DD128691A5 - Neue chromogensubstrate fuer thrombin - Google Patents

Neue chromogensubstrate fuer thrombin

Info

Publication number
DD128691A5
DD128691A5 DD7600193785A DD19378576A DD128691A5 DD 128691 A5 DD128691 A5 DD 128691A5 DD 7600193785 A DD7600193785 A DD 7600193785A DD 19378576 A DD19378576 A DD 19378576A DD 128691 A5 DD128691 A5 DD 128691A5
Authority
DD
German Democratic Republic
Prior art keywords
thrombin
chromogen substrate
new
new chromogen
substrate
Prior art date
Application number
DD7600193785A
Other languages
German (de)
English (en)
Inventor
Ekenstam Bo T Af
Leif E Aurell
Karl G Claeson
Birgitta G Karlsson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of DD128691A5 publication Critical patent/DD128691A5/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/064General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for omega-amino or -guanidino functions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10Anilides
    • C12Q2337/12Para-Nitroanilides p-NA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/30Naphthyl amides, e.g. beta-NA, 2-NA, 4-methoxy-beta-naphthylamine, i.e. 4MNA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DD7600193785A 1975-07-11 1976-07-09 Neue chromogensubstrate fuer thrombin DD128691A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7507975-6A SE407405B (sv) 1975-07-11 1975-07-11 Nya kromogena trombinsubstrat

Publications (1)

Publication Number Publication Date
DD128691A5 true DD128691A5 (de) 1977-12-07

Family

ID=20325116

Family Applications (1)

Application Number Title Priority Date Filing Date
DD7600193785A DD128691A5 (de) 1975-07-11 1976-07-09 Neue chromogensubstrate fuer thrombin

Country Status (22)

Country Link
JP (1) JPS5224590A (sv)
AT (1) AT348686B (sv)
AU (1) AU497547B2 (sv)
BE (1) BE843970A (sv)
CA (1) CA1068261A (sv)
CH (1) CH622287A5 (sv)
CS (1) CS196314B2 (sv)
DD (1) DD128691A5 (sv)
DE (1) DE2629195C3 (sv)
DK (1) DK145799C (sv)
ES (1) ES449739A1 (sv)
FI (1) FI56525C (sv)
FR (1) FR2317280A1 (sv)
GB (1) GB1510926A (sv)
IL (1) IL49829A (sv)
IT (1) IT1062605B (sv)
NL (1) NL188355C (sv)
NO (1) NO142576C (sv)
PL (1) PL103003B1 (sv)
SE (1) SE407405B (sv)
SU (1) SU719492A3 (sv)
ZA (1) ZA763586B (sv)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004271A2 (de) * 1978-03-23 1979-10-03 Roche Diagnostics GmbH Verfahren und Reagens zur Bestimmung des biologisch aktiven Heparins im Plasma
EP0090359A2 (de) * 1982-03-26 1983-10-05 Roche Diagnostics GmbH Verfahren zum Nachweis des Vorliegens einer Allergie und zum spezifischen Nachweis des für die Allergie verantwortlichen Allergens

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5255593A (en) * 1975-10-30 1977-05-07 Ajinomoto Kk Measuring method of enzyme activity
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
US4289498A (en) * 1979-01-08 1981-09-15 Ortho Diagnostics, Inc. One-stage prothrombin assay and compositions useful therein
DE3061860D1 (en) * 1979-04-24 1983-03-17 Marcel Jozefonvicz Process for the determination of proteases and antiproteases
FR2471410A2 (fr) * 1979-12-17 1981-06-19 Jozefonvicz Marcel Perfectionnements apportes a un procede de dosage des proteases et des anti-proteases et notamment des proteases et antiproteases des systemes de la coagulation et du complement
DE3005540A1 (de) * 1980-02-14 1981-08-20 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagens zur bestimmung der biologischen aktivitaet von heparin im plasma
DK155051C (da) * 1980-05-06 1989-07-03 Pentapharm Ag Tripeptidderivater samt fremgangsmaade til kvantitativ analyse for proteolytiske enzymer under anvendelse deraf
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
DK201084A (da) * 1983-04-28 1984-10-29 Kimberly Clark Co Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden
US20090075298A1 (en) 2005-05-20 2009-03-19 Mitsubishi Kagaku Iatron, Inc. Method of analyzing enzyme

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0004271A2 (de) * 1978-03-23 1979-10-03 Roche Diagnostics GmbH Verfahren und Reagens zur Bestimmung des biologisch aktiven Heparins im Plasma
DE2812943A1 (de) * 1978-03-23 1979-10-04 Boehringer Mannheim Gmbh Verfahren und reagens zur bestimmung des biologisch aktiven heparins im plasma
EP0004271A3 (de) * 1978-03-23 1980-04-02 Roche Diagnostics GmbH Verfahren und Reagens zur Bestimmung des biologisch aktiven Heparins im Plasma
EP0090359A2 (de) * 1982-03-26 1983-10-05 Roche Diagnostics GmbH Verfahren zum Nachweis des Vorliegens einer Allergie und zum spezifischen Nachweis des für die Allergie verantwortlichen Allergens
EP0090359A3 (en) * 1982-03-26 1985-04-10 Boehringer Mannheim Gmbh Method for the determination of an allergy and method for the specific determination of the allergen responsible for the allergy

Also Published As

Publication number Publication date
NO142576B (no) 1980-06-02
AT348686B (de) 1979-02-26
GB1510926A (en) 1978-05-17
FR2317280A1 (fr) 1977-02-04
CH622287A5 (en) 1981-03-31
DE2629195A1 (de) 1977-01-13
NL188355B (nl) 1992-01-02
JPS5615239B2 (sv) 1981-04-09
CA1068261A (en) 1979-12-18
IL49829A0 (en) 1976-08-31
FR2317280B1 (sv) 1980-05-16
JPS5224590A (en) 1977-02-24
FI56525B (fi) 1979-10-31
SE407405B (sv) 1979-03-26
ES449739A1 (es) 1978-01-16
CS196314B2 (en) 1980-03-31
IL49829A (en) 1978-12-17
NL7607104A (nl) 1977-01-13
ATA463976A (de) 1978-07-15
AU497547B2 (en) 1978-12-14
IT1062605B (it) 1984-10-20
DK145799C (da) 1983-08-29
FI762010A (sv) 1977-01-12
NO762407L (sv) 1977-01-12
DE2629195B2 (de) 1980-01-10
DK145799B (da) 1983-03-07
FI56525C (fi) 1980-02-11
NL188355C (nl) 1992-06-01
SU719492A3 (ru) 1980-02-29
AU1530576A (en) 1978-01-05
DK312676A (da) 1977-01-12
PL103003B1 (pl) 1979-05-31
ZA763586B (en) 1977-05-25
SE7507975L (sv) 1977-01-12
DE2629195C3 (de) 1983-11-17
NO142576C (no) 1980-09-10
BE843970A (fr) 1976-11-03

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