AU2864100A - Methods of identifying therapeutically effective antineoplastic agents with cultured cells having intact cell membranes and corresponding products - Google Patents
Methods of identifying therapeutically effective antineoplastic agents with cultured cells having intact cell membranes and corresponding productsInfo
- Publication number
- AU2864100A AU2864100A AU28641/00A AU2864100A AU2864100A AU 2864100 A AU2864100 A AU 2864100A AU 28641/00 A AU28641/00 A AU 28641/00A AU 2864100 A AU2864100 A AU 2864100A AU 2864100 A AU2864100 A AU 2864100A
- Authority
- AU
- Australia
- Prior art keywords
- methods
- therapeutically effective
- cultured cells
- cell membranes
- antineoplastic agents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940034982 antineoplastic agent Drugs 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 210000000170 cell membrane Anatomy 0.000 title 1
- 210000004748 cultured cell Anatomy 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11810299P | 1999-02-01 | 1999-02-01 | |
US60118102 | 1999-02-01 | ||
US45459599A | 1999-12-07 | 1999-12-07 | |
US09454595 | 1999-12-07 | ||
PCT/US2000/002329 WO2000045165A1 (en) | 1999-02-01 | 2000-02-01 | Methods of identifying therapeutically effective antineoplastic agents with cultured cells having intact cell membranes and corresponding products |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2864100A true AU2864100A (en) | 2000-08-18 |
Family
ID=26815975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU28641/00A Abandoned AU2864100A (en) | 1999-02-01 | 2000-02-01 | Methods of identifying therapeutically effective antineoplastic agents with cultured cells having intact cell membranes and corresponding products |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1151295A4 (en) |
AU (1) | AU2864100A (en) |
WO (1) | WO2000045165A1 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6342611B1 (en) | 1997-10-10 | 2002-01-29 | Cytovia, Inc. | Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof |
DE69920473T2 (en) | 1998-07-21 | 2006-02-23 | Cytovia, Inc., San Diego | NEW FLUORESCENCE DYES AND THEIR APPLICATION IN FLUORESCENCE DETECTION METHODS OF FULL CELLS FOR CASAS, PEPTIDASES, PROTEASES AND OTHER ENZYMES AND THEIR USE |
WO2002012545A2 (en) | 2000-08-03 | 2002-02-14 | Cytovia, Inc. | Method of identifying immunosuppressive agents |
KR100545930B1 (en) * | 2001-05-11 | 2006-01-25 | 우석대학교 산학협력단 | Pharmaceutical compositions comprising cellidonin or derivatives thereof |
US7253206B2 (en) | 2002-02-18 | 2007-08-07 | Sanofi-Aventis Deutschland Gmbh | Phenalenone derivatives, processes for preparation and use thereof |
DE10206849A1 (en) * | 2002-02-18 | 2005-07-28 | Aventis Pharma Deutschland Gmbh | Phenalenone derivatives, process for making and using same |
US8053477B2 (en) * | 2002-03-29 | 2011-11-08 | University Of Maryland, Baltimore | Inhibitors of the S100-p53 protein-protein interaction and method of inhibiting cancer employing the same |
WO2004002428A2 (en) * | 2002-07-01 | 2004-01-08 | Cytovia, Inc. | Derivatives of gambogic acid and induce apoptosis |
AU2003284081A1 (en) * | 2002-10-11 | 2004-05-04 | Board Of Regents, The University Of Texas System | Deguelin as a chemopreventive agent for lung cancer |
EP1789090A2 (en) * | 2004-09-02 | 2007-05-30 | Bionaut Pharmaceuticals, Inc. | Combinatorial chemotherapy treatment using na+/k+-atpase inhibitors |
WO2006028969A1 (en) * | 2004-09-02 | 2006-03-16 | Bionaut Pharmaceuticals, Inc. | Pancreatic cancer treatment using na+/k+ atpase inhibitors |
EP1655027A1 (en) * | 2004-11-04 | 2006-05-10 | Biofrontera Pharmaceuticals GmbH | 9-(N-methyl-piperidyliden-4)-thioxanthene for treatment of pulmonary hypertension and migraine |
JP2009274956A (en) * | 2006-08-28 | 2009-11-26 | Univ Nihon | Malignant tumor-treating agent originated from neem seed |
US20100305068A1 (en) * | 2006-11-09 | 2010-12-02 | Foldrx Pharmaceuticals, Inc. | Compounds and methods for modulating protein trafficking |
