CS196314B2 - Process for preparing new chromogenous substrates specific especially for thrombine - Google Patents
Process for preparing new chromogenous substrates specific especially for thrombine Download PDFInfo
- Publication number
- CS196314B2 CS196314B2 CS764544A CS454476A CS196314B2 CS 196314 B2 CS196314 B2 CS 196314B2 CS 764544 A CS764544 A CS 764544A CS 454476 A CS454476 A CS 454476A CS 196314 B2 CS196314 B2 CS 196314B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- group
- substrate
- arg
- reaction
- product
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
- C07K1/064—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/30—Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7507975-6A SE407405B (sv) | 1975-07-11 | 1975-07-11 | Nya kromogena trombinsubstrat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS196314B2 true CS196314B2 (en) | 1980-03-31 |
Family
ID=20325116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS764544A CS196314B2 (en) | 1975-07-11 | 1976-07-08 | Process for preparing new chromogenous substrates specific especially for thrombine |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5224590A (fr) |
| AT (1) | AT348686B (fr) |
| AU (1) | AU497547B2 (fr) |
| BE (1) | BE843970A (fr) |
| CA (1) | CA1068261A (fr) |
| CH (1) | CH622287A5 (fr) |
| CS (1) | CS196314B2 (fr) |
| DD (1) | DD128691A5 (fr) |
| DE (1) | DE2629195C3 (fr) |
| DK (1) | DK145799C (fr) |
| ES (1) | ES449739A1 (fr) |
| FI (1) | FI56525C (fr) |
| FR (1) | FR2317280A1 (fr) |
| GB (1) | GB1510926A (fr) |
| IL (1) | IL49829A (fr) |
| IT (1) | IT1062605B (fr) |
| NL (1) | NL188355C (fr) |
| NO (1) | NO142576C (fr) |
| PL (1) | PL103003B1 (fr) |
| SE (1) | SE407405B (fr) |
| SU (1) | SU719492A3 (fr) |
| ZA (1) | ZA763586B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5255593A (en) * | 1975-10-30 | 1977-05-07 | Ajinomoto Kk | Measuring method of enzyme activity |
| DE2757992A1 (de) * | 1977-12-24 | 1979-06-28 | Boehringer Mannheim Gmbh | Verfahren zur prothrombin-bestimmung |
| DE2812943C3 (de) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma |
| US4289498A (en) * | 1979-01-08 | 1981-09-15 | Ortho Diagnostics, Inc. | One-stage prothrombin assay and compositions useful therein |
| EP0018002B1 (fr) * | 1979-04-24 | 1983-02-09 | Marcel Jozefonvicz | Procédé pour la détermination de protéases et d'anti-protéases |
| FR2471410A2 (fr) * | 1979-12-17 | 1981-06-19 | Jozefonvicz Marcel | Perfectionnements apportes a un procede de dosage des proteases et des anti-proteases et notamment des proteases et antiproteases des systemes de la coagulation et du complement |
| DE3005540A1 (de) * | 1980-02-14 | 1981-08-20 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagens zur bestimmung der biologischen aktivitaet von heparin im plasma |
| DK155051C (da) * | 1980-05-06 | 1989-07-03 | Pentapharm Ag | Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf |
| JPS5856695A (ja) * | 1981-09-28 | 1983-04-04 | Nitto Boseki Co Ltd | 新規なトロンビン測定用基質 |
| DE3211254A1 (de) * | 1982-03-26 | 1983-09-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens |
| DK201084A (da) * | 1983-04-28 | 1984-10-29 | Kimberly Clark Co | Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden |
| WO2006123789A1 (fr) | 2005-05-20 | 2006-11-23 | Mitsubishi Kagaku Iatron, Inc. | Procede d’analyse d’une enzyme |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL42124A (en) * | 1972-05-02 | 1977-02-28 | Kabi Ab | Substrate for the determination of proteolytic enzymes |
| SE380257B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser |
-
1975
- 1975-07-11 SE SE7507975-6A patent/SE407405B/xx not_active IP Right Cessation
-
1976
- 1976-06-16 ZA ZA763586A patent/ZA763586B/xx unknown
- 1976-06-17 IL IL49829A patent/IL49829A/xx unknown
- 1976-06-21 GB GB25580/76A patent/GB1510926A/en not_active Expired
- 1976-06-25 AT AT463976A patent/AT348686B/de not_active IP Right Cessation
- 1976-06-25 AU AU15305/76A patent/AU497547B2/en not_active Expired
- 1976-06-29 DE DE2629195A patent/DE2629195C3/de not_active Expired
- 1976-06-29 NL NLAANVRAGE7607104,A patent/NL188355C/xx not_active IP Right Cessation
- 1976-07-06 CA CA256,417A patent/CA1068261A/fr not_active Expired
- 1976-07-08 CS CS764544A patent/CS196314B2/cs unknown
- 1976-07-09 NO NO762407A patent/NO142576C/no unknown
- 1976-07-09 PL PL1976191068A patent/PL103003B1/pl unknown
- 1976-07-09 BE BE168774A patent/BE843970A/fr not_active IP Right Cessation
- 1976-07-09 DK DK312676A patent/DK145799C/da not_active IP Right Cessation
- 1976-07-09 CH CH887476A patent/CH622287A5/de not_active IP Right Cessation
- 1976-07-09 DD DD7600193785A patent/DD128691A5/xx unknown
- 1976-07-09 IT IT50364/76A patent/IT1062605B/it active
- 1976-07-09 SU SU762379659A patent/SU719492A3/ru active
- 1976-07-09 FR FR7621196A patent/FR2317280A1/fr active Granted
- 1976-07-09 ES ES449739A patent/ES449739A1/es not_active Expired
- 1976-07-09 FI FI762010A patent/FI56525C/fi not_active IP Right Cessation
- 1976-07-10 JP JP51082442A patent/JPS5224590A/ja active Granted
Also Published As
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