FR2317280A1 - Nouveaux substrats chromogenes pour la thrombine - Google Patents

Nouveaux substrats chromogenes pour la thrombine

Info

Publication number
FR2317280A1
FR2317280A1 FR7621196A FR7621196A FR2317280A1 FR 2317280 A1 FR2317280 A1 FR 2317280A1 FR 7621196 A FR7621196 A FR 7621196A FR 7621196 A FR7621196 A FR 7621196A FR 2317280 A1 FR2317280 A1 FR 2317280A1
Authority
FR
France
Prior art keywords
thrombin
chromogenic substrates
new chromogenic
new
substrates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7621196A
Other languages
English (en)
Other versions
FR2317280B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phadia AB
Original Assignee
Kabi AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi AB filed Critical Kabi AB
Publication of FR2317280A1 publication Critical patent/FR2317280A1/fr
Application granted granted Critical
Publication of FR2317280B1 publication Critical patent/FR2317280B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7621196A 1975-07-11 1976-07-09 Nouveaux substrats chromogenes pour la thrombine Granted FR2317280A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (sv) 1975-07-11 1975-07-11 Nya kromogena trombinsubstrat

Publications (2)

Publication Number Publication Date
FR2317280A1 true FR2317280A1 (fr) 1977-02-04
FR2317280B1 FR2317280B1 (fr) 1980-05-16

Family

ID=20325116

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7621196A Granted FR2317280A1 (fr) 1975-07-11 1976-07-09 Nouveaux substrats chromogenes pour la thrombine

Country Status (22)

Country Link
JP (1) JPS5224590A (fr)
AT (1) AT348686B (fr)
AU (1) AU497547B2 (fr)
BE (1) BE843970A (fr)
CA (1) CA1068261A (fr)
CH (1) CH622287A5 (fr)
CS (1) CS196314B2 (fr)
DD (1) DD128691A5 (fr)
DE (1) DE2629195C3 (fr)
DK (1) DK145799C (fr)
ES (1) ES449739A1 (fr)
FI (1) FI56525C (fr)
FR (1) FR2317280A1 (fr)
GB (1) GB1510926A (fr)
IL (1) IL49829A (fr)
IT (1) IT1062605B (fr)
NL (1) NL188355C (fr)
NO (1) NO142576C (fr)
PL (1) PL103003B1 (fr)
SE (1) SE407405B (fr)
SU (1) SU719492A3 (fr)
ZA (1) ZA763586B (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2329646A1 (fr) * 1975-10-30 1977-05-27 Ajinomoto Kk Nouveaux derives dipeptidiques, sels correspondants et procede de mesure d'une activite enzymatique les utilisant
FR2420764A1 (fr) * 1978-03-23 1979-10-19 Boehringer Mannheim Gmbh Procede et reactif pour le dosage de l'heparine bio-active dans le plasma
EP0014039A1 (fr) * 1979-01-08 1980-08-06 Ortho Diagnostic Systems Inc. Méthode comportant un essai de temps de prothrombine en une étape pour la détermination d'un mécanisme de coagulation du sang
EP0018002A1 (fr) * 1979-04-24 1980-10-29 Marcel Jozefonvicz Procédé pour la détermination de protéases et d'anti-protéases
FR2471410A2 (fr) * 1979-12-17 1981-06-19 Jozefonvicz Marcel Perfectionnements apportes a un procede de dosage des proteases et des anti-proteases et notamment des proteases et antiproteases des systemes de la coagulation et du complement
EP0034320A1 (fr) * 1980-02-14 1981-08-26 Roche Diagnostics GmbH Procédé et réactif pour la détermination de l'activité biologique de l'héparine dans le plasma

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
DE3211254A1 (de) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
EP1889919A4 (fr) 2005-05-20 2009-04-15 Mitsubishi Kagaku Iatron Inc Procédé d'analyse d'une enzyme

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183188A1 (fr) * 1972-05-02 1973-12-14 Bofors Ab
FR2183170A1 (fr) * 1972-05-02 1973-12-14 Bofors Ab

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2183188A1 (fr) * 1972-05-02 1973-12-14 Bofors Ab
FR2183170A1 (fr) * 1972-05-02 1973-12-14 Bofors Ab

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2329646A1 (fr) * 1975-10-30 1977-05-27 Ajinomoto Kk Nouveaux derives dipeptidiques, sels correspondants et procede de mesure d'une activite enzymatique les utilisant
FR2420764A1 (fr) * 1978-03-23 1979-10-19 Boehringer Mannheim Gmbh Procede et reactif pour le dosage de l'heparine bio-active dans le plasma
EP0014039A1 (fr) * 1979-01-08 1980-08-06 Ortho Diagnostic Systems Inc. Méthode comportant un essai de temps de prothrombine en une étape pour la détermination d'un mécanisme de coagulation du sang
EP0018002A1 (fr) * 1979-04-24 1980-10-29 Marcel Jozefonvicz Procédé pour la détermination de protéases et d'anti-protéases
FR2471410A2 (fr) * 1979-12-17 1981-06-19 Jozefonvicz Marcel Perfectionnements apportes a un procede de dosage des proteases et des anti-proteases et notamment des proteases et antiproteases des systemes de la coagulation et du complement
EP0034320A1 (fr) * 1980-02-14 1981-08-26 Roche Diagnostics GmbH Procédé et réactif pour la détermination de l'activité biologique de l'héparine dans le plasma

Also Published As

Publication number Publication date
FI56525B (fi) 1979-10-31
AU497547B2 (en) 1978-12-14
FI56525C (fi) 1980-02-11
SU719492A3 (ru) 1980-02-29
FI762010A (fr) 1977-01-12
DE2629195C3 (de) 1983-11-17
NL7607104A (nl) 1977-01-13
IT1062605B (it) 1984-10-20
CH622287A5 (en) 1981-03-31
DE2629195A1 (de) 1977-01-13
DK145799B (da) 1983-03-07
DD128691A5 (de) 1977-12-07
DK312676A (da) 1977-01-12
ES449739A1 (es) 1978-01-16
PL103003B1 (pl) 1979-05-31
JPS5224590A (en) 1977-02-24
CA1068261A (fr) 1979-12-18
DK145799C (da) 1983-08-29
NL188355B (nl) 1992-01-02
ATA463976A (de) 1978-07-15
DE2629195B2 (de) 1980-01-10
NO762407L (fr) 1977-01-12
IL49829A0 (en) 1976-08-31
BE843970A (fr) 1976-11-03
NL188355C (nl) 1992-06-01
IL49829A (en) 1978-12-17
SE407405B (sv) 1979-03-26
AU1530576A (en) 1978-01-05
CS196314B2 (en) 1980-03-31
GB1510926A (en) 1978-05-17
NO142576B (no) 1980-06-02
NO142576C (no) 1980-09-10
SE7507975L (sv) 1977-01-12
AT348686B (de) 1979-02-26
FR2317280B1 (fr) 1980-05-16
JPS5615239B2 (fr) 1981-04-09
ZA763586B (en) 1977-05-25

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