JP2008222603A (en) * | 2007-03-09 | 2008-09-25 | Institute Of Physical & Chemical Research | Preventive and therapeutic agent of neurodegenerative disease |
EP2139325B1 (en) * | 2007-04-13 | 2015-01-14 | Southern Research Institute | Bithionol as anti-angiogenic agent |
WO2010027818A2 (en) * | 2008-08-25 | 2010-03-11 | Dana-Farber Cancer Institute, Inc. | Conserved hemagglutinin epitope, antibodies to the epitope, and methods of use |
CN101869574B (en) * | 2010-07-24 | 2011-12-21 | 南京大学 | Application of uabain for enhancing cellular sensitivity of non-small cell lung cancer (NSCLC) |
CN103764659A (en) * | 2011-06-15 | 2014-04-30 | 生命与大脑有限公司 | Glioblastoma inhibiting compounds and their use |
CN102675273A (en) * | 2012-05-03 | 2012-09-19 | 吉林大学 | 3-aryl-8-allyl-7-hydroxy (methoxyl) coumarin and application in preparation of antitumor drugs |
US10976306B2 (en) * | 2015-06-19 | 2021-04-13 | Tokyo University Of Science Foundation | Protein degradation inducing tag and usage thereof |
AU2015101721A4 (en) * | 2015-11-26 | 2016-01-07 | Macau University Of Science And Technology | Prenylated isoflavones for treatment of subjects with multidrug-resistant cancer |
CN107602445B (en) * | 2016-07-12 | 2020-12-01 | 中国科学院上海药物研究所 | Loperamide derivative and application thereof in preparation of medicine for treating mixed lineage leukemia |
KR102600091B1 (en) * | 2016-08-24 | 2023-11-09 | (주)아모레퍼시픽 | Composition for skin-whitening comprising cytochalasin d |
JP7061801B2 (en) | 2016-11-15 | 2022-05-02 | 学校法人東京理科大学 | p53 Degradation Inducing Molecules and Pharmaceutical Compositions |
EP3542824A4 (en) | 2016-11-15 | 2020-11-04 | Tokyo University of Science Foundation | Ras PROTEIN DEGRADATION INDUCING MOLECULE AND PHARMACEUTICAL COMPOSITION |
CN108096246B (en) * | 2017-03-08 | 2020-07-14 | 中国农业科学院饲料研究所 | Application of quercetin and aconitine in preparation of medicine for treating cervical cancer and medicine for treating cervical cancer |
CN107219201B (en) * | 2017-04-20 | 2019-11-12 | 浙江工商大学 | Utilize the immune rear bullfrog antibody of fluorescence microscope citrinin and affine method |
CN112516134B (en) * | 2019-09-18 | 2023-06-06 | 上海医药集团股份有限公司 | Application of hydroxyl-containing compound in preparation of medicines |
WO2021067799A1 (en) * | 2019-10-02 | 2021-04-08 | The General Hospital Corporation | Methods and materials for modulating nrf2 pathway |
CA3154468A1 (en) * | 2019-10-17 | 2021-04-22 | Chengdu Anticancer Bioscience, Ltd. | Benzophenanthridine alkaloids and their methods of use |
CN111317734A (en) * | 2020-03-27 | 2020-06-23 | 广州医科大学附属第二医院 | Wnt signal pathway inhibitor and application |
CN112545979B (en) * | 2021-01-12 | 2022-07-19 | 山西省肿瘤研究所 | Perfusion gel for preventing postoperative recurrence of bladder cancer and preparation method and application thereof |
CN113559110A (en) * | 2021-08-27 | 2021-10-29 | 上海市第一人民医院 | Application of ouabain in preparation of Nrf2 inhibitor and medicine for treating diseases related to abnormal activation of Nrf2 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5821072A (en) * | 1996-02-20 | 1998-10-13 | Sloan-Kettering Institute For Cancer Research | Combinations of PKC inhibitors and therapaeutic agents for treating cancers |
DE69840928D1 (en) * | 1997-05-22 | 2009-08-06 | Burnham Inst | DETECTION METHODS FOR REAGENTS REGULATING THE "INHIBITOR DER APOPTOSIS PROTEIN" (IAP) AND THEREFORE ACTUATING CASPASE ACTIVITY |
US6270980B1 (en) * | 1997-06-05 | 2001-08-07 | Idun Pharmaceuticals, Inc. | Rapid methods for identifying modifiers of cellular apoptosis activity |
-
2000
- 2000-02-01 AU AU28641/00A patent/AU2864100A/en not_active Abandoned
- 2000-02-01 EP EP00907081A patent/EP1151295A4/en not_active Withdrawn
- 2000-02-01 WO PCT/US2000/002329 patent/WO2000045165A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1151295A1 (en) | 2001-11-07 |
EP1151295A4 (en) | 2005-03-30 |
WO2000045165A1 (en) | 2000-08-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |