DE60040397D1 - Substituierte alpha-hydroxy-säuren als caspase-hemmer und ihre verwendung - Google Patents

Substituierte alpha-hydroxy-säuren als caspase-hemmer und ihre verwendung

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Publication number
DE60040397D1
DE60040397D1 DE60040397T DE60040397T DE60040397D1 DE 60040397 D1 DE60040397 D1 DE 60040397D1 DE 60040397 T DE60040397 T DE 60040397T DE 60040397 T DE60040397 T DE 60040397T DE 60040397 D1 DE60040397 D1 DE 60040397D1
Authority
DE
Germany
Prior art keywords
substituted alpha
hydroxy acids
alpha hydroxy
caspase inhibitors
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60040397T
Other languages
English (en)
Inventor
Yan Wang
Sui Xiong Cai
Eckard Weber
Gordon B Mills
Douglas R Green
Lufeng Guan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytovia Therapeutics LLC
Original Assignee
Cytovia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytovia Inc filed Critical Cytovia Inc
Application granted granted Critical
Publication of DE60040397D1 publication Critical patent/DE60040397D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
DE60040397T 1999-08-27 2000-08-28 Substituierte alpha-hydroxy-säuren als caspase-hemmer und ihre verwendung Expired - Fee Related DE60040397D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15107799P 1999-08-27 1999-08-27
US15837399P 1999-10-12 1999-10-12
PCT/US2000/023566 WO2001016093A1 (en) 1999-08-27 2000-08-28 SUBSTITUTED α-HYDROXY ACID CASPASE INHIBITORS AND THE USE THEREOF

Publications (1)

Publication Number Publication Date
DE60040397D1 true DE60040397D1 (de) 2008-11-13

Family

ID=26848309

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60040397T Expired - Fee Related DE60040397D1 (de) 1999-08-27 2000-08-28 Substituierte alpha-hydroxy-säuren als caspase-hemmer und ihre verwendung

Country Status (15)

Country Link
US (1) US6495522B1 (de)
EP (1) EP1212295B1 (de)
JP (1) JP2003508379A (de)
KR (1) KR20020033777A (de)
CN (1) CN1235875C (de)
AT (1) ATE409688T1 (de)
AU (1) AU775291B2 (de)
BR (1) BR0013666A (de)
CA (1) CA2383002A1 (de)
DE (1) DE60040397D1 (de)
EA (1) EA200200301A1 (de)
IL (1) IL148426A0 (de)
MX (1) MXPA02002038A (de)
NO (1) NO20020938L (de)
WO (1) WO2001016093A1 (de)

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AU5116099A (en) * 1998-07-21 2000-02-14 Sui Xiong Cai Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof
DE60030097T2 (de) * 1999-03-16 2007-03-08 Cytovia, Inc., San Diego Substituierte 2-aminobenzamin caspase inhibitoren und ihre verwendung
MXPA01010127A (es) * 1999-04-09 2002-08-20 Cytovia Inc Inhibidores de la caspasa y el uso de los mismos.
CN1994298A (zh) * 2000-03-29 2007-07-11 沃泰克斯药物股份有限公司 氨基甲酸酯天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途
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EP1373515A2 (de) * 2001-03-29 2004-01-02 Nsgene A/S Mittel zur hemmung der proteolyse von parkin
US6777443B2 (en) * 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
US7351702B2 (en) * 2001-05-23 2008-04-01 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
WO2003008373A1 (de) * 2001-07-19 2003-01-30 Merck Patent Gmbh Tyrosinhydrazide
EP1485107A1 (de) 2002-02-11 2004-12-15 Vertex Pharmaceuticals Incorporated Phospholipide als caspase-hemmer-prodrugs
EP1494700A2 (de) * 2002-04-05 2005-01-12 Cytovia, Inc. Caspase-hemmer zur behandlung von erkrankungen und zuständen, die durch kontakt mit radionucliden, biologischen mitteln oder chemischen mitteln verursacht wurden
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CA2524882A1 (en) * 2003-05-06 2004-11-25 Cytovia, Inc. Protease inhibitors for coronaviruses and sars-cov and the use thereof
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JP4848367B2 (ja) 2004-05-15 2011-12-28 バーテックス ファーマシューティカルズ インコーポレイテッド Ｉｃｅインヒビターを使用した発作の処置
EP2295054A1 (de) 2004-05-27 2011-03-16 Vertex Pharmaceuticals Incorporated Ice-hemmer zur Behandlung von autoinflammatorischen Erkrankungen
WO2009076598A1 (en) 2007-12-12 2009-06-18 Children's Hospital & Research Center At Oakland Use of unsaturated sphingosine compounds as chemotherapeutic agents for the treatment of cancer
US8497307B2 (en) * 2008-09-11 2013-07-30 The Regents Of The University Of Michigan Aryl guanidine F1F0-ATPase inhibitors and related methods
HUP1000243A2 (en) 2010-05-06 2012-01-30 Avidin Kft 8-hidroxy-quinoline derivatives
US20140309172A1 (en) 2010-11-05 2014-10-16 Dagmar Ringe Ice inhibiting compounds and uses thereof
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
KR102310615B1 (ko) * 2013-11-21 2021-10-08 알러간, 인코포레이티드 페닐카바메이트 유도체로서의 포밀 펩타이드 수용체 조절제
CN104803864B (zh) * 2014-01-29 2017-01-11 华东师范大学 β-羟基-α-氨基酸衍生物及其合成方法和应用
GB201712282D0 (en) * 2017-07-31 2017-09-13 Nodthera Ltd Selective inhibitors of NLRP3 inflammasome

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Also Published As

Publication number Publication date
JP2003508379A (ja) 2003-03-04
EP1212295A1 (de) 2002-06-12
KR20020033777A (ko) 2002-05-07
BR0013666A (pt) 2002-05-14
US6495522B1 (en) 2002-12-17
CA2383002A1 (en) 2001-03-08
NO20020938L (no) 2002-04-15
ATE409688T1 (de) 2008-10-15
NO20020938D0 (no) 2002-02-26
EA200200301A1 (ru) 2002-08-29
CN1235875C (zh) 2006-01-11
AU775291B2 (en) 2004-07-29
IL148426A0 (en) 2002-09-12
MXPA02002038A (es) 2002-10-31
CN1382119A (zh) 2002-11-27
AU7080900A (en) 2001-03-26
EP1212295B1 (de) 2008-10-01
WO2001016093A1 (en) 2001-03-08

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