RU92016490A - Новые 2-сахаринилметил(арил и арокси)ацетаты, применимые в качестве ингибиторов протеолитических ферментов, их композиции и способ их применения - Google Patents
Новые 2-сахаринилметил(арил и арокси)ацетаты, применимые в качестве ингибиторов протеолитических ферментов, их композиции и способ их примененияInfo
- Publication number
- RU92016490A RU92016490A RU92016490/33A RU92016490A RU92016490A RU 92016490 A RU92016490 A RU 92016490A RU 92016490/33 A RU92016490/33 A RU 92016490/33A RU 92016490 A RU92016490 A RU 92016490A RU 92016490 A RU92016490 A RU 92016490A
- Authority
- RU
- Russia
- Prior art keywords
- aryl
- acetates
- applicable
- saharinilmethil
- aroxy
- Prior art date
Links
- 150000001242 acetic acid derivatives Chemical class 0.000 title claims 2
- 101700018994 ARYL Proteins 0.000 title 1
- 102000035443 Peptidases Human genes 0.000 title 1
- 108091005771 Peptidases Proteins 0.000 title 1
- 229940024999 Proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000002253 acid Substances 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
Claims (1)
- 4-R4-R5-2-Сахаринилметил(арил- и арилокси)ацетаты, применимые для лечения перерожденных заболеваний, получают реакцией 4-R4-R5-2-галоидметилсахарин с арил- или арилоксиуксусной кислотой в присутствии акцептора кислоты.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81574091A | 1991-12-30 | 1991-12-30 | |
US815740 | 1991-12-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU92016490A true RU92016490A (ru) | 1995-06-19 |
RU2081871C1 RU2081871C1 (ru) | 1997-06-20 |
Family
ID=25218721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU9292016490A RU2081871C1 (ru) | 1991-12-30 | 1992-12-29 | 2-сахаринилметил(арил или арилокси) ацетаты, или их соли, образованные добавлением кислот к этим соединениям основного характера, или их соли, образованные добавлением оснований к этим соединениям кислотного характера, и фармацевтическая композиция, ингибирующая активность протеолитических ферментов |
Country Status (17)
Country | Link |
---|---|
US (3) | US5385923A (ru) |
EP (1) | EP0550112A1 (ru) |
JP (1) | JPH05255286A (ru) |
AU (1) | AU651746B2 (ru) |
CA (1) | CA2086348A1 (ru) |
CZ (1) | CZ386992A3 (ru) |
FI (1) | FI925946A (ru) |
HU (2) | HUT65736A (ru) |
IL (1) | IL104259A (ru) |
MX (1) | MX9207274A (ru) |
MY (1) | MY108926A (ru) |
NO (1) | NO303446B1 (ru) |
NZ (1) | NZ245586A (ru) |
PH (1) | PH30411A (ru) |
RU (1) | RU2081871C1 (ru) |
SG (1) | SG48025A1 (ru) |
TW (1) | TW226016B (ru) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5380737A (en) * | 1989-05-04 | 1995-01-10 | Sterling Winthrop Inc. | Saccharin derivative proteolytic enzyme inhibitors |
US5306818A (en) * | 1990-11-01 | 1994-04-26 | Sterling Winthrop Inc. | Tetrahydro 2-saccharinylmerthyl aryl carboxylates |
DE19533643A1 (de) * | 1995-09-12 | 1997-03-13 | Nycomed Arzneimittel Gmbh | Neue cyclische Derivate von Benzolsulfonamiden |
DE19748470A1 (de) * | 1997-11-03 | 1999-05-06 | Hoechst Schering Agrevo Gmbh | Carbamoylphenylsulfonylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
US20090053221A1 (en) * | 2006-01-17 | 2009-02-26 | Cheung Nai-Kong V | Immune response enhancing glucan |
HRP20171415T4 (hr) | 2009-06-25 | 2023-03-03 | Alkermes Pharma Ireland Limited | Heterociklični spojevi za liječenje neuroloških i psiholoških poremećaja |
WO2010151711A1 (en) | 2009-06-25 | 2010-12-29 | Alkermes, Inc. | Prodrugs of nh-acidic compounds |
JP6076740B2 (ja) * | 2010-01-07 | 2017-02-08 | アルカーメス ファーマ アイルランド リミテッド | 第四級アンモニウム塩プロドラッグ |
EP2585066B1 (en) | 2010-06-24 | 2018-09-26 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
US9034867B2 (en) | 2011-03-18 | 2015-05-19 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising sorbitan esters |
NZ722096A (en) | 2011-12-15 | 2016-11-25 | Alkermes Pharma Ireland Ltd | Prodrugs of secondary amine compounds |
CA2867137C (en) | 2012-03-19 | 2020-12-08 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising aripiprazole prodrugs and benzyl alcohol |
JP6471089B2 (ja) | 2012-03-19 | 2019-02-13 | アルカームス ファーマ アイルランド リミテッド | 脂肪酸エステルを含む医薬組成物 |
JP6219918B2 (ja) | 2012-03-19 | 2017-10-25 | アルカームス ファーマ アイルランド リミテッド | グリセロールエステルを含む医薬組成物 |
ES2792149T3 (es) | 2012-09-19 | 2020-11-10 | Alkermes Pharma Ireland Ltd | Composiciones farmacéuticas que tienen estabilidad de almacenamiento mejorada |
MX2016008494A (es) | 2013-12-31 | 2016-10-28 | Saint Gobain Abrasives Inc | Articulo abrasivo que incluye partículas abrasivas perfiladas. |
US20150253127A1 (en) * | 2014-03-04 | 2015-09-10 | Honeywell Asca Inc. | Thickness Determination of Web Product by Mid-infrared Wavelength Scanning Interferometry |
MX2016012041A (es) | 2014-03-20 | 2017-01-19 | Alkermes Pharma Ireland Ltd | Formulaciones de aripiprazol que tienen mayores velocidades de inyeccion. |
US10346168B2 (en) | 2015-06-26 | 2019-07-09 | Microsoft Technology Licensing, Llc | Decoupled processor instruction window and operand buffer |
JP7384812B2 (ja) | 2018-03-05 | 2023-11-21 | アルカームス ファーマ アイルランド リミテッド | アリピプラゾール投与戦略 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3002884A (en) * | 1959-04-15 | 1961-10-03 | Rohm & Haas | Horticultural process with n-halomethyl-1,2-benzisothiazolin - 3 - one-1,1-dioxides for controlling fungus diseases |
US3314960A (en) * | 1964-08-25 | 1967-04-18 | American Home Prod | Benzisothiazol glutarimides |
FR1451417A (fr) * | 1965-07-15 | 1966-01-07 | Roussel Uclaf | Nouveaux esters d'acides cycliques et leur procédé de préparation |
JPS4835457A (ru) * | 1971-09-02 | 1973-05-24 | ||
US4195023A (en) * | 1975-08-20 | 1980-03-25 | Merck & Co., Inc. | 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin |
US4276298A (en) * | 1978-03-24 | 1981-06-30 | Merck & Co., Inc. | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
US4263393A (en) * | 1979-09-06 | 1981-04-21 | Eastman Kodak Company | Novel electron donor precursors and photographic element containing them |
US4350752A (en) * | 1980-12-29 | 1982-09-21 | Eastman Kodak Company | Photographic elements and film units containing imidomethyl blocked photographic reagents |
US4363865A (en) * | 1981-03-04 | 1982-12-14 | Eastman Kodak Company | Imido methyl blocked photographic dyes and dye releasing compounds |
US4410618A (en) * | 1982-06-11 | 1983-10-18 | Eastman Kodak Company | Blocked photographic reagents |
US4547371A (en) * | 1983-04-18 | 1985-10-15 | Merck & Co., Inc. | Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents |
US4623645A (en) * | 1983-04-18 | 1986-11-18 | Merck & Co., Inc. | Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents |
US4659855A (en) * | 1983-05-09 | 1987-04-21 | Georgia Tech Research Corporation | Aryl sulfonyl fluoride compounds |
DE3617976A1 (de) * | 1986-05-28 | 1988-01-14 | Alter Sa | 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten |
EP0253029A1 (en) * | 1986-07-10 | 1988-01-20 | Keng-Ben Wang | A distilled drinking water fountain |
ATE159720T1 (de) * | 1989-05-04 | 1997-11-15 | Sanofi Sa | Saccharinderivate zur verwendung als proteolytische enzyminhibitoren sowie verfahren zur herstellung |
US5128339A (en) * | 1990-11-01 | 1992-07-07 | Sterling Winthrop Inc. | Proteolytic enzyme inhibition method |
FR2659327A1 (fr) * | 1990-03-08 | 1991-09-13 | Centre Nat Rech Scient | Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases. |
AU642537B2 (en) * | 1990-11-01 | 1993-10-21 | Sanofi | 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
US5279758A (en) * | 1991-10-22 | 1994-01-18 | The Clorox Company | Thickened aqueous cleaning compositions |
AU656027B2 (en) * | 1991-11-15 | 1995-01-19 | Sanofi | Saccharin derivative proteolytic enzime inhibitors |
AU653279B2 (en) * | 1991-12-30 | 1994-09-22 | Sanofi | Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
JPH07200419A (ja) * | 1993-12-28 | 1995-08-04 | Nec Corp | バスインタフェース装置 |
DE4420271B4 (de) * | 1994-06-10 | 2007-09-27 | Robert Bosch Gmbh | Zündspulensatz für eine Mehrzylinder-Brennkraftmaschine |
-
1992
- 1992-11-20 TW TW081109302A patent/TW226016B/zh active
- 1992-11-27 AU AU29669/92A patent/AU651746B2/en not_active Ceased
- 1992-12-15 MX MX9207274A patent/MX9207274A/es not_active IP Right Cessation
- 1992-12-23 CZ CS923869A patent/CZ386992A3/cs unknown
- 1992-12-23 EP EP92204072A patent/EP0550112A1/en not_active Withdrawn
- 1992-12-23 NZ NZ245586A patent/NZ245586A/en unknown
- 1992-12-23 PH PH45501A patent/PH30411A/en unknown
- 1992-12-23 SG SG1996006248A patent/SG48025A1/en unknown
- 1992-12-28 JP JP4349483A patent/JPH05255286A/ja not_active Withdrawn
- 1992-12-29 CA CA002086348A patent/CA2086348A1/en not_active Abandoned
- 1992-12-29 IL IL104259A patent/IL104259A/xx not_active IP Right Cessation
- 1992-12-29 RU RU9292016490A patent/RU2081871C1/ru active
- 1992-12-30 MY MYPI92002397A patent/MY108926A/en unknown
- 1992-12-30 FI FI925946A patent/FI925946A/fi unknown
- 1992-12-30 HU HU9204166A patent/HUT65736A/hu unknown
- 1992-12-30 NO NO925041A patent/NO303446B1/no unknown
-
1993
- 1993-08-20 US US08/109,849 patent/US5385923A/en not_active Expired - Fee Related
-
1994
- 1994-08-08 US US08/287,372 patent/US5489604A/en not_active Expired - Fee Related
-
1995
- 1995-05-24 US US08/449,641 patent/US5783589A/en not_active Expired - Fee Related
- 1995-06-30 HU HU95P/P00619P patent/HU211625A9/hu unknown
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