CH622286A5 - - Google Patents

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Publication number
CH622286A5
CH622286A5 CH822475A CH822475A CH622286A5 CH 622286 A5 CH622286 A5 CH 622286A5 CH 822475 A CH822475 A CH 822475A CH 822475 A CH822475 A CH 822475A CH 622286 A5 CH622286 A5 CH 622286A5
Authority
CH
Switzerland
Prior art keywords
group
hcl
thrombin
substrate
arginine
Prior art date
Application number
CH822475A
Other languages
German (de)
English (en)
Inventor
Lars Gundro Svendsen
Original Assignee
Pentapharm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pentapharm Ag filed Critical Pentapharm Ag
Priority to CH822475A priority Critical patent/CH622286A5/de
Priority to IL49774A priority patent/IL49774A/xx
Priority to IT24281/76A priority patent/IT1070002B/it
Priority to AU14952/76A priority patent/AU511716B2/en
Priority to US05/697,550 priority patent/US4070245A/en
Priority to SU762373901A priority patent/SU673165A3/ru
Priority to CA255,304A priority patent/CA1079167A/en
Priority to DK278576A priority patent/DK149333C/da
Priority to DE19762627925 priority patent/DE2627925A1/de
Priority to FR7618995A priority patent/FR2315695A1/fr
Priority to NO762163A priority patent/NO147213C/no
Priority to DE2661080A priority patent/DE2661080C2/de
Priority to BE168177A priority patent/BE843245A/xx
Priority to NLAANVRAGE7606768,A priority patent/NL183038C/xx
Priority to LU75212A priority patent/LU75212A1/xx
Priority to GB25832/76A priority patent/GB1553272A/en
Priority to AT453876A priority patent/AT349154B/de
Priority to SE7607173A priority patent/SE430059B/sv
Priority to JP51074273A priority patent/JPS523494A/ja
Priority to SU772440347A priority patent/SU1099839A3/ru
Publication of CH622286A5 publication Critical patent/CH622286A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
    • C12Q2337/10—Anilides
    • C12Q2337/12—Para-Nitroanilides p-NA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/976—Trypsin; Chymotrypsin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/802—Chromogenic or luminescent peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CH822475A 1975-06-23 1975-06-23 CH622286A5 (sv)

Priority Applications (20)

Application Number Priority Date Filing Date Title
CH822475A CH622286A5 (sv) 1975-06-23 1975-06-23
IL49774A IL49774A (en) 1975-06-23 1976-06-11 Substrate for the quantitative determination of enzymes
IT24281/76A IT1070002B (it) 1975-06-23 1976-06-14 Substrato cromogeno o fluorescente impiegabile come reagente per la determinazione quantitativa di enzimi proteolitici del gruppo e.c. 3.4.4.
AU14952/76A AU511716B2 (en) 1975-06-23 1976-06-16 Substrate for quantitative determination of proteolytic enzymes ofthe classe. C. 3. 4. 4
US05/697,550 US4070245A (en) 1975-06-23 1976-06-18 Substrate for the quantitative determination of proteolytic enzymes
SU762373901A SU673165A3 (ru) 1975-06-23 1976-06-21 Способ получени пептидов
CA255,304A CA1079167A (en) 1975-06-23 1976-06-21 Substrate for the quantitative determination of enzymes
DK278576A DK149333C (da) 1975-06-23 1976-06-22 Tripeptidderivater samt salte deraf med mineralsyrer eller organiske syrer til anvendelse som substrater til kvantitativ bestemmelse af thrombin og thrombinlignende enzymer, ecarinthrombin, plasmin og plasminlignende enzymer samt proenzymer, proenzymaktivatorer og enzyminhibitorer herfor i legemsvaeskerfra mennesker og pattedyr samt i dyriske celleekstrakter
DE19762627925 DE2627925A1 (de) 1975-06-23 1976-06-22 Chromogenes bzw. fluoreszierendes substrat
FR7618995A FR2315695A1 (fr) 1975-06-23 1976-06-22 Substrat chromogene ou fluorescent
NO762163A NO147213C (no) 1975-06-23 1976-06-22 Tripeptider for anvendelse som kromogene h.h.v. fluorescerende substrater ved enzymatiske bestemmelser
DE2661080A DE2661080C2 (sv) 1975-06-23 1976-06-22
BE168177A BE843245A (fr) 1975-06-23 1976-06-22 Substrat chromogene ou fluorescent
NLAANVRAGE7606768,A NL183038C (nl) 1975-06-23 1976-06-22 Werkwijze voor het bereiden van een substraat voor de kwantitatieve bepaling van proteolytische enzymen uit de groep e.c.3.4.21. en werkwijze voor het kwantitatief bepalen van dergelijke enzymen.
LU75212A LU75212A1 (sv) 1975-06-23 1976-06-22
GB25832/76A GB1553272A (en) 1975-06-23 1976-06-22 Substrate for the quantitative determination of enzymes
AT453876A AT349154B (de) 1975-06-23 1976-06-22 Verfahren zur bestimmung von proteolytischen enzymen der gruppe e.c. 3.4.4.
SE7607173A SE430059B (sv) 1975-06-23 1976-06-22 Tripeptidderivat till anvendning som substrat for kvantitativ bestemning av proteolytiska enzymer samt anvendning av nemnda tripeptidderivat
JP51074273A JPS523494A (en) 1975-06-23 1976-06-23 Reagents and method of proteolytic enzyme determination
SU772440347A SU1099839A3 (ru) 1975-06-23 1977-01-21 Способ определени тромбина, плазмина, трипсина и тромбиноподобных ферментов в биологических жидкост х

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH822475A CH622286A5 (sv) 1975-06-23 1975-06-23

Publications (1)

Publication Number Publication Date
CH622286A5 true CH622286A5 (sv) 1981-03-31

Family

ID=4337046

Family Applications (1)

Application Number Title Priority Date Filing Date
CH822475A CH622286A5 (sv) 1975-06-23 1975-06-23

Country Status (18)

Country Link
US (1) US4070245A (sv)
JP (1) JPS523494A (sv)
AT (1) AT349154B (sv)
AU (1) AU511716B2 (sv)
BE (1) BE843245A (sv)
CA (1) CA1079167A (sv)
CH (1) CH622286A5 (sv)
DE (2) DE2627925A1 (sv)
DK (1) DK149333C (sv)
FR (1) FR2315695A1 (sv)
GB (1) GB1553272A (sv)
IL (1) IL49774A (sv)
IT (1) IT1070002B (sv)
LU (1) LU75212A1 (sv)
NL (1) NL183038C (sv)
NO (1) NO147213C (sv)
SE (1) SE430059B (sv)
SU (2) SU673165A3 (sv)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE407571B (sv) * 1975-07-11 1979-04-02 Kabi Ab Nya kromogena enzymsubstrat for serinproteaser
US4169015A (en) * 1975-07-11 1979-09-25 Ab Kabi Novel chromogenic thrombin substrates
US4191808A (en) * 1975-10-30 1980-03-04 Ajinomoto Co., Inc. Method of measuring dipeptidyl-amino-peptidase activity
US4176009A (en) * 1976-01-24 1979-11-27 Ajinomoto Co., Inc. Method of measuring collagenase activity
CH634662A5 (de) * 1976-05-28 1983-02-15 Pentapharm Ag Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren.
US4167449A (en) * 1976-07-29 1979-09-11 American Hospital Supply Corporation Composition and method for determining transferase and protease activity
SE437153B (sv) * 1976-12-01 1985-02-11 Kabi Ab Specifika kromogena enzymsubstrat for serinproteaser
US4191809A (en) * 1977-02-26 1980-03-04 Ajinomoto Co., Inc. Method of measuring enzymatic activity using novel peptide derivatives
CA1087075A (en) * 1977-08-05 1980-10-07 Robert J. Gargiulo Composition and method for determining transferase and protease activity
DE2757992A1 (de) * 1977-12-24 1979-06-28 Boehringer Mannheim Gmbh Verfahren zur prothrombin-bestimmung
SE7801373L (sv) * 1978-02-07 1979-08-08 Kabi Ab Lett spjelkbara substrat for kvantifiering av proteaser
DE2812943C3 (de) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
US4275153A (en) * 1978-08-03 1981-06-23 American Hospital Supply Corporation Analytical fluorogenic substrates for proteolytic enzymes
US4336186A (en) * 1978-08-03 1982-06-22 Gargiulo Robert J Analytical fluorogenic substrates for proteolytic enzymes
US4216142A (en) * 1978-12-18 1980-08-05 Abbott Laboratories Chromogenic substrates for the proteolytic enzymes
US4217269A (en) * 1979-03-23 1980-08-12 Abbott Laboratories Dipeptide chromogenic substrates
US4219497A (en) * 1979-04-06 1980-08-26 Abbott Laboratories Chromogenic substrates
EP0018002B1 (de) * 1979-04-24 1983-02-09 Marcel Jozefonvicz Neues Bestimmungsverfahren für Proteasen und Antiproteasen
US4327178A (en) * 1979-05-01 1982-04-27 University Of Miami Urinary kallikrein assay: specific substrates and assay method
US4221706A (en) * 1979-06-14 1980-09-09 Abbott Laboratories Chromogenic substrates
US4244865A (en) * 1979-12-03 1981-01-13 Abbott Laboratories α hydroxy tripeptide substrates
CA1161432A (en) * 1980-02-12 1984-01-31 Lars G. Svendsen Tripeptide derivatives and their application in assaying enzymes
DE3108322A1 (de) 1980-03-18 1981-12-24 Immuno Aktiengesellschaft für chemisch-medizinische Produkte, 1220 Wien Chromogenes enzymsubstrat
EP0046742B1 (en) * 1980-08-25 1984-06-27 KabiVitrum AB Peptide substrates for determination of protease activity
DE3163764D1 (en) * 1980-10-09 1984-06-28 Boehringer Mannheim Gmbh Method and reagent for the determination of antithrombin-bm
US4563305A (en) * 1981-01-07 1986-01-07 University Of Miami Radiolabelled substrates for assaying mammalian enzymes
DE3113350A1 (de) * 1981-04-02 1982-10-21 Boehringer Mannheim Gmbh, 6800 Mannheim Reagens zur optischen bestimmung des blutgerinnungsverhaltens
US4434096A (en) 1981-06-30 1984-02-28 E. I. Du Pont De Nemours And Company Substrates for the quantitative determination of proteolytic enzymes
JPS5856695A (ja) * 1981-09-28 1983-04-04 Nitto Boseki Co Ltd 新規なトロンビン測定用基質
JPS5863399A (ja) * 1981-10-14 1983-04-15 Nitto Boseki Co Ltd 新規なプラスミン測定用基質
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
DE3211254A1 (de) * 1982-03-26 1983-09-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens
DE3244030A1 (de) * 1982-11-27 1984-05-30 Behringwerke Ag, 3550 Marburg Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
JPS6061557A (ja) * 1983-09-14 1985-04-09 Nitto Boseki Co Ltd アルギニル−ｐ−ニトロアニリド化合物の製造方法
DE3413311A1 (de) * 1984-04-09 1985-10-17 Behringwerke Ag, 3550 Marburg Reagenz zur bestimmung der thromboplastinzeit
US4897444A (en) * 1985-05-31 1990-01-30 The Research Foundation Of The State University Of New York Immobilized fluorogenic substrates for enzymes; and processes for their preparation
JP2516365B2 (ja) * 1987-05-09 1996-07-24 サンスタ−株式会社 歯周疾患検査薬
DE3710937A1 (de) * 1987-04-01 1988-10-13 Boehringer Mannheim Gmbh Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate
JPH01112157A (ja) * 1987-07-10 1989-04-28 Yamanouchi Pharmaceut Co Ltd 組織プラスミノーゲンアクチベーター活性の測定法，測定具及び測定用キット
FR2689640B1 (fr) * 1992-04-06 1997-08-08 Bio Merieux Procede pour la determination d'une activite proteine c et/ou proteine s dans un echantillon plasmatique.
CA2133983C (en) * 1992-04-27 2004-04-06 Stephen E. Zweig Test article and method for performing blood coagulation assays
NL1006429C2 (nl) * 1997-06-27 1998-12-29 Univ Maastricht Werkwijze voor het bepalen van het heparinegehalte.
DE19904674A1 (de) * 1999-02-04 2000-08-31 Haemosys Gmbh Verfahren zur Bestimmung der Konzentration von Thrombininhibitoren
EP1367135A1 (en) * 2002-05-29 2003-12-03 Pentapharm AG Improved method for the assessment of thrombin formation in blood or plasma
EP1802649B1 (en) 2004-10-12 2011-01-19 F. Hoffmann-La Roche AG Solid phase peptide sythesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE380257B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser
SE380258B (sv) * 1972-05-02 1975-11-03 Bofors Ab Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser

Also Published As

Publication number Publication date
US4070245A (en) 1978-01-24
NO147213B (no) 1982-11-15
NL183038B (nl) 1988-02-01
AT349154B (de) 1979-03-26
DK149333C (da) 1986-10-20
IT1070002B (it) 1985-03-25
FR2315695A1 (fr) 1977-01-21
SE7607173L (sv) 1976-12-24
JPS523494A (en) 1977-01-11
SU673165A3 (ru) 1979-07-05
IL49774A (en) 1979-11-30
DK278576A (da) 1976-12-24
DK149333B (da) 1986-05-05
JPS5622519B2 (sv) 1981-05-26
LU75212A1 (sv) 1977-02-17
DE2627925C2 (sv) 1987-07-16
NO147213C (no) 1983-02-23
SU1099839A3 (ru) 1984-06-23
FR2315695B1 (sv) 1980-07-25
IL49774A0 (en) 1976-08-31
DE2627925A1 (de) 1976-12-30
GB1553272A (en) 1979-09-26
NO762163L (sv) 1976-12-27
AU1495276A (en) 1977-12-22
AU511716B2 (en) 1980-09-04
DE2661080C2 (sv) 1990-03-22
NL7606768A (nl) 1976-12-27
CA1079167A (en) 1980-06-10
ATA453876A (de) 1978-08-15
BE843245A (fr) 1976-10-18
NL183038C (nl) 1988-07-01
SE430059B (sv) 1983-10-17

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