) AT348686B (sv)
AU (1) AU497547B2 (sv)
BE (1) BE843970A (sv)
CA (1) CA1068261A (sv)
CH (1) CH622287A5 (sv)
CS (1) CS196314B2 (sv)
DD (1) DD128691A5 (sv)
DE (1) DE2629195C3 (sv)
DK (1) DK145799C (sv)
ES (1) ES449739A1 (sv)
FI (1) FI56525C (sv)
FR (1) FR2317280A1 (sv)
GB (1) GB1510926A (sv)
IL (1) IL49829A (sv)
IT (1) IT1062605B (sv)
NL (1) NL188355C (sv)
NO (1) NO142576C (sv)
PL (1) PL103003B1 (sv)
SE (1) SE407405B (sv)
SU (1) SU719492A3 (sv)
ZA (1) ZA763586B (sv)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
DE2812943C3 (de) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
FR2471410A2 (fr) * 1979-12-17 1981-06-19 Jozefonvicz Marcel Perfectionnements apportes a un procede de dosage des proteases et des anti-proteases et notamment des proteases et antiproteases des systemes de la coagulation et du complement
DE3061860D1 (en) * 1979-04-24 1983-03-17 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
DE3005540A1 (de) * 1980-02-14 1981-08-20 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagens zur bestimmung der biologischen aktivitaet von heparin im plasma
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
DE3211254A1 (de) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
EP1889919A4 (en) 2005-05-20 2009-04-15 Mitsubishi Kagaku Iatron Inc METHOD FOR ANALYZING AN ENZYME

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser

Also Published As

Publication number Publication date
FI56525B (fi) 1979-10-31
AU497547B2 (en) 1978-12-14
FI56525C (fi) 1980-02-11
SU719492A3 (ru) 1980-02-29
FI762010A (sv) 1977-01-12
DE2629195C3 (de) 1983-11-17
NL7607104A (nl) 1977-01-13
IT1062605B (it) 1984-10-20
CH622287A5 (en) 1981-03-31
DE2629195A1 (de) 1977-01-13
DK145799B (da) 1983-03-07
DD128691A5 (de) 1977-12-07
DK312676A (da) 1977-01-12
ES449739A1 (es) 1978-01-16
PL103003B1 (pl) 1979-05-31
JPS5224590A (en) 1977-02-24
CA1068261A (en) 1979-12-18
DK145799C (da) 1983-08-29
NL188355B (nl) 1992-01-02
ATA463976A (de) 1978-07-15
DE2629195B2 (de) 1980-01-10
FR2317280A1 (fr) 1977-02-04
NO762407L (sv) 1977-01-12
IL49829A0 (en) 1976-08-31
BE843970A (fr) 1976-11-03
NL188355C (nl) 1992-06-01
IL49829A (en) 1978-12-17
SE407405B (sv) 1979-03-26
AU1530576A (en) 1978-01-05
CS196314B2 (en) 1980-03-31
GB1510926A (en) 1978-05-17
NO142576B (no) 1980-06-02
NO142576C (no) 1980-09-10
SE7507975L (sv) 1977-01-12
FR2317280B1 (sv) 1980-05-16
JPS5615239B2 (sv) 1981-04-09
ZA763586B (en) 1977-05-25

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EIH Change in the person of patent owner
ELA Expired due to lapse of time