NO147213B - Tripeptider for anvendelse som kromogene h.h.v. fluorescerende substrater ved enzymatiske bestemmelser - Google Patents
Tripeptider for anvendelse som kromogene h.h.v. fluorescerende substrater ved enzymatiske bestemmelser Download PDFInfo
- Publication number
- NO147213B NO147213B NO762163A NO762163A NO147213B NO 147213 B NO147213 B NO 147213B NO 762163 A NO762163 A NO 762163A NO 762163 A NO762163 A NO 762163A NO 147213 B NO147213 B NO 147213B
- Authority
- NO
- Norway
- Prior art keywords
- chromogenes
- tripeptides
- fluorescing
- substrates
- locking element
- Prior art date
Links
- 230000002255 enzymatic effect Effects 0.000 title 1
- 239000000758 substrate Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims description 5
- 238000010276 construction Methods 0.000 claims description 3
- 238000003466 welding Methods 0.000 claims description 3
- 238000005452 bending Methods 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/974—Thrombin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/976—Trypsin; Chymotrypsin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/802—Chromogenic or luminescent peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Description
Fremgangsmåte for sammenbinding av takbjelker og åser, samt
låselement for anvendelse ved fremgangsmåten.
Ved jernkonstruksjoner festes åsene
e. 1. elementer vanligvis til hovedbjelken
ved hjelp av gjennomgående bolter eller ved
sveising, hvilket påvirker byggverkets om-kostninger i ugunstig retning.
Foreliggende oppfinnelse har til hen-sikt å tilveiebringe en fremgangsmåte for
sammenbinding av takbjelker og åser, samt
et festeorgan for å feste åsene til takbjelk-ene uten gjennomhulling og bolter eller
sveising. For å oppnå dette festes en rekke
bøyde stenger av ulike lengder til bjelkens
øvre del, slik at stengenes bøyde deler fester
åsen, hvoretter et låselement låser åsen.
De vedlagte tegninger viser festeorgan-ets detaljer: Fig. 1 er en perspektivskisse som viser
den øvre del av en takbjelke 1 som har tre
spor, i hvis midtre spor er fastsveiset en
stang 2 hvis øvre del 3 er bøyd. Denne del
er forbundet med den C-formede del av
åsen 4 ved hjelp av låselementet 5, som er
låst ved hjelp av kilen 11.
Fig. 2 er et tverrsnitt av åsen 4 hvis C-formede del er forbundet med stangen 2
ved hjelp av låselementet 5, som er formet
som en omvendt U og omfatter en åpning 6
hvorigjennom den bøyde stang 3 har fri
passasje, og åsens del 10 låses mellom lås-
elementets del 9 og stangen ved hjelp av kilen 11 som slås inn i" hullet 6.
Fig. 3 er en perspektivskisse som viser det omvendte U-formede låselement 5, i hvis bunn det er anordnet et hull 6, dannet ved oppbøyning av tungen 7.
Claims (2)
1. Fremgangsmåte for sammenbinding av takbjelker og åser ved metallkonstruk-sjoner uten anvendelse av bolter eller sveising, karakterisert ved at stenger av forskjellig lengde med ombøyde ender, hver med sin ene bøyde ende festes i et langsgående spor i bjelkens vertikale steg mens den andre bøyde ende føres gjennom en åpning i et låselement og festes ved hjelp av en kile, under fastlåsing av en ås til denne bøyde ende.
2. Låselement for anvendelse ved fremgangsmåten i henhold til påstand 1, karakterisert ved at det har en omvendt U-form i hvis bunn det er anordnet et hull dannet ved oppbøyning av en tungeformet del.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH822475A CH622286A5 (no) | 1975-06-23 | 1975-06-23 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO762163L NO762163L (no) | 1976-12-27 |
| NO147213B true NO147213B (no) | 1982-11-15 |
| NO147213C NO147213C (no) | 1983-02-23 |
Family
ID=4337046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO762163A NO147213C (no) | 1975-06-23 | 1976-06-22 | Tripeptider for anvendelse som kromogene h.h.v. fluorescerende substrater ved enzymatiske bestemmelser |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4070245A (no) |
| JP (1) | JPS523494A (no) |
| AT (1) | AT349154B (no) |
| AU (1) | AU511716B2 (no) |
| BE (1) | BE843245A (no) |
| CA (1) | CA1079167A (no) |
| CH (1) | CH622286A5 (no) |
| DE (2) | DE2661080C2 (no) |
| DK (1) | DK149333C (no) |
| FR (1) | FR2315695A1 (no) |
| GB (1) | GB1553272A (no) |
| IL (1) | IL49774A (no) |
| IT (1) | IT1070002B (no) |
| LU (1) | LU75212A1 (no) |
| NL (1) | NL183038C (no) |
| NO (1) | NO147213C (no) |
| SE (1) | SE430059B (no) |
| SU (2) | SU673165A3 (no) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE407571B (sv) * | 1975-07-11 | 1979-04-02 | Kabi Ab | Nya kromogena enzymsubstrat for serinproteaser |
| US4169015A (en) * | 1975-07-11 | 1979-09-25 | Ab Kabi | Novel chromogenic thrombin substrates |
| US4191808A (en) * | 1975-10-30 | 1980-03-04 | Ajinomoto Co., Inc. | Method of measuring dipeptidyl-amino-peptidase activity |
| US4176009A (en) * | 1976-01-24 | 1979-11-27 | Ajinomoto Co., Inc. | Method of measuring collagenase activity |
| CH634662A5 (de) * | 1976-05-28 | 1983-02-15 | Pentapharm Ag | Verwendung von tripeptidderivaten zur quantitativen bestimmung von plasminogen-aktivatoren. |
| US4167449A (en) * | 1976-07-29 | 1979-09-11 | American Hospital Supply Corporation | Composition and method for determining transferase and protease activity |
| SE437153B (sv) * | 1976-12-01 | 1985-02-11 | Kabi Ab | Specifika kromogena enzymsubstrat for serinproteaser |
| US4191809A (en) * | 1977-02-26 | 1980-03-04 | Ajinomoto Co., Inc. | Method of measuring enzymatic activity using novel peptide derivatives |
| CA1087075A (en) * | 1977-08-05 | 1980-10-07 | Robert J. Gargiulo | Composition and method for determining transferase and protease activity |
| DE2757992A1 (de) * | 1977-12-24 | 1979-06-28 | Boehringer Mannheim Gmbh | Verfahren zur prothrombin-bestimmung |
| SE7801373L (sv) * | 1978-02-07 | 1979-08-08 | Kabi Ab | Lett spjelkbara substrat for kvantifiering av proteaser |
| DE2812943C3 (de) * | 1978-03-23 | 1981-05-14 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma |
| US4275153A (en) * | 1978-08-03 | 1981-06-23 | American Hospital Supply Corporation | Analytical fluorogenic substrates for proteolytic enzymes |
| US4336186A (en) * | 1978-08-03 | 1982-06-22 | Gargiulo Robert J | Analytical fluorogenic substrates for proteolytic enzymes |
| US4216142A (en) * | 1978-12-18 | 1980-08-05 | Abbott Laboratories | Chromogenic substrates for the proteolytic enzymes |
| US4217269A (en) * | 1979-03-23 | 1980-08-12 | Abbott Laboratories | Dipeptide chromogenic substrates |
| US4219497A (en) * | 1979-04-06 | 1980-08-26 | Abbott Laboratories | Chromogenic substrates |
| DE3061860D1 (en) * | 1979-04-24 | 1983-03-17 | Marcel Jozefonvicz | Process for the determination of proteases and antiproteases |
| US4327178A (en) * | 1979-05-01 | 1982-04-27 | University Of Miami | Urinary kallikrein assay: specific substrates and assay method |
| US4221706A (en) * | 1979-06-14 | 1980-09-09 | Abbott Laboratories | Chromogenic substrates |
| US4244865A (en) * | 1979-12-03 | 1981-01-13 | Abbott Laboratories | α hydroxy tripeptide substrates |
| CA1161432A (en) * | 1980-02-12 | 1984-01-31 | Lars G. Svendsen | Tripeptide derivatives and their application in assaying enzymes |
| DE3108322A1 (de) | 1980-03-18 | 1981-12-24 | Immuno Aktiengesellschaft für chemisch-medizinische Produkte, 1220 Wien | Chromogenes enzymsubstrat |
| EP0046742B1 (en) * | 1980-08-25 | 1984-06-27 | KabiVitrum AB | Peptide substrates for determination of protease activity |
| WO1982001377A1 (en) * | 1980-10-09 | 1982-04-29 | Lill Helmut | Method for determining a bm-antithrombin |
| US4563305A (en) * | 1981-01-07 | 1986-01-07 | University Of Miami | Radiolabelled substrates for assaying mammalian enzymes |
| DE3113350A1 (de) * | 1981-04-02 | 1982-10-21 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reagens zur optischen bestimmung des blutgerinnungsverhaltens |
| US4434096A (en) | 1981-06-30 | 1984-02-28 | E. I. Du Pont De Nemours And Company | Substrates for the quantitative determination of proteolytic enzymes |
| JPS5856695A (ja) * | 1981-09-28 | 1983-04-04 | Nitto Boseki Co Ltd | 新規なトロンビン測定用基質 |
| JPS5863399A (ja) * | 1981-10-14 | 1983-04-15 | Nitto Boseki Co Ltd | 新規なプラスミン測定用基質 |
| US4448715A (en) * | 1981-11-02 | 1984-05-15 | University Of Miami | Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein |
| DE3211254A1 (de) * | 1982-03-26 | 1983-09-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens |
| DE3244030A1 (de) * | 1982-11-27 | 1984-05-30 | Behringwerke Ag, 3550 Marburg | Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung |
| JPS6061557A (ja) * | 1983-09-14 | 1985-04-09 | Nitto Boseki Co Ltd | アルギニル−ｐ−ニトロアニリド化合物の製造方法 |
| DE3413311A1 (de) * | 1984-04-09 | 1985-10-17 | Behringwerke Ag, 3550 Marburg | Reagenz zur bestimmung der thromboplastinzeit |
| US4897444A (en) * | 1985-05-31 | 1990-01-30 | The Research Foundation Of The State University Of New York | Immobilized fluorogenic substrates for enzymes; and processes for their preparation |
| JP2516365B2 (ja) * | 1987-05-09 | 1996-07-24 | サンスタ−株式会社 | 歯周疾患検査薬 |
| DE3710937A1 (de) * | 1987-04-01 | 1988-10-13 | Boehringer Mannheim Gmbh | Chromogene verbindungen, ihre herstellung und verwendung als enzymsubstrate |
| JPH01112157A (ja) * | 1987-07-10 | 1989-04-28 | Yamanouchi Pharmaceut Co Ltd | 組織プラスミノーゲンアクチベーター活性の測定法，測定具及び測定用キット |
| FR2689640B1 (fr) * | 1992-04-06 | 1997-08-08 | Bio Merieux | Procede pour la determination d'une activite proteine c et/ou proteine s dans un echantillon plasmatique. |
| DE69329280T2 (de) * | 1992-04-27 | 2001-03-15 | Avocet Medical, Inc. | Testvorrichtung und verfahren zur durchführung von blutgerinnungstests |
| NL1006429C2 (nl) * | 1997-06-27 | 1998-12-29 | Univ Maastricht | Werkwijze voor het bepalen van het heparinegehalte. |
