DE60008574D1 - Substituierte 4h-chromene und ähnliche verbindungen als kaspasis aktivatoren und apoptosis induktoren und deren verwendung - Google Patents
Substituierte 4h-chromene und ähnliche verbindungen als kaspasis aktivatoren und apoptosis induktoren und deren verwendungInfo
- Publication number
- DE60008574D1 DE60008574D1 DE60008574T DE60008574T DE60008574D1 DE 60008574 D1 DE60008574 D1 DE 60008574D1 DE 60008574 T DE60008574 T DE 60008574T DE 60008574 T DE60008574 T DE 60008574T DE 60008574 D1 DE60008574 D1 DE 60008574D1
- Authority
- DE
- Germany
- Prior art keywords
- activators
- apoptosis
- substituted
- kaspasis
- chromenes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012190 activator Substances 0.000 title abstract 3
- 230000006907 apoptotic process Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 102000011727 Caspases Human genes 0.000 abstract 2
- 108010076667 Caspases Proteins 0.000 abstract 2
- 239000000411 inducer Substances 0.000 abstract 2
- 125000001819 4H-chromenyl group Chemical class O1C(=CCC2=CC=CC=C12)* 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 230000030833 cell death Effects 0.000 abstract 1
- 230000004222 uncontrolled growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16358499P | 1999-11-05 | 1999-11-05 | |
US163584P | 1999-11-05 | ||
US18521100P | 2000-02-24 | 2000-02-24 | |
US185211P | 2000-02-24 | ||
PCT/US2000/030374 WO2001034591A2 (en) | 1999-11-05 | 2000-11-03 | Substituted 4h-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60008574D1 true DE60008574D1 (de) | 2004-04-01 |
DE60008574T2 DE60008574T2 (de) | 2009-10-01 |
Family
ID=26859774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60008574T Expired - Lifetime DE60008574T2 (de) | 1999-11-05 | 2000-11-03 | Substituierte 4H-Chromene und Analoga als Caspase-Aktivatoren und Apoptose-Induktoren und deren Verwendung |
Country Status (13)
Country | Link |
---|---|
US (2) | US6906203B1 (de) |
EP (1) | EP1230232B1 (de) |
JP (1) | JP2003513967A (de) |
AT (1) | ATE260269T1 (de) |
AU (1) | AU781986B2 (de) |
CA (1) | CA2390164C (de) |
DE (1) | DE60008574T2 (de) |
DK (1) | DK1230232T3 (de) |
ES (1) | ES2216987T3 (de) |
PT (1) | PT1230232E (de) |
SI (1) | SI1230232T1 (de) |
TR (1) | TR200401209T4 (de) |
WO (1) | WO2001034591A2 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE260269T1 (de) * | 1999-11-05 | 2004-03-15 | Cytovia Inc | Substituierte 4h-chromene und ähnliche verbindungen als kaspasis aktivatoren und apoptosis induktoren und deren verwendung |
WO2002092083A1 (en) * | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | 7,8-fused 4$i(h)-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US6858607B1 (en) | 2001-05-16 | 2005-02-22 | Cytovia, Inc. | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
ATE450531T1 (de) * | 2001-05-16 | 2009-12-15 | Cytovia Inc | Substituierte 4h-chromene und analoga als aktivatoren von caspasen und induktoren von apoptose, und deren verwendung als antikrebsmittel |
EP1392283A4 (de) * | 2001-05-16 | 2004-10-20 | Cytovia Inc | Substituierte cumarine und chinoline als caspase-aktivatoren |
US20050165053A1 (en) * | 2001-06-04 | 2005-07-28 | Cytovia, Inc. | Substituted4-aryl-3-(3-aryl-1-oxo-2-propenyl)-2(1h)-quinolinones and analogs as activators of caspases and inducers of apoptosis and the use thereof |
JP2005516927A (ja) * | 2001-12-13 | 2005-06-09 | アボット・ラボラトリーズ | 癌治療用のキナーゼ阻害剤としての3−(フェニル−アルコキシ)−5−(フェニル)−ピリジン誘導体および関連化合物 |
US7476741B2 (en) | 2002-05-16 | 2009-01-13 | Cytovia, Inc. | Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
EP1509515A4 (de) * | 2002-05-16 | 2006-07-05 | Cytovia Inc | SUBSTITUIERTE 4-ARYL-4H-PYRROLO ç2,3-H]CHROMENE UND ANALOGA ALS AKTIVATOREN VON CASPASEN UND APOPTOSEINDUKTOREN UND DEREN VERWENDUNG |
WO2004094647A2 (en) | 2003-04-18 | 2004-11-04 | Cytovia, Inc. | Methods of treating diseases responsive to induction of apoptosis and screening assays |
EP1807426A2 (de) * | 2004-10-07 | 2007-07-18 | Cytovia, Inc. | Substituierte n-aryl-1h-pyrazolo[3,4-b]chinolin-4-amine und deren analoge als aktivatoren von caspasen und induktoren von apoptose |
CN101171241A (zh) * | 2005-03-11 | 2008-04-30 | 密执安州立大学董事会 | 抗细胞凋亡的bcl-2家族成员的色烯-4-酮抑制剂及其应用 |
EP2049101A4 (de) | 2006-07-06 | 2010-09-15 | Cytovia Inc | Substituiertes 4-aryl-chromen als caspasen-aktivator, apoptose-induktor und antivaskuläres mittel sowie seine verwendung |
US20080090234A1 (en) * | 2006-10-13 | 2008-04-17 | Kejian Zhang | Diagnostic assay for autoimmune lymphoproliferative syndrome (ALPS) and genetically related disorders |
WO2009065169A1 (en) | 2007-11-19 | 2009-05-28 | Howard Florey Institute | Insulin-regulated aminopeptidase (irap) inhibitors and uses thereof |
US8349864B2 (en) * | 2008-03-25 | 2013-01-08 | New Mexico Technical Research Foundation | Pyrano [3,2-C] pyridones and related heterocyclic compounds as pharmaceutical agents for treating disorders responsive to apoptosis, antiproliferation or vascular disruption, and the use thereof |
ES2331451B1 (es) | 2008-06-30 | 2010-10-21 | Consejo Superior De Investigaciones Cientificas (Csic) | Inmunosupresor basado en la interrupcion de la interaccion tcr-nck. |
WO2010051664A1 (zh) * | 2008-11-05 | 2010-05-14 | 沈阳中海药业有限公司 | 7H-咪唑并[1,2-a]吡喃并[2,3-c]吡啶类衍生物及其应用 |
US9371333B2 (en) | 2010-11-12 | 2016-06-21 | Deutsches Krebsforschungszentrum | Chromene derivatives and their analoga as Wnt pathway antagonists |
AU2012335665A1 (en) * | 2011-11-10 | 2014-07-03 | Memorial Sloan-Kettering Cancer Center | Treatment of ovarian cancer with 2-amino-4H-naphtho[1,2-B]pyran-3-carbonitriles |
ES2534336B1 (es) | 2013-10-18 | 2016-01-28 | Artax Biopharma Inc. | Derivados de cromeno como inhibidores de la interacción TCR-Nck |
ES2534318B1 (es) | 2013-10-18 | 2016-01-28 | Artax Biopharma Inc. | Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck |
CN108191806A (zh) * | 2017-12-29 | 2018-06-22 | 五邑大学 | 一种联苯型4H-苯并[b]吡喃类化合物的合成方法 |
CN108358880A (zh) * | 2017-12-29 | 2018-08-03 | 五邑大学 | 一种4H-苯并[b]吡喃类化合物的合成方法 |
CN117304157A (zh) | 2018-02-27 | 2023-12-29 | 阿塔克斯生物制药有限公司 | 作为tcr-nck相互作用的抑制剂的色烯衍生物 |
RU2674987C1 (ru) * | 2018-04-17 | 2018-12-14 | Акционерное общество "Всесоюзный научный центр по безопасности биологически активных веществ" АО "ВНЦ БАВ" | 2-Аминия-7-(диэтиламино)-4-(4-метоксибензо[d][1,3]диоксол-5-ил)-4Н-хромен-3-карбонитрила N-ацетиламиноэтаноат, проявляющий противоопухолевую активность |
RU2704262C1 (ru) * | 2018-12-27 | 2019-10-25 | Акционерное общество "Всесоюзный научный центр по безопасности биологически активных веществ" АО "ВНЦ БАВ" | Производные 2-аминохроменов проявляющие противоопухолевую активность. Фармацевтические композиции |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8402047D0 (en) * | 1984-01-26 | 1984-02-29 | Fisons Plc | Nitrogen heterocycles |
US5284868A (en) | 1991-10-09 | 1994-02-08 | Eli Lilly And Company | Pharmaceutical compounds |
US5281619A (en) | 1992-09-25 | 1994-01-25 | Eli Lilly And Company | Therapy for diabetic complications |
EP0599514A3 (en) | 1992-11-18 | 1994-07-06 | Lilly Industries Ltd | Pyranoquinoline derivatives as inhibitors of cell proliferation. |
GB9306062D0 (en) | 1993-03-24 | 1993-05-12 | Lilly Industries Ltd | Pharmaceutical compounds |
EP0619314A1 (de) * | 1993-04-09 | 1994-10-12 | Eli Lilly And Company | 4-Phenyl-4H-Naphtho 2,1-b pyran Derivate und ihre Verwendung als Arzneimittel |
US6087160A (en) | 1993-06-24 | 2000-07-11 | The General Hospital Corporation | Programmed cell death genes and proteins |
US5637589A (en) | 1993-10-29 | 1997-06-10 | University Of North Carolina At Chapel Hill | Suksdorfin, analogs, compositions thereof, and methods for making and using thereof |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
PL341661A1 (en) | 1997-10-10 | 2001-04-23 | Cytovia | Novel fluorescent reporter particles and their application in combination with testing capsizes |
AU3653099A (en) | 1998-04-17 | 1999-11-08 | Parker Hughes Institute | Btk inhibitors and methods for their identification and use |
US6303652B1 (en) | 1998-08-21 | 2001-10-16 | Hughes Institute | BTK inhibitors and methods for their identification and use |
US6492389B1 (en) | 1998-07-21 | 2002-12-10 | Thomas Jefferson University | Small molecule inhibitors of BCL-2 proteins |
HUP0105231A3 (en) | 1999-02-11 | 2003-01-28 | Pfizer Prod Inc | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents and medicaments containing the compounds |
ATE260269T1 (de) * | 1999-11-05 | 2004-03-15 | Cytovia Inc | Substituierte 4h-chromene und ähnliche verbindungen als kaspasis aktivatoren und apoptosis induktoren und deren verwendung |
US6858607B1 (en) * | 2001-05-16 | 2005-02-22 | Cytovia, Inc. | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
ATE450531T1 (de) | 2001-05-16 | 2009-12-15 | Cytovia Inc | Substituierte 4h-chromene und analoga als aktivatoren von caspasen und induktoren von apoptose, und deren verwendung als antikrebsmittel |
EP1392283A4 (de) | 2001-05-16 | 2004-10-20 | Cytovia Inc | Substituierte cumarine und chinoline als caspase-aktivatoren |
WO2002092083A1 (en) | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | 7,8-fused 4$i(h)-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US7476741B2 (en) | 2002-05-16 | 2009-01-13 | Cytovia, Inc. | Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
EP1509515A4 (de) | 2002-05-16 | 2006-07-05 | Cytovia Inc | SUBSTITUIERTE 4-ARYL-4H-PYRROLO ç2,3-H]CHROMENE UND ANALOGA ALS AKTIVATOREN VON CASPASEN UND APOPTOSEINDUKTOREN UND DEREN VERWENDUNG |
-
2000
- 2000-11-03 AT AT00976912T patent/ATE260269T1/de not_active IP Right Cessation
- 2000-11-03 AU AU14619/01A patent/AU781986B2/en not_active Ceased
- 2000-11-03 PT PT00976912T patent/PT1230232E/pt unknown
- 2000-11-03 EP EP00976912A patent/EP1230232B1/de not_active Expired - Lifetime
- 2000-11-03 JP JP2001536538A patent/JP2003513967A/ja active Pending
- 2000-11-03 CA CA2390164A patent/CA2390164C/en not_active Expired - Fee Related
- 2000-11-03 DK DK00976912T patent/DK1230232T3/da active
- 2000-11-03 ES ES00976912T patent/ES2216987T3/es not_active Expired - Lifetime
- 2000-11-03 DE DE60008574T patent/DE60008574T2/de not_active Expired - Lifetime
- 2000-11-03 SI SI200030376T patent/SI1230232T1/xx unknown
- 2000-11-03 TR TR2004/01209T patent/TR200401209T4/xx unknown
- 2000-11-03 WO PCT/US2000/030374 patent/WO2001034591A2/en active IP Right Grant
- 2000-11-06 US US09/705,840 patent/US6906203B1/en not_active Expired - Fee Related
-
2005
- 2005-03-07 US US11/072,499 patent/US7507762B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20050154015A1 (en) | 2005-07-14 |
WO2001034591A3 (en) | 2001-09-20 |
ES2216987T3 (es) | 2004-11-01 |
US7507762B2 (en) | 2009-03-24 |
TR200401209T4 (tr) | 2004-07-21 |
EP1230232B1 (de) | 2004-02-25 |
AU781986B2 (en) | 2005-06-23 |
DK1230232T3 (da) | 2004-06-28 |
JP2003513967A (ja) | 2003-04-15 |
WO2001034591A2 (en) | 2001-05-17 |
PT1230232E (pt) | 2004-07-30 |
CA2390164A1 (en) | 2001-05-17 |
US6906203B1 (en) | 2005-06-14 |
EP1230232A2 (de) | 2002-08-14 |
CA2390164C (en) | 2011-03-29 |
SI1230232T1 (en) | 2004-08-31 |
AU1461901A (en) | 2001-06-06 |
ATE260269T1 (de) | 2004-03-15 |
DE60008574T2 (de) | 2009-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |