ATE454468T1 - Nachweis der instabilität von mikrosatelliten und verwendung davon bei der tumordiagnose - Google Patents

Nachweis der instabilität von mikrosatelliten und verwendung davon bei der tumordiagnose

Info

Publication number
ATE454468T1
ATE454468T1 AT02731467T AT02731467T ATE454468T1 AT E454468 T1 ATE454468 T1 AT E454468T1 AT 02731467 T AT02731467 T AT 02731467T AT 02731467 T AT02731467 T AT 02731467T AT E454468 T1 ATE454468 T1 AT E454468T1
Authority
AT
Austria
Prior art keywords
instability
microsatellites
detection
kits
methods
Prior art date
Application number
AT02731467T
Other languages
English (en)
Inventor
Jeffery Bacher
Laura Flanagan
Nadine Nassif
Original Assignee
Promega Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Promega Corp filed Critical Promega Corp
Application granted granted Critical
Publication of ATE454468T1 publication Critical patent/ATE454468T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
AT02731467T 2001-04-24 2002-04-24 Nachweis der instabilität von mikrosatelliten und verwendung davon bei der tumordiagnose ATE454468T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/841,366 US20020058265A1 (en) 2000-09-15 2001-04-24 Detection of microsatellite instability and its use in diagnosis of tumors
PCT/US2002/012779 WO2002086448A2 (en) 2001-04-24 2002-04-24 Detection of microsatellite instability and its use in diagnosis of tumors

Publications (1)

Publication Number Publication Date
ATE454468T1 true ATE454468T1 (de) 2010-01-15

Family

ID=25284685

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02731467T ATE454468T1 (de) 2001-04-24 2002-04-24 Nachweis der instabilität von mikrosatelliten und verwendung davon bei der tumordiagnose

Country Status (8)

Country Link
US (3) US20020058265A1 (de)
EP (1) EP1390538B1 (de)
JP (1) JP2004533241A (de)
AT (1) ATE454468T1 (de)
AU (1) AU2002303444A1 (de)
DE (1) DE60235005D1 (de)
ES (1) ES2338765T3 (de)
WO (1) WO2002086448A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020058265A1 (en) 2000-09-15 2002-05-16 Promega Corporation Detection of microsatellite instability and its use in diagnosis of tumors
US6844152B1 (en) * 2000-09-15 2005-01-18 Promega Corporation Detection of microsatellite instability and its use in diagnosis of tumors
JP2008517601A (ja) * 2004-10-22 2008-05-29 プロメガ コーポレイション 生殖細胞のゲノム不安定性を検出するための方法及びキット
EP1812601A2 (de) 2004-10-22 2007-08-01 Redpath Integrated Pathology, Inc. Dynamische expansion genomischer deletion und formulierung aus molekularmarkerpanels für integrierte molekulare pathologiediagnose und charakterisierung von gewebe, zellflüssigkeit und reinen flüssigproben
JP4713138B2 (ja) * 2004-12-06 2011-06-29 株式会社日立ソリューションズ 遺伝子情報の表示方法及び表示装置及びプログラム
EP2218794A1 (de) * 2009-02-13 2010-08-18 Alphagenics International SA Instabilitätserkennung in Regionen mit genomischem DNA mit einfacher Tandemwiederholung
US20100317534A1 (en) * 2009-06-12 2010-12-16 Board Of Regents, The University Of Texas System Global germ line and tumor microsatellite patterns are cancer biomarkers
FR2960552B1 (fr) * 2010-06-01 2015-08-07 Ct Europ D Expertise Et De Rech Sur Les Agents Microbiens Ceeram Procede de genotypage de legionella pneumophila
FR2960553B1 (fr) * 2010-06-01 2014-09-05 Ct Europ D Expertise Et De Rech Sur Les Agents Microbiens Ceeram Procede de genotypage de staphylococcus aureus
US20120238464A1 (en) * 2011-03-18 2012-09-20 Baylor Research Institute Biomarkers for Predicting the Recurrence of Colorectal Cancer Metastasis
EP2744916A4 (de) 2011-07-13 2015-06-17 Primeradx Inc Multimodale verfahren zur simultanen erkennung und quantifizierung mehrerer nukleinsäuren in einer probe
JP5895290B2 (ja) * 2011-08-15 2016-03-30 有限会社カホテクノ 非ヒト被験体から取得した乳腺腫瘍サンプルが悪性腫瘍である可能性を診断する方法、システムおよびキット
US9341628B2 (en) 2012-11-30 2016-05-17 Interpace Diagnostics Corporation Methods for measuring carcinoembryonic antigen
WO2014099979A2 (en) * 2012-12-17 2014-06-26 Virginia Tech Intellectual Properties, Inc. Methods and compositions for identifying global microsatellite instability and for characterizing informative microsatellite loci
CN106701978A (zh) * 2017-01-24 2017-05-24 厦门艾德生物医药科技股份有限公司 一种人类微卫星不稳定性msi检测扩增引物组合物及试剂盒
CA3056896A1 (en) * 2017-03-20 2018-09-27 Caris Mpi, Inc. Genomic stability profiling
WO2018237088A1 (en) 2017-06-20 2018-12-27 Bio-Rad Laboratories, Inc. DIGITAL AMPLIFICATION ASSAYS FOR GENETIC INSTABILITY
US11773449B2 (en) 2017-09-01 2023-10-03 The Hospital For Sick Children Profiling and treatment of hypermutant cancer
US20200332367A1 (en) * 2017-10-19 2020-10-22 Nantomics MSI From Liquid Biopsies
CN108841960B (zh) * 2018-07-12 2022-02-01 吉林大学 一种结肠腺癌易感性预测试剂盒及系统
CN108676891B (zh) * 2018-07-12 2022-02-01 吉林大学 一种直肠腺癌易感性预测试剂盒及系统
CN108866188B (zh) * 2018-07-12 2022-03-01 吉林大学 一种消化道恶性肿瘤易感性预测试剂盒及系统
EP3739064A1 (de) 2019-05-15 2020-11-18 Biotype GmbH Vergleichende analyse von mikrosatelliten mittels kapillarelektrophorese (ce) -dna-profile
US20210147946A1 (en) * 2019-11-08 2021-05-20 Life Technologies Corporation Systems and assays for assessing microsatellite instability
US20210139950A1 (en) * 2019-11-08 2021-05-13 Life Technologies Corporation Microsatellite instability measurement
CN114761580A (zh) * 2019-11-08 2022-07-15 生命技术公司 用于评估微卫星不稳定性的系统和测定
CN110951851A (zh) * 2019-12-24 2020-04-03 北京优迅医学检验实验室有限公司 用于微卫星不稳定检测的引物组和方法
CN111763739B (zh) * 2020-08-11 2022-08-23 郑州科蒂亚生物技术有限公司 一种肿瘤微卫星不稳定检测引物及其应用和试剂盒

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
JP2527340B2 (ja) 1986-12-15 1996-08-21 アプライド バイオシステムズ インコーポレイテッド ロ―ダミン染料の５−及び６−スクシニミジルカルボキシレ―ト異性体
US5075217A (en) * 1989-04-21 1991-12-24 Marshfield Clinic Length polymorphisms in (dC-dA)n ·(dG-dT)n sequences
WO1994011531A1 (en) 1992-11-13 1994-05-26 California Institute Of Biological Research Identification of neoplasms by detection of genetic insertions and deletions
WO1994019492A1 (en) * 1993-02-24 1994-09-01 Mayo Foundation For Medical Education And Research Tumor-specific genomic instability as a prognostic indicator
US5492808A (en) * 1993-05-05 1996-02-20 The Johns Hopkins University Means for detecting familial colon cancer (FCC)
US7326778B1 (en) * 1993-05-05 2008-02-05 The John Hopkins University Mutator gene and hereditary non-polyposis colorectal cancer
US5470723A (en) * 1993-05-05 1995-11-28 Becton, Dickinson And Company Detection of mycobacteria by multiplex nucleic acid amplification
US5591826A (en) * 1993-05-05 1997-01-07 The Johns Hopkins University Human MSH2 protein
WO1995015400A1 (en) 1993-12-03 1995-06-08 The Johns Hopkins University Genotyping by simultaneous analysis of multiple microsatellite loci
CH686982A5 (fr) * 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US5922855A (en) * 1993-12-17 1999-07-13 Oregon Health Sciences University Mammalian DNA mismatch repair genes MLH1 and PMS1
CA2198702C (en) * 1994-08-31 2010-11-02 The Johns Hopkins University School Of Medicine Detection of hypermutable nucleic acid sequence in tissue
US5843660A (en) * 1994-09-30 1998-12-01 Promega Corporation Multiplex amplification of short tandem repeat loci
US5569753A (en) * 1994-12-20 1996-10-29 Cold Spring Harbor Laboratory Cancer detection probes
US5866323A (en) * 1995-04-07 1999-02-02 Case Western Reserve University Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors
US5856094A (en) * 1995-05-12 1999-01-05 The Johns Hopkins University School Of Medicine Method of detection of neoplastic cells
US5776682A (en) * 1995-06-07 1998-07-07 Promega Corporation Male infertility y-deletion detection battery
US5840549A (en) * 1995-06-07 1998-11-24 Promega Corporation Male infertility Y-deletion detection battery
US5783390A (en) * 1995-06-07 1998-07-21 Promega Corporation Male infertility Y-deletion detection battery
US5843757A (en) * 1995-08-24 1998-12-01 The Johns Hopkins University Human JTV1 gene overlaps PMS2 gene
US5874217A (en) * 1996-03-27 1999-02-23 The Perkin-Elmer Corporation Microsatellite sequences for canine genotyping
US5645995A (en) * 1996-04-12 1997-07-08 Baylor College Of Medicine Methods for diagnosing an increased risk for breast or ovarian cancer
CA2410120A1 (en) 1996-08-28 1998-03-05 The Johns Hopkins University School Of Medicine Method for detecting cell proliferative disorders
US5912147A (en) * 1996-10-22 1999-06-15 Health Research, Inc. Rapid means of quantitating genomic instability
DE19712332A1 (de) 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Verfahren zum Nachweis von Mikrosatelliten-Instabilität zur Tumordiagnostik
US6090558A (en) * 1997-09-19 2000-07-18 Genetrace Systems, Inc. DNA typing by mass spectrometry with polymorphic DNA repeat markers
ES2279582T3 (es) * 1997-09-25 2007-08-16 Biotechnology Research And Development Corporation Mutante de delecion de lkta de p. hemolitica.
US20030049613A1 (en) 1998-08-17 2003-03-13 Manuel Perucho Methods for identifying somatic changes in genomic sequences useful for cancer diagnosis and prognosis
US6280947B1 (en) * 1999-08-11 2001-08-28 Exact Sciences Corporation Methods for detecting nucleotide insertion or deletion using primer extension
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US6531282B1 (en) * 2000-05-30 2003-03-11 Oligotrail, Llc Multiplex amplification and analysis of selected STR loci
US20020058265A1 (en) 2000-09-15 2002-05-16 Promega Corporation Detection of microsatellite instability and its use in diagnosis of tumors
US6844152B1 (en) * 2000-09-15 2005-01-18 Promega Corporation Detection of microsatellite instability and its use in diagnosis of tumors

Also Published As

Publication number Publication date
US20020058265A1 (en) 2002-05-16
WO2002086448B1 (en) 2003-12-11
DE60235005D1 (de) 2010-02-25
WO2002086448A3 (en) 2003-11-13
JP2004533241A (ja) 2004-11-04
EP1390538A4 (de) 2005-08-03
US20030180758A1 (en) 2003-09-25
ES2338765T3 (es) 2010-05-12
EP1390538B1 (de) 2010-01-06
US7749706B2 (en) 2010-07-06
US7202031B2 (en) 2007-04-10
EP1390538A2 (de) 2004-02-25
WO2002086448A2 (en) 2002-10-31
AU2002303444A1 (en) 2002-11-05
US20070117136A1 (en) 2007-05-24

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