| DE19904674A1 (de) | 1999-02-04 | 2000-08-31 | Haemosys Gmbh | Verfahren zur Bestimmung der Konzentration von Thrombininhibitoren |
| EP1367135A1 (en) * | 2002-05-29 | 2003-12-03 | Pentapharm AG | Improved method for the assessment of thrombin formation in blood or plasma |
| ES2359252T3 (es) * | 2004-10-12 | 2011-05-19 | F. Hoffmann-La Roche Ag | Síntesis de péptidos en fase sólida. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE380258B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trypsin och andra enzymer av typen peptidyl-peptid-hydrolaser |
| SE380257B (sv) * | 1972-05-02 | 1975-11-03 | Bofors Ab | Nya diagnostiskt verksamma substrat med hog specificitet till trombin och andra proteolytiska enzymer av typen peptidyl-peptid-hydrolaser |
-
1975
- 1975-06-23 CH CH822475A patent/CH622286A5/de not_active IP Right Cessation
-
1976
- 1976-06-11 IL IL49774A patent/IL49774A/xx unknown
- 1976-06-14 IT IT24281/76A patent/IT1070002B/it active
- 1976-06-16 AU AU14952/76A patent/AU511716B2/en not_active Expired
- 1976-06-18 US US05/697,550 patent/US4070245A/en not_active Expired - Lifetime
- 1976-06-21 CA CA255,304A patent/CA1079167A/en not_active Expired
- 1976-06-21 SU SU762373901A patent/SU673165A3/ru active
- 1976-06-22 DE DE2661080A patent/DE2661080C2/de not_active Expired - Lifetime
- 1976-06-22 FR FR7618995A patent/FR2315695A1/fr active Granted
- 1976-06-22 NO NO762163A patent/NO147213C/no unknown
- 1976-06-22 BE BE168177A patent/BE843245A/xx not_active IP Right Cessation
- 1976-06-22 AT AT453876A patent/AT349154B/de not_active IP Right Cessation
- 1976-06-22 SE SE7607173A patent/SE430059B/xx not_active IP Right Cessation
- 1976-06-22 LU LU75212A patent/LU75212A1/xx unknown
- 1976-06-22 NL NLAANVRAGE7606768,A patent/NL183038C/xx not_active IP Right Cessation
- 1976-06-22 GB GB25832/76A patent/GB1553272A/en not_active Expired
- 1976-06-22 DK DK278576A patent/DK149333C/da not_active IP Right Cessation
- 1976-06-22 DE DE19762627925 patent/DE2627925A1/de active Granted
- 1976-06-23 JP JP51074273A patent/JPS523494A/ja active Granted
-
1977
- 1977-01-21 SU SU772440347A patent/SU1099839A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| NL183038C (nl) | 1988-07-01 |
| BE843245A (fr) | 1976-10-18 |
| SU1099839A3 (ru) | 1984-06-23 |
| JPS5622519B2 (no) | 1981-05-26 |
| AT349154B (de) | 1979-03-26 |
| AU1495276A (en) | 1977-12-22 |
| IT1070002B (it) | 1985-03-25 |
| LU75212A1 (no) | 1977-02-17 |
| IL49774A (en) | 1979-11-30 |
| SE7607173L (sv) | 1976-12-24 |
| GB1553272A (en) | 1979-09-26 |
| DE2627925C2 (no) | 1987-07-16 |
| US4070245A (en) | 1978-01-24 |
| NO762163L (no) | 1976-12-27 |
| DE2661080C2 (no) | 1990-03-22 |
| NL183038B (nl) | 1988-02-01 |
| JPS523494A (en) | 1977-01-11 |
| DE2627925A1 (de) | 1976-12-30 |
| CA1079167A (en) | 1980-06-10 |
| DK149333B (da) | 1986-05-05 |
| SU673165A3 (ru) | 1979-07-05 |
| DK278576A (da) | 1976-12-24 |
| DK149333C (da) | 1986-10-20 |
| NL7606768A (nl) | 1976-12-27 |
| SE430059B (sv) | 1983-10-17 |
| FR2315695A1 (fr) | 1977-01-21 |
| CH622286A5 (no) | 1981-03-31 |
| NO147213C (no) | 1983-02-23 |
| AU511716B2 (en) | 1980-09-04 |
| ATA453876A (de) | 1978-08-15 |
| FR2315695B1 (no) | 1980-07-25 |
| IL49774A0 (en) | 1976-08-31 |